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14 similar compounds to monomer 50232430

Compile data set for download or QSAR
Wt: 204.2
BDBM50198897
Wt: 769.8
BDBM50232417
Wt: 820.9
BDBM50232419
Wt: 1180.4
BDBM50232420
Wt: 531.9
BDBM50232421
Wt: 303.7
BDBM50232426
Wt: 683.7
BDBM50232418
Wt: 287.2
BDBM50232428
Wt: 364.2
BDBM50232429
Wt: 868.9
BDBM50232415
Wt: 486.6
BDBM50232431
Wt: 472.5
BDBM50232432
Wt: 498.3
BDBM50232422
Wt: 303.7
BDBM50232425

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 41 hits for monomerid = 50198897,50232417,50232419,50232420,50232421,50232426,50232418,50232428,50232429,50232415,50232431,50232432,50232422,50232425   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM50232425
PNG
(CHEMBL4061639)
Show SMILES Cn1ncc2cc(ccc12)C(=O)Nc1ccc(F)c(Cl)c1
Show InChI InChI=1S/C15H11ClFN3O/c1-20-14-5-2-9(6-10(14)8-18-20)15(21)19-11-3-4-13(17)12(16)7-11/h2-8H,1H3,(H,19,21)
PDB

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Article
PubMed
0.290n/an/an/an/an/an/an/an/a



NTZ Lab Ltd.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human MAOB expressed in baculovirus-infected BTI insect cells using p-tyramine as substrate measured for 45 mins in presenc...


Eur J Med Chem 127: 470-492 (2017)


Article DOI: 10.1016/j.ejmech.2017.01.011
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM50232429
PNG
(CHEMBL4104691)
Show SMILES COCCn1ncc2cc(ccc12)C(=O)Nc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C17H15Cl2N3O2/c1-24-7-6-22-16-5-2-11(8-12(16)10-20-22)17(23)21-13-3-4-14(18)15(19)9-13/h2-5,8-10H,6-7H2,1H3,(H,21,23)
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0.480n/an/an/an/an/an/an/an/a



NTZ Lab Ltd.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human MAOB expressed in baculovirus-infected BTI insect cells using p-tyramine as substrate measured for 45 mins in presenc...


Eur J Med Chem 127: 470-492 (2017)


Article DOI: 10.1016/j.ejmech.2017.01.011
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM50232426
PNG
(CHEMBL4089754)
Show SMILES Cn1cc2cc(ccc2n1)C(=O)Nc1ccc(F)c(Cl)c1
Show InChI InChI=1S/C15H11ClFN3O/c1-20-8-10-6-9(2-5-14(10)19-20)15(21)18-11-3-4-13(17)12(16)7-11/h2-8H,1H3,(H,18,21)
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3.60n/an/an/an/an/an/an/an/a



NTZ Lab Ltd.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human MAOB expressed in baculovirus-infected BTI insect cells using p-tyramine as substrate measured for 45 mins in presenc...


Eur J Med Chem 127: 470-492 (2017)


Article DOI: 10.1016/j.ejmech.2017.01.011
More data for this
Ligand-Target Pair
CDGSH iron-sulfur domain-containing protein 1


(Homo sapiens (Human))
BDBM50198897
PNG
(CHEMBL568596)
Show SMILES N=C1NC(=O)\C(S1)=C\c1ccccc1
Show InChI InChI=1S/C10H8N2OS/c11-10-12-9(13)8(14-10)6-7-4-2-1-3-5-7/h1-6H,(H2,11,12,13)/b8-6-
PDB
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KEGG

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B.MOAD
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Article
PubMed
1.59E+6n/an/an/an/an/an/an/an/a



West Virginia University

Curated by ChEMBL


Assay Description
Displacement of [3H]rosiglitazone from recombinant human C-terminal His-tagged MitoNEET cytosolic domain (32 to 108 residues) expressed in Escherichi...


Bioorg Med Chem Lett 26: 5350-5353 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.009
BindingDB Entry DOI: 10.7270/Q2ZP483C
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Mus musculus (Mouse))
BDBM50232417
PNG
(CHEMBL4062633)
Show SMILES NC[C@@H]1NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O
Show InChI InChI=1S/C39H51N11O6/c40-21-30-37(55)50-18-8-15-32(50)38(56)49-17-7-14-31(49)36(54)47-28(19-23-9-2-1-3-10-23)34(52)45-27(13-6-16-43-39(41)42)33(51)46-29(35(53)48-30)20-24-22-44-26-12-5-4-11-25(24)26/h1-5,9-12,22,27-32,44H,6-8,13-21,40H2,(H,45,52)(H,46,51)(H,47,54)(H,48,53)(H4,41,42,43)/t27-,28+,29-,30-,31-,32+/m0/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed ...


