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25 similar compounds to monomer 50154867

Compile data set for download or QSAR
Wt: 506.5
BDBM50154904
Wt: 455.4
BDBM50154805
Wt: 488.5
BDBM50154860
Wt: 428.4
BDBM50154829
Wt: 494.5
BDBM50154863
Wt: 417.8
BDBM50154807
Wt: 462.5
BDBM50154812
Wt: 500.3
BDBM50154814
Wt: 494.4
BDBM50154815
Wt: 482.3
BDBM50154816
Wt: 505.5
BDBM50154879
Wt: 451.5
BDBM50154880
Wt: 439.5
BDBM50154886
Wt: 460.5
BDBM50154892
Wt: 516.8
BDBM50154839
Displayed 1 to 15 (of 25 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 50154904,50154805,50154860,50154829,50154863,50154807,50154812,50154814,50154815,50154816,50154879,50154880,50154886,50154892,50154839   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50154863
PNG
(CHEMBL3775256)
Show SMILES Cn1c(SCCCN2CC3CCN(C3C2)c2ccc(cc2)C(F)(F)F)nnc1-c1nccs1
Show InChI InChI=1S/C22H25F3N6S2/c1-29-19(20-26-8-12-32-20)27-28-21(29)33-11-2-9-30-13-15-7-10-31(18(15)14-30)17-5-3-16(4-6-17)22(23,24)25/h3-6,8,12,15,18H,2,7,9-11,13-14H2,1H3
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2n/an/an/an/an/an/an/an/a



Aptuit s.r.l

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from human dopamine D3 receptor expressed in CHO-K1 cell membranes after 90 mins by liquid scintillation counter metho...


Bioorg Med Chem 24: 1619-36 (2016)


Article DOI: 10.1016/j.bmc.2016.02.031
BindingDB Entry DOI: 10.7270/Q29P33JV
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50154860
PNG
(CHEMBL3774490)
Show SMILES Cn1c(SCCCN2CC3CCN(C3C2)c2ccc(cc2)C(F)(F)F)nnc1-c1ccncc1
Show InChI InChI=1S/C24H27F3N6S/c1-31-22(17-7-10-28-11-8-17)29-30-23(31)34-14-2-12-32-15-18-9-13-33(21(18)16-32)20-5-3-19(4-6-20)24(25,26)27/h3-8,10-11,18,21H,2,9,12-16H2,1H3
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2n/an/an/an/an/an/an/an/a



Aptuit s.r.l

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from human dopamine D3 receptor expressed in CHO-K1 cell membranes after 90 mins by liquid scintillation counter metho...


Bioorg Med Chem 24: 1619-36 (2016)


Article DOI: 10.1016/j.bmc.2016.02.031
BindingDB Entry DOI: 10.7270/Q29P33JV
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50154892
PNG
(CHEMBL3775967)
Show SMILES Cc1ncoc1-c1nnc(SCCCN2CC3CCN(C3C2)c2c(F)cccc2F)n1C
Show InChI InChI=1S/C22H26F2N6OS/c1-14-20(31-13-25-14)21-26-27-22(28(21)2)32-10-4-8-29-11-15-7-9-30(18(15)12-29)19-16(23)5-3-6-17(19)24/h3,5-6,13,15,18H,4,7-12H2,1-2H3
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2.5n/an/an/an/an/an/an/an/a



Aptuit s.r.l

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from human dopamine D3 receptor expressed in CHO-K1 cell membranes after 90 mins by liquid scintillation counter metho...


Bioorg Med Chem 24: 1619-36 (2016)


Article DOI: 10.1016/j.bmc.2016.02.031
BindingDB Entry DOI: 10.7270/Q29P33JV
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50154904
PNG
(CHEMBL3775961)
Show SMILES Cc1ncoc1-c1nnc(SCCCN2CC3CCCN(C3C2)c2ccc(cc2)C(F)(F)F)n1C
Show InChI InChI=1S/C24H29F3N6OS/c1-16-21(34-15-28-16)22-29-30-23(31(22)2)35-12-4-10-32-13-17-5-3-11-33(20(17)14-32)19-8-6-18(7-9-19)24(25,26)27/h6-9,15,17,20H,3-5,10-14H2,1-2H3
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13n/an/an/an/an/an/an/an/a



Aptuit s.r.l

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from human dopamine D3 receptor expressed in CHO-K1 cell membranes after 90 mins by liquid scintillation counter metho...


