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4 similar compounds to monomer 50153099

Wt: 401.4
BDBM50153094
Wt: 400.4
BDBM50153095
Wt: 399.4
BDBM50153096
Wt: 438.5
BDBM50153100

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50153094,50153095,50153096,50153100   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM50153096
PNG
(CHEMBL3774922)
Show SMILES CN(CCCc1cnn(c1)-c1nccc2c1nc[nH]c2=O)Cc1ccc(cc1)C#N
Show InChI InChI=1S/C22H21N7O/c1-28(13-17-6-4-16(11-23)5-7-17)10-2-3-18-12-27-29(14-18)21-20-19(8-9-24-21)22(30)26-15-25-20/h4-9,12,14-15H,2-3,10,13H2,1H3,(H,25,26,30)
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n/an/a 48n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of KDM5B (unknown origin) using biotin-H3K4me3 as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins...


J Med Chem 59: 1388-409 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01635
BindingDB Entry DOI: 10.7270/Q2W097TR
More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM50153094
PNG
(CHEMBL3775277)
Show SMILES O=c1[nH]cnc2c(nccc12)-n1cc(CCN2CCC(CC2)c2ccncc2)cn1
Show InChI InChI=1S/C22H23N7O/c30-22-19-3-9-24-21(20(19)25-15-26-22)29-14-16(13-27-29)4-10-28-11-5-18(6-12-28)17-1-7-23-8-2-17/h1-3,7-9,13-15,18H,4-6,10-12H2,(H,25,26,30)
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n/an/a 15n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of KDM5B (unknown origin) using biotin-H3K4me3 as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins...


J Med Chem 59: 1388-409 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01635
BindingDB Entry DOI: 10.7270/Q2W097TR
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A


(Homo sapiens (Human))
BDBM50153096
PNG
(CHEMBL3774922)
Show SMILES CN(CCCc1cnn(c1)-c1nccc2c1nc[nH]c2=O)Cc1ccc(cc1)C#N
Show InChI InChI=1S/C22H21N7O/c1-28(13-17-6-4-16(11-23)5-7-17)10-2-3-18-12-27-29(14-18)21-20-19(8-9-24-21)22(30)26-15-25-20/h4-9,12,14-15H,2-3,10,13H2,1H3,(H,25,26,30)
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n/an/a 880n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal His-tagged KDM4A (1 to 359 residues) expressed in Escherichia coli using biotin-H3K9me3 as substrate preincubated for ...


J Med Chem 59: 1388-409 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01635
BindingDB Entry DOI: 10.7270/Q2W097TR
More data for this
Ligand-Target Pair
Lysine-specific demethylase 5C


(Homo sapiens)
BDBM50153094
PNG
(CHEMBL3775277)
Show SMILES O=c1[nH]cnc2c(nccc12)-n1cc(CCN2CCC(CC2)c2ccncc2)cn1
Show InChI InChI=1S/C22H23N7O/c30-22-19-3-9-24-21(20(19)25-15-26-22)29-14-16(13-27-29)4-10-28-11-5-18(6-12-28)17-1-7-23-8-2-17/h1-3,7-9,13-15,18H,4-6,10-12H2,(H,25,26,30)
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The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of KDM5C (unknown origin) using biotin-H3K4me3 as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins...


J Med Chem 59: 1388-409 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01635
BindingDB Entry DOI: 10.7270/Q2W097TR
More data for this
Ligand-Target Pair
Lysine-specific demethylase 5C


(Homo sapiens)
BDBM50153095
PNG
(CHEMBL3774457)
Show SMILES O=c1[nH]cnc2c(nccc12)-n1cc(CCN2CCC(CC2)c2ccccc2)cn1
Show InChI InChI=1S/C23H24N6O/c30-23-20-6-10-24-22(21(20)25-16-26-23)29-15-17(14-27-29)7-11-28-12-8-19(9-13-28)18-4-2-1-3-5-18/h1-6,10,14-16,19H,7-9,11-13H2,(H,25,26,30)
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n/an/a 142n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of KDM5C (unknown origin) using biotin-H3K4me3 as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins...