J Med Chem 60: 805-813 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01707
More data for this
Ligand-Target Pair
Melanocortin receptor 1


(Mus musculus)
BDBM50232419
PNG
(CHEMBL4060767)
Show SMILES NC(=N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O
Show InChI InChI=1S/C42H52N12O6/c43-42(44)46-16-6-13-30-36(55)52-33(20-26-22-47-29-12-5-4-11-28(26)29)40(59)54-18-8-15-35(54)41(60)53-17-7-14-34(53)39(58)51-32(21-27-23-45-24-48-27)38(57)50-31(37(56)49-30)19-25-9-2-1-3-10-25/h1-5,9-12,22-24,30-35,47H,6-8,13-21H2,(H,45,48)(H,49,56)(H,50,57)(H,51,58)(H,52,55)(H4,43,44,46)/t30-,31+,32-,33-,34-,35+/m0/s1
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n/an/an/an/a 900n/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC1R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed ...


J Med Chem 60: 805-813 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01707
More data for this
Ligand-Target Pair
Melanocortin receptor 1


(Mus musculus)
BDBM50232417
PNG
(CHEMBL4062633)
Show SMILES NC[C@@H]1NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O
Show InChI InChI=1S/C39H51N11O6/c40-21-30-37(55)50-18-8-15-32(50)38(56)49-17-7-14-31(49)36(54)47-28(19-23-9-2-1-3-10-23)34(52)45-27(13-6-16-43-39(41)42)33(51)46-29(35(53)48-30)20-24-22-44-26-12-5-4-11-25(24)26/h1-5,9-12,22,27-32,44H,6-8,13-21,40H2,(H,45,52)(H,46,51)(H,47,54)(H,48,53)(H4,41,42,43)/t27-,28+,29-,30-,31-,32+/m0/s1
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n/an/an/an/a 110n/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC1R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed ...


J Med Chem 60: 805-813 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01707
More data for this
Ligand-Target Pair
Melanocortin receptor 1


(Mus musculus)
BDBM50232418
PNG
(CHEMBL4084327)
Show SMILES NC(=N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O
Show InChI InChI=1S/C36H45N9O5/c37-36(38)39-16-6-13-26-31(46)43-28(20-23-21-40-25-12-5-4-11-24(23)25)34(49)45-18-8-15-30(45)35(50)44-17-7-14-29(44)33(48)42-27(32(47)41-26)19-22-9-2-1-3-10-22/h1-5,9-12,21,26-30,40H,6-8,13-20H2,(H,41,47)(H,42,48)(H,43,46)(H4,37,38,39)/t26-,27+,28-,29-,30+/m0/s1
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n/an/an/an/a 1.80E+3n/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC1R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed ...


J Med Chem 60: 805-813 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01707
More data for this
Ligand-Target Pair
Melanocortin receptor 1


(Mus musculus)
BDBM50232415
PNG
(CHEMBL4103508)
Show SMILES C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O
Show InChI InChI=1S/C43H56N12O8/c1-24-41(62)55-19-9-16-34(55)42(63)54-18-8-15-33(54)40(61)53-30(20-25-10-3-2-4-11-25)38(59)50-29(14-7-17-47-43(45)46)36(57)51-31(21-26-23-48-28-13-6-5-12-27(26)28)39(60)52-32(22-35(44)56)37(58)49-24/h2-6,10-13,23-24,29-34,48H,7-9,14-22H2,1H3,(H2,44,56)(H,49,58)(H,50,59)(H,51,57)(H,52,60)(H,53,61)(H4,45,46,47)/t24-,29-,30+,31-,32-,33-,34+/m0/s1
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n/an/an/an/a 500n/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC1R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed ...


