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12 similar compounds to monomer 50171649

Compile data set for download or QSAR
Wt: 212.0
BDBM50171658
Wt: 306.2
BDBM50171644
Wt: 310.2
BDBM50171645
Wt: 320.2
BDBM50171646
Wt: 306.2
BDBM50171647
Wt: 350.3
BDBM50171648
Wt: 282.1
BDBM50171650
Wt: 240.1
BDBM50171651
Wt: 348.2
BDBM50171652
Wt: 226.0
BDBM50171655
Wt: 254.1
BDBM50171656
Wt: 306.2
BDBM50276652

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 35 hits for monomerid = 50171658,50171644,50171645,50171646,50171647,50171648,50171650,50171651,50171652,50171655,50171656,50276652   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast activation protein alpha


(Homo sapiens (Human))
BDBM50171644
PNG
(CHEMBL427012 | N-alkyl Gly-boro-Pro derivative)
Show SMILES OB(O)[C@H]1CCCN1C(=O)CNC1C2CC3CC(C2)CC1C3
Show InChI InChI=1S/C16H27BN2O3/c20-15(19-3-1-2-14(19)17(21)22)9-18-16-12-5-10-4-11(7-12)8-13(16)6-10/h10-14,16,18,21-22H,1-9H2/t10?,11?,12?,13?,14-,16?/m1/s1
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n/an/a 99n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human FAP using Lys-Pro-AMC in fluorometric assay


Bioorg Med Chem Lett 15: 4239-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.075
BindingDB Entry DOI: 10.7270/Q2CJ8D2F
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM50276652
PNG
(2-(adamantan-1-ylamino)-1-[(2R)-2-(dihydroxyborany...)
Show SMILES OB(O)[C@@H]1CCCN1C(=O)CNC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C16H27BN2O3/c20-15(19-3-1-2-14(19)17(21)22)10-18-16-7-11-4-12(8-16)6-13(5-11)9-16/h11-14,18,21-22H,1-10H2/t11?,12?,13?,14-,16?/m0/s1
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n/an/a 420n/an/an/an/an/an/a



Matrix Laboratories Limited

Curated by ChEMBL


Assay Description
Inhibition of DPP7


Bioorg Med Chem 17: 1783-802 (2009)


Article DOI: 10.1016/j.bmc.2009.01.061
BindingDB Entry DOI: 10.7270/Q2VD70DJ
More data for this
Ligand-Target Pair
Fibroblast activation protein alpha


(Homo sapiens (Human))
BDBM50171655
PNG
(2-Cyclobutylamino-1-pyrrolidin-1-yl--2-borandihydr...)
Show SMILES OB(O)[C@@H]1CCCN1C(=O)CNC1CCC1
Show InChI InChI=1S/C10H19BN2O3/c14-10(7-12-8-3-1-4-8)13-6-2-5-9(13)11(15)16/h8-9,12,15-16H,1-7H2/t9-/m0/s1
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n/an/a 2.40E+4n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human FAP using Lys-Pro-AMC in fluorometric assay


Bioorg Med Chem Lett 15: 4239-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.075
BindingDB Entry DOI: 10.7270/Q2CJ8D2F
More data for this
Ligand-Target Pair
Fibroblast activation protein alpha


(Homo sapiens (Human))
BDBM50171651
PNG
(2-Cyclopentylamino-1-pyrrolidin-1-yl--2-borandihyd...)
Show SMILES OB(O)[C@@H]1CCCN1C(=O)CNC1CCCC1
Show InChI InChI=1S/C11H21BN2O3/c15-11(8-13-9-4-1-2-5-9)14-7-3-6-10(14)12(16)17/h9-10,13,16-17H,1-8H2/t10-/m0/s1
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n/an/a 6.50E+3n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human FAP using Lys-Pro-AMC in fluorometric assay


