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16 similar compounds to monomer 50158027

Compile data set for download or QSAR
Wt: 406.4
BDBM50158020
Wt: 428.5
BDBM50158021
Wt: 353.4
BDBM50158023
Wt: 418.5
BDBM50158025
Wt: 356.4
BDBM50158026
Wt: 387.8
BDBM50158030
Wt: 371.4
BDBM50158031
Wt: 372.8
BDBM50158032
Wt: 356.4
BDBM50158038
Wt: 352.4
BDBM50158040
Wt: 338.4
BDBM50158041
Wt: 459.5
BDBM50158043
Wt: 388.4
BDBM50158049
Wt: 368.4
BDBM50158050
Wt: 432.3
BDBM50158052
Displayed 1 to 15 (of 16 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 38 hits for monomerid = 50158020,50158021,50158023,50158025,50158026,50158030,50158031,50158032,50158038,50158040,50158041,50158043,50158049,50158050,50158052   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50158032
PNG
(1-(2-Chloro-benzenesulfonyl)-3-(1,2,3,6-tetrahydro...)
Show SMILES Clc1ccccc1S(=O)(=O)n1cc(C2=CCNCC2)c2ccccc12
Show InChI InChI=1S/C19H17ClN2O2S/c20-17-6-2-4-8-19(17)25(23,24)22-13-16(14-9-11-21-12-10-14)15-5-1-3-7-18(15)22/h1-9,13,21H,10-12H2
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0.400n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity against cloned human 5-hydroxytryptamine 6 receptor expressed in HeLa cells using [3H]-LSD


Bioorg Med Chem Lett 15: 379-83 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.064
BindingDB Entry DOI: 10.7270/Q20G3JNQ
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50158031
PNG
(4-[5-Fluoro-3-(1,2,3,6-tetrahydro-pyridin-4-yl)-in...)
Show SMILES Nc1ccc(cc1)S(=O)(=O)n1cc(C2=CCNCC2)c2cc(F)ccc12
Show InChI InChI=1S/C19H18FN3O2S/c20-14-1-6-19-17(11-14)18(13-7-9-22-10-8-13)12-23(19)26(24,25)16-4-2-15(21)3-5-16/h1-7,11-12,22H,8-10,21H2
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1n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity against cloned human 5-hydroxytryptamine 6 receptor expressed in HeLa cells using [3H]-LSD


Bioorg Med Chem Lett 15: 379-83 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.064
BindingDB Entry DOI: 10.7270/Q20G3JNQ
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50158026
PNG
(1-(2-Fluoro-benzenesulfonyl)-3-(1,2,3,6-tetrahydro...)
Show SMILES Fc1ccccc1S(=O)(=O)n1cc(C2=CCNCC2)c2ccccc12
Show InChI InChI=1S/C19H17FN2O2S/c20-17-6-2-4-8-19(17)25(23,24)22-13-16(14-9-11-21-12-10-14)15-5-1-3-7-18(15)22/h1-9,13,21H,10-12H2
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1n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity against cloned human 5-hydroxytryptamine 6 receptor expressed in HeLa cells using [3H]-LSD


Bioorg Med Chem Lett 15: 379-83 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.064
BindingDB Entry DOI: 10.7270/Q20G3JNQ
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50158023
PNG
(4-[3-(1,2,3,6-Tetrahydro-pyridin-4-yl)-indole-1-su...)
Show SMILES Nc1ccc(cc1)S(=O)(=O)n1cc(C2=CCNCC2)c2ccccc12
Show InChI InChI=1S/C19H19N3O2S/c20-15-5-7-16(8-6-15)25(23,24)22-13-18(14-9-11-21-12-10-14)17-3-1-2-4-19(17)22/h1-9,13,21H,10-12,20H2
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2n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity against cloned human 5-hydroxytryptamine 6 receptor expressed in HeLa cells using [3H]-LSD


Bioorg Med Chem Lett 15: 379-83 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.064
BindingDB Entry DOI: 10.7270/Q20G3JNQ
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50158040
PNG
(1-Benzenesulfonyl-3-(1-methyl-1,2,3,6-tetrahydro-p...)
Show SMILES CN1CCC(=CC1)c1cn(c2ccccc12)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C20H20N2O2S/c1-21-13-11-16(12-14-21)19-15-22(20-10-6-5-9-18(19)20)25(23,24)17-7-3-2-4-8-17/h2-11,15H,12-14H2,1H3
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2n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity against cloned human 5-hydroxytryptamine 6 receptor expressed in HeLa cells using [3H]-LSD


