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| Wt: 298.1 BDBM50187455  | Wt: 284.1 BDBM50224458  | Wt: 284.1 BDBM50224459  |
| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Neuronal acetylcholine receptor subunit alpha-4 (Homo sapiens (Human)) | BDBM50187455 (1-(6-Bromo-5-vinylpyridin-3-yl)-[1,4]diazepane | 1...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 0.646 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Turin Curated by ChEMBL | Assay Description Displacement of [3H]cytisine from human alpha4beta2 nAChR expressed in HEK293 cells | J Med Chem 52: 2311-6 (2009) Article DOI: 10.1021/jm801060h BindingDB Entry DOI: 10.7270/Q2XK8GS0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Neuronal acetylcholine receptor subunit alpha-4 (Homo sapiens (Human)) | BDBM50187455 (1-(6-Bromo-5-vinylpyridin-3-yl)-[1,4]diazepane | 1...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 110 | n/a | n/a | n/a | n/a |
University of Turin Curated by ChEMBL | Assay Description Agonist activity at human alpha4beta2 nAChR expressed in HEK293 cells assessed as intracellular calcium level by FLIPR assay | J Med Chem 52: 2311-6 (2009) Article DOI: 10.1021/jm801060h BindingDB Entry DOI: 10.7270/Q2XK8GS0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit (Rattus norvegicus (Rat)) | BDBM50187455 (1-(6-Bromo-5-vinylpyridin-3-yl)-[1,4]diazepane | 1...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 0.640 | n/a | n/a | n/a | n/a | n/a | n/a |
NeuroSearch A/S Curated by ChEMBL | Assay Description Inhibition of [3H]cytisine binding to alpha4beta2 nACHR in Wistar rat cerebral cortical membrane | J Med Chem 49: 3159-71 (2006) Article DOI: 10.1021/jm058058h BindingDB Entry DOI: 10.7270/Q2C53PM7 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Neuronal acetylcholine receptor Alpha-4/Beta-2 (Homo sapiens (Human)) | BDBM50224459 ((1S,5S)-3-(6-bromo-5-methoxypyridin-3-yl)-3,6-diaz...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a |
Neuroscience Research Curated by ChEMBL | Assay Description Agonist activity at recombinant human alpha-4-beta-2 nAChR expressed in HEK293 cells assessed as induction of calcium influx by FLIPR assay | J Med Chem 50: 5493-508 (2007) Article DOI: 10.1021/jm070755h BindingDB Entry DOI: 10.7270/Q2F190ZZ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Neuronal acetylcholine receptor Alpha-4/Beta-2 (Homo sapiens (Human)) | BDBM50224458 ((1R,5R)-3-(6-bromo-5-methoxypyridin-3-yl)-3,6-diaz...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 200 | n/a | n/a | n/a | n/a |
Neuroscience Research Curated by ChEMBL | Assay Description Agonist activity at recombinant human alpha-4-beta-2 nAChR expressed in HEK293 cells assessed as induction of calcium influx by FLIPR assay | J Med Chem 50: 5493-508 (2007) Article DOI: 10.1021/jm070755h BindingDB Entry DOI: 10.7270/Q2F190ZZ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
