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12 similar compounds to monomer 50268995

Compile data set for download or QSAR
Wt: 336.3
BDBM50204898
Wt: 371.4
BDBM50268946
Wt: 369.4
BDBM50268947
Wt: 385.4
BDBM50268948
Wt: 371.4
BDBM50268949
Wt: 383.5
BDBM50268950
Wt: 399.5
BDBM50268994
Wt: 405.4
BDBM50268997
Wt: 371.4
BDBM50269052
Wt: 411.5
BDBM50297719
Wt: 383.4
BDBM50297720
Wt: 353.4
BDBM50297722

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 50204898,50268946,50268947,50268948,50268949,50268950,50268994,50268997,50269052,50297719,50297720,50297722   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50268997
PNG
((4,4-Difluoropiperidin-1-yl)[5-(1-isopropyl-piperi...)
Show SMILES CC(C)N1CCC(CC1)Oc1ccc2[nH]c(cc2c1)C(=O)N1CCC(F)(F)CC1
Show InChI InChI=1S/C22H29F2N3O2/c1-15(2)26-9-5-17(6-10-26)29-18-3-4-19-16(13-18)14-20(25-19)21(28)27-11-7-22(23,24)8-12-27/h3-4,13-15,17,25H,5-12H2,1-2H3
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2n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H](R)-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in CHO cells by liquid scintillation counting


J Med Chem 52: 3855-68 (2009)


Article DOI: 10.1021/jm900409x
BindingDB Entry DOI: 10.7270/Q2SB46NQ
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50268947
PNG
((5-(1-cyclopropylpiperidin-4-yloxy)-1H-indol-2-yl)...)
Show SMILES O=C(N1CCOCC1)c1cc2cc(OC3CCN(CC3)C3CC3)ccc2[nH]1
Show InChI InChI=1S/C21H27N3O3/c25-21(24-9-11-26-12-10-24)20-14-15-13-18(3-4-19(15)22-20)27-17-5-7-23(8-6-17)16-1-2-16/h3-4,13-14,16-17,22H,1-2,5-12H2
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2n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H](R)-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in CHO cells by liquid scintillation counting


J Med Chem 52: 3855-68 (2009)


Article DOI: 10.1021/jm900409x
BindingDB Entry DOI: 10.7270/Q2SB46NQ
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50268947
PNG
((5-(1-cyclopropylpiperidin-4-yloxy)-1H-indol-2-yl)...)
Show SMILES O=C(N1CCOCC1)c1cc2cc(OC3CCN(CC3)C3CC3)ccc2[nH]1
Show InChI InChI=1S/C21H27N3O3/c25-21(24-9-11-26-12-10-24)20-14-15-13-18(3-4-19(15)22-20)27-17-5-7-23(8-6-17)16-1-2-16/h3-4,13-14,16-17,22H,1-2,5-12H2
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2n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H](R)-alpha-methylhistamine from rat recombinant histamine H3 receptor expressed in CHO cells by liquid scintillation counting


J Med Chem 52: 3855-68 (2009)


Article DOI: 10.1021/jm900409x
BindingDB Entry DOI: 10.7270/Q2SB46NQ
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50268997
PNG
((4,4-Difluoropiperidin-1-yl)[5-(1-isopropyl-piperi...)
Show SMILES CC(C)N1CCC(CC1)Oc1ccc2[nH]c(cc2c1)C(=O)N1CCC(F)(F)CC1
Show InChI InChI=1S/C22H29F2N3O2/c1-15(2)26-9-5-17(6-10-26)29-18-3-4-19-16(13-18)14-20(25-19)21(28)27-11-7-22(23,24)8-12-27/h3-4,13-15,17,25H,5-12H2,1-2H3
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3n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H](R)-alpha-methylhistamine from rat recombinant histamine H3 receptor expressed in CHO cells by liquid scintillation counting


J Med Chem 52: 3855-68 (2009)


Article DOI: 10.1021/jm900409x
BindingDB Entry DOI: 10.7270/Q2SB46NQ
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50268948
PNG
((5-(1-tert-butylpiperidin-4-yloxy)-1H-indol-2-yl)(...)
Show SMILES CC(C)(C)N1CCC(CC1)Oc1ccc2[nH]c(cc2c1)C(=O)N1CCOCC1
Show InChI InChI=1S/C22H31N3O3/c1-22(2,3)25-8-6-17(7-9-25)28-18-4-5-19-16(14-18)15-20(23-19)21(26)24-10-12-27-13-11-24/h4-5,14-15,17,23H,6-13H2,1-3H3
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4n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H](R)-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in CHO cells by liquid scintillation counting


