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10 similar compounds to monomer 50191842

Compile data set for download or QSAR
Wt: 351.4
BDBM50191833
Wt: 333.4
BDBM50191834
Wt: 333.4
BDBM50191836
Wt: 386.8
BDBM50191839
Wt: 319.4
BDBM50191841
Wt: 353.8
BDBM50191845
Wt: 371.8
BDBM50191847
Wt: 385.8
BDBM50191848
Wt: 333.4
BDBM50191850
Wt: 353.8
BDBM50191851

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50191833,50191834,50191836,50191839,50191841,50191845,50191847,50191848,50191850,50191851   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium/hydrogen exchanger 1


(Homo sapiens)
BDBM50191833
PNG
(5-(4-fluoro-3-methylphenyl)-4-(4-(4-methyl-1H-imid...)
Show SMILES Cc1nc[nH]c1C1CCN(CC1)c1ncncc1-c1ccc(F)c(C)c1
Show InChI InChI=1S/C20H22FN5/c1-13-9-16(3-4-18(13)21)17-10-22-11-25-20(17)26-7-5-15(6-8-26)19-14(2)23-12-24-19/h3-4,9-12,15H,5-8H2,1-2H3,(H,23,24)
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PubMed
n/an/a 21n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human NHE1 expressed in Ap1 cell line


Bioorg Med Chem Lett 16: 4796-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.077
BindingDB Entry DOI: 10.7270/Q2DN44P1
More data for this
Ligand-Target Pair
Sodium/hydrogen exchanger 1


(Homo sapiens)
BDBM50191834
PNG
(4-(4-(4-methyl-1H-imidazol-5-yl)piperidin-1-yl)-5-...)
Show SMILES Cc1nc[nH]c1C1CCN(CC1)c1ncncc1-c1ccc(C)cc1
Show InChI InChI=1S/C20H23N5/c1-14-3-5-16(6-4-14)18-11-21-12-24-20(18)25-9-7-17(8-10-25)19-15(2)22-13-23-19/h3-6,11-13,17H,7-10H2,1-2H3,(H,22,23)
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PubMed
n/an/a 1.00E+3n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human NHE1 expressed in Ap1 cell line


Bioorg Med Chem Lett 16: 4796-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.077
BindingDB Entry DOI: 10.7270/Q2DN44P1
More data for this
Ligand-Target Pair
Sodium/hydrogen exchanger 1


(Homo sapiens)
BDBM50191836
PNG
(4-(4-(4-methyl-1H-imidazol-5-yl)piperidin-1-yl)-5-...)
Show SMILES Cc1nc[nH]c1C1CCN(CC1)c1ncncc1-c1ccccc1C
Show InChI InChI=1S/C20H23N5/c1-14-5-3-4-6-17(14)18-11-21-12-24-20(18)25-9-7-16(8-10-25)19-15(2)22-13-23-19/h3-6,11-13,16H,7-10H2,1-2H3,(H,22,23)
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n/an/a 250n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human NHE1 expressed in Ap1 cell line


Bioorg Med Chem Lett 16: 4796-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.077
BindingDB Entry DOI: 10.7270/Q2DN44P1
More data for this
Ligand-Target Pair
Sodium/hydrogen exchanger 1


(Homo sapiens)
BDBM50191841
PNG
(4-(4-(4-methyl-1H-imidazol-5-yl)piperidin-1-yl)-5-...)
Show SMILES Cc1nc[nH]c1C1CCN(CC1)c1ncncc1-c1ccccc1
Show InChI InChI=1S/C19H21N5/c1-14-18(22-13-21-14)16-7-9-24(10-8-16)19-17(11-20-12-23-19)15-5-3-2-4-6-15/h2-6,11-13,16H,7-10H2,1H3,(H,21,22)
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PubMed
n/an/a 520n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human NHE1 expressed in Ap1 cell line


Bioorg Med Chem Lett 16: 4796-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.077
BindingDB Entry DOI: 10.7270/Q2DN44P1
More data for this
Ligand-Target Pair
Sodium/hydrogen exchanger 1


(Homo sapiens)
BDBM50191848
PNG
(5-(3-chloro-4-fluorophenyl)-4-(4-(1,4-dimethyl-1H-...)
Show SMILES Cc1ncn(C)c1C1CCN(CC1)c1ncncc1-c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C20H21ClFN5/c1-13-19(26(2)12-25-13)14-5-7-27(8-6-14)20-16(10-23-11-24-20)15-3-4-18(22)17(21)9-15/h3-4,9-12,14H,5-8H2,1-2H3
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n/an/a 1.10E+4n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human NHE1 expressed in Ap1 cell line


