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5 similar compounds to monomer 50153308

Compile data set for download or QSAR
Wt: 496.5
BDBM50153307
Wt: 475.4
BDBM50153311
Wt: 468.4
BDBM50153312
Wt: 461.5
BDBM50153297
Wt: 482.5
BDBM50153305

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50153307,50153311,50153312,50153297,50153305   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50153312
PNG
(1-[2-Hydroxy-4-methyl-6-(3,4,5-trihydroxy-6-hydrox...)
Show SMILES Cc1cc(O)c(C(=O)CCc2ccc3ccccc3c2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1
Show InChI InChI=1S/C26H28O8/c1-14-10-19(29)22(18(28)9-7-15-6-8-16-4-2-3-5-17(16)12-15)20(11-14)33-26-25(32)24(31)23(30)21(13-27)34-26/h2-6,8,10-12,21,23-27,29-32H,7,9,13H2,1H3/t21-,23-,24+,25-,26-/m1/s1
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10n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2


Bioorg Med Chem Lett 14: 5121-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.082
BindingDB Entry DOI: 10.7270/Q2VD6XX2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50153305
PNG
(1-[4-Ethyl-2-hydroxy-6-(3,4,5-trihydroxy-6-hydroxy...)
Show SMILES CCc1cc(O)c(C(=O)CCc2ccc3ccccc3c2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1
Show InChI InChI=1S/C27H30O8/c1-2-15-12-20(30)23(19(29)10-8-16-7-9-17-5-3-4-6-18(17)11-16)21(13-15)34-27-26(33)25(32)24(31)22(14-28)35-27/h3-7,9,11-13,22,24-28,30-33H,2,8,10,14H2,1H3/t22-,24-,25+,26-,27-/m1/s1
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10n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2


Bioorg Med Chem Lett 14: 5121-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.082
BindingDB Entry DOI: 10.7270/Q2VD6XX2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50153307
PNG
(1-[2-Hydroxy-4-isopropyl-6-(3,4,5-trihydroxy-6-hyd...)
Show SMILES CC(C)c1cc(O)c(C(=O)CCc2ccc3ccccc3c2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1
Show InChI InChI=1S/C28H32O8/c1-15(2)19-12-21(31)24(20(30)10-8-16-7-9-17-5-3-4-6-18(17)11-16)22(13-19)35-28-27(34)26(33)25(32)23(14-29)36-28/h3-7,9,11-13,15,23,25-29,31-34H,8,10,14H2,1-2H3/t23-,25-,26+,27-,28-/m1/s1
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150n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2


Bioorg Med Chem Lett 14: 5121-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.082
BindingDB Entry DOI: 10.7270/Q2VD6XX2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50153311
PNG
(1-[2-Amino-4-methyl-6-(3,4,5-trihydroxy-6-hydroxym...)
Show SMILES Cc1cc(N)c(C(=O)CCc2ccc3OCCOc3c2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1
Show InChI InChI=1S/C24H29NO9/c1-12-8-14(25)20(15(27)4-2-13-3-5-16-17(10-13)32-7-6-31-16)18(9-12)33-24-23(30)22(29)21(28)19(11-26)34-24/h3,5,8-10,19,21-24,26,28-30H,2,4,6-7,11,25H2,1H3/t19-,21-,22+,23-,24-/m1/s1
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290n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2


Bioorg Med Chem Lett 14: 5121-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.082
BindingDB Entry DOI: 10.7270/Q2VD6XX2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50153297
PNG
(1-[2-Amino-4-methyl-6-(3,4,5-trihydroxy-6-hydroxym...)
Show SMILES CCOc1ccc(CCC(=O)c2c(N)cc(C)cc2O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C24H31NO8/c1-3-31-15-7-4-14(5-8-15)6-9-17(27)20-16(25)10-13(2)11-18(20)32-24-23(30)22(29)21(28)19(12-26)33-24/h4-5,7-8,10-11,19,21-24,26,28-30H,3,6,9,12,25H2,1-2H3/t19-,21-,22+,23-,24-/m1/s1
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1.28E+3n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2