J Med Chem 52: 3855-68 (2009)


Article DOI: 10.1021/jm900409x
BindingDB Entry DOI: 10.7270/Q2SB46NQ
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50268948
PNG
((5-(1-tert-butylpiperidin-4-yloxy)-1H-indol-2-yl)(...)
Show SMILES CC(C)(C)N1CCC(CC1)Oc1ccc2[nH]c(cc2c1)C(=O)N1CCOCC1
Show InChI InChI=1S/C22H31N3O3/c1-22(2,3)25-8-6-17(7-9-25)28-18-4-5-19-16(14-18)15-20(23-19)21(26)24-10-12-27-13-11-24/h4-5,14-15,17,23H,6-13H2,1-3H3
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4n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H](R)-alpha-methylhistamine from rat recombinant histamine H3 receptor expressed in CHO cells by liquid scintillation counting


J Med Chem 52: 3855-68 (2009)


Article DOI: 10.1021/jm900409x
BindingDB Entry DOI: 10.7270/Q2SB46NQ
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50268949
PNG
((5-(1-isopropylpiperidin-4-yloxy)-1H-indol-2-yl)(m...)
Show SMILES CC(C)N1CCC(CC1)Oc1ccc2[nH]c(cc2c1)C(=O)N1CCOCC1
Show InChI InChI=1S/C21H29N3O3/c1-15(2)23-7-5-17(6-8-23)27-18-3-4-19-16(13-18)14-20(22-19)21(25)24-9-11-26-12-10-24/h3-4,13-15,17,22H,5-12H2,1-2H3
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5n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H](R)-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in CHO cells by liquid scintillation counting


J Med Chem 52: 3855-68 (2009)


Article DOI: 10.1021/jm900409x
BindingDB Entry DOI: 10.7270/Q2SB46NQ
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50268950
PNG
(CHEMBL522715 | azepan-1-yl(5-(1-isopropylpiperidin...)
Show SMILES CC(C)N1CCC(CC1)Oc1ccc2[nH]c(cc2c1)C(=O)N1CCCCCC1
Show InChI InChI=1S/C23H33N3O2/c1-17(2)25-13-9-19(10-14-25)28-20-7-8-21-18(15-20)16-22(24-21)23(27)26-11-5-3-4-6-12-26/h7-8,15-17,19,24H,3-6,9-14H2,1-2H3
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6n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H](R)-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in CHO cells by liquid scintillation counting


J Med Chem 52: 3855-68 (2009)


Article DOI: 10.1021/jm900409x
BindingDB Entry DOI: 10.7270/Q2SB46NQ
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50268949
PNG
((5-(1-isopropylpiperidin-4-yloxy)-1H-indol-2-yl)(m...)
Show SMILES CC(C)N1CCC(CC1)Oc1ccc2[nH]c(cc2c1)C(=O)N1CCOCC1
Show InChI InChI=1S/C21H29N3O3/c1-15(2)23-7-5-17(6-8-23)27-18-3-4-19-16(13-18)14-20(22-19)21(25)24-9-11-26-12-10-24/h3-4,13-15,17,22H,5-12H2,1-2H3
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7n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H](R)-alpha-methylhistamine from rat recombinant histamine H3 receptor expressed in CHO cells by liquid scintillation counting


J Med Chem 52: 3855-68 (2009)


Article DOI: 10.1021/jm900409x
BindingDB Entry DOI: 10.7270/Q2SB46NQ
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50268994
PNG
((5-(1-isopropylpiperidin-4-yloxy)-1H-indol-2-yl)(4...)
Show SMILES COC1CCN(CC1)C(=O)c1cc2cc(OC3CCN(CC3)C(C)C)ccc2[nH]1
Show InChI InChI=1S/C23H33N3O3/c1-16(2)25-10-8-19(9-11-25)29-20-4-5-21-17(14-20)15-22(24-21)23(27)26-12-6-18(28-3)7-13-26/h4-5,14-16,18-19,24H,6-13H2,1-3H3
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9n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H](R)-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in CHO cells by liquid scintillation counting


J Med Chem 52: 3855-68 (2009)