Bioorg Med Chem Lett 15: 379-83 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.064
BindingDB Entry DOI: 10.7270/Q20G3JNQ
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50158041
PNG
(1-Benzenesulfonyl-3-(1,2,3,6-tetrahydro-pyridin-4-...)
Show SMILES O=S(=O)(c1ccccc1)n1cc(C2=CCNCC2)c2ccccc12
Show InChI InChI=1S/C19H18N2O2S/c22-24(23,16-6-2-1-3-7-16)21-14-18(15-10-12-20-13-11-15)17-8-4-5-9-19(17)21/h1-10,14,20H,11-13H2
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2n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-hydroxytryptamine 6 receptor expressed in HeLa cells


Bioorg Med Chem Lett 15: 4780-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.07.028
BindingDB Entry DOI: 10.7270/Q2RN37DD
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50158041
PNG
(1-Benzenesulfonyl-3-(1,2,3,6-tetrahydro-pyridin-4-...)
Show SMILES O=S(=O)(c1ccccc1)n1cc(C2=CCNCC2)c2ccccc12
Show InChI InChI=1S/C19H18N2O2S/c22-24(23,16-6-2-1-3-7-16)21-14-18(15-10-12-20-13-11-15)17-8-4-5-9-19(17)21/h1-10,14,20H,11-13H2
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2n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity against cloned human 5-hydroxytryptamine 6 receptor expressed in HeLa cells using [3H]-LSD


Bioorg Med Chem Lett 15: 379-83 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.064
BindingDB Entry DOI: 10.7270/Q20G3JNQ
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50158038
PNG
(1-Benzenesulfonyl-5-fluoro-3-(1,2,3,6-tetrahydro-p...)
Show SMILES Fc1ccc2n(cc(C3=CCNCC3)c2c1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C19H17FN2O2S/c20-15-6-7-19-17(12-15)18(14-8-10-21-11-9-14)13-22(19)25(23,24)16-4-2-1-3-5-16/h1-8,12-13,21H,9-11H2
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2.40n/an/an/an/an/an/an/an/a



Universidad Complutense de Madrid

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in CHO cells


J Med Chem 57: 7160-81 (2014)


Article DOI: 10.1021/jm5003952
BindingDB Entry DOI: 10.7270/Q2X92CZZ
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50158038
PNG
(1-Benzenesulfonyl-5-fluoro-3-(1,2,3,6-tetrahydro-p...)
Show SMILES Fc1ccc2n(cc(C3=CCNCC3)c2c1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C19H17FN2O2S/c20-15-6-7-19-17(12-15)18(14-8-10-21-11-9-14)13-22(19)25(23,24)16-4-2-1-3-5-16/h1-8,12-13,21H,9-11H2
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2.40n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity against cloned human 5-hydroxytryptamine 6 receptor expressed in HeLa cells using [3H]-LSD


Bioorg Med Chem Lett 15: 379-83 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.064
BindingDB Entry DOI: 10.7270/Q20G3JNQ
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50158030
PNG
(4-[6-Chloro-3-(1,2,3,6-tetrahydro-pyridin-4-yl)-in...)
Show SMILES Nc1ccc(cc1)S(=O)(=O)n1cc(C2=CCNCC2)c2ccc(Cl)cc12
Show InChI InChI=1S/C19H18ClN3O2S/c20-14-1-6-17-18(13-7-9-22-10-8-13)12-23(19(17)11-14)26(24,25)16-4-2-15(21)3-5-16/h1-7,11-12,22H,8-10,21H2
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3n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity against cloned human 5-hydroxytryptamine 6 receptor expressed in HeLa cells using [3H]-LSD


Bioorg Med Chem Lett 15: 379-83 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.064
BindingDB Entry DOI: 10.7270/Q20G3JNQ
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50158052
PNG
(4-[5-Bromo-3-(1,2,3,6-tetrahydro-pyridin-4-yl)-ind...)
Show SMILES Nc1ccc(cc1)S(=O)(=O)n1cc(C2=CCNCC2)c2cc(Br)ccc12
Show InChI InChI=1S/C19H18BrN3O2S/c20-14-1-6-19-17(11-14)18(13-7-9-22-10-8-13)12-23(19)26(24,25)16-4-2-15(21)3-5-16/h1-7,11-12,22H,8-10,21H2
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7n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity against cloned human 5-hydroxytryptamine 6 receptor expressed in HeLa cells using [3H]-LSD