Bioorg Med Chem Lett 15: 4239-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.075
BindingDB Entry DOI: 10.7270/Q2CJ8D2F
More data for this
Ligand-Target Pair
Fibroblast activation protein alpha


(Homo sapiens (Human))
BDBM50171645
PNG
(2-Cyclodecylamino-1-pyrrolidin-1-yl--2-borandihydr...)
Show SMILES OB(O)[C@@H]1CCCN1C(=O)CNC1CCCCCCCCC1
Show InChI InChI=1S/C16H31BN2O3/c20-16(19-12-8-11-15(19)17(21)22)13-18-14-9-6-4-2-1-3-5-7-10-14/h14-15,18,21-22H,1-13H2/t15-/m0/s1
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n/an/a 530n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human FAP using Lys-Pro-AMC in fluorometric assay


Bioorg Med Chem Lett 15: 4239-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.075
BindingDB Entry DOI: 10.7270/Q2CJ8D2F
More data for this
Ligand-Target Pair
Fibroblast activation protein alpha


(Homo sapiens (Human))
BDBM50171646
PNG
(CHEMBL196188 | N-alkyl Gly-boro-Pro derivative)
Show SMILES CN(CC(=O)N1CCC[C@@H]1B(O)O)C1C2CC3CC(C2)CC1C3
Show InChI InChI=1S/C17H29BN2O3/c1-19(10-16(21)20-4-2-3-15(20)18(22)23)17-13-6-11-5-12(8-13)9-14(17)7-11/h11-15,17,22-23H,2-10H2,1H3/t11?,12?,13?,14?,15-,17?/m1/s1
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n/an/a 3.70E+4n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human FAP using Lys-Pro-AMC in fluorometric assay


Bioorg Med Chem Lett 15: 4239-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.075
BindingDB Entry DOI: 10.7270/Q2CJ8D2F
More data for this
Ligand-Target Pair
Fibroblast activation protein alpha


(Homo sapiens (Human))
BDBM50171656
PNG
(2-Cyclohexylamino-1-pyrrolidin-1-yl--2-borandihydr...)
Show SMILES OB(O)[C@@H]1CCCN1C(=O)CNC1CCCCC1
Show InChI InChI=1S/C12H23BN2O3/c16-12(9-14-10-5-2-1-3-6-10)15-8-4-7-11(15)13(17)18/h10-11,14,17-18H,1-9H2/t11-/m0/s1
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n/an/a 650n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human FAP using Lys-Pro-AMC in fluorometric assay


Bioorg Med Chem Lett 15: 4239-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.075
BindingDB Entry DOI: 10.7270/Q2CJ8D2F
More data for this
Ligand-Target Pair
Fibroblast activation protein alpha


(Homo sapiens (Human))
BDBM50171647
PNG
(CHEMBL373269 | N-alkyl Gly-boro-Pro derivative)
Show SMILES OB(O)[C@H]1CCCN1C(=O)CNC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C16H27BN2O3/c20-15(19-3-1-2-14(19)17(21)22)10-18-16-7-11-4-12(8-16)6-13(5-11)9-16/h11-14,18,21-22H,1-10H2/t11?,12?,13?,14-,16?/m1/s1
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n/an/a 4.60n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human FAP using Lys-Pro-AMC in fluorometric assay


Bioorg Med Chem Lett 15: 4239-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.075
BindingDB Entry DOI: 10.7270/Q2CJ8D2F
More data for this
Ligand-Target Pair
Fibroblast activation protein alpha


(Homo sapiens (Human))
BDBM50171650
PNG
(2-Cyclooctonylamino-1-pyrrolidin-1-yl--2-borandihy...)
Show SMILES OB(O)[C@@H]1CCCN1C(=O)CNC1CCCCCCC1
Show InChI InChI=1S/C14H27BN2O3/c18-14(17-10-6-9-13(17)15(19)20)11-16-12-7-4-2-1-3-5-8-12/h12-13,16,19-20H,1-11H2/t13-/m0/s1
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n/an/a 290n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human FAP using Lys-Pro-AMC in fluorometric assay


Bioorg Med Chem Lett 15: 4239-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.075
BindingDB Entry DOI: 10.7270/Q2CJ8D2F
More data for this
Ligand-Target Pair
Fibroblast activation protein alpha


(Homo sapiens (Human))
BDBM50171648
PNG
(CHEMBL372180 | N-alkyl Gly-boro-Pro derivative)
Show SMILES CCCCCC12CCC(CC1)(CC2)NCC(=O)N1CCC[C@H]1B(O)O
Show InChI InChI=1S/C19H35BN2O3/c1-2-3-4-7-18-8-11-19(12-9-18,13-10-18)21-15-17(23)22-14-5-6-16(22)20(24)25/h16,21,24-25H,2-15H2,1H3/t16-,18?,19?/m0/s1
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n/an/a 270n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human FAP using Lys-Pro-AMC in fluorometric assay


Bioorg Med Chem Lett 15: 4239-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.075
BindingDB Entry DOI: 10.7270/Q2CJ8D2F
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50171655
PNG
(2-Cyclobutylamino-1-pyrrolidin-1-yl--2-borandihydr...)
Show SMILES OB(O)[C@@H]1CCCN1C(=O)CNC1CCC1
Show InChI InChI=1S/C10H19BN2O3/c14-10(7-12-8-3-1-4-8)13-6-2-5-9(13)11(15)16/h8-9,12,15-16H,1-7H2/t9-/m0/s1
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n/an/a 75n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human DPP4 using Gly-Pro-AMC in fluorometric assay


Bioorg Med Chem Lett 15: 4239-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.075
BindingDB Entry DOI: 10.7270/Q2CJ8D2F
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50171651
PNG
(2-Cyclopentylamino-1-pyrrolidin-1-yl--2-borandihyd...)
Show SMILES OB(O)[C@@H]1CCCN1C(=O)CNC1CCCC1
Show InChI InChI=1S/C11H21BN2O3/c15-11(8-13-9-4-1-2-5-9)14-7-3-6-10(14)12(16)17/h9-10,13,16-17H,1-8H2/t10-/m0/s1
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ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human DPP4 using Gly-Pro-AMC in fluorometric assay


Bioorg Med Chem Lett 15: 4239-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.075
BindingDB Entry DOI: 10.7270/Q2CJ8D2F
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM50171650
PNG
(2-Cyclooctonylamino-1-pyrrolidin-1-yl--2-borandihy...)
Show SMILES OB(O)[C@@H]1CCCN1C(=O)CNC1CCCCCCC1
Show InChI InChI=1S/C14H27BN2O3/c18-14(17-10-6-9-13(17)15(19)20)11-16-12-7-4-2-1-3-5-8-12/h12-13,16,19-20H,1-11H2/t13-/m0/s1
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n/an/a 4n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human DPP7 using Ala-Pro-AMC in fluorometric assay


Bioorg Med Chem Lett 15: 4239-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.075
BindingDB Entry DOI: 10.7270/Q2CJ8D2F
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM50171658
PNG
(2-Cyclopropylamino-1-pyrrolidin-1-yl--2-borandihyd...)
Show SMILES OB(O)[C@@H]1CCCN1C(=O)CNC1CC1
Show InChI InChI=1S/C9H17BN2O3/c13-9(6-11-7-3-4-7)12-5-1-2-8(12)10(14)15/h7-8,11,14-15H,1-6H2/t8-/m0/s1
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n/an/a 570n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human DPP7 using Ala-Pro-AMC in fluorometric assay


Bioorg Med Chem Lett 15: 4239-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.075
BindingDB Entry DOI: 10.7270/Q2CJ8D2F
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM50171645
PNG
(2-Cyclodecylamino-1-pyrrolidin-1-yl--2-borandihydr...)
Show SMILES OB(O)[C@@H]1CCCN1C(=O)CNC1CCCCCCCCC1
Show InChI InChI=1S/C16H31BN2O3/c20-16(19-12-8-11-15(19)17(21)22)13-18-14-9-6-4-2-1-3-5-7-10-14/h14-15,18,21-22H,1-13H2/t15-/m0/s1
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n/an/a 2.20n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human DPP7 using Ala-Pro-AMC in fluorometric assay


Bioorg Med Chem Lett 15: 4239-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.075
BindingDB Entry DOI: 10.7270/Q2CJ8D2F
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50171650
PNG
(2-Cyclooctonylamino-1-pyrrolidin-1-yl--2-borandihy...)
Show SMILES OB(O)[C@@H]1CCCN1C(=O)CNC1CCCCCCC1
Show InChI InChI=1S/C14H27BN2O3/c18-14(17-10-6-9-13(17)15(19)20)11-16-12-7-4-2-1-3-5-8-12/h12-13,16,19-20H,1-11H2/t13-/m0/s1
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n/an/a 27n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human DPP4 using Gly-Pro-AMC in fluorometric assay


Bioorg Med Chem Lett 15: 4239-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.075
BindingDB Entry DOI: 10.7270/Q2CJ8D2F
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50171658
PNG
(2-Cyclopropylamino-1-pyrrolidin-1-yl--2-borandihyd...)
Show SMILES OB(O)[C@@H]1CCCN1C(=O)CNC1CC1
Show InChI InChI=1S/C9H17BN2O3/c13-9(6-11-7-3-4-7)12-5-1-2-8(12)10(14)15/h7-8,11,14-15H,1-6H2/t8-/m0/s1
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n/an/a 130n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human DPP4 using Gly-Pro-AMC in fluorometric assay


Bioorg Med Chem Lett 15: 4239-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.075
BindingDB Entry DOI: 10.7270/Q2CJ8D2F
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM50171644
PNG
(CHEMBL427012 | N-alkyl Gly-boro-Pro derivative)
Show SMILES OB(O)[C@H]1CCCN1C(=O)CNC1C2CC3CC(C2)CC1C3
Show InChI InChI=1S/C16H27BN2O3/c20-15(19-3-1-2-14(19)17(21)22)9-18-16-12-5-10-4-11(7-12)8-13(16)6-10/h10-14,16,18,21-22H,1-9H2/t10?,11?,12?,13?,14-,16?/m1/s1
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ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human DPP7 using Ala-Pro-AMC in fluorometric assay


Bioorg Med Chem Lett 15: 4239-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.075
BindingDB Entry DOI: 10.7270/Q2CJ8D2F
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50171645
PNG
(2-Cyclodecylamino-1-pyrrolidin-1-yl--2-borandihydr...)
Show SMILES OB(O)[C@@H]1CCCN1C(=O)CNC1CCCCCCCCC1
Show InChI InChI=1S/C16H31BN2O3/c20-16(19-12-8-11-15(19)17(21)22)13-18-14-9-6-4-2-1-3-5-7-10-14/h14-15,18,21-22H,1-13H2/t15-/m0/s1
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n/an/a 58n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human DPP4 using Gly-Pro-AMC in fluorometric assay


Bioorg Med Chem Lett 15: 4239-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.075
BindingDB Entry DOI: 10.7270/Q2CJ8D2F
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM50171647
PNG
(CHEMBL373269 | N-alkyl Gly-boro-Pro derivative)
Show SMILES OB(O)[C@H]1CCCN1C(=O)CNC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C16H27BN2O3/c20-15(19-3-1-2-14(19)17(21)22)10-18-16-7-11-4-12(8-16)6-13(5-11)9-16/h11-14,18,21-22H,1-10H2/t11?,12?,13?,14-,16?/m1/s1
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n/an/a 420n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human DPP7 using Ala-Pro-AMC in fluorometric assay


Bioorg Med Chem Lett 15: 4239-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.075
BindingDB Entry DOI: 10.7270/Q2CJ8D2F
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50171648
PNG
(CHEMBL372180 | N-alkyl Gly-boro-Pro derivative)
Show SMILES CCCCCC12CCC(CC1)(CC2)NCC(=O)N1CCC[C@H]1B(O)O
Show InChI InChI=1S/C19H35BN2O3/c1-2-3-4-7-18-8-11-19(12-9-18,13-10-18)21-15-17(23)22-14-5-6-16(22)20(24)25/h16,21,24-25H,2-15H2,1H3/t16-,18?,19?/m0/s1
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n/an/a 61n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human DPP4 using Gly-Pro-AMC in fluorometric assay


Bioorg Med Chem Lett 15: 4239-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.075
BindingDB Entry DOI: 10.7270/Q2CJ8D2F
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50171646
PNG
(CHEMBL196188 | N-alkyl Gly-boro-Pro derivative)
Show SMILES CN(CC(=O)N1CCC[C@@H]1B(O)O)C1C2CC3CC(C2)CC1C3
Show InChI InChI=1S/C17H29BN2O3/c1-19(10-16(21)20-4-2-3-15(20)18(22)23)17-13-6-11-5-12(8-13)9-14(17)7-11/h11-15,17,22-23H,2-10H2,1H3/t11?,12?,13?,14?,15-,17?/m1/s1
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n/an/a 1.60E+3n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human DPP4 using Gly-Pro-AMC in fluorometric assay


Bioorg Med Chem Lett 15: 4239-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.075
BindingDB Entry DOI: 10.7270/Q2CJ8D2F
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50171652
PNG
(CHEMBL381444 | N-alkyl Gly-boro-Pro derivative)
Show SMILES CC12CC3(C)CC(C)(C1)CC(C2)(C3)NCC(=O)N1CCC[C@@H]1B(O)O
Show InChI InChI=1S/C19H33BN2O3/c1-16-8-17(2)10-18(3,9-16)13-19(11-16,12-17)21-7-15(23)22-6-4-5-14(22)20(24)25/h14,21,24-25H,4-13H2,1-3H3/t14-,16?,17?,18?,19?/m1/s1
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n/an/a 560n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human DPP4 using Gly-Pro-AMC in fluorometric assay


Bioorg Med Chem Lett 15: 4239-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.075
BindingDB Entry DOI: 10.7270/Q2CJ8D2F
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM50171646
PNG
(CHEMBL196188 | N-alkyl Gly-boro-Pro derivative)
Show SMILES CN(CC(=O)N1CCC[C@@H]1B(O)O)C1C2CC3CC(C2)CC1C3
Show InChI InChI=1S/C17H29BN2O3/c1-19(10-16(21)20-4-2-3-15(20)18(22)23)17-13-6-11-5-12(8-13)9-14(17)7-11/h11-15,17,22-23H,2-10H2,1H3/t11?,12?,13?,14?,15-,17?/m1/s1
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n/an/a 4.60E+3n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human DPP7 using Ala-Pro-AMC in fluorometric assay


Bioorg Med Chem Lett 15: 4239-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.075
BindingDB Entry DOI: 10.7270/Q2CJ8D2F
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM50171652
PNG
(CHEMBL381444 | N-alkyl Gly-boro-Pro derivative)
Show SMILES CC12CC3(C)CC(C)(C1)CC(C2)(C3)NCC(=O)N1CCC[C@@H]1B(O)O
Show InChI InChI=1S/C19H33BN2O3/c1-16-8-17(2)10-18(3,9-16)13-19(11-16,12-17)21-7-15(23)22-6-4-5-14(22)20(24)25/h14,21,24-25H,4-13H2,1-3H3/t14-,16?,17?,18?,19?/m1/s1
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n/an/a 35n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human DPP7 using Ala-Pro-AMC in fluorometric assay


Bioorg Med Chem Lett 15: 4239-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.075
BindingDB Entry DOI: 10.7270/Q2CJ8D2F
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM50171656
PNG
(2-Cyclohexylamino-1-pyrrolidin-1-yl--2-borandihydr...)
Show SMILES OB(O)[C@@H]1CCCN1C(=O)CNC1CCCCC1
Show InChI InChI=1S/C12H23BN2O3/c16-12(9-14-10-5-2-1-3-6-10)15-8-4-7-11(15)13(17)18/h10-11,14,17-18H,1-9H2/t11-/m0/s1
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n/an/a 4.10n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human DPP7 using Ala-Pro-AMC in fluorometric assay


Bioorg Med Chem Lett 15: 4239-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.075
BindingDB Entry DOI: 10.7270/Q2CJ8D2F
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM50171655
PNG
(2-Cyclobutylamino-1-pyrrolidin-1-yl--2-borandihydr...)
Show SMILES OB(O)[C@@H]1CCCN1C(=O)CNC1CCC1
Show InChI InChI=1S/C10H19BN2O3/c14-10(7-12-8-3-1-4-8)13-6-2-5-9(13)11(15)16/h8-9,12,15-16H,1-7H2/t9-/m0/s1
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n/an/a 140n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human DPP7 using Ala-Pro-AMC in fluorometric assay


Bioorg Med Chem Lett 15: 4239-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.075
BindingDB Entry DOI: 10.7270/Q2CJ8D2F
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50171644
PNG
(CHEMBL427012 | N-alkyl Gly-boro-Pro derivative)
Show SMILES OB(O)[C@H]1CCCN1C(=O)CNC1C2CC3CC(C2)CC1C3
Show InChI InChI=1S/C16H27BN2O3/c20-15(19-3-1-2-14(19)17(21)22)9-18-16-12-5-10-4-11(7-12)8-13(16)6-10/h10-14,16,18,21-22H,1-9H2/t10?,11?,12?,13?,14-,16?/m1/s1
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n/an/a 12n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human DPP4 using Gly-Pro-AMC in fluorometric assay


Bioorg Med Chem Lett 15: 4239-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.075
BindingDB Entry DOI: 10.7270/Q2CJ8D2F
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50171647
PNG
(CHEMBL373269 | N-alkyl Gly-boro-Pro derivative)
Show SMILES OB(O)[C@H]1CCCN1C(=O)CNC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C16H27BN2O3/c20-15(19-3-1-2-14(19)17(21)22)10-18-16-7-11-4-12(8-16)6-13(5-11)9-16/h11-14,18,21-22H,1-10H2/t11?,12?,13?,14-,16?/m1/s1
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n/an/a 8n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human DPP4 using Gly-Pro-AMC in fluorometric assay


Bioorg Med Chem Lett 15: 4239-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.075
BindingDB Entry DOI: 10.7270/Q2CJ8D2F
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM50171651
PNG
(2-Cyclopentylamino-1-pyrrolidin-1-yl--2-borandihyd...)
Show SMILES OB(O)[C@@H]1CCCN1C(=O)CNC1CCCC1
Show InChI InChI=1S/C11H21BN2O3/c15-11(8-13-9-4-1-2-5-9)14-7-3-6-10(14)12(16)17/h9-10,13,16-17H,1-8H2/t10-/m0/s1
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n/an/a 15n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human DPP7 using Ala-Pro-AMC in fluorometric assay


Bioorg Med Chem Lett 15: 4239-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.075
BindingDB Entry DOI: 10.7270/Q2CJ8D2F
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50171656
PNG
(2-Cyclohexylamino-1-pyrrolidin-1-yl--2-borandihydr...)
Show SMILES OB(O)[C@@H]1CCCN1C(=O)CNC1CCCCC1
Show InChI InChI=1S/C12H23BN2O3/c16-12(9-14-10-5-2-1-3-6-10)15-8-4-7-11(15)13(17)18/h10-11,14,17-18H,1-9H2/t11-/m0/s1
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n/an/a 27n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human DPP4 using Gly-Pro-AMC in fluorometric assay


Bioorg Med Chem Lett 15: 4239-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.075
BindingDB Entry DOI: 10.7270/Q2CJ8D2F
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM50171648
PNG
(CHEMBL372180 | N-alkyl Gly-boro-Pro derivative)
Show SMILES CCCCCC12CCC(CC1)(CC2)NCC(=O)N1CCC[C@H]1B(O)O
Show InChI InChI=1S/C19H35BN2O3/c1-2-3-4-7-18-8-11-19(12-9-18,13-10-18)21-15-17(23)22-14-5-6-16(22)20(24)25/h16,21,24-25H,2-15H2,1H3/t16-,18?,19?/m0/s1
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n/an/a 1n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human DPP7 using Ala-Pro-AMC in fluorometric assay


Bioorg Med Chem Lett 15: 4239-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.075
BindingDB Entry DOI: 10.7270/Q2CJ8D2F
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50276652
PNG
(2-(adamantan-1-ylamino)-1-[(2R)-2-(dihydroxyborany...)
Show SMILES OB(O)[C@@H]1CCCN1C(=O)CNC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C16H27BN2O3/c20-15(19-3-1-2-14(19)17(21)22)10-18-16-7-11-4-12(8-16)6-13(5-11)9-16/h11-14,18,21-22H,1-10H2/t11?,12?,13?,14-,16?/m0/s1
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n/an/a 8n/an/an/an/an/an/a



Matrix Laboratories Limited

Curated by ChEMBL


Assay Description
Inhibition of DPP4


Bioorg Med Chem 17: 1783-802 (2009)


Article DOI: 10.1016/j.bmc.2009.01.061
BindingDB Entry DOI: 10.7270/Q2VD70DJ
More data for this
Ligand-Target Pair
Fibroblast activation protein alpha


(Homo sapiens (Human))
BDBM50276652
PNG
(2-(adamantan-1-ylamino)-1-[(2R)-2-(dihydroxyborany...)
Show SMILES OB(O)[C@@H]1CCCN1C(=O)CNC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C16H27BN2O3/c20-15(19-3-1-2-14(19)17(21)22)10-18-16-7-11-4-12(8-16)6-13(5-11)9-16/h11-14,18,21-22H,1-10H2/t11?,12?,13?,14-,16?/m0/s1
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n/an/a 46n/an/an/an/an/an/a



Matrix Laboratories Limited

Curated by ChEMBL


Assay Description
Inhibition of FAP


Bioorg Med Chem 17: 1783-802 (2009)


Article DOI: 10.1016/j.bmc.2009.01.061
BindingDB Entry DOI: 10.7270/Q2VD70DJ
More data for this
Ligand-Target Pair
Fibroblast activation protein alpha


(Homo sapiens (Human))
BDBM50171652
PNG
(CHEMBL381444 | N-alkyl Gly-boro-Pro derivative)
Show SMILES CC12CC3(C)CC(C)(C1)CC(C2)(C3)NCC(=O)N1CCC[C@@H]1B(O)O
Show InChI InChI=1S/C19H33BN2O3/c1-16-8-17(2)10-18(3,9-16)13-19(11-16,12-17)21-7-15(23)22-6-4-5-14(22)20(24)25/h14,21,24-25H,4-13H2,1-3H3/t14-,16?,17?,18?,19?/m1/s1
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n/an/a 770n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human FAP using Lys-Pro-AMC in fluorometric assay


Bioorg Med Chem Lett 15: 4239-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.075
BindingDB Entry DOI: 10.7270/Q2CJ8D2F
More data for this
Ligand-Target Pair