Article DOI: 10.1021/jm900409x
BindingDB Entry DOI: 10.7270/Q2SB46NQ
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50269052
PNG
((6-(1-isopropylpiperidin-4-yloxy)-1H-indol-2-yl)(m...)
Show SMILES CC(C)N1CCC(CC1)Oc1ccc2cc([nH]c2c1)C(=O)N1CCOCC1
Show InChI InChI=1S/C21H29N3O3/c1-15(2)23-7-5-17(6-8-23)27-18-4-3-16-13-20(22-19(16)14-18)21(25)24-9-11-26-12-10-24/h3-4,13-15,17,22H,5-12H2,1-2H3
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33n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H](R)-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in CHO cells by liquid scintillation counting


J Med Chem 52: 3855-68 (2009)


Article DOI: 10.1021/jm900409x
BindingDB Entry DOI: 10.7270/Q2SB46NQ
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50268994
PNG
((5-(1-isopropylpiperidin-4-yloxy)-1H-indol-2-yl)(4...)
Show SMILES COC1CCN(CC1)C(=O)c1cc2cc(OC3CCN(CC3)C(C)C)ccc2[nH]1
Show InChI InChI=1S/C23H33N3O3/c1-16(2)25-10-8-19(9-11-25)29-20-4-5-21-17(14-20)15-22(24-21)23(27)26-12-6-18(28-3)7-13-26/h4-5,14-16,18-19,24H,6-13H2,1-3H3
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37n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H](R)-alpha-methylhistamine from rat recombinant histamine H3 receptor expressed in CHO cells by liquid scintillation counting


J Med Chem 52: 3855-68 (2009)


Article DOI: 10.1021/jm900409x
BindingDB Entry DOI: 10.7270/Q2SB46NQ
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50268950
PNG
(CHEMBL522715 | azepan-1-yl(5-(1-isopropylpiperidin...)
Show SMILES CC(C)N1CCC(CC1)Oc1ccc2[nH]c(cc2c1)C(=O)N1CCCCCC1
Show InChI InChI=1S/C23H33N3O2/c1-17(2)25-13-9-19(10-14-25)28-20-7-8-21-18(15-20)16-22(24-21)23(27)26-11-5-3-4-6-12-26/h7-8,15-17,19,24H,3-6,9-14H2,1-2H3
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53n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H](R)-alpha-methylhistamine from rat recombinant histamine H3 receptor expressed in CHO cells by liquid scintillation counting


J Med Chem 52: 3855-68 (2009)


Article DOI: 10.1021/jm900409x
BindingDB Entry DOI: 10.7270/Q2SB46NQ
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50297722
PNG
(CHEMBL540415 | azetidin-1-yl(6-(1-isopropylpiperid...)
Show SMILES CC(C)N1CCC(CC1)Oc1ccc2nc(ccc2c1)C(=O)N1CCC1
Show InChI InChI=1S/C21H27N3O2/c1-15(2)23-12-8-17(9-13-23)26-18-5-7-19-16(14-18)4-6-20(22-19)21(25)24-10-3-11-24/h4-7,14-15,17H,3,8-13H2,1-2H3
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62n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human histamine H3 expressed in CHO cells by saturation binding experiment


Bioorg Med Chem Lett 19: 4495-500 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.100
BindingDB Entry DOI: 10.7270/Q2MS3STJ
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50268946
PNG
(CHEMBL522555 | morpholino(5-(3-(piperidin-1-yl)pro...)
Show SMILES O=C(N1CCOCC1)c1cc2cc(OCCCN3CCCCC3)ccc2[nH]1
Show InChI InChI=1S/C21H29N3O3/c25-21(24-10-13-26-14-11-24)20-16-17-15-18(5-6-19(17)22-20)27-12-4-9-23-7-2-1-3-8-23/h5-6,15-16,22H,1-4,7-14H2
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71n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H](R)-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in CHO cells by liquid scintillation counting


J Med Chem 52: 3855-68 (2009)


Article DOI: 10.1021/jm900409x
BindingDB Entry DOI: 10.7270/Q2SB46NQ
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50268946
PNG
(CHEMBL522555 | morpholino(5-(3-(piperidin-1-yl)pro...)
Show SMILES O=C(N1CCOCC1)c1cc2cc(OCCCN3CCCCC3)ccc2[nH]1
Show InChI InChI=1S/C21H29N3O3/c25-21(24-10-13-26-14-11-24)20-16-17-15-18(5-6-19(17)22-20)27-12-4-9-23-7-2-1-3-8-23/h5-6,15-16,22H,1-4,7-14H2
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91n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H](R)-alpha-methylhistamine from rat recombinant histamine H3 receptor expressed in CHO cells by liquid scintillation counting