Bioorg Med Chem Lett 15: 379-83 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.064
BindingDB Entry DOI: 10.7270/Q20G3JNQ
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50158050
PNG
(1-(4-Methoxy-benzenesulfonyl)-3-(1,2,3,6-tetrahydr...)
Show SMILES COc1ccc(cc1)S(=O)(=O)n1cc(C2=CCNCC2)c2ccccc12
Show InChI InChI=1S/C20H20N2O3S/c1-25-16-6-8-17(9-7-16)26(23,24)22-14-19(15-10-12-21-13-11-15)18-4-2-3-5-20(18)22/h2-10,14,21H,11-13H2,1H3
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18n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity against cloned human 5-hydroxytryptamine 6 receptor expressed in HeLa cells using [3H]-LSD


Bioorg Med Chem Lett 15: 379-83 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.064
BindingDB Entry DOI: 10.7270/Q20G3JNQ
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50158025
PNG
(5-Methoxy-1-(naphthalene-2-sulfonyl)-3-(1,2,3,6-te...)
Show SMILES COc1ccc2n(cc(C3=CCNCC3)c2c1)S(=O)(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C24H22N2O3S/c1-29-20-7-9-24-22(15-20)23(18-10-12-25-13-11-18)16-26(24)30(27,28)21-8-6-17-4-2-3-5-19(17)14-21/h2-10,14-16,25H,11-13H2,1H3
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19n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity against cloned human 5-hydroxytryptamine 6 receptor expressed in HeLa cells using [3H]-LSD


Bioorg Med Chem Lett 15: 379-83 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.064
BindingDB Entry DOI: 10.7270/Q20G3JNQ
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50158020
PNG
(3-(1,2,3,6-Tetrahydro-pyridin-4-yl)-1-(4-trifluoro...)
Show SMILES FC(F)(F)c1ccc(cc1)S(=O)(=O)n1cc(C2=CCNCC2)c2ccccc12
Show InChI InChI=1S/C20H17F3N2O2S/c21-20(22,23)15-5-7-16(8-6-15)28(26,27)25-13-18(14-9-11-24-12-10-14)17-3-1-2-4-19(17)25/h1-9,13,24H,10-12H2
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20n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity against cloned human 5-hydroxytryptamine 6 receptor expressed in HeLa cells using [3H]-LSD


Bioorg Med Chem Lett 15: 379-83 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.064
BindingDB Entry DOI: 10.7270/Q20G3JNQ
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50158049
PNG
(1-(Naphthalene-2-sulfonyl)-3-(1,2,3,6-tetrahydro-p...)
Show SMILES O=S(=O)(c1ccc2ccccc2c1)n1cc(C2=CCNCC2)c2ccccc12
Show InChI InChI=1S/C23H20N2O2S/c26-28(27,20-10-9-17-5-1-2-6-19(17)15-20)25-16-22(18-11-13-24-14-12-18)21-7-3-4-8-23(21)25/h1-11,15-16,24H,12-14H2
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27n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity against cloned human 5-hydroxytryptamine 6 receptor expressed in HeLa cells using [3H]-LSD


Bioorg Med Chem Lett 15: 379-83 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.064
BindingDB Entry DOI: 10.7270/Q20G3JNQ
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50158043
PNG
(4-[5-Benzyloxy-3-(1,2,3,6-tetrahydro-pyridin-4-yl)...)
Show SMILES Nc1ccc(cc1)S(=O)(=O)n1cc(C2=CCNCC2)c2cc(OCc3ccccc3)ccc12
Show InChI InChI=1S/C26H25N3O3S/c27-21-6-9-23(10-7-21)33(30,31)29-17-25(20-12-14-28-15-13-20)24-16-22(8-11-26(24)29)32-18-19-4-2-1-3-5-19/h1-12,16-17,28H,13-15,18,27H2
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50n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity against cloned human 5-hydroxytryptamine 6 receptor expressed in HeLa cells using [3H]-LSD