J Med Chem 60: 805-813 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01707
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50232420
PNG
(CHEMBL4089689)
Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O
Show InChI InChI=1S/C59H85N15O11/c1-5-6-20-40(66-35(4)75)51(78)71-45-32-48(76)63-26-13-12-22-42(57(84)73-28-16-25-47(73)56(83)72-49(34(2)3)50(60)77)68-54(81)44(31-37-33-65-39-21-11-10-19-38(37)39)69-52(79)41(23-14-27-64-59(61)62)67-53(80)43(30-36-17-8-7-9-18-36)70-55(82)46-24-15-29-74(46)58(45)85/h7-11,17-19,21,33-34,40-47,49,65H,5-6,12-16,20,22-32H2,1-4H3,(H2,60,77)(H,63,76)(H,66,75)(H,67,80)(H,68,81)(H,69,79)(H,70,82)(H,71,78)(H,72,83)(H4,61,62,64)/t40-,41-,42-,43+,44-,45-,46-,47-,49-/m0/s1
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n/an/an/an/a 29n/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Agonist activity at human MC4R expressed in CHO cells assessed as increase in IBMX-induced cAMP accumulation after 45 mins by [125I]cAMP flash plate ...


J Med Chem 60: 805-813 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01707
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Mus musculus)
BDBM50232415
PNG
(CHEMBL4103508)
Show SMILES C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O
Show InChI InChI=1S/C43H56N12O8/c1-24-41(62)55-19-9-16-34(55)42(63)54-18-8-15-33(54)40(61)53-30(20-25-10-3-2-4-11-25)38(59)50-29(14-7-17-47-43(45)46)36(57)51-31(21-26-23-48-28-13-6-5-12-27(26)28)39(60)52-32(22-35(44)56)37(58)49-24/h2-6,10-13,23-24,29-34,48H,7-9,14-22H2,1H3,(H2,44,56)(H,49,58)(H,50,59)(H,51,57)(H,52,60)(H,53,61)(H4,45,46,47)/t24-,29-,30+,31-,32-,33-,34+/m0/s1
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n/an/an/an/a 420n/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC4R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed ...


J Med Chem 60: 805-813 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01707
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Mus musculus (Mouse))
BDBM50232419
PNG
(CHEMBL4060767)
Show SMILES NC(=N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O
Show InChI InChI=1S/C42H52N12O6/c43-42(44)46-16-6-13-30-36(55)52-33(20-26-22-47-29-12-5-4-11-28(26)29)40(59)54-18-8-15-35(54)41(60)53-17-7-14-34(53)39(58)51-32(21-27-23-45-24-48-27)38(57)50-31(37(56)49-30)19-25-9-2-1-3-10-25/h1-5,9-12,22-24,30-35,47H,6-8,13-21H2,(H,45,48)(H,49,56)(H,50,57)(H,51,58)(H,52,55)(H4,43,44,46)/t30-,31+,32-,33-,34-,35+/m0/s1
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n/an/an/an/a 6.00E+3n/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed ...


J Med Chem 60: 805-813 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01707
More data for this
Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50232421
PNG
(CHEMBL4100501)
Show SMILES COc1cc2cc(Oc3ccc(NC(=O)Nc4ccc(Cl)c(c4)C(F)(F)F)cc3)c(C)nc2cc1OC
Show InChI InChI=1S/C26H21ClF3N3O4/c1-14-22(10-15-11-23(35-2)24(36-3)13-21(15)31-14)37-18-7-4-16(5-8-18)32-25(34)33-17-6-9-20(27)19(12-17)26(28,29)30/h4-13H,1-3H3,(H2,32,33,34)
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n/an/a 100n/an/an/an/an/an/a



University of Sharjah

Curated by ChEMBL


Assay Description
Inhibition of human c-RAF using MEK1 as substrate in presence of [33P]ATP by Hotspot assay


Eur J Med Chem 127: 413-423 (2017)


Article DOI: 10.1016/j.ejmech.2017.01.006
More data for this
Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50232422
PNG
(CHEMBL4073684)
Show SMILES COc1cc2cc(Oc3ccc(NC(=O)Nc4ccc(Cl)c(Cl)c4)cc3)c(C)nc2cc1OC
Show InChI InChI=1S/C25H21Cl2N3O4/c1-14-22(10-15-11-23(32-2)24(33-3)13-21(15)28-14)34-18-7-4-16(5-8-18)29-25(31)30-17-6-9-19(26)20(27)12-17/h4-13H,1-3H3,(H2,29,30,31)
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n/an/a 220n/an/an/an/an/an/a