J Med Chem 52: 3855-68 (2009)


Article DOI: 10.1021/jm900409x
BindingDB Entry DOI: 10.7270/Q2SB46NQ
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50269052
PNG
((6-(1-isopropylpiperidin-4-yloxy)-1H-indol-2-yl)(m...)
Show SMILES CC(C)N1CCC(CC1)Oc1ccc2cc([nH]c2c1)C(=O)N1CCOCC1
Show InChI InChI=1S/C21H29N3O3/c1-15(2)23-7-5-17(6-8-23)27-18-4-3-16-13-20(22-19(16)14-18)21(25)24-9-11-26-12-10-24/h3-4,13-15,17,22H,5-12H2,1-2H3
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95n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H](R)-alpha-methylhistamine from rat recombinant histamine H3 receptor expressed in CHO cells by liquid scintillation counting


J Med Chem 52: 3855-68 (2009)


Article DOI: 10.1021/jm900409x
BindingDB Entry DOI: 10.7270/Q2SB46NQ
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50297719
PNG
((6-(1-isopropylpiperidin-4-yloxy)quinolin-2-yl)(4-...)
Show SMILES COC1CCN(CC1)C(=O)c1ccc2cc(OC3CCN(CC3)C(C)C)ccc2n1
Show InChI InChI=1S/C24H33N3O3/c1-17(2)26-12-10-20(11-13-26)30-21-5-7-22-18(16-21)4-6-23(25-22)24(28)27-14-8-19(29-3)9-15-27/h4-7,16-17,19-20H,8-15H2,1-3H3
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125n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human histamine H3 expressed in CHO cells by saturation binding experiment


Bioorg Med Chem Lett 19: 4495-500 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.100
BindingDB Entry DOI: 10.7270/Q2MS3STJ
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50297720
PNG
((6-(1-isopropylpiperidin-4-yloxy)quinolin-2-yl)(mo...)
Show SMILES CC(C)N1CCC(CC1)Oc1ccc2nc(ccc2c1)C(=O)N1CCOCC1
Show InChI InChI=1S/C22H29N3O3/c1-16(2)24-9-7-18(8-10-24)28-19-4-6-20-17(15-19)3-5-21(23-20)22(26)25-11-13-27-14-12-25/h3-6,15-16,18H,7-14H2,1-2H3
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238n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of human histamine H3 expressed in CHO cells by saturation binding experiment


Bioorg Med Chem Lett 19: 4495-500 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.100
BindingDB Entry DOI: 10.7270/Q2MS3STJ
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50269052
PNG
((6-(1-isopropylpiperidin-4-yloxy)-1H-indol-2-yl)(m...)
Show SMILES CC(C)N1CCC(CC1)Oc1ccc2cc([nH]c2c1)C(=O)N1CCOCC1
Show InChI InChI=1S/C21H29N3O3/c1-15(2)23-7-5-17(6-8-23)27-18-4-3-16-13-20(22-19(16)14-18)21(25)24-9-11-26-12-10-24/h3-4,13-15,17,22H,5-12H2,1-2H3
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n/an/an/an/a 23n/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Inverse agonist activity at human histamine H3 receptor expressed in CHO cells by GTPgamma[35S] binding assay


J Med Chem 52: 3855-68 (2009)


Article DOI: 10.1021/jm900409x
BindingDB Entry DOI: 10.7270/Q2SB46NQ
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50268997
PNG
((4,4-Difluoropiperidin-1-yl)[5-(1-isopropyl-piperi...)
Show SMILES CC(C)N1CCC(CC1)Oc1ccc2[nH]c(cc2c1)C(=O)N1CCC(F)(F)CC1
Show InChI InChI=1S/C22H29F2N3O2/c1-15(2)26-9-5-17(6-10-26)29-18-3-4-19-16(13-18)14-20(25-19)21(28)27-11-7-22(23,24)8-12-27/h3-4,13-15,17,25H,5-12H2,1-2H3
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n/an/an/an/a 4n/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Inverse agonist activity at human histamine H3 receptor expressed in CHO cells by GTPgamma[35S] binding assay


J Med Chem 52: 3855-68 (2009)