Bioorg Med Chem Lett 15: 379-83 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.064
BindingDB Entry DOI: 10.7270/Q20G3JNQ
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50158021
PNG
(1-Benzenesulfonyl-3-(1-benzyl-1,2,3,6-tetrahydro-p...)
Show SMILES O=S(=O)(c1ccccc1)n1cc(C2=CCN(Cc3ccccc3)CC2)c2ccccc12
Show InChI InChI=1S/C26H24N2O2S/c29-31(30,23-11-5-2-6-12-23)28-20-25(24-13-7-8-14-26(24)28)22-15-17-27(18-16-22)19-21-9-3-1-4-10-21/h1-15,20H,16-19H2
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246n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity against cloned human 5-hydroxytryptamine 6 receptor expressed in HeLa cells using [3H]-LSD


Bioorg Med Chem Lett 15: 379-83 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.064
BindingDB Entry DOI: 10.7270/Q20G3JNQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50158032
PNG
(1-(2-Chloro-benzenesulfonyl)-3-(1,2,3,6-tetrahydro...)
Show SMILES Clc1ccccc1S(=O)(=O)n1cc(C2=CCNCC2)c2ccccc12
Show InChI InChI=1S/C19H17ClN2O2S/c20-17-6-2-4-8-19(17)25(23,24)22-13-16(14-9-11-21-12-10-14)15-5-1-3-7-18(15)22/h1-9,13,21H,10-12H2
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383n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity against human cloned 5-hydroxytryptamine 2C receptor stably expressed in CHO cells using [3H]-5-HT


Bioorg Med Chem Lett 15: 379-83 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.064
BindingDB Entry DOI: 10.7270/Q20G3JNQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50158032
PNG
(1-(2-Chloro-benzenesulfonyl)-3-(1,2,3,6-tetrahydro...)
Show SMILES Clc1ccccc1S(=O)(=O)n1cc(C2=CCNCC2)c2ccccc12
Show InChI InChI=1S/C19H17ClN2O2S/c20-17-6-2-4-8-19(17)25(23,24)22-13-16(14-9-11-21-12-10-14)15-5-1-3-7-18(15)22/h1-9,13,21H,10-12H2
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599n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity against human cloned 5-hydroxytryptamine 2A receptor stably expressed in CHO cells using [125I]-DOI


Bioorg Med Chem Lett 15: 379-83 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.064
BindingDB Entry DOI: 10.7270/Q20G3JNQ
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50158032
PNG
(1-(2-Chloro-benzenesulfonyl)-3-(1,2,3,6-tetrahydro...)
Show SMILES Clc1ccccc1S(=O)(=O)n1cc(C2=CCNCC2)c2ccccc12
Show InChI InChI=1S/C19H17ClN2O2S/c20-17-6-2-4-8-19(17)25(23,24)22-13-16(14-9-11-21-12-10-14)15-5-1-3-7-18(15)22/h1-9,13,21H,10-12H2
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627n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity against human cloned Dopamine receptor D3 stably expressed in CHO-K1 cells using [3H]-spiperone


Bioorg Med Chem Lett 15: 379-83 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.064
BindingDB Entry DOI: 10.7270/Q20G3JNQ
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50158026
PNG
(1-(2-Fluoro-benzenesulfonyl)-3-(1,2,3,6-tetrahydro...)
Show SMILES Fc1ccccc1S(=O)(=O)n1cc(C2=CCNCC2)c2ccccc12
Show InChI InChI=1S/C19H17FN2O2S/c20-17-6-2-4-8-19(17)25(23,24)22-13-16(14-9-11-21-12-10-14)15-5-1-3-7-18(15)22/h1-9,13,21H,10-12H2
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741n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity against human cloned Dopamine receptor D3 stably expressed in CHO-K1 cells using [3H]-spiperone


Bioorg Med Chem Lett 15: 379-83 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.064
BindingDB Entry DOI: 10.7270/Q20G3JNQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50158026
PNG
(1-(2-Fluoro-benzenesulfonyl)-3-(1,2,3,6-tetrahydro...)
Show SMILES Fc1ccccc1S(=O)(=O)n1cc(C2=CCNCC2)c2ccccc12
Show InChI InChI=1S/C19H17FN2O2S/c20-17-6-2-4-8-19(17)25(23,24)22-13-16(14-9-11-21-12-10-14)15-5-1-3-7-18(15)22/h1-9,13,21H,10-12H2
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875n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity against human cloned 5-hydroxytryptamine 1A receptor stably expressed in CHO cells using [3H]-5-HT


