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33 similar compounds to monomer 50199219

Compile data set for download or QSAR
Wt: 509.0
BDBM50199224
Wt: 510.6
BDBM50199225
Wt: 472.5
BDBM50199226
Wt: 563.1
BDBM50199229
Wt: 454.5
BDBM50199230
Wt: 389.8
BDBM50199231
Wt: 631.1
BDBM50199235
Wt: 502.0
BDBM50199236
Wt: 488.9
BDBM50199237
Wt: 522.5
BDBM50199238
Wt: 581.1
BDBM50199240
Wt: 556.1
BDBM50199241
Wt: 479.5
BDBM50199242
Wt: 485.9
BDBM50199245
Wt: 543.0
BDBM50199250
Displayed 1 to 15 (of 33 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50199224,50199225,50199226,50199229,50199230,50199231,50199235,50199236,50199237,50199238,50199240,50199241,50199242,50199245,50199250   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50199236
PNG
(6-(4-chlorophenyl)-3-{2-[(4-methyl-1-piperazinyl)m...)
Show SMILES CN1CCN(Cc2ccc3cc(ccc3n2)-n2cnc3cc(sc3c2=O)-c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C27H24ClN5OS/c1-31-10-12-32(13-11-31)16-21-7-4-19-14-22(8-9-23(19)30-21)33-17-29-24-15-25(35-26(24)27(33)34)18-2-5-20(28)6-3-18/h2-9,14-15,17H,10-13,16H2,1H3
PDB
MMDB

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n/an/a 2.19E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibitory activity against hERG by patch-clamp assay


J Med Chem 49: 7095-107 (2006)


Article DOI: 10.1021/jm060572f
BindingDB Entry DOI: 10.7270/Q2P26XS8
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50199250
PNG
(6-[6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-...)
Show SMILES Clc1ccc(cc1)-c1cc2ncn(-c3ccc4cc(ccc4c3)C(=O)NCCCN3CCCC3)c(=O)c2s1
Show InChI InChI=1S/C30H27ClN4O2S/c31-24-9-6-20(7-10-24)27-18-26-28(38-27)30(37)35(19-33-26)25-11-8-21-16-23(5-4-22(21)17-25)29(36)32-12-3-15-34-13-1-2-14-34/h4-11,16-19H,1-3,12-15H2,(H,32,36)
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n/an/a 1.41E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against human MCH1 receptor stably-expressed in CHO cells by Gal4/Elk1-Luc reporter assay


J Med Chem 49: 7108-18 (2006)


Article DOI: 10.1021/jm060814b
BindingDB Entry DOI: 10.7270/Q2JD4WFT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50199226
PNG
(6-(4-fluorophenyl)-3-[2-(4-morpholinylmethyl)-6-qu...)
Show SMILES Fc1ccc(cc1)-c1cc2ncn(-c3ccc4nc(CN5CCOCC5)ccc4c3)c(=O)c2s1
Show InChI InChI=1S/C26H21FN4O2S/c27-19-4-1-17(2-5-19)24-14-23-25(34-24)26(32)31(16-28-23)21-7-8-22-18(13-21)3-6-20(29-22)15-30-9-11-33-12-10-30/h1-8,13-14,16H,9-12,15H2
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n/an/a 501n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against human MCHR1 expressed in CHO cells by Gal4/Elk1-Luc reporter assay


J Med Chem 49: 7095-107 (2006)


Article DOI: 10.1021/jm060572f
BindingDB Entry DOI: 10.7270/Q2P26XS8
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50199224
PNG
(6-(4-chlorophenyl)-3-(2-{[methyl(phenyl)amino]meth...)
Show SMILES CN(Cc1ccc2cc(ccc2n1)-n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1)c1ccccc1
Show InChI InChI=1S/C29H21ClN4OS/c1-33(23-5-3-2-4-6-23)17-22-12-9-20-15-24(13-14-25(20)32-22)34-18-31-26-16-27(36-28(26)29(34)35)19-7-10-21(30)11-8-19/h2-16,18H,17H2,1H3
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n/an/a 87n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against human MCHR1 expressed in CHO cells by Gal4/Elk1-Luc reporter assay


J Med Chem 49: 7095-107 (2006)


Article DOI: 10.1021/jm060572f
BindingDB Entry DOI: 10.7270/Q2P26XS8
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50199231
PNG
(6-(4-chlorophenyl)-3-(6-quinolinyl)thieno[3,2-d]py...)
Show SMILES Clc1ccc(cc1)-c1cc2ncn(-c3ccc4ncccc4c3)c(=O)c2s1
Show InChI InChI=1S/C21H12ClN3OS/c22-15-5-3-13(4-6-15)19-11-18-20(27-19)21(26)25(12-24-18)16-7-8-17-14(10-16)2-1-9-23-17/h1-12H
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n/an/a 63n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against human MCHR1 expressed in CHO cells by Gal4/Elk1-Luc reporter assay


J Med Chem 49: 7095-107 (2006)