Bioorg Med Chem Lett 16: 4796-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.077
BindingDB Entry DOI: 10.7270/Q2DN44P1
More data for this
Ligand-Target Pair
Sodium/hydrogen exchanger 1


(Homo sapiens)
BDBM50191845
PNG
(5-(4-chlorophenyl)-4-(4-(4-methyl-1H-imidazol-5-yl...)
Show SMILES Cc1nc[nH]c1C1CCN(CC1)c1ncncc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C19H20ClN5/c1-13-18(23-12-22-13)15-6-8-25(9-7-15)19-17(10-21-11-24-19)14-2-4-16(20)5-3-14/h2-5,10-12,15H,6-9H2,1H3,(H,22,23)
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PubMed
n/an/a 350n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human NHE1 expressed in Ap1 cell line


Bioorg Med Chem Lett 16: 4796-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.077
BindingDB Entry DOI: 10.7270/Q2DN44P1
More data for this
Ligand-Target Pair
Sodium/hydrogen exchanger 1


(Homo sapiens)
BDBM50191847
PNG
(5-(3-chloro-4-fluorophenyl)-4-(4-(4-methyl-1H-imid...)
Show SMILES Cc1nc[nH]c1C1CCN(CC1)c1ncncc1-c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C19H19ClFN5/c1-12-18(24-11-23-12)13-4-6-26(7-5-13)19-15(9-22-10-25-19)14-2-3-17(21)16(20)8-14/h2-3,8-11,13H,4-7H2,1H3,(H,23,24)
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PubMed
n/an/a 41n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human NHE1 expressed in Ap1 cell line


Bioorg Med Chem Lett 16: 4796-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.077
BindingDB Entry DOI: 10.7270/Q2DN44P1
More data for this
Ligand-Target Pair
Sodium/hydrogen exchanger 1


(Homo sapiens)
BDBM50191850
PNG
(4-(4-(4-methyl-1H-imidazol-5-yl)piperidin-1-yl)-5-...)
Show SMILES Cc1nc[nH]c1C1CCN(CC1)c1ncncc1-c1cccc(C)c1
Show InChI InChI=1S/C20H23N5/c1-14-4-3-5-17(10-14)18-11-21-12-24-20(18)25-8-6-16(7-9-25)19-15(2)22-13-23-19/h3-5,10-13,16H,6-9H2,1-2H3,(H,22,23)
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n/an/a 27n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human NHE1 expressed in Ap1 cell line


Bioorg Med Chem Lett 16: 4796-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.077
BindingDB Entry DOI: 10.7270/Q2DN44P1
More data for this
Ligand-Target Pair
Sodium/hydrogen exchanger 1


(Homo sapiens)
BDBM50191851
PNG
(5-(2-chlorophenyl)-4-(4-(4-methyl-1H-imidazol-5-yl...)
Show SMILES Cc1nc[nH]c1C1CCN(CC1)c1ncncc1-c1ccccc1Cl
Show InChI InChI=1S/C19H20ClN5/c1-13-18(23-12-22-13)14-6-8-25(9-7-14)19-16(10-21-11-24-19)15-4-2-3-5-17(15)20/h2-5,10-12,14H,6-9H2,1H3,(H,22,23)
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PubMed
n/an/a 61n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human NHE1 expressed in Ap1 cell line


Bioorg Med Chem Lett 16: 4796-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.077
BindingDB Entry DOI: 10.7270/Q2DN44P1
More data for this
Ligand-Target Pair
Sodium/hydrogen exchanger 1


(Homo sapiens)
BDBM50191839
PNG
(5-(1-(5-(3-chloro-4-fluorophenyl)pyrimidin-4-yl)pi...)
Show SMILES Cc1nc(N)[nH]c1C1CCN(CC1)c1ncncc1-c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C19H20ClFN6/c1-11-17(26-19(22)25-11)12-4-6-27(7-5-12)18-14(9-23-10-24-18)13-2-3-16(21)15(20)8-13/h2-3,8-10,12H,4-7H2,1H3,(H3,22,25,26)
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n/an/a 5.40n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human NHE1 expressed in Ap1 cell line


Bioorg Med Chem Lett 16: 4796-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.077
BindingDB Entry DOI: 10.7270/Q2DN44P1
More data for this
Ligand-Target Pair