Bioorg Med Chem 24: 1619-36 (2016)


Article DOI: 10.1016/j.bmc.2016.02.031
BindingDB Entry DOI: 10.7270/Q29P33JV
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50154886
PNG
(CHEMBL3775294)
Show SMILES Cn1c(SCCCN2CC3CCN(C3C2)c2ccccc2F)nnc1-c1cnccn1
Show InChI InChI=1S/C22H26FN7S/c1-28-21(18-13-24-8-9-25-18)26-27-22(28)31-12-4-10-29-14-16-7-11-30(20(16)15-29)19-6-3-2-5-17(19)23/h2-3,5-6,8-9,13,16,20H,4,7,10-12,14-15H2,1H3
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13n/an/an/an/an/an/an/an/a



Aptuit s.r.l

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from human dopamine D3 receptor expressed in CHO-K1 cell membranes after 90 mins by liquid scintillation counter metho...


Bioorg Med Chem 24: 1619-36 (2016)


Article DOI: 10.1016/j.bmc.2016.02.031
BindingDB Entry DOI: 10.7270/Q29P33JV
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50154879
PNG
(CHEMBL3775386)
Show SMILES Cn1c(SCCCN2CC3CCN(C3C2)c2ccc(OC(F)(F)F)cc2)nnc1-c1cnccn1
Show InChI InChI=1S/C23H26F3N7OS/c1-31-21(19-13-27-8-9-28-19)29-30-22(31)35-12-2-10-32-14-16-7-11-33(20(16)15-32)17-3-5-18(6-4-17)34-23(24,25)26/h3-6,8-9,13,16,20H,2,7,10-12,14-15H2,1H3
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13n/an/an/an/an/an/an/an/a



Aptuit s.r.l

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from human dopamine D3 receptor expressed in CHO-K1 cell membranes after 90 mins by liquid scintillation counter metho...


Bioorg Med Chem 24: 1619-36 (2016)


Article DOI: 10.1016/j.bmc.2016.02.031
BindingDB Entry DOI: 10.7270/Q29P33JV
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50154880
PNG
(CHEMBL3775618)
Show SMILES COc1ccccc1N1CCC2CN(CCCSc3nnc(-c4cnccn4)n3C)CC12
Show InChI InChI=1S/C23H29N7OS/c1-28-22(18-14-24-9-10-25-18)26-27-23(28)32-13-5-11-29-15-17-8-12-30(20(17)16-29)19-6-3-4-7-21(19)31-2/h3-4,6-7,9-10,14,17,20H,5,8,11-13,15-16H2,1-2H3
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16n/an/an/an/an/an/an/an/a



Aptuit s.r.l

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from human dopamine D3 receptor expressed in CHO-K1 cell membranes after 90 mins by liquid scintillation counter metho...


Bioorg Med Chem 24: 1619-36 (2016)


Article DOI: 10.1016/j.bmc.2016.02.031
BindingDB Entry DOI: 10.7270/Q29P33JV
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50154863
PNG
(CHEMBL3775256)
Show SMILES Cn1c(SCCCN2CC3CCN(C3C2)c2ccc(cc2)C(F)(F)F)nnc1-c1nccs1
Show InChI InChI=1S/C22H25F3N6S2/c1-29-19(20-26-8-12-32-20)27-28-21(29)33-11-2-9-30-13-15-7-10-31(18(15)14-30)17-5-3-16(4-6-17)22(23,24)25/h3-6,8,12,15,18H,2,7,9-11,13-14H2,1H3
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158n/an/an/an/an/an/an/an/a



Aptuit s.r.l

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from human dopamine D2 receptor expressed in CHO-K1 cell membranes after 120 mins by liquid scintillation counter meth...


Bioorg Med Chem 24: 1619-36 (2016)


Article DOI: 10.1016/j.bmc.2016.02.031
BindingDB Entry DOI: 10.7270/Q29P33JV
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50154880
PNG
(CHEMBL3775618)
Show SMILES COc1ccccc1N1CCC2CN(CCCSc3nnc(-c4cnccn4)n3C)CC12
Show InChI InChI=1S/C23H29N7OS/c1-28-22(18-14-24-9-10-25-18)26-27-23(28)32-13-5-11-29-15-17-8-12-30(20(17)16-29)19-6-3-4-7-21(19)31-2/h3-4,6-7,9-10,14,17,20H,5,8,11-13,15-16H2,1-2H3
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316n/an/an/an/an/an/an/an/a



Aptuit s.r.l

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from human dopamine D2 receptor expressed in CHO-K1 cell membranes after 120 mins by liquid scintillation counter meth...