Article DOI: 10.1021/jm900409x
BindingDB Entry DOI: 10.7270/Q2SB46NQ
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50268994
PNG
((5-(1-isopropylpiperidin-4-yloxy)-1H-indol-2-yl)(4...)
Show SMILES COC1CCN(CC1)C(=O)c1cc2cc(OC3CCN(CC3)C(C)C)ccc2[nH]1
Show InChI InChI=1S/C23H33N3O3/c1-16(2)25-10-8-19(9-11-25)29-20-4-5-21-17(14-20)15-22(24-21)23(27)26-12-6-18(28-3)7-13-26/h4-5,14-16,18-19,24H,6-13H2,1-3H3
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n/an/an/an/a 9n/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Inverse agonist activity at human histamine H3 receptor expressed in CHO cells by GTPgamma[35S] binding assay


J Med Chem 52: 3855-68 (2009)


Article DOI: 10.1021/jm900409x
BindingDB Entry DOI: 10.7270/Q2SB46NQ
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50268948
PNG
((5-(1-tert-butylpiperidin-4-yloxy)-1H-indol-2-yl)(...)
Show SMILES CC(C)(C)N1CCC(CC1)Oc1ccc2[nH]c(cc2c1)C(=O)N1CCOCC1
Show InChI InChI=1S/C22H31N3O3/c1-22(2,3)25-8-6-17(7-9-25)28-18-4-5-19-16(14-18)15-20(23-19)21(26)24-10-12-27-13-11-24/h4-5,14-15,17,23H,6-13H2,1-3H3
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n/an/an/an/a 6n/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Inverse agonist activity at human histamine H3 receptor expressed in CHO cells by GTPgamma[35S] binding assay


J Med Chem 52: 3855-68 (2009)


Article DOI: 10.1021/jm900409x
BindingDB Entry DOI: 10.7270/Q2SB46NQ
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50268947
PNG
((5-(1-cyclopropylpiperidin-4-yloxy)-1H-indol-2-yl)...)
Show SMILES O=C(N1CCOCC1)c1cc2cc(OC3CCN(CC3)C3CC3)ccc2[nH]1
Show InChI InChI=1S/C21H27N3O3/c25-21(24-9-11-26-12-10-24)20-14-15-13-18(3-4-19(15)22-20)27-17-5-7-23(8-6-17)16-1-2-16/h3-4,13-14,16-17,22H,1-2,5-12H2
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n/an/an/an/a 4n/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Inverse agonist activity at human histamine H3 receptor expressed in CHO cells by GTPgamma[35S] binding assay


J Med Chem 52: 3855-68 (2009)


Article DOI: 10.1021/jm900409x
BindingDB Entry DOI: 10.7270/Q2SB46NQ
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50268946
PNG
(CHEMBL522555 | morpholino(5-(3-(piperidin-1-yl)pro...)
Show SMILES O=C(N1CCOCC1)c1cc2cc(OCCCN3CCCCC3)ccc2[nH]1
Show InChI InChI=1S/C21H29N3O3/c25-21(24-10-13-26-14-11-24)20-16-17-15-18(5-6-19(17)22-20)27-12-4-9-23-7-2-1-3-8-23/h5-6,15-16,22H,1-4,7-14H2
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n/an/an/an/a 54n/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Inverse agonist activity at human histamine H3 receptor expressed in CHO cells by GTPgamma[35S] binding assay


J Med Chem 52: 3855-68 (2009)


Article DOI: 10.1021/jm900409x
BindingDB Entry DOI: 10.7270/Q2SB46NQ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Rattus norvegicus (Rat))
BDBM50204898
PNG
((6-hydroxy-1H-indole-2-yl)-(4-phenoxypiperidine)-m...)
Show SMILES Oc1ccc2cc([nH]c2c1)C(=O)N1CCC(CC1)Oc1ccccc1
Show InChI InChI=1S/C20H20N2O3/c23-15-7-6-14-12-19(21-18(14)13-15)20(24)22-10-8-17(9-11-22)25-16-4-2-1-3-5-16/h1-7,12-13,17,21,23H,8-11H2
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n/an/a 107n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Rattus norvegicus (Rat))
BDBM50204898
PNG
((6-hydroxy-1H-indole-2-yl)-(4-phenoxypiperidine)-m...)
Show SMILES Oc1ccc2cc([nH]c2c1)C(=O)N1CCC(CC1)Oc1ccccc1
Show InChI InChI=1S/C20H20N2O3/c23-15-7-6-14-12-19(21-18(14)13-15)20(24)22-10-8-17(9-11-22)25-16-4-2-1-3-5-16/h1-7,12-13,17,21,23H,8-11H2
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n/an/a 89n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair