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30 similar compounds to monomer 50326387

Compile data set for download or QSAR
Wt: 249.3
BDBM50205125
Wt: 235.3
BDBM50205133
Wt: 276.3
BDBM50205200
Wt: 292.3
BDBM50205202
Wt: 318.4
BDBM50205203
Wt: 236.2
BDBM50205204
Wt: 292.3
BDBM50205205
Wt: 290.3
BDBM50205207
Wt: 290.3
BDBM50205208
Wt: 278.3
BDBM50205206
Wt: 278.3
BDBM50205210
Wt: 304.3
BDBM50205211
Wt: 304.3
BDBM50205212
Wt: 264.3
BDBM50205215
Wt: 264.3
BDBM50205216
Displayed 1 to 15 (of 30 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50205125,50205133,50205200,50205202,50205203,50205204,50205205,50205207,50205208,50205206,50205210,50205211,50205212,50205215,50205216   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50205125
PNG
((2S)-1-{[(2S,4S)-4-isobutyl-2-pyrrolidinyl]carbony...)
Show SMILES CC(C)C[C@@H]1CN[C@@H](C1)C(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C14H23N3O/c1-10(2)6-11-7-13(16-9-11)14(18)17-5-3-4-12(17)8-15/h10-13,16H,3-7,9H2,1-2H3/t11-,12-,13-/m0/s1
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n/an/a 2.90n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human DPP4


Bioorg Med Chem 15: 2715-35 (2007)


Article DOI: 10.1016/j.bmc.2007.01.033
BindingDB Entry DOI: 10.7270/Q2NC60W7
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50205206
PNG
((2S,3S,5S)-5-((S)-2-cyanopyrrolidine-1-carbonyl)-N...)
Show SMILES C[C@@H]1N[C@@H](C[C@@H]1C(=O)N(C)C)C(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C14H22N4O2/c1-9-11(13(19)17(2)3)7-12(16-9)14(20)18-6-4-5-10(18)8-15/h9-12,16H,4-7H2,1-3H3/t9-,10-,11-,12-/m0/s1
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n/an/a 1.40E+4n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human DPP8


Bioorg Med Chem 16: 190-208 (2008)


Article DOI: 10.1016/j.bmc.2007.10.005
BindingDB Entry DOI: 10.7270/Q20C4WN6
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50205200
PNG
((2S)-1-{[(2S,4S)-4-(1-azetidinylcarbonyl)-2-pyrrol...)
Show SMILES O=C([C@@H]1CN[C@@H](C1)C(=O)N1CCC[C@H]1C#N)N1CCC1
Show InChI InChI=1S/C14H20N4O2/c15-8-11-3-1-6-18(11)14(20)12-7-10(9-16-12)13(19)17-4-2-5-17/h10-12,16H,1-7,9H2/t10-,11-,12-/m0/s1
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n/an/a 4n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human DPP4


Bioorg Med Chem 15: 2631-50 (2007)


Article DOI: 10.1016/j.bmc.2007.01.041
BindingDB Entry DOI: 10.7270/Q2CV4HDR
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50205202
PNG
(3-((3S,5S)-5-{[(2S)-2-cyano-1-pyrrolidinyl]carbony...)
Show SMILES CN(C)C(=O)CC[C@@H]1CN[C@@H](C1)C(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C15H24N4O2/c1-18(2)14(20)6-5-11-8-13(17-10-11)15(21)19-7-3-4-12(19)9-16/h11-13,17H,3-8,10H2,1-2H3/t11-,12-,13-/m0/s1
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n/an/a 2.40n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human DPP4


Bioorg Med Chem 15: 2631-50 (2007)


Article DOI: 10.1016/j.bmc.2007.01.041
BindingDB Entry DOI: 10.7270/Q2CV4HDR
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50205203
PNG
((2S)-1-{[(2S,4S)-4-(1-azepanylcarbonyl)-2-pyrrolid...)
Show SMILES O=C([C@@H]1C[C@@H](CN1)C(=O)N1CCCCCC1)N1CCC[C@H]1C#N
Show InChI InChI=1S/C17H26N4O2/c18-11-14-6-5-9-21(14)17(23)15-10-13(12-19-15)16(22)20-7-3-1-2-4-8-20/h13-15,19H,1-10,12H2/t13-,14-,15-/m0/s1
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n/an/a 8.30n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human DPP4


Bioorg Med Chem 15: 2631-50 (2007)


Article DOI: 10.1016/j.bmc.2007.01.041
BindingDB Entry DOI: 10.7270/Q2CV4HDR
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50205204
PNG
((3S,5S)-5-{[(2S)-2-cyano-1-pyrrolidinyl]carbonyl}-...)
Show SMILES NC(=O)[C@@H]1CN[C@@H](C1)C(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C11H16N4O2/c12-5-8-2-1-3-15(8)11(17)9-4-7(6-14-9)10(13)16/h7-9,14H,1-4,6H2,(H2,13,16)/t7-,8-,9-/m0/s1
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n/an/a 7.70n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human DPP4