Bioorg Med Chem Lett 14: 5121-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.082
BindingDB Entry DOI: 10.7270/Q2VD6XX2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM50153312
PNG
(1-[2-Hydroxy-4-methyl-6-(3,4,5-trihydroxy-6-hydrox...)
Show SMILES Cc1cc(O)c(C(=O)CCc2ccc3ccccc3c2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1
Show InChI InChI=1S/C26H28O8/c1-14-10-19(29)22(18(28)9-7-15-6-8-16-4-2-3-5-17(16)12-15)20(11-14)33-26-25(32)24(31)23(30)21(13-27)34-26/h2-6,8,10-12,21,23-27,29-32H,7,9,13H2,1H3/t21-,23-,24+,25-,26-/m1/s1
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1.32E+3n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 1


Bioorg Med Chem Lett 14: 5121-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.082
BindingDB Entry DOI: 10.7270/Q2VD6XX2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM50153305
PNG
(1-[4-Ethyl-2-hydroxy-6-(3,4,5-trihydroxy-6-hydroxy...)
Show SMILES CCc1cc(O)c(C(=O)CCc2ccc3ccccc3c2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1
Show InChI InChI=1S/C27H30O8/c1-2-15-12-20(30)23(19(29)10-8-16-7-9-17-5-3-4-6-18(17)11-16)21(13-15)34-27-26(33)25(32)24(31)22(14-28)35-27/h3-7,9,11-13,22,24-28,30-33H,2,8,10,14H2,1H3/t22-,24-,25+,26-,27-/m1/s1
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6.50E+3n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 1


Bioorg Med Chem Lett 14: 5121-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.082
BindingDB Entry DOI: 10.7270/Q2VD6XX2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM50153307
PNG
(1-[2-Hydroxy-4-isopropyl-6-(3,4,5-trihydroxy-6-hyd...)
Show SMILES CC(C)c1cc(O)c(C(=O)CCc2ccc3ccccc3c2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1
Show InChI InChI=1S/C28H32O8/c1-15(2)19-12-21(31)24(20(30)10-8-16-7-9-17-5-3-4-6-18(17)11-16)22(13-19)35-28-27(34)26(33)25(32)23(14-29)36-28/h3-7,9,11-13,15,23,25-29,31-34H,8,10,14H2,1-2H3/t23-,25-,26+,27-,28-/m1/s1
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8.59E+3n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 1


Bioorg Med Chem Lett 14: 5121-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.082
BindingDB Entry DOI: 10.7270/Q2VD6XX2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM50153297
PNG
(1-[2-Amino-4-methyl-6-(3,4,5-trihydroxy-6-hydroxym...)
Show SMILES CCOc1ccc(CCC(=O)c2c(N)cc(C)cc2O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C24H31NO8/c1-3-31-15-7-4-14(5-8-15)6-9-17(27)20-16(25)10-13(2)11-18(20)32-24-23(30)22(29)21(28)19(12-26)33-24/h4-5,7-8,10-11,19,21-24,26,28-30H,3,6,9,12,25H2,1-2H3/t19-,21-,22+,23-,24-/m1/s1
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1.35E+4n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 1


Bioorg Med Chem Lett 14: 5121-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.082
BindingDB Entry DOI: 10.7270/Q2VD6XX2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM50153311
PNG
(1-[2-Amino-4-methyl-6-(3,4,5-trihydroxy-6-hydroxym...)
Show SMILES Cc1cc(N)c(C(=O)CCc2ccc3OCCOc3c2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1
Show InChI InChI=1S/C24H29NO9/c1-12-8-14(25)20(15(27)4-2-13-3-5-16-17(10-13)32-7-6-31-16)18(9-12)33-24-23(30)22(29)21(28)19(11-26)34-24/h3,5,8-10,19,21-24,26,28-30H,2,4,6-7,11,25H2,1H3/t19-,21-,22+,23-,24-/m1/s1
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1.62E+4n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 1


Bioorg Med Chem Lett 14: 5121-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.082
BindingDB Entry DOI: 10.7270/Q2VD6XX2
More data for this
Ligand-Target Pair