Bioorg Med Chem 24: 1619-36 (2016)


Article DOI: 10.1016/j.bmc.2016.02.031
BindingDB Entry DOI: 10.7270/Q29P33JV
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50154879
PNG
(CHEMBL3775386)
Show SMILES Cn1c(SCCCN2CC3CCN(C3C2)c2ccc(OC(F)(F)F)cc2)nnc1-c1cnccn1
Show InChI InChI=1S/C23H26F3N7OS/c1-31-21(19-13-27-8-9-28-19)29-30-22(31)35-12-2-10-32-14-16-7-11-33(20(16)15-32)17-3-5-18(6-4-17)34-23(24,25)26/h3-6,8-9,13,16,20H,2,7,10-12,14-15H2,1H3
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316n/an/an/an/an/an/an/an/a



Aptuit s.r.l

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from human dopamine D2 receptor expressed in CHO-K1 cell membranes after 120 mins by liquid scintillation counter meth...


Bioorg Med Chem 24: 1619-36 (2016)


Article DOI: 10.1016/j.bmc.2016.02.031
BindingDB Entry DOI: 10.7270/Q29P33JV
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50154860
PNG
(CHEMBL3774490)
Show SMILES Cn1c(SCCCN2CC3CCN(C3C2)c2ccc(cc2)C(F)(F)F)nnc1-c1ccncc1
Show InChI InChI=1S/C24H27F3N6S/c1-31-22(17-7-10-28-11-8-17)29-30-23(31)34-14-2-12-32-15-18-9-13-33(21(18)16-32)20-5-3-19(4-6-20)24(25,26)27/h3-8,10-11,18,21H,2,9,12-16H2,1H3
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398n/an/an/an/an/an/an/an/a



Aptuit s.r.l

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from human dopamine D2 receptor expressed in CHO-K1 cell membranes after 120 mins by liquid scintillation counter meth...


Bioorg Med Chem 24: 1619-36 (2016)


Article DOI: 10.1016/j.bmc.2016.02.031
BindingDB Entry DOI: 10.7270/Q29P33JV
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50154886
PNG
(CHEMBL3775294)
Show SMILES Cn1c(SCCCN2CC3CCN(C3C2)c2ccccc2F)nnc1-c1cnccn1
Show InChI InChI=1S/C22H26FN7S/c1-28-21(18-13-24-8-9-25-18)26-27-22(28)31-12-4-10-29-14-16-7-11-30(20(16)15-29)19-6-3-2-5-17(19)23/h2-3,5-6,8-9,13,16,20H,4,7,10-12,14-15H2,1H3
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398n/an/an/an/an/an/an/an/a



Aptuit s.r.l

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from human dopamine D2 receptor expressed in CHO-K1 cell membranes after 120 mins by liquid scintillation counter meth...


Bioorg Med Chem 24: 1619-36 (2016)


Article DOI: 10.1016/j.bmc.2016.02.031
BindingDB Entry DOI: 10.7270/Q29P33JV
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50154892
PNG
(CHEMBL3775967)
Show SMILES Cc1ncoc1-c1nnc(SCCCN2CC3CCN(C3C2)c2c(F)cccc2F)n1C
Show InChI InChI=1S/C22H26F2N6OS/c1-14-20(31-13-25-14)21-26-27-22(28(21)2)32-10-4-8-29-11-15-7-9-30(18(15)12-29)19-16(23)5-3-6-17(19)24/h3,5-6,13,15,18H,4,7-12H2,1-2H3
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501n/an/an/an/an/an/an/an/a



Aptuit s.r.l

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from human dopamine D2 receptor expressed in CHO-K1 cell membranes after 120 mins by liquid scintillation counter meth...