University of Sharjah

Curated by ChEMBL


Assay Description
Inhibition of human c-RAF using MEK1 as substrate in presence of [33P]ATP by Hotspot assay


Eur J Med Chem 127: 413-423 (2017)


Article DOI: 10.1016/j.ejmech.2017.01.006
More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (Human))
BDBM50232421
PNG
(CHEMBL4100501)
Show SMILES COc1cc2cc(Oc3ccc(NC(=O)Nc4ccc(Cl)c(c4)C(F)(F)F)cc3)c(C)nc2cc1OC
Show InChI InChI=1S/C26H21ClF3N3O4/c1-14-22(10-15-11-23(35-2)24(36-3)13-21(15)31-14)37-18-7-4-16(5-8-18)32-25(34)33-17-6-9-20(27)19(12-17)26(28,29)30/h4-13H,1-3H3,(H2,32,33,34)
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n/an/a 1.33E+3n/an/an/an/an/an/a



University of Sharjah

Curated by ChEMBL


Assay Description
Inhibition of human BRAF using MEK1 as substrate in presence of [33P]ATP by Hotspot assay


Eur J Med Chem 127: 413-423 (2017)


Article DOI: 10.1016/j.ejmech.2017.01.006
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM50232426
PNG
(CHEMBL4089754)
Show SMILES Cn1cc2cc(ccc2n1)C(=O)Nc1ccc(F)c(Cl)c1
Show InChI InChI=1S/C15H11ClFN3O/c1-20-8-10-6-9(2-5-14(10)19-20)15(21)18-11-3-4-13(17)12(16)7-11/h2-8H,1H3,(H,18,21)
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n/an/a 8.10n/an/an/an/an/an/a



NTZ Lab Ltd.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human MAOA expressed in baculovirus-infected BTI insect cells using p-tyramine as substrate measured for 45 mins in presenc...


Eur J Med Chem 127: 470-492 (2017)


Article DOI: 10.1016/j.ejmech.2017.01.011
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM50232425
PNG
(CHEMBL4061639)
Show SMILES Cn1ncc2cc(ccc12)C(=O)Nc1ccc(F)c(Cl)c1
Show InChI InChI=1S/C15H11ClFN3O/c1-20-14-5-2-9(6-10(14)8-18-20)15(21)19-11-3-4-13(17)12(16)7-11/h2-8H,1H3,(H,19,21)
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n/an/a 0.662n/an/an/an/an/an/a



NTZ Lab Ltd.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human MAOB expressed in baculovirus-infected BTI insect cells using p-tyramine as substrate measured for 45 mins in presenc...


Eur J Med Chem 127: 470-492 (2017)


Article DOI: 10.1016/j.ejmech.2017.01.011
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50232431
PNG
(CHEMBL4087086 | US10214537, Example 263)
Show SMILES C[C@H]1CN(C)C[C@@H](C)N1c1cccc(c1)-c1cc(-c2ccnn2C2CCOCC2)c2c(N)ncnn12
Show InChI InChI=1S/C27H34N8O/c1-18-15-32(3)16-19(2)33(18)22-6-4-5-20(13-22)25-14-23(26-27(28)29-17-31-35(25)26)24-7-10-30-34(24)21-8-11-36-12-9-21/h4-7,10,13-14,17-19,21H,8-9,11-12,15-16H2,1-3H3,(H2,28,29,31)/t18-,19+
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n/an/a 6n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10214537 (2019)

More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM50232428
PNG
(CHEMBL4097487)
Show SMILES Cn1cc2cc(ccc2n1)C(=O)Nc1ccc(F)c(F)c1
Show InChI InChI=1S/C15H11F2N3O/c1-20-8-10-6-9(2-5-14(10)19-20)15(21)18-11-3-4-12(16)13(17)7-11/h2-8H,1H3,(H,18,21)
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n/an/a 38n/an/an/an/an/an/a



NTZ Lab Ltd.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human MAOB expressed in baculovirus-infected BTI insect cells using p-tyramine as substrate measured for 45 mins in presenc...