J Med Chem 59: 1388-409 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01635
BindingDB Entry DOI: 10.7270/Q2W097TR
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4B


(Homo sapiens)
BDBM50153096
PNG
(CHEMBL3774922)
Show SMILES CN(CCCc1cnn(c1)-c1nccc2c1nc[nH]c2=O)Cc1ccc(cc1)C#N
Show InChI InChI=1S/C22H21N7O/c1-28(13-17-6-4-16(11-23)5-7-17)10-2-3-18-12-27-29(14-18)21-20-19(8-9-24-21)22(30)26-15-25-20/h4-9,12,14-15H,2-3,10,13H2,1H3,(H,25,26,30)
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n/an/a 260n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human N-terminal GST-tagged KDM4B (1 to 500 residues) expressed in baculovirus infected sf9 cells using biotin-H3K9me3 as s...


J Med Chem 59: 1388-409 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01635
BindingDB Entry DOI: 10.7270/Q2W097TR
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4B


(Homo sapiens)
BDBM50153100
PNG
(CHEMBL3774701)
Show SMILES CN(CCc1cnn(c1)-c1nccc2c1nc[nH]c2=O)Cc1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C21H22N6O3S/c1-26(12-15-3-5-17(6-4-15)31(2,29)30)10-8-16-11-25-27(13-16)20-19-18(7-9-22-20)21(28)24-14-23-19/h3-7,9,11,13-14H,8,10,12H2,1-2H3,(H,23,24,28)
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n/an/a 400n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human N-terminal GST-tagged KDM4B (1 to 500 residues) expressed in baculovirus infected sf9 cells using biotin-H3K9me3 as s...


J Med Chem 59: 1388-409 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01635
BindingDB Entry DOI: 10.7270/Q2W097TR
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A


(Homo sapiens (Human))
BDBM50153100
PNG
(CHEMBL3774701)
Show SMILES CN(CCc1cnn(c1)-c1nccc2c1nc[nH]c2=O)Cc1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C21H22N6O3S/c1-26(12-15-3-5-17(6-4-15)31(2,29)30)10-8-16-11-25-27(13-16)20-19-18(7-9-22-20)21(28)24-14-23-19/h3-7,9,11,13-14H,8,10,12H2,1-2H3,(H,23,24,28)
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n/an/a 660n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal His-tagged KDM4A (1 to 359 residues) expressed in Escherichia coli using biotin-H3K9me3 as substrate preincubated for ...


J Med Chem 59: 1388-409 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01635
BindingDB Entry DOI: 10.7270/Q2W097TR
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A


(Homo sapiens (Human))
BDBM50153095
PNG
(CHEMBL3774457)
Show SMILES O=c1[nH]cnc2c(nccc12)-n1cc(CCN2CCC(CC2)c2ccccc2)cn1
Show InChI InChI=1S/C23H24N6O/c30-23-20-6-10-24-22(21(20)25-16-26-23)29-15-17(14-27-29)7-11-28-12-8-19(9-13-28)18-4-2-1-3-5-18/h1-6,10,14-16,19H,7-9,11-13H2,(H,25,26,30)
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n/an/a 456n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal His-tagged KDM4A (1 to 359 residues) expressed in Escherichia coli using biotin-H3K9me3 as substrate preincubated for ...


J Med Chem 59: 1388-409 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01635
BindingDB Entry DOI: 10.7270/Q2W097TR
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A


(Homo sapiens (Human))
BDBM50153094
PNG
(CHEMBL3775277)
Show SMILES O=c1[nH]cnc2c(nccc12)-n1cc(CCN2CCC(CC2)c2ccncc2)cn1
Show InChI InChI=1S/C22H23N7O/c30-22-19-3-9-24-21(20(19)25-15-26-22)29-14-16(13-27-29)4-10-28-11-5-18(6-12-28)17-1-7-23-8-2-17/h1-3,7-9,13-15,18H,4-6,10-12H2,(H,25,26,30)
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n/an/a 145n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal His-tagged KDM4A (1 to 359 residues) expressed in Escherichia coli using biotin-H3K9me3 as substrate preincubated for ...


J Med Chem 59: 1388-409 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01635
BindingDB Entry DOI: 10.7270/Q2W097TR
More data for this
Ligand-Target Pair
Lysine-specific demethylase 5C


(Homo sapiens)
BDBM50153096
PNG
(CHEMBL3774922)
Show SMILES CN(CCCc1cnn(c1)-c1nccc2c1nc[nH]c2=O)Cc1ccc(cc1)C#N
Show InChI InChI=1S/C22H21N7O/c1-28(13-17-6-4-16(11-23)5-7-17)10-2-3-18-12-27-29(14-18)21-20-19(8-9-24-21)22(30)26-15-25-20/h4-9,12,14-15H,2-3,10,13H2,1H3,(H,25,26,30)
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n/an/a 64n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of KDM5C (unknown origin) using biotin-H3K4me3 as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins...


J Med Chem 59: 1388-409 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01635
BindingDB Entry DOI: 10.7270/Q2W097TR
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4B


(Homo sapiens)
BDBM50153095
PNG
(CHEMBL3774457)
Show SMILES O=c1[nH]cnc2c(nccc12)-n1cc(CCN2CCC(CC2)c2ccccc2)cn1
Show InChI InChI=1S/C23H24N6O/c30-23-20-6-10-24-22(21(20)25-16-26-23)29-15-17(14-27-29)7-11-28-12-8-19(9-13-28)18-4-2-1-3-5-18/h1-6,10,14-16,19H,7-9,11-13H2,(H,25,26,30)
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n/an/a 274n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human N-terminal GST-tagged KDM4B (1 to 500 residues) expressed in baculovirus infected sf9 cells using biotin-H3K9me3 as s...


J Med Chem 59: 1388-409 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01635
BindingDB Entry DOI: 10.7270/Q2W097TR
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4B


(Homo sapiens)
BDBM50153094
PNG
(CHEMBL3775277)
Show SMILES O=c1[nH]cnc2c(nccc12)-n1cc(CCN2CCC(CC2)c2ccncc2)cn1
Show InChI InChI=1S/C22H23N7O/c30-22-19-3-9-24-21(20(19)25-15-26-22)29-14-16(13-27-29)4-10-28-11-5-18(6-12-28)17-1-7-23-8-2-17/h1-3,7-9,13-15,18H,4-6,10-12H2,(H,25,26,30)
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n/an/a 55n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human N-terminal GST-tagged KDM4B (1 to 500 residues) expressed in baculovirus infected sf9 cells using biotin-H3K9me3 as s...


J Med Chem 59: 1388-409 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01635
BindingDB Entry DOI: 10.7270/Q2W097TR
More data for this
Ligand-Target Pair
Lysine-specific demethylase 5C


(Homo sapiens)
BDBM50153100
PNG
(CHEMBL3774701)
Show SMILES CN(CCc1cnn(c1)-c1nccc2c1nc[nH]c2=O)Cc1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C21H22N6O3S/c1-26(12-15-3-5-17(6-4-15)31(2,29)30)10-8-16-11-25-27(13-16)20-19-18(7-9-22-20)21(28)24-14-23-19/h3-7,9,11,13-14H,8,10,12H2,1-2H3,(H,23,24,28)
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n/an/a 136n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of KDM5C (unknown origin) using biotin-H3K4me3 as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins...


J Med Chem 59: 1388-409 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01635
BindingDB Entry DOI: 10.7270/Q2W097TR
More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM50153095
PNG
(CHEMBL3774457)
Show SMILES O=c1[nH]cnc2c(nccc12)-n1cc(CCN2CCC(CC2)c2ccccc2)cn1
Show InChI InChI=1S/C23H24N6O/c30-23-20-6-10-24-22(21(20)25-16-26-23)29-15-17(14-27-29)7-11-28-12-8-19(9-13-28)18-4-2-1-3-5-18/h1-6,10,14-16,19H,7-9,11-13H2,(H,25,26,30)
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n/an/a 58n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of KDM5B (unknown origin) using biotin-H3K4me3 as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins...


J Med Chem 59: 1388-409 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01635
BindingDB Entry DOI: 10.7270/Q2W097TR
More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM50153100
PNG
(CHEMBL3774701)
Show SMILES CN(CCc1cnn(c1)-c1nccc2c1nc[nH]c2=O)Cc1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C21H22N6O3S/c1-26(12-15-3-5-17(6-4-15)31(2,29)30)10-8-16-11-25-27(13-16)20-19-18(7-9-22-20)21(28)24-14-23-19/h3-7,9,11,13-14H,8,10,12H2,1-2H3,(H,23,24,28)
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n/an/a 72n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of KDM5B (unknown origin) using biotin-H3K4me3 as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins...


J Med Chem 59: 1388-409 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01635
BindingDB Entry DOI: 10.7270/Q2W097TR
More data for this
Ligand-Target Pair