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17 similar compounds to monomer 25045

Wt: 461.5
BDBM50207163
Wt: 332.3
BDBM50207165
Wt: 347.3
BDBM50207167
Wt: 348.3
BDBM50207168
Wt: 348.3
BDBM50207169
Wt: 362.3
BDBM50207170
Wt: 406.3
BDBM50207172
Wt: 477.5
BDBM50207173
Wt: 459.5
BDBM50207175
Wt: 416.3
BDBM50446237
Wt: 362.3
BDBM50446238
Wt: 393.3
BDBM50446239
Wt: 427.2
BDBM50446240
Wt: 382.8
BDBM50446241
Wt: 366.3
BDBM50446242
Displayed 1 to 15 (of 17 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50207163,50207165,50207167,50207168,50207169,50207170,50207172,50207173,50207175,50446237,50446238,50446239,50446240,50446241,50446242   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM50207165
PNG
(4-morpholin-4-yl-2-phenyl-pyrido[3',2':4,5]furo[3,...)
Show SMILES C1CN(CCO1)c1nc(nc2c3cccnc3oc12)-c1ccccc1
Show InChI InChI=1S/C19H16N4O2/c1-2-5-13(6-3-1)17-21-15-14-7-4-8-20-19(14)25-16(15)18(22-17)23-9-11-24-12-10-23/h1-8H,9-12H2
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n/an/a 160n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of p110alpha by SPA assay


Bioorg Med Chem Lett 17: 2438-42 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.032
BindingDB Entry DOI: 10.7270/Q28053F2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM50446242
PNG
(CHEMBL3109182)
Show SMILES Oc1cc(F)cc(c1)-c1nc(N2CCOCC2)c2oc3ncccc3c2n1
Show InChI InChI=1S/C19H15FN4O3/c20-12-8-11(9-13(25)10-12)17-22-15-14-2-1-3-21-19(14)27-16(15)18(23-17)24-4-6-26-7-5-24/h1-3,8-10,25H,4-7H2
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TBA

Assay Description
Inhibition of N-terminal His-6-tagged full length human PI3Kalpha expressed in baculovirus-infected sf9 cells after 30 mins by TR-FRET assay


Citation and Details

Article DOI: 10.1021/ml400378e
BindingDB Entry DOI: 10.7270/Q2MK6FB6
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM50207168
PNG
(2-(4-morpholin-4-yl-pyrido[3',2':4,5]furo[3,2-d]py...)
Show SMILES Oc1ccccc1-c1nc(N2CCOCC2)c2oc3ncccc3c2n1
Show InChI InChI=1S/C19H16N4O3/c24-14-6-2-1-4-12(14)17-21-15-13-5-3-7-20-19(13)26-16(15)18(22-17)23-8-10-25-11-9-23/h1-7,24H,8-11H2
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n/an/a 400n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of p110alpha by SPA assay


Bioorg Med Chem Lett 17: 2438-42 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.032
BindingDB Entry DOI: 10.7270/Q28053F2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM50207163
PNG
(4-morpholin-4-yl-2-[3-(2-morpholin-4-yl-ethoxy)-ph...)
Show SMILES C(CN1CCOCC1)Oc1cccc(c1)-c1nc(N2CCOCC2)c2oc3ncccc3c2n1
Show InChI InChI=1S/C25H27N5O4/c1-3-18(17-19(4-1)33-16-9-29-7-12-31-13-8-29)23-27-21-20-5-2-6-26-25(20)34-22(21)24(28-23)30-10-14-32-15-11-30/h1-6,17H,7-16H2
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n/an/a 16n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of p110alpha by SPA assay


Bioorg Med Chem Lett 17: 2438-42 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.032
BindingDB Entry DOI: 10.7270/Q28053F2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM50207172
PNG
(CHEMBL534951 | [3-(4-morpholin-4-yl-pyrido[3',2':4...)
Show SMILES OC(=O)COc1cccc(c1)-c1nc(N2CCOCC2)c2oc3ncccc3c2n1
Show InChI InChI=1S/C21H18N4O5/c26-16(27)12-29-14-4-1-3-13(11-14)19-23-17-15-5-2-6-22-21(15)30-18(17)20(24-19)25-7-9-28-10-8-25/h1-6,11H,7-10,12H2,(H,26,27)
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n/an/a 24n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of p110alpha by SPA assay


Bioorg Med Chem Lett 17: 2438-42 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.032
BindingDB Entry DOI: 10.7270/Q28053F2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM50207170
PNG
(2-(3-methoxy-phenyl)-4-morpholin-4-yl-pyrido[3',2'...)
Show SMILES COc1cccc(c1)-c1nc(N2CCOCC2)c2oc3ncccc3c2n1
Show InChI InChI=1S/C20H18N4O3/c1-25-14-5-2-4-13(12-14)18-22-16-15-6-3-7-21-20(15)27-17(16)19(23-18)24-8-10-26-11-9-24/h2-7,12H,8-11H2,1H3
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n/an/a 100n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of p110alpha by SPA assay


Bioorg Med Chem Lett 17: 2438-42 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.032
BindingDB Entry DOI: 10.7270/Q28053F2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM50207173
PNG
(4-morpholin-4-yl-2-[3-(2-thiomorpholin-4-yl-ethoxy...)
Show SMILES C(CN1CCSCC1)Oc1cccc(c1)-c1nc(N2CCOCC2)c2oc3ncccc3c2n1
Show InChI InChI=1S/C25H27N5O3S/c1-3-18(17-19(4-1)32-14-7-29-10-15-34-16-11-29)23-27-21-20-5-2-6-26-25(20)33-22(21)24(28-23)30-8-12-31-13-9-30/h1-6,17H,7-16H2
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n/an/a 79n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of p110alpha by SPA assay


Bioorg Med Chem Lett 17: 2438-42 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.032
BindingDB Entry DOI: 10.7270/Q28053F2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM50207169
PNG
(4-(4-morpholin-4-yl-pyrido[3',2':4,5]furo[3,2-d]py...)
Show SMILES Oc1ccc(cc1)-c1nc(N2CCOCC2)c2oc3ncccc3c2n1
Show InChI InChI=1S/C19H16N4O3/c24-13-5-3-12(4-6-13)17-21-15-14-2-1-7-20-19(14)26-16(15)18(22-17)23-8-10-25-11-9-23/h1-7,24H,8-11H2
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n/an/a 26n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of p110alpha by SPA assay


Bioorg Med Chem Lett 17: 2438-42 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.032
BindingDB Entry DOI: 10.7270/Q28053F2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM50207175
PNG
(4-morpholin-4-yl-2-[3-(2-piperidin-1-yl-ethoxy)-ph...)
Show SMILES C(CN1CCCCC1)Oc1cccc(c1)-c1nc(N2CCOCC2)c2oc3ncccc3c2n1
Show InChI InChI=1S/C26H29N5O3/c1-2-10-30(11-3-1)12-17-33-20-7-4-6-19(18-20)24-28-22-21-8-5-9-27-26(21)34-23(22)25(29-24)31-13-15-32-16-14-31/h4-9,18H,1-3,10-17H2
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n/an/a 170n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of p110alpha by SPA assay


Bioorg Med Chem Lett 17: 2438-42 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.032
BindingDB Entry DOI: 10.7270/Q28053F2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM50446237
PNG
(CHEMBL3109181)
Show SMILES Oc1cc(cc(c1)C(F)(F)F)-c1nc(N2CCOCC2)c2oc3ncccc3c2n1
Show InChI InChI=1S/C20H15F3N4O3/c21-20(22,23)12-8-11(9-13(28)10-12)17-25-15-14-2-1-3-24-19(14)30-16(15)18(26-17)27-4-6-29-7-5-27/h1-3,8-10,28H,4-7H2
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n/an/a>1.00E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of N-terminal His-6-tagged full length human PI3Kalpha expressed in baculovirus-infected sf9 cells after 30 mins by TR-FRET assay


Citation and Details

Article DOI: 10.1021/ml400378e
BindingDB Entry DOI: 10.7270/Q2MK6FB6
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM50446238
PNG
(CHEMBL3109180)
Show SMILES Cc1cc(O)cc(c1)-c1nc(N2CCOCC2)c2oc3ncccc3c2n1
Show InChI InChI=1S/C20H18N4O3/c1-12-9-13(11-14(25)10-12)18-22-16-15-3-2-4-21-20(15)27-17(16)19(23-18)24-5-7-26-8-6-24/h2-4,9-11,25H,5-8H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of N-terminal His-6-tagged full length human PI3Kalpha expressed in baculovirus-infected sf9 cells after 30 mins by TR-FRET assay


Citation and Details

Article DOI: 10.1021/ml400378e
BindingDB Entry DOI: 10.7270/Q2MK6FB6
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM50446239
PNG
(CHEMBL3109179)
Show SMILES Oc1cc(cc(c1)[N+]([O-])=O)-c1nc(N2CCOCC2)c2oc3ncccc3c2n1
Show InChI InChI=1S/C19H15N5O5/c25-13-9-11(8-12(10-13)24(26)27)17-21-15-14-2-1-3-20-19(14)29-16(15)18(22-17)23-4-6-28-7-5-23/h1-3,8-10,25H,4-7H2
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n/an/a>1.00E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of N-terminal His-6-tagged full length human PI3Kalpha expressed in baculovirus-infected sf9 cells after 30 mins by TR-FRET assay


Citation and Details

Article DOI: 10.1021/ml400378e
BindingDB Entry DOI: 10.7270/Q2MK6FB6
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM50446240
PNG
(CHEMBL3109184)
Show SMILES Oc1cc(Br)cc(c1)-c1nc(N2CCOCC2)c2oc3ncccc3c2n1
Show InChI InChI=1S/C19H15BrN4O3/c20-12-8-11(9-13(25)10-12)17-22-15-14-2-1-3-21-19(14)27-16(15)18(23-17)24-4-6-26-7-5-24/h1-3,8-10,25H,4-7H2
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n/an/a 1.21E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of N-terminal His-6-tagged full length human PI3Kalpha expressed in baculovirus-infected sf9 cells after 30 mins by TR-FRET assay


Citation and Details

Article DOI: 10.1021/ml400378e
BindingDB Entry DOI: 10.7270/Q2MK6FB6
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM50446241
PNG
(CHEMBL3109183)
Show SMILES Oc1cc(Cl)cc(c1)-c1nc(N2CCOCC2)c2oc3ncccc3c2n1
Show InChI InChI=1S/C19H15ClN4O3/c20-12-8-11(9-13(25)10-12)17-22-15-14-2-1-3-21-19(14)27-16(15)18(23-17)24-4-6-26-7-5-24/h1-3,8-10,25H,4-7H2
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n/an/a 990n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of N-terminal His-6-tagged full length human PI3Kalpha expressed in baculovirus-infected sf9 cells after 30 mins by TR-FRET assay


Citation and Details

Article DOI: 10.1021/ml400378e
BindingDB Entry DOI: 10.7270/Q2MK6FB6
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM50207167
PNG
(3-(4-morpholin-4-yl-pyrido[3',2':4,5]furo[3,2-d]py...)
Show SMILES Nc1cccc(c1)-c1nc(N2CCOCC2)c2oc3ncccc3c2n1
Show InChI InChI=1S/C19H17N5O2/c20-13-4-1-3-12(11-13)17-22-15-14-5-2-6-21-19(14)26-16(15)18(23-17)24-7-9-25-10-8-24/h1-6,11H,7-10,20H2
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n/an/a 140n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of p110alpha by SPA assay


Bioorg Med Chem Lett 17: 2438-42 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.032
BindingDB Entry DOI: 10.7270/Q28053F2
More data for this
Ligand-Target Pair