Eur J Med Chem 127: 470-492 (2017)


Article DOI: 10.1016/j.ejmech.2017.01.011
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM50232425
PNG
(CHEMBL4061639)
Show SMILES Cn1ncc2cc(ccc12)C(=O)Nc1ccc(F)c(Cl)c1
Show InChI InChI=1S/C15H11ClFN3O/c1-20-14-5-2-9(6-10(14)8-18-20)15(21)19-11-3-4-13(17)12(16)7-11/h2-8H,1H3,(H,19,21)
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n/an/a>1.00E+4n/an/an/an/an/an/a



NTZ Lab Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MAOA in Sprague-Dawley rat liver mitochondria using p-tyramine as substrate measured for 45 mins in presence of MAOB inhibitor selegili...


Eur J Med Chem 127: 470-492 (2017)


Article DOI: 10.1016/j.ejmech.2017.01.011
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM50232428
PNG
(CHEMBL4097487)
Show SMILES Cn1cc2cc(ccc2n1)C(=O)Nc1ccc(F)c(F)c1
Show InChI InChI=1S/C15H11F2N3O/c1-20-8-10-6-9(2-5-14(10)19-20)15(21)18-11-3-4-12(16)13(17)7-11/h2-8H,1H3,(H,18,21)
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n/an/a 1.88E+3n/an/an/an/an/an/a



NTZ Lab Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MAOA in Sprague-Dawley rat liver mitochondria using p-tyramine as substrate measured for 45 mins in presence of MAOB inhibitor selegili...


Eur J Med Chem 127: 470-492 (2017)


Article DOI: 10.1016/j.ejmech.2017.01.011
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM50232429
PNG
(CHEMBL4104691)
Show SMILES COCCn1ncc2cc(ccc12)C(=O)Nc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C17H15Cl2N3O2/c1-24-7-6-22-16-5-2-11(8-12(16)10-20-22)17(23)21-13-3-4-14(18)15(19)9-13/h2-5,8-10H,6-7H2,1H3,(H,21,23)
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n/an/a>1.00E+4n/an/an/an/an/an/a



NTZ Lab Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MAOA in Sprague-Dawley rat liver mitochondria using p-tyramine as substrate measured for 45 mins in presence of MAOB inhibitor selegili...


Eur J Med Chem 127: 470-492 (2017)


Article DOI: 10.1016/j.ejmech.2017.01.011
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM50232426
PNG
(CHEMBL4089754)
Show SMILES Cn1cc2cc(ccc2n1)C(=O)Nc1ccc(F)c(Cl)c1
Show InChI InChI=1S/C15H11ClFN3O/c1-20-8-10-6-9(2-5-14(10)19-20)15(21)18-11-3-4-13(17)12(16)7-11/h2-8H,1H3,(H,18,21)
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n/an/a 562n/an/an/an/an/an/a



NTZ Lab Ltd.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human MAOA expressed in baculovirus-infected BTI insect cells using p-tyramine as substrate measured for 45 mins in presenc...


Eur J Med Chem 127: 470-492 (2017)


Article DOI: 10.1016/j.ejmech.2017.01.011
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM50232428
PNG
(CHEMBL4097487)
Show SMILES Cn1cc2cc(ccc2n1)C(=O)Nc1ccc(F)c(F)c1
Show InChI InChI=1S/C15H11F2N3O/c1-20-8-10-6-9(2-5-14(10)19-20)15(21)18-11-3-4-12(16)13(17)7-11/h2-8H,1H3,(H,18,21)
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n/an/a 764n/an/an/an/an/an/a



NTZ Lab Ltd.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human MAOA expressed in baculovirus-infected BTI insect cells using p-tyramine as substrate measured for 45 mins in presenc...


Eur J Med Chem 127: 470-492 (2017)


Article DOI: 10.1016/j.ejmech.2017.01.011
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM50232426
PNG
(CHEMBL4089754)
Show SMILES Cn1cc2cc(ccc2n1)C(=O)Nc1ccc(F)c(Cl)c1
Show InChI InChI=1S/C15H11ClFN3O/c1-20-8-10-6-9(2-5-14(10)19-20)15(21)18-11-3-4-13(17)12(16)7-11/h2-8H,1H3,(H,18,21)
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n/an/a 20n/an/an/an/an/an/a



NTZ Lab Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MAOB in Sprague-Dawley rat liver mitochondria using p-tyramine as substrate measured for 45 mins in presence of MAOA inhibitor clorgyli...


Eur J Med Chem 127: 470-492 (2017)


Article DOI: 10.1016/j.ejmech.2017.01.011
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM50232428
PNG
(CHEMBL4097487)
Show SMILES Cn1cc2cc(ccc2n1)C(=O)Nc1ccc(F)c(F)c1
Show InChI InChI=1S/C15H11F2N3O/c1-20-8-10-6-9(2-5-14(10)19-20)15(21)18-11-3-4-12(16)13(17)7-11/h2-8H,1H3,(H,18,21)
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n/an/a 221n/an/an/an/an/an/a



NTZ Lab Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MAOB in Sprague-Dawley rat liver mitochondria using p-tyramine as substrate measured for 45 mins in presence of MAOA inhibitor clorgyli...


Eur J Med Chem 127: 470-492 (2017)


Article DOI: 10.1016/j.ejmech.2017.01.011
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM50232425
PNG
(CHEMBL4061639)
Show SMILES Cn1ncc2cc(ccc12)C(=O)Nc1ccc(F)c(Cl)c1
Show InChI InChI=1S/C15H11ClFN3O/c1-20-14-5-2-9(6-10(14)8-18-20)15(21)19-11-3-4-13(17)12(16)7-11/h2-8H,1H3,(H,19,21)
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n/an/a 0.661n/an/an/an/an/an/a



NTZ Lab Ltd.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human MAOA expressed in baculovirus-infected BTI insect cells using p-tyramine as substrate measured for 45 mins in presenc...


Eur J Med Chem 127: 470-492 (2017)


Article DOI: 10.1016/j.ejmech.2017.01.011
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM50232426
PNG
(CHEMBL4089754)
Show SMILES Cn1cc2cc(ccc2n1)C(=O)Nc1ccc(F)c(Cl)c1
Show InChI InChI=1S/C15H11ClFN3O/c1-20-8-10-6-9(2-5-14(10)19-20)15(21)18-11-3-4-13(17)12(16)7-11/h2-8H,1H3,(H,18,21)
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n/an/a 1.69E+3n/an/an/an/an/an/a



NTZ Lab Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MAOA in Sprague-Dawley rat liver mitochondria using p-tyramine as substrate measured for 45 mins in presence of MAOB inhibitor selegili...


Eur J Med Chem 127: 470-492 (2017)


Article DOI: 10.1016/j.ejmech.2017.01.011
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM50232429
PNG
(CHEMBL4104691)
Show SMILES COCCn1ncc2cc(ccc12)C(=O)Nc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C17H15Cl2N3O2/c1-24-7-6-22-16-5-2-11(8-12(16)10-20-22)17(23)21-13-3-4-14(18)15(19)9-13/h2-5,8-10H,6-7H2,1H3,(H,21,23)
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n/an/a 2.87E+3n/an/an/an/an/an/a



NTZ Lab Ltd.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human MAOA expressed in baculovirus-infected BTI insect cells using p-tyramine as substrate measured for 45 mins in presenc...


Eur J Med Chem 127: 470-492 (2017)


Article DOI: 10.1016/j.ejmech.2017.01.011
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM50232425
PNG
(CHEMBL4061639)
Show SMILES Cn1ncc2cc(ccc12)C(=O)Nc1ccc(F)c(Cl)c1
Show InChI InChI=1S/C15H11ClFN3O/c1-20-14-5-2-9(6-10(14)8-18-20)15(21)19-11-3-4-13(17)12(16)7-11/h2-8H,1H3,(H,19,21)
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n/an/a 1.40n/an/an/an/an/an/a



NTZ Lab Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MAOB in Sprague-Dawley rat liver mitochondria using p-tyramine as substrate measured for 45 mins in presence of MAOA inhibitor clorgyli...


Eur J Med Chem 127: 470-492 (2017)


Article DOI: 10.1016/j.ejmech.2017.01.011
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM50232429
PNG
(CHEMBL4104691)
Show SMILES COCCn1ncc2cc(ccc12)C(=O)Nc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C17H15Cl2N3O2/c1-24-7-6-22-16-5-2-11(8-12(16)10-20-22)17(23)21-13-3-4-14(18)15(19)9-13/h2-5,8-10H,6-7H2,1H3,(H,21,23)
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n/an/a 3.80n/an/an/an/an/an/a



NTZ Lab Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MAOB in Sprague-Dawley rat liver mitochondria using p-tyramine as substrate measured for 45 mins in presence of MAOA inhibitor clorgyli...


