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6 similar compounds to monomer 50184695

Compile data set for download or QSAR
Wt: 326.3
BDBM50184693
Wt: 340.3
BDBM50184696
Wt: 366.3
BDBM50184702
Wt: 310.3
BDBM50184709
Purchase
Wt: 354.3
BDBM50184718
Wt: 380.3
BDBM50184724

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50184693,50184696,50184702,50184709,50184718,50184724   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50184693
PNG
(CHEMBL379985 | N-(1-(2-hydroxyethyl)-1H-benzo[d]im...)
Show SMILES OCCn1c(NC(=O)c2cccc(c2)[N+]([O-])=O)nc2ccccc12
Show InChI InChI=1S/C16H14N4O4/c21-9-8-19-14-7-2-1-6-13(14)17-16(19)18-15(22)11-4-3-5-12(10-11)20(23)24/h1-7,10,21H,8-9H2,(H,17,18,22)
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n/an/a 400n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of IRAK4


Bioorg Med Chem Lett 16: 2842-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.020
BindingDB Entry DOI: 10.7270/Q2JM297D
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50184696
PNG
(CHEMBL210354 | N-(1-(2-methoxyethyl)-1H-benzo[d]im...)
Show SMILES COCCn1c(NC(=O)c2cccc(c2)[N+]([O-])=O)nc2ccccc12
Show InChI InChI=1S/C17H16N4O4/c1-25-10-9-20-15-8-3-2-7-14(15)18-17(20)19-16(22)12-5-4-6-13(11-12)21(23)24/h2-8,11H,9-10H2,1H3,(H,18,19,22)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of IRAK4


Bioorg Med Chem Lett 16: 2842-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.020
BindingDB Entry DOI: 10.7270/Q2JM297D
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50184724
PNG
(CHEMBL208743 | N-methyl-3-nitro-N-(1-(2-oxo-tetrah...)
Show SMILES CN(C(=O)c1cccc(c1)[N+]([O-])=O)c1nc2ccccc2n1C1CCOC1=O
Show InChI InChI=1S/C19H16N4O5/c1-21(17(24)12-5-4-6-13(11-12)23(26)27)19-20-14-7-2-3-8-15(14)22(19)16-9-10-28-18(16)25/h2-8,11,16H,9-10H2,1H3
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n/an/a>3.00E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of IRAK4


Bioorg Med Chem Lett 16: 2842-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.020
BindingDB Entry DOI: 10.7270/Q2JM297D
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50184709
PNG
(CHEMBL210822 | N-(1-ethyl-1H-benzo[d]imidazol-2-yl...)
Show SMILES CCn1c(NC(=O)c2cccc(c2)[N+]([O-])=O)nc2ccccc12
Show InChI InChI=1S/C16H14N4O3/c1-2-19-14-9-4-3-8-13(14)17-16(19)18-15(21)11-6-5-7-12(10-11)20(22)23/h3-10H,2H2,1H3,(H,17,18,21)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of IRAK4


Bioorg Med Chem Lett 16: 2842-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.020
BindingDB Entry DOI: 10.7270/Q2JM297D
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50184718
PNG
(CHEMBL210366 | N-(1-(2-ethoxyethyl)-1H-benzo[d]imi...)
Show SMILES CCOCCn1c(NC(=O)c2cccc(c2)[N+]([O-])=O)nc2ccccc12
Show InChI InChI=1S/C18H18N4O4/c1-2-26-11-10-21-16-9-4-3-8-15(16)19-18(21)20-17(23)13-6-5-7-14(12-13)22(24)25/h3-9,12H,2,10-11H2,1H3,(H,19,20,23)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of IRAK4


Bioorg Med Chem Lett 16: 2842-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.020
BindingDB Entry DOI: 10.7270/Q2JM297D
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50184702
PNG
(3-nitro-N-(1-(2-oxo-tetrahydrofuran-3-yl)-1H-benzo...)
Show SMILES [O-][N+](=O)c1cccc(c1)C(=O)Nc1nc2ccccc2n1C1CCOC1=O
Show InChI InChI=1S/C18H14N4O5/c23-16(11-4-3-5-12(10-11)22(25)26)20-18-19-13-6-1-2-7-14(13)21(18)15-8-9-27-17(15)24/h1-7,10,15H,8-9H2,(H,19,20,23)
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n/an/a 550n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of IRAK4


Bioorg Med Chem Lett 16: 2842-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.020
BindingDB Entry DOI: 10.7270/Q2JM297D
More data for this
Ligand-Target Pair