Bioorg Med Chem 15: 2631-50 (2007)


Article DOI: 10.1016/j.bmc.2007.01.041
BindingDB Entry DOI: 10.7270/Q2CV4HDR
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50205205
PNG
((2S,3S,5S)-5-{[(2S)-2-cyano-1-pyrrolidinyl]carbony...)
Show SMILES CCN(C)C(=O)[C@H]1C[C@H](N[C@H]1C)C(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C15H24N4O2/c1-4-18(3)14(20)12-8-13(17-10(12)2)15(21)19-7-5-6-11(19)9-16/h10-13,17H,4-8H2,1-3H3/t10-,11-,12-,13-/m0/s1
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n/an/a 15n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human DPP4


Bioorg Med Chem 15: 2631-50 (2007)


Article DOI: 10.1016/j.bmc.2007.01.041
BindingDB Entry DOI: 10.7270/Q2CV4HDR
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50205206
PNG
((2S,3S,5S)-5-((S)-2-cyanopyrrolidine-1-carbonyl)-N...)
Show SMILES C[C@@H]1N[C@@H](C[C@@H]1C(=O)N(C)C)C(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C14H22N4O2/c1-9-11(13(19)17(2)3)7-12(16-9)14(20)18-6-4-5-10(18)8-15/h9-12,16H,4-7H2,1-3H3/t9-,10-,11-,12-/m0/s1
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n/an/a 10n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human DPP4


Bioorg Med Chem 15: 2631-50 (2007)


Article DOI: 10.1016/j.bmc.2007.01.041
BindingDB Entry DOI: 10.7270/Q2CV4HDR
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50205207
PNG
((2S)-1-{[(2S,4S,5S)-4-(1-azetidinylcarbonyl)-5-met...)
Show SMILES C[C@@H]1N[C@@H](C[C@@H]1C(=O)N1CCC1)C(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C15H22N4O2/c1-10-12(14(20)18-5-3-6-18)8-13(17-10)15(21)19-7-2-4-11(19)9-16/h10-13,17H,2-8H2,1H3/t10-,11-,12-,13-/m0/s1
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n/an/a 13n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human DPP4


Bioorg Med Chem 15: 2631-50 (2007)


Article DOI: 10.1016/j.bmc.2007.01.041
BindingDB Entry DOI: 10.7270/Q2CV4HDR
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50205208
PNG
((2S)-1-{[(2S,4S)-4-(1-pyrrolidinylcarbonyl)-2-pyrr...)
Show SMILES O=C([C@@H]1CN[C@@H](C1)C(=O)N1CCC[C@H]1C#N)N1CCCC1
Show InChI InChI=1S/C15H22N4O2/c16-9-12-4-3-7-19(12)15(21)13-8-11(10-17-13)14(20)18-5-1-2-6-18/h11-13,17H,1-8,10H2/t11-,12-,13-/m0/s1
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n/an/a 5.60n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human DPP4


Bioorg Med Chem 15: 2631-50 (2007)


Article DOI: 10.1016/j.bmc.2007.01.041
BindingDB Entry DOI: 10.7270/Q2CV4HDR
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50205210
PNG
((3S,5S)-5-{[(2S)-2-cyano-1-pyrrolidinyl]carbonyl}-...)
Show SMILES CCN(C)C(=O)[C@@H]1CN[C@@H](C1)C(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C14H22N4O2/c1-3-17(2)13(19)10-7-12(16-9-10)14(20)18-6-4-5-11(18)8-15/h10-12,16H,3-7,9H2,1-2H3/t10-,11-,12-/m0/s1
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n/an/a 4.90n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human DPP4


Bioorg Med Chem 15: 2631-50 (2007)


Article DOI: 10.1016/j.bmc.2007.01.041
BindingDB Entry DOI: 10.7270/Q2CV4HDR
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50205211
PNG
((2S)-1-{[(2S,4S,5S)-5-Methyl-4-(1-pyrrolidinylcarb...)
Show SMILES C[C@@H]1N[C@@H](C[C@@H]1C(=O)N1CCCC1)C(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C16H24N4O2/c1-11-13(15(21)19-6-2-3-7-19)9-14(18-11)16(22)20-8-4-5-12(20)10-17/h11-14,18H,2-9H2,1H3/t11-,12-,13-,14-/m0/s1
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n/an/a 6.5n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human DPP4


Bioorg Med Chem 15: 2631-50 (2007)


Article DOI: 10.1016/j.bmc.2007.01.041
BindingDB Entry DOI: 10.7270/Q2CV4HDR
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50205212
PNG
((2S)-1-{[(2S,4S)-4-(1-piperidinylcarbonyl)-2-pyrro...)
Show SMILES O=C([C@@H]1C[C@@H](CN1)C(=O)N1CCCCC1)N1CCC[C@H]1C#N
Show InChI InChI=1S/C16H24N4O2/c17-10-13-5-4-8-20(13)16(22)14-9-12(11-18-14)15(21)19-6-2-1-3-7-19/h12-14,18H,1-9,11H2/t12-,13-,14-/m0/s1
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n/an/a 4.90n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human DPP4


Bioorg Med Chem 15: 2631-50 (2007)


Article DOI: 10.1016/j.bmc.2007.01.041
BindingDB Entry DOI: 10.7270/Q2CV4HDR
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50205216
PNG
((3S,5S)-5-{[(2S)-2-cyano-1-pyrrolidinyl]carbonyl}-...)
Show SMILES CN(C)C(=O)[C@@H]1CN[C@@H](C1)C(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C13H20N4O2/c1-16(2)12(18)9-6-11(15-8-9)13(19)17-5-3-4-10(17)7-14/h9-11,15H,3-6,8H2,1-2H3/t9-,10-,11-/m0/s1
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n/an/a 1.80n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human DPP4


Bioorg Med Chem 15: 2631-50 (2007)


Article DOI: 10.1016/j.bmc.2007.01.041
BindingDB Entry DOI: 10.7270/Q2CV4HDR
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50205215
PNG
((3S,5S)-5-{[(2S)-2-cyano-1-pyrrolidinyl]carbonyl}-...)
Show SMILES CCNC(=O)[C@@H]1CN[C@@H](C1)C(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C13H20N4O2/c1-2-15-12(18)9-6-11(16-8-9)13(19)17-5-3-4-10(17)7-14/h9-11,16H,2-6,8H2,1H3,(H,15,18)/t9-,10-,11-/m0/s1
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n/an/a 4.40n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human DPP4


Bioorg Med Chem 15: 2631-50 (2007)


Article DOI: 10.1016/j.bmc.2007.01.041
BindingDB Entry DOI: 10.7270/Q2CV4HDR
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50205133
PNG
((2S)-1-{[(2S,4S)-4-propyl-2-pyrrolidinyl]carbonyl}...)
Show SMILES CCC[C@@H]1CN[C@@H](C1)C(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C13H21N3O/c1-2-4-10-7-12(15-9-10)13(17)16-6-3-5-11(16)8-14/h10-12,15H,2-7,9H2,1H3/t10-,11-,12-/m0/s1
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n/an/a 3.40n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human DPP4


Bioorg Med Chem 15: 2631-50 (2007)


Article DOI: 10.1016/j.bmc.2007.01.041
BindingDB Entry DOI: 10.7270/Q2CV4HDR
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM50205206
PNG
((2S,3S,5S)-5-((S)-2-cyanopyrrolidine-1-carbonyl)-N...)
Show SMILES C[C@@H]1N[C@@H](C[C@@H]1C(=O)N(C)C)C(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C14H22N4O2/c1-9-11(13(19)17(2)3)7-12(16-9)14(20)18-6-4-5-10(18)8-15/h9-12,16H,4-7H2,1-3H3/t9-,10-,11-,12-/m0/s1
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n/an/a 2.50E+3n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human DPP9


Bioorg Med Chem 16: 190-208 (2008)


Article DOI: 10.1016/j.bmc.2007.10.005
BindingDB Entry DOI: 10.7270/Q20C4WN6
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50205206
PNG
((2S,3S,5S)-5-((S)-2-cyanopyrrolidine-1-carbonyl)-N...)
Show SMILES C[C@@H]1N[C@@H](C[C@@H]1C(=O)N(C)C)C(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C14H22N4O2/c1-9-11(13(19)17(2)3)7-12(16-9)14(20)18-6-4-5-10(18)8-15/h9-12,16H,4-7H2,1-3H3/t9-,10-,11-,12-/m0/s1
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n/an/a 10n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human DPP4


Bioorg Med Chem 16: 190-208 (2008)


Article DOI: 10.1016/j.bmc.2007.10.005
BindingDB Entry DOI: 10.7270/Q20C4WN6
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50205133
PNG
((2S)-1-{[(2S,4S)-4-propyl-2-pyrrolidinyl]carbonyl}...)
Show SMILES CCC[C@@H]1CN[C@@H](C1)C(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C13H21N3O/c1-2-4-10-7-12(15-9-10)13(17)16-6-3-5-11(16)8-14/h10-12,15H,2-7,9H2,1H3/t10-,11-,12-/m0/s1
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n/an/a 3.40n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human DPP4


Bioorg Med Chem 15: 2715-35 (2007)


Article DOI: 10.1016/j.bmc.2007.01.033
BindingDB Entry DOI: 10.7270/Q2NC60W7
More data for this
Ligand-Target Pair