Eur J Med Chem 127: 470-492 (2017)


Article DOI: 10.1016/j.ejmech.2017.01.011
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM50232429
PNG
(CHEMBL4104691)
Show SMILES COCCn1ncc2cc(ccc12)C(=O)Nc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C17H15Cl2N3O2/c1-24-7-6-22-16-5-2-11(8-12(16)10-20-22)17(23)21-13-3-4-14(18)15(19)9-13/h2-5,8-10H,6-7H2,1H3,(H,21,23)
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n/an/a 1.10n/an/an/an/an/an/a



NTZ Lab Ltd.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human MAOB expressed in baculovirus-infected BTI insect cells using p-tyramine as substrate measured for 45 mins in presenc...


Eur J Med Chem 127: 470-492 (2017)


Article DOI: 10.1016/j.ejmech.2017.01.011
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50232431
PNG
(CHEMBL4087086 | US10214537, Example 263)
Show SMILES C[C@H]1CN(C)C[C@@H](C)N1c1cccc(c1)-c1cc(-c2ccnn2C2CCOCC2)c2c(N)ncnn12
Show InChI InChI=1S/C27H34N8O/c1-18-15-32(3)16-19(2)33(18)22-6-4-5-20(13-22)25-14-23(26-27(28)29-17-31-35(25)26)24-7-10-30-34(24)21-8-11-36-12-9-21/h4-7,10,13-14,17-19,21H,8-9,11-12,15-16H2,1-3H3,(H2,28,29,31)/t18-,19+
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n/an/a 6.40n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of PI3Kdelta (unknown origin) using PIP2:PS as substrate incubated for 3 hrs by ADP-Glo assay


Bioorg Med Chem Lett 27: 855-861 (2017)


Article DOI: 10.1016/j.bmcl.2017.01.016
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50232432
PNG
(CHEMBL4065659)
Show SMILES C[C@H]1CNC[C@@H](C)N1c1cccc(c1)-c1cc(-c2ccnn2C2CCOCC2)c2c(N)ncnn12
Show InChI InChI=1S/C26H32N8O/c1-17-14-28-15-18(2)32(17)21-5-3-4-19(12-21)24-13-22(25-26(27)29-16-31-34(24)25)23-6-9-30-33(23)20-7-10-35-11-8-20/h3-6,9,12-13,16-18,20,28H,7-8,10-11,14-15H2,1-2H3,(H2,27,29,31)/t17-,18+
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n/an/a 11n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of PI3Kdelta (unknown origin) using PIP2:PS as substrate incubated for 3 hrs by ADP-Glo assay


Bioorg Med Chem Lett 27: 855-861 (2017)


Article DOI: 10.1016/j.bmcl.2017.01.016
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50232432
PNG
(CHEMBL4065659)
Show SMILES C[C@H]1CNC[C@@H](C)N1c1cccc(c1)-c1cc(-c2ccnn2C2CCOCC2)c2c(N)ncnn12
Show InChI InChI=1S/C26H32N8O/c1-17-14-28-15-18(2)32(17)21-5-3-4-19(12-21)24-13-22(25-26(27)29-16-31-34(24)25)23-6-9-30-33(23)20-7-10-35-11-8-20/h3-6,9,12-13,16-18,20,28H,7-8,10-11,14-15H2,1-2H3,(H2,27,29,31)/t17-,18+
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n/an/a 314n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of PI3Kdelta in human whole blood assessed as suppression of CD69 expression incubated for 60 mins


Bioorg Med Chem Lett 27: 855-861 (2017)


Article DOI: 10.1016/j.bmcl.2017.01.016
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50232431
PNG
(CHEMBL4087086 | US10214537, Example 263)
Show SMILES C[C@H]1CN(C)C[C@@H](C)N1c1cccc(c1)-c1cc(-c2ccnn2C2CCOCC2)c2c(N)ncnn12
Show InChI InChI=1S/C27H34N8O/c1-18-15-32(3)16-19(2)33(18)22-6-4-5-20(13-22)25-14-23(26-27(28)29-17-31-35(25)26)24-7-10-30-34(24)21-8-11-36-12-9-21/h4-7,10,13-14,17-19,21H,8-9,11-12,15-16H2,1-3H3,(H2,28,29,31)/t18-,19+
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n/an/a 239n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of PI3Kdelta in human whole blood assessed as suppression of CD69 expression incubated for 60 mins


Bioorg Med Chem Lett 27: 855-861 (2017)