Bioorg Med Chem 24: 1619-36 (2016)


Article DOI: 10.1016/j.bmc.2016.02.031
BindingDB Entry DOI: 10.7270/Q29P33JV
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50154805
PNG
(CHEMBL3775213)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2ccc(F)cc2)c2c(CCCC2=O)n1CC(O)=O
Show InChI InChI=1S/C24H22FNO5S/c1-15-19(24-20(6-4-7-21(24)27)26(15)14-23(28)29)13-16-5-2-3-8-22(16)32(30,31)18-11-9-17(25)10-12-18/h2-3,5,8-12H,4,6-7,13-14H2,1H3,(H,28,29)
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n/an/a 2n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [35S]-GTPgammaS from CRTH2 receptor (unknown origin) expressed in CHOK1 cell membrane after 1 hr by liquid scintillation counter


Eur J Med Chem 113: 102-33 (2016)


Article DOI: 10.1016/j.ejmech.2016.02.023
BindingDB Entry DOI: 10.7270/Q2K64KXM
More data for this
Ligand-Target Pair
1,3-beta-glucan synthase component GLS2


(Saccharomyces cerevisiae)
BDBM50154860
PNG
(CHEMBL3774490)
Show SMILES Cn1c(SCCCN2CC3CCN(C3C2)c2ccc(cc2)C(F)(F)F)nnc1-c1ccncc1
Show InChI InChI=1S/C24H27F3N6S/c1-31-22(17-7-10-28-11-8-17)29-30-23(31)34-14-2-12-32-15-18-9-13-33(21(18)16-32)20-5-3-19(4-6-20)24(25,26)27/h3-8,10-11,18,21H,2,9,12-16H2,1H3
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n/an/a>100n/an/an/an/an/an/a



Aptuit s.r.l

Curated by ChEMBL


Assay Description
Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assay


Bioorg Med Chem 24: 1619-36 (2016)


Article DOI: 10.1016/j.bmc.2016.02.031
BindingDB Entry DOI: 10.7270/Q29P33JV
More data for this
Ligand-Target Pair
1,3-beta-glucan synthase component GLS2


(Saccharomyces cerevisiae)
BDBM50154863
PNG
(CHEMBL3775256)
Show SMILES Cn1c(SCCCN2CC3CCN(C3C2)c2ccc(cc2)C(F)(F)F)nnc1-c1nccs1
Show InChI InChI=1S/C22H25F3N6S2/c1-29-19(20-26-8-12-32-20)27-28-21(29)33-11-2-9-30-13-15-7-10-31(18(15)14-30)17-5-3-16(4-6-17)22(23,24)25/h3-6,8,12,15,18H,2,7,9-11,13-14H2,1H3
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n/an/a>100n/an/an/an/an/an/a



Aptuit s.r.l

Curated by ChEMBL


Assay Description
Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assay


Bioorg Med Chem 24: 1619-36 (2016)


Article DOI: 10.1016/j.bmc.2016.02.031
BindingDB Entry DOI: 10.7270/Q29P33JV
More data for this
Ligand-Target Pair
1,3-beta-glucan synthase component GLS2


(Saccharomyces cerevisiae)
BDBM50154879
PNG
(CHEMBL3775386)
Show SMILES Cn1c(SCCCN2CC3CCN(C3C2)c2ccc(OC(F)(F)F)cc2)nnc1-c1cnccn1
Show InChI InChI=1S/C23H26F3N7OS/c1-31-21(19-13-27-8-9-28-19)29-30-22(31)35-12-2-10-32-14-16-7-11-33(20(16)15-32)17-3-5-18(6-4-17)34-23(24,25)26/h3-6,8-9,13,16,20H,2,7,10-12,14-15H2,1H3
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n/an/a>100n/an/an/an/an/an/a



Aptuit s.r.l

Curated by ChEMBL


Assay Description
Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assay


Bioorg Med Chem 24: 1619-36 (2016)


Article DOI: 10.1016/j.bmc.2016.02.031
BindingDB Entry DOI: 10.7270/Q29P33JV
More data for this
Ligand-Target Pair
1,3-beta-glucan synthase component GLS2


(Saccharomyces cerevisiae)
BDBM50154880
PNG
(CHEMBL3775618)
Show SMILES COc1ccccc1N1CCC2CN(CCCSc3nnc(-c4cnccn4)n3C)CC12
Show InChI InChI=1S/C23H29N7OS/c1-28-22(18-14-24-9-10-25-18)26-27-23(28)32-13-5-11-29-15-17-8-12-30(20(17)16-29)19-6-3-4-7-21(19)31-2/h3-4,6-7,9-10,14,17,20H,5,8,11-13,15-16H2,1-2H3
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n/an/a 2.00E+3n/an/an/an/an/an/a



Aptuit s.r.l

Curated by ChEMBL


Assay Description
Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assay


Bioorg Med Chem 24: 1619-36 (2016)


Article DOI: 10.1016/j.bmc.2016.02.031
BindingDB Entry DOI: 10.7270/Q29P33JV
More data for this
Ligand-Target Pair
1,3-beta-glucan synthase component GLS2


(Saccharomyces cerevisiae)
BDBM50154886
PNG
(CHEMBL3775294)
Show SMILES Cn1c(SCCCN2CC3CCN(C3C2)c2ccccc2F)nnc1-c1cnccn1
Show InChI InChI=1S/C22H26FN7S/c1-28-21(18-13-24-8-9-25-18)26-27-22(28)31-12-4-10-29-14-16-7-11-30(20(16)15-29)19-6-3-2-5-17(19)23/h2-3,5-6,8-9,13,16,20H,4,7,10-12,14-15H2,1H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



Aptuit s.r.l

Curated by ChEMBL


Assay Description
Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assay


Bioorg Med Chem 24: 1619-36 (2016)


Article DOI: 10.1016/j.bmc.2016.02.031
BindingDB Entry DOI: 10.7270/Q29P33JV
More data for this
Ligand-Target Pair
1,3-beta-glucan synthase component GLS2


(Saccharomyces cerevisiae)
BDBM50154892
PNG
(CHEMBL3775967)
Show SMILES Cc1ncoc1-c1nnc(SCCCN2CC3CCN(C3C2)c2c(F)cccc2F)n1C
Show InChI InChI=1S/C22H26F2N6OS/c1-14-20(31-13-25-14)21-26-27-22(28(21)2)32-10-4-8-29-11-15-7-9-30(18(15)12-29)19-16(23)5-3-6-17(19)24/h3,5-6,13,15,18H,4,7-12H2,1-2H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



Aptuit s.r.l

Curated by ChEMBL


Assay Description
Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assay


Bioorg Med Chem 24: 1619-36 (2016)


Article DOI: 10.1016/j.bmc.2016.02.031
BindingDB Entry DOI: 10.7270/Q29P33JV
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50154807
PNG
(CHEMBL3774574)
Show SMILES OC(=O)Cc1cc(Cl)c(=O)n(Cc2ccccc2S(=O)(=O)c2ccccc2)c1
Show InChI InChI=1S/C20H16ClNO5S/c21-17-10-14(11-19(23)24)12-22(20(17)25)13-15-6-4-5-9-18(15)28(26,27)16-7-2-1-3-8-16/h1-10,12H,11,13H2,(H,23,24)
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n/an/a 860n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [35S]-GTPgammaS from CRTH2 receptor (unknown origin) expressed in CHOK1 cell membrane after 1 hr by liquid scintillation counter


Eur J Med Chem 113: 102-33 (2016)


Article DOI: 10.1016/j.ejmech.2016.02.023
BindingDB Entry DOI: 10.7270/Q2K64KXM
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50154812
PNG
(CHEMBL3775461)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2ccccc2)c(=O)n(-c2ccccc2)n1CC(O)=O
Show InChI InChI=1S/C25H22N2O5S/c1-18-22(25(30)27(26(18)17-24(28)29)20-11-4-2-5-12-20)16-19-10-8-9-15-23(19)33(31,32)21-13-6-3-7-14-21/h2-15H,16-17H2,1H3,(H,28,29)
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n/an/a 970n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [35S]-GTPgammaS from CRTH2 receptor (unknown origin) expressed in CHOK1 cell membrane after 1 hr by liquid scintillation counter


Eur J Med Chem 113: 102-33 (2016)


Article DOI: 10.1016/j.ejmech.2016.02.023
BindingDB Entry DOI: 10.7270/Q2K64KXM
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50154814
PNG
(CHEMBL3775648)
Show SMILES Fc1ccc(cc1F)-n1nnc(C(=O)Nc2ccc(Oc3ccnc4[nH]ccc34)cc2)c1C(F)(F)F
Show InChI InChI=1S/C23H13F5N6O2/c24-16-6-3-13(11-17(16)25)34-20(23(26,27)28)19(32-33-34)22(35)31-12-1-4-14(5-2-12)36-18-8-10-30-21-15(18)7-9-29-21/h1-11H,(H,29,30)(H,31,35)
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n/an/a 21n/an/an/an/an/an/a