Bioorg Med Chem Lett 15: 379-83 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.064
BindingDB Entry DOI: 10.7270/Q20G3JNQ
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 7 (5-HT7)


(Homo sapiens (Human))
BDBM50158023
PNG
(4-[3-(1,2,3,6-Tetrahydro-pyridin-4-yl)-indole-1-su...)
Show SMILES Nc1ccc(cc1)S(=O)(=O)n1cc(C2=CCNCC2)c2ccccc12
Show InChI InChI=1S/C19H19N3O2S/c20-15-5-7-16(8-6-15)25(23,24)22-13-18(14-9-11-21-12-10-14)17-3-1-2-4-19(17)22/h1-9,13,21H,10-12,20H2
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1.56E+3n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity against human cloned 5-hydroxytryptamine 7 receptor stably expressed in CHO cells using [3H]-LSD


Bioorg Med Chem Lett 15: 379-83 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.064
BindingDB Entry DOI: 10.7270/Q20G3JNQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50158023
PNG
(4-[3-(1,2,3,6-Tetrahydro-pyridin-4-yl)-indole-1-su...)
Show SMILES Nc1ccc(cc1)S(=O)(=O)n1cc(C2=CCNCC2)c2ccccc12
Show InChI InChI=1S/C19H19N3O2S/c20-15-5-7-16(8-6-15)25(23,24)22-13-18(14-9-11-21-12-10-14)17-3-1-2-4-19(17)22/h1-9,13,21H,10-12,20H2
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1.67E+3n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity against human cloned 5-hydroxytryptamine 1A receptor stably expressed in CHO cells using [3H]-5-HT


Bioorg Med Chem Lett 15: 379-83 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.064
BindingDB Entry DOI: 10.7270/Q20G3JNQ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50158032
PNG
(1-(2-Chloro-benzenesulfonyl)-3-(1,2,3,6-tetrahydro...)
Show SMILES Clc1ccccc1S(=O)(=O)n1cc(C2=CCNCC2)c2ccccc12
Show InChI InChI=1S/C19H17ClN2O2S/c20-17-6-2-4-8-19(17)25(23,24)22-13-16(14-9-11-21-12-10-14)15-5-1-3-7-18(15)22/h1-9,13,21H,10-12H2
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>2.00E+3n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity against human cloned Dopamine receptor D2 stably expressed in CHO-K1 cells using [3H]-spiperone


Bioorg Med Chem Lett 15: 379-83 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.064
BindingDB Entry DOI: 10.7270/Q20G3JNQ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50158026
PNG
(1-(2-Fluoro-benzenesulfonyl)-3-(1,2,3,6-tetrahydro...)
Show SMILES Fc1ccccc1S(=O)(=O)n1cc(C2=CCNCC2)c2ccccc12
Show InChI InChI=1S/C19H17FN2O2S/c20-17-6-2-4-8-19(17)25(23,24)22-13-16(14-9-11-21-12-10-14)15-5-1-3-7-18(15)22/h1-9,13,21H,10-12H2
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>2.00E+3n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity against human cloned Dopamine receptor D2 stably expressed in CHO-K1 cells using [3H]-spiperone


Bioorg Med Chem Lett 15: 379-83 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.064
BindingDB Entry DOI: 10.7270/Q20G3JNQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50158032
PNG
(1-(2-Chloro-benzenesulfonyl)-3-(1,2,3,6-tetrahydro...)
Show SMILES Clc1ccccc1S(=O)(=O)n1cc(C2=CCNCC2)c2ccccc12
Show InChI InChI=1S/C19H17ClN2O2S/c20-17-6-2-4-8-19(17)25(23,24)22-13-16(14-9-11-21-12-10-14)15-5-1-3-7-18(15)22/h1-9,13,21H,10-12H2
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>2.00E+3n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity against human cloned 5-hydroxytryptamine 1A receptor stably expressed in CHO cells using [3H]-5-HT


Bioorg Med Chem Lett 15: 379-83 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.064
BindingDB Entry DOI: 10.7270/Q20G3JNQ
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50158032
PNG
(1-(2-Chloro-benzenesulfonyl)-3-(1,2,3,6-tetrahydro...)
Show SMILES Clc1ccccc1S(=O)(=O)n1cc(C2=CCNCC2)c2ccccc12
Show InChI InChI=1S/C19H17ClN2O2S/c20-17-6-2-4-8-19(17)25(23,24)22-13-16(14-9-11-21-12-10-14)15-5-1-3-7-18(15)22/h1-9,13,21H,10-12H2
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>5.00E+3n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity against human cloned Dopamine receptor D4 stably expressed in CHO-K1 cells using [3H]-spiperone


Bioorg Med Chem Lett 15: 379-83 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.064
BindingDB Entry DOI: 10.7270/Q20G3JNQ
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50158026
PNG
(1-(2-Fluoro-benzenesulfonyl)-3-(1,2,3,6-tetrahydro...)
Show SMILES Fc1ccccc1S(=O)(=O)n1cc(C2=CCNCC2)c2ccccc12
Show InChI InChI=1S/C19H17FN2O2S/c20-17-6-2-4-8-19(17)25(23,24)22-13-16(14-9-11-21-12-10-14)15-5-1-3-7-18(15)22/h1-9,13,21H,10-12H2
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>5.00E+3n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity against human cloned Dopamine receptor D4 stably expressed in CHO-K1 cells using [3H]-spiperone


Bioorg Med Chem Lett 15: 379-83 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.064
BindingDB Entry DOI: 10.7270/Q20G3JNQ
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50158032
PNG
(1-(2-Chloro-benzenesulfonyl)-3-(1,2,3,6-tetrahydro...)
Show SMILES Clc1ccccc1S(=O)(=O)n1cc(C2=CCNCC2)c2ccccc12
Show InChI InChI=1S/C19H17ClN2O2S/c20-17-6-2-4-8-19(17)25(23,24)22-13-16(14-9-11-21-12-10-14)15-5-1-3-7-18(15)22/h1-9,13,21H,10-12H2
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n/an/a 8.80n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibitory concentration against 5-HT stimulated cAMP production in HeLa cells stably transfected with human 5-HT6 receptor


Bioorg Med Chem Lett 15: 379-83 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.064
BindingDB Entry DOI: 10.7270/Q20G3JNQ
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50158030
PNG
(4-[6-Chloro-3-(1,2,3,6-tetrahydro-pyridin-4-yl)-in...)
Show SMILES Nc1ccc(cc1)S(=O)(=O)n1cc(C2=CCNCC2)c2ccc(Cl)cc12
Show InChI InChI=1S/C19H18ClN3O2S/c20-14-1-6-17-18(13-7-9-22-10-8-13)12-23(19(17)11-14)26(24,25)16-4-2-15(21)3-5-16/h1-7,11-12,22H,8-10,21H2
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n/an/a 11.2n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibitory concentration against 5-HT stimulated cAMP production in HeLa cells stably transfected with human 5-HT6 receptor


Bioorg Med Chem Lett 15: 379-83 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.064
BindingDB Entry DOI: 10.7270/Q20G3JNQ
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50158052
PNG
(4-[5-Bromo-3-(1,2,3,6-tetrahydro-pyridin-4-yl)-ind...)
Show SMILES Nc1ccc(cc1)S(=O)(=O)n1cc(C2=CCNCC2)c2cc(Br)ccc12
Show InChI InChI=1S/C19H18BrN3O2S/c20-14-1-6-19-17(11-14)18(13-7-9-22-10-8-13)12-23(19)26(24,25)16-4-2-15(21)3-5-16/h1-7,11-12,22H,8-10,21H2
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n/an/a 33.7n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibitory concentration against 5-HT stimulated cAMP production in HeLa cells stably transfected with human 5-HT6 receptor


Bioorg Med Chem Lett 15: 379-83 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.064
BindingDB Entry DOI: 10.7270/Q20G3JNQ
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50158025
PNG
(5-Methoxy-1-(naphthalene-2-sulfonyl)-3-(1,2,3,6-te...)
Show SMILES COc1ccc2n(cc(C3=CCNCC3)c2c1)S(=O)(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C24H22N2O3S/c1-29-20-7-9-24-22(15-20)23(18-10-12-25-13-11-18)16-26(24)30(27,28)21-8-6-17-4-2-3-5-19(17)14-21/h2-10,14-16,25H,11-13H2,1H3
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n/an/a 4.10n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibitory concentration against 5-HT stimulated cAMP production in HeLa cells stably transfected with human 5-HT6 receptor