Article DOI: 10.1016/j.bmcl.2017.01.016
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Mus musculus)
BDBM50232418
PNG
(CHEMBL4084327)
Show SMILES NC(=N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O
Show InChI InChI=1S/C36H45N9O5/c37-36(38)39-16-6-13-26-31(46)43-28(20-23-21-40-25-12-5-4-11-24(23)25)34(49)45-18-8-15-30(45)35(50)44-17-7-14-29(44)33(48)42-27(32(47)41-26)19-22-9-2-1-3-10-22/h1-5,9-12,21,26-30,40H,6-8,13-20H2,(H,41,47)(H,42,48)(H,43,46)(H4,37,38,39)/t26-,27+,28-,29-,30+/m0/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed ...


J Med Chem 60: 805-813 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01707
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Mus musculus)
BDBM50232417
PNG
(CHEMBL4062633)
Show SMILES NC[C@@H]1NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O
Show InChI InChI=1S/C39H51N11O6/c40-21-30-37(55)50-18-8-15-32(50)38(56)49-17-7-14-31(49)36(54)47-28(19-23-9-2-1-3-10-23)34(52)45-27(13-6-16-43-39(41)42)33(51)46-29(35(53)48-30)20-24-22-44-26-12-5-4-11-25(24)26/h1-5,9-12,22,27-32,44H,6-8,13-21,40H2,(H,45,52)(H,46,51)(H,47,54)(H,48,53)(H4,41,42,43)/t27-,28+,29-,30-,31-,32+/m0/s1
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CHEMBL
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UniChem

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PubMed
n/an/an/an/a>1.00E+5n/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed ...


J Med Chem 60: 805-813 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01707
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Mus musculus (Mouse))
BDBM50232415
PNG
(CHEMBL4103508)
Show SMILES C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O
Show InChI InChI=1S/C43H56N12O8/c1-24-41(62)55-19-9-16-34(55)42(63)54-18-8-15-33(54)40(61)53-30(20-25-10-3-2-4-11-25)38(59)50-29(14-7-17-47-43(45)46)36(57)51-31(21-26-23-48-28-13-6-5-12-27(26)28)39(60)52-32(22-35(44)56)37(58)49-24/h2-6,10-13,23-24,29-34,48H,7-9,14-22H2,1H3,(H2,44,56)(H,49,58)(H,50,59)(H,51,57)(H,52,60)(H,53,61)(H4,45,46,47)/t24-,29-,30+,31-,32-,33-,34+/m0/s1
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n/an/an/an/a 70n/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed ...


J Med Chem 60: 805-813 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01707
More data for this
Ligand-Target Pair
CDGSH iron-sulfur domain-containing protein 1


(Homo sapiens (Human))
BDBM50198897
PNG
(CHEMBL568596)
Show SMILES N=C1NC(=O)\C(S1)=C\c1ccccc1
Show InChI InChI=1S/C10H8N2OS/c11-10-12-9(13)8(14-10)6-7-4-2-1-3-5-7/h1-6H,(H2,11,12,13)/b8-6-
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
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PubMed
n/an/a 3.73E+7n/an/an/an/an/an/a



West Virginia University

Curated by ChEMBL


Assay Description
Displacement of [3H]rosiglitazone from recombinant human C-terminal His-tagged MitoNEET cytosolic domain (32 to 108 residues) expressed in Escherichi...


Bioorg Med Chem Lett 26: 5350-5353 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.009
BindingDB Entry DOI: 10.7270/Q2ZP483C
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM50232426
PNG
(CHEMBL4089754)
Show SMILES Cn1cc2cc(ccc2n1)C(=O)Nc1ccc(F)c(Cl)c1
Show InChI InChI=1S/C15H11ClFN3O/c1-20-8-10-6-9(2-5-14(10)19-20)15(21)18-11-3-4-13(17)12(16)7-11/h2-8H,1H3,(H,18,21)
PDB

UniProtKB/SwissProt

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PubMed
n/an/a 8.10n/an/an/an/an/an/a



NTZ Lab Ltd.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human MAOB expressed in baculovirus-infected BTI insect cells using p-tyramine as substrate measured for 45 mins in presenc...


Eur J Med Chem 127: 470-492 (2017)


Article DOI: 10.1016/j.ejmech.2017.01.011
More data for this
Ligand-Target Pair