Jiangxi Science and Technology Normal University

Curated by ChEMBL


Assay Description
Inhibition of cMet (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay


Bioorg Med Chem Lett 26: 1680-4 (2016)


Article DOI: 10.1016/j.bmcl.2016.02.059
BindingDB Entry DOI: 10.7270/Q2FF3V7R
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50154839
PNG
(CHEMBL3775327)
Show SMILES Fc1ccc(cc1Cl)-n1nnc(C(=O)Nc2ccc(Oc3ccnc4[nH]ccc34)cc2)c1C(F)(F)F
Show InChI InChI=1S/C23H13ClF4N6O2/c24-16-11-13(3-6-17(16)25)34-20(23(26,27)28)19(32-33-34)22(35)31-12-1-4-14(5-2-12)36-18-8-10-30-21-15(18)7-9-29-21/h1-11H,(H,29,30)(H,31,35)
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n/an/a 19n/an/an/an/an/an/a



Jiangxi Science and Technology Normal University

Curated by ChEMBL


Assay Description
Inhibition of cMet (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay


Bioorg Med Chem Lett 26: 1680-4 (2016)


Article DOI: 10.1016/j.bmcl.2016.02.059
BindingDB Entry DOI: 10.7270/Q2FF3V7R
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50154815
PNG
(CHEMBL3774679)
Show SMILES COc1ccc(cc1)-n1nnc(C(=O)Nc2ccc(Oc3ccnc4[nH]ccc34)cc2)c1C(F)(F)F
Show InChI InChI=1S/C24H17F3N6O3/c1-35-16-8-4-15(5-9-16)33-21(24(25,26)27)20(31-32-33)23(34)30-14-2-6-17(7-3-14)36-19-11-13-29-22-18(19)10-12-28-22/h2-13H,1H3,(H,28,29)(H,30,34)
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n/an/a 16n/an/an/an/an/an/a



Jiangxi Science and Technology Normal University

Curated by ChEMBL


Assay Description
Inhibition of cMet (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay


Bioorg Med Chem Lett 26: 1680-4 (2016)


Article DOI: 10.1016/j.bmcl.2016.02.059
BindingDB Entry DOI: 10.7270/Q2FF3V7R
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50154816
PNG
(CHEMBL3774862)
Show SMILES Fc1ccc(cc1)-n1nnc(C(=O)Nc2ccc(Oc3ccnc4[nH]ccc34)cc2)c1C(F)(F)F
Show InChI InChI=1S/C23H14F4N6O2/c24-13-1-5-15(6-2-13)33-20(23(25,26)27)19(31-32-33)22(34)30-14-3-7-16(8-4-14)35-18-10-12-29-21-17(18)9-11-28-21/h1-12H,(H,28,29)(H,30,34)
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n/an/a 6.40n/an/an/an/an/an/a



Jiangxi Science and Technology Normal University

Curated by ChEMBL


Assay Description
Inhibition of cMet (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay


Bioorg Med Chem Lett 26: 1680-4 (2016)


Article DOI: 10.1016/j.bmcl.2016.02.059
BindingDB Entry DOI: 10.7270/Q2FF3V7R
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50154829
PNG
(CHEMBL3775300)
Show SMILES Cc1c(nnn1-c1ccc(F)cc1)C(=O)Nc1ccc(Oc2ccnc3[nH]ccc23)cc1
Show InChI InChI=1S/C23H17FN6O2/c1-14-21(28-29-30(14)17-6-2-15(24)3-7-17)23(31)27-16-4-8-18(9-5-16)32-20-11-13-26-22-19(20)10-12-25-22/h2-13H,1H3,(H,25,26)(H,27,31)
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n/an/a 15n/an/an/an/an/an/a



Jiangxi Science and Technology Normal University

Curated by ChEMBL


Assay Description
Inhibition of cMet (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay


Bioorg Med Chem Lett 26: 1680-4 (2016)


Article DOI: 10.1016/j.bmcl.2016.02.059
BindingDB Entry DOI: 10.7270/Q2FF3V7R
More data for this
Ligand-Target Pair