Article DOI: 10.1021/jm060572f
BindingDB Entry DOI: 10.7270/Q2P26XS8
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50199229
PNG
(6-(4-chlorophenyl)-3-{2-[(4-phenyl-1-piperidinyl)m...)
Show SMILES Clc1ccc(cc1)-c1cc2ncn(-c3ccc4nc(CN5CCC(CC5)c5ccccc5)ccc4c3)c(=O)c2s1
Show InChI InChI=1S/C33H27ClN4OS/c34-26-9-6-24(7-10-26)31-19-30-32(40-31)33(39)38(21-35-30)28-12-13-29-25(18-28)8-11-27(36-29)20-37-16-14-23(15-17-37)22-4-2-1-3-5-22/h1-13,18-19,21,23H,14-17,20H2
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n/an/a 1.30n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against human MCHR1 expressed in CHO cells by Gal4/Elk1-Luc reporter assay


J Med Chem 49: 7095-107 (2006)


Article DOI: 10.1021/jm060572f
BindingDB Entry DOI: 10.7270/Q2P26XS8
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50199230
PNG
(3-[2-(4-morpholinylmethyl)-6-quinolinyl]-6-phenylt...)
Show SMILES O=c1n(cnc2cc(sc12)-c1ccccc1)-c1ccc2nc(CN3CCOCC3)ccc2c1
Show InChI InChI=1S/C26H22N4O2S/c31-26-25-23(15-24(33-25)18-4-2-1-3-5-18)27-17-30(26)21-8-9-22-19(14-21)6-7-20(28-22)16-29-10-12-32-13-11-29/h1-9,14-15,17H,10-13,16H2
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n/an/a 794n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against human MCHR1 expressed in CHO cells by Gal4/Elk1-Luc reporter assay


J Med Chem 49: 7095-107 (2006)


Article DOI: 10.1021/jm060572f
BindingDB Entry DOI: 10.7270/Q2P26XS8
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50199238
PNG
(3-[2-(4-morpholinylmethyl)-6-quinolinyl]-6-[4-(tri...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cc2ncn(-c3ccc4nc(CN5CCOCC5)ccc4c3)c(=O)c2s1
Show InChI InChI=1S/C27H21F3N4O2S/c28-27(29,30)19-4-1-17(2-5-19)24-14-23-25(37-24)26(35)34(16-31-23)21-7-8-22-18(13-21)3-6-20(32-22)15-33-9-11-36-12-10-33/h1-8,13-14,16H,9-12,15H2
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n/an/a 36n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against human MCHR1 expressed in CHO cells by Gal4/Elk1-Luc reporter assay


J Med Chem 49: 7095-107 (2006)


Article DOI: 10.1021/jm060572f
BindingDB Entry DOI: 10.7270/Q2P26XS8
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50199235
PNG
(6-(4-chlorophenyl)-3-[2-({4-[4-(trifluoromethyl)ph...)
Show SMILES FC(F)(F)c1ccc(cc1)C1CCN(Cc2ccc3cc(ccc3n2)-n2cnc3cc(sc3c2=O)-c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C34H26ClF3N4OS/c35-26-8-3-23(4-9-26)31-18-30-32(44-31)33(43)42(20-39-30)28-11-12-29-24(17-28)5-10-27(40-29)19-41-15-13-22(14-16-41)21-1-6-25(7-2-21)34(36,37)38/h1-12,17-18,20,22H,13-16,19H2
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n/an/a 6.10n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against human MCHR1 expressed in CHO cells by Gal4/Elk1-Luc reporter assay


J Med Chem 49: 7095-107 (2006)


Article DOI: 10.1021/jm060572f
BindingDB Entry DOI: 10.7270/Q2P26XS8
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50199237
PNG
(6-(2-chlorophenyl)-3-[2-(4-morpholinylmethyl)-6-qu...)
Show SMILES Clc1ccccc1-c1cc2ncn(-c3ccc4nc(CN5CCOCC5)ccc4c3)c(=O)c2s1
Show InChI InChI=1S/C26H21ClN4O2S/c27-21-4-2-1-3-20(21)24-14-23-25(34-24)26(32)31(16-28-23)19-7-8-22-17(13-19)5-6-18(29-22)15-30-9-11-33-12-10-30/h1-8,13-14,16H,9-12,15H2
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n/an/a 1.26E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against human MCHR1 expressed in CHO cells by Gal4/Elk1-Luc reporter assay


J Med Chem 49: 7095-107 (2006)


Article DOI: 10.1021/jm060572f
BindingDB Entry DOI: 10.7270/Q2P26XS8
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50199236
PNG
(6-(4-chlorophenyl)-3-{2-[(4-methyl-1-piperazinyl)m...)
Show SMILES CN1CCN(Cc2ccc3cc(ccc3n2)-n2cnc3cc(sc3c2=O)-c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C27H24ClN5OS/c1-31-10-12-32(13-11-31)16-21-7-4-19-14-22(8-9-23(19)30-21)33-17-29-24-15-25(35-26(24)27(33)34)18-2-5-20(28)6-3-18/h2-9,14-15,17H,10-13,16H2,1H3
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n/an/a 3.10n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against human MCHR1 expressed in CHO cells by Gal4/Elk1-Luc reporter assay


J Med Chem 49: 7095-107 (2006)


Article DOI: 10.1021/jm060572f
BindingDB Entry DOI: 10.7270/Q2P26XS8
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50199240
PNG
(6-(4-chlorophenyl)-3-(2-{[4-(4-fluorophenyl)-1-pip...)
Show SMILES Fc1ccc(cc1)C1CCN(Cc2ccc3cc(ccc3n2)-n2cnc3cc(sc3c2=O)-c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C33H26ClFN4OS/c34-25-6-1-23(2-7-25)31-18-30-32(41-31)33(40)39(20-36-30)28-11-12-29-24(17-28)5-10-27(37-29)19-38-15-13-22(14-16-38)21-3-8-26(35)9-4-21/h1-12,17-18,20,22H,13-16,19H2
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n/an/a 3.10n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against human MCHR1 expressed in CHO cells by Gal4/Elk1-Luc reporter assay


J Med Chem 49: 7095-107 (2006)


Article DOI: 10.1021/jm060572f
BindingDB Entry DOI: 10.7270/Q2P26XS8
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50199241
PNG
(6-(4-chlorophenyl)-3-(2-{[4-(1-pyrrolidinyl)-1-pip...)
Show SMILES Clc1ccc(cc1)-c1cc2ncn(-c3ccc4nc(CN5CCC(CC5)N5CCCC5)ccc4c3)c(=O)c2s1
Show InChI InChI=1S/C31H30ClN5OS/c32-23-6-3-21(4-7-23)29-18-28-30(39-29)31(38)37(20-33-28)26-9-10-27-22(17-26)5-8-24(34-27)19-35-15-11-25(12-16-35)36-13-1-2-14-36/h3-10,17-18,20,25H,1-2,11-16,19H2
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n/an/a 5.60n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against human MCHR1 expressed in CHO cells by Gal4/Elk1-Luc reporter assay


J Med Chem 49: 7095-107 (2006)


Article DOI: 10.1021/jm060572f
BindingDB Entry DOI: 10.7270/Q2P26XS8
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50199242
PNG
(6-(4-cyano)-3-[2-(4-morpholinylmethyl)-6-quinoliny...)
Show SMILES O=c1n(cnc2cc(sc12)-c1ccc(cc1)C#N)-c1ccc2nc(CN3CCOCC3)ccc2c1
Show InChI InChI=1S/C27H21N5O2S/c28-15-18-1-3-19(4-2-18)25-14-24-26(35-25)27(33)32(17-29-24)22-7-8-23-20(13-22)5-6-21(30-23)16-31-9-11-34-12-10-31/h1-8,13-14,17H,9-12,16H2
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n/an/a 478n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against human MCHR1 expressed in CHO cells by Gal4/Elk1-Luc reporter assay


J Med Chem 49: 7095-107 (2006)


Article DOI: 10.1021/jm060572f
BindingDB Entry DOI: 10.7270/Q2P26XS8
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50199245
PNG
(6-(4-chlorophenyl)-3-[6-(1-pyrrolidinylcarbonyl)-2...)
Show SMILES Clc1ccc(cc1)-c1cc2ncn(-c3ccc4cc(ccc4c3)C(=O)N3CCCC3)c(=O)c2s1
Show InChI InChI=1S/C27H20ClN3O2S/c28-21-8-5-17(6-9-21)24-15-23-25(34-24)27(33)31(16-29-23)22-10-7-18-13-20(4-3-19(18)14-22)26(32)30-11-1-2-12-30/h3-10,13-16H,1-2,11-12H2
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n/an/a>1.00E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against human MCH1 receptor stably-expressed in CHO cells by Gal4/Elk1-Luc reporter assay


J Med Chem 49: 7108-18 (2006)


Article DOI: 10.1021/jm060814b
BindingDB Entry DOI: 10.7270/Q2JD4WFT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50199225
PNG
(6-[4-(1,1-dimethylethyl)phenyl]-3-[2-(4-morpholiny...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1cc2ncn(-c3ccc4nc(CN5CCOCC5)ccc4c3)c(=O)c2s1
Show InChI InChI=1S/C30H30N4O2S/c1-30(2,3)22-7-4-20(5-8-22)27-17-26-28(37-27)29(35)34(19-31-26)24-10-11-25-21(16-24)6-9-23(32-25)18-33-12-14-36-15-13-33/h4-11,16-17,19H,12-15,18H2,1-3H3
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n/an/a 501n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against human MCHR1 expressed in CHO cells by Gal4/Elk1-Luc reporter assay


J Med Chem 49: 7095-107 (2006)


Article DOI: 10.1021/jm060572f
BindingDB Entry DOI: 10.7270/Q2P26XS8
More data for this
Ligand-Target Pair