Bioorg Med Chem Lett 15: 379-83 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.064
BindingDB Entry DOI: 10.7270/Q20G3JNQ
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50158023
PNG
(4-[3-(1,2,3,6-Tetrahydro-pyridin-4-yl)-indole-1-su...)
Show SMILES Nc1ccc(cc1)S(=O)(=O)n1cc(C2=CCNCC2)c2ccccc12
Show InChI InChI=1S/C19H19N3O2S/c20-15-5-7-16(8-6-15)25(23,24)22-13-18(14-9-11-21-12-10-14)17-3-1-2-4-19(17)22/h1-9,13,21H,10-12,20H2
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n/an/a 0.800n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibitory concentration against 5-HT stimulated cAMP production in HeLa cells stably transfected with human 5-HT6 receptor


Bioorg Med Chem Lett 15: 379-83 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.064
BindingDB Entry DOI: 10.7270/Q20G3JNQ
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50158031
PNG
(4-[5-Fluoro-3-(1,2,3,6-tetrahydro-pyridin-4-yl)-in...)
Show SMILES Nc1ccc(cc1)S(=O)(=O)n1cc(C2=CCNCC2)c2cc(F)ccc12
Show InChI InChI=1S/C19H18FN3O2S/c20-14-1-6-19-17(11-14)18(13-7-9-22-10-8-13)12-23(19)26(24,25)16-4-2-15(21)3-5-16/h1-7,11-12,22H,8-10,21H2
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n/an/a 9.70n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibitory concentration against 5-HT stimulated cAMP production in HeLa cells stably transfected with human 5-HT6 receptor


Bioorg Med Chem Lett 15: 379-83 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.064
BindingDB Entry DOI: 10.7270/Q20G3JNQ
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50158040
PNG
(1-Benzenesulfonyl-3-(1-methyl-1,2,3,6-tetrahydro-p...)
Show SMILES CN1CCC(=CC1)c1cn(c2ccccc12)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C20H20N2O2S/c1-21-13-11-16(12-14-21)19-15-22(20-10-6-5-9-18(19)20)25(23,24)17-7-3-2-4-8-17/h2-11,15H,12-14H2,1H3
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n/an/a 13.8n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibitory concentration against 5-HT stimulated cAMP production in HeLa cells stably transfected with human 5-HT6 receptor


Bioorg Med Chem Lett 15: 379-83 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.064
BindingDB Entry DOI: 10.7270/Q20G3JNQ
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50158026
PNG
(1-(2-Fluoro-benzenesulfonyl)-3-(1,2,3,6-tetrahydro...)
Show SMILES Fc1ccccc1S(=O)(=O)n1cc(C2=CCNCC2)c2ccccc12
Show InChI InChI=1S/C19H17FN2O2S/c20-17-6-2-4-8-19(17)25(23,24)22-13-16(14-9-11-21-12-10-14)15-5-1-3-7-18(15)22/h1-9,13,21H,10-12H2
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n/an/a 2.70n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibitory concentration against 5-HT stimulated cAMP production in HeLa cells stably transfected with human 5-HT6 receptor


Bioorg Med Chem Lett 15: 379-83 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.064
BindingDB Entry DOI: 10.7270/Q20G3JNQ
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50158041
PNG
(1-Benzenesulfonyl-3-(1,2,3,6-tetrahydro-pyridin-4-...)
Show SMILES O=S(=O)(c1ccccc1)n1cc(C2=CCNCC2)c2ccccc12
Show InChI InChI=1S/C19H18N2O2S/c22-24(23,16-6-2-1-3-7-16)21-14-18(15-10-12-20-13-11-15)17-8-4-5-9-19(17)21/h1-10,14,20H,11-13H2
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n/an/a 43n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibitory concentration against 5-HT stimulated cAMP production in HeLa cells stably transfected with human 5-HT6 receptor


Bioorg Med Chem Lett 15: 379-83 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.064
BindingDB Entry DOI: 10.7270/Q20G3JNQ
More data for this
Ligand-Target Pair