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1 similar compounds to monomer 50208340

Compile data set for download or QSAR
Wt: 464.5
BDBM50208344

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50208344   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Collagenase


(Homo sapiens (Human))
BDBM50208344
PNG
(4-((2-methylquinolin-4-yl)methoxy)-N-(2-((2-oxo-2,...)
Show SMILES Cc1cc(COc2ccc(cc2)C(=O)Nc2ccccc2Cc2c[nH]c(=O)[nH]2)c2ccccc2n1
Show InChI InChI=1S/C28H24N4O3/c1-18-14-21(24-7-3-5-9-26(24)30-18)17-35-23-12-10-19(11-13-23)27(33)32-25-8-4-2-6-20(25)15-22-16-29-28(34)31-22/h2-14,16H,15,17H2,1H3,(H,32,33)(H2,29,31,34)
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Article
PubMed
>3.33E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to MMP2


Bioorg Med Chem Lett 17: 2769-74 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.076
BindingDB Entry DOI: 10.7270/Q2ZC82J4
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM50208344
PNG
(4-((2-methylquinolin-4-yl)methoxy)-N-(2-((2-oxo-2,...)
Show SMILES Cc1cc(COc2ccc(cc2)C(=O)Nc2ccccc2Cc2c[nH]c(=O)[nH]2)c2ccccc2n1
Show InChI InChI=1S/C28H24N4O3/c1-18-14-21(24-7-3-5-9-26(24)30-18)17-35-23-12-10-19(11-13-23)27(33)32-25-8-4-2-6-20(25)15-22-16-29-28(34)31-22/h2-14,16H,15,17H2,1H3,(H,32,33)(H2,29,31,34)
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Article
PubMed
>4.50E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to MMP3


Bioorg Med Chem Lett 17: 2769-74 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.076
BindingDB Entry DOI: 10.7270/Q2ZC82J4
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50208344
PNG
(4-((2-methylquinolin-4-yl)methoxy)-N-(2-((2-oxo-2,...)
Show SMILES Cc1cc(COc2ccc(cc2)C(=O)Nc2ccccc2Cc2c[nH]c(=O)[nH]2)c2ccccc2n1
Show InChI InChI=1S/C28H24N4O3/c1-18-14-21(24-7-3-5-9-26(24)30-18)17-35-23-12-10-19(11-13-23)27(33)32-25-8-4-2-6-20(25)15-22-16-29-28(34)31-22/h2-14,16H,15,17H2,1H3,(H,32,33)(H2,29,31,34)
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Article
PubMed
>5.03E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to MMP13


Bioorg Med Chem Lett 17: 2769-74 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.076
BindingDB Entry DOI: 10.7270/Q2ZC82J4
More data for this
Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12)


(Homo sapiens (Human))
BDBM50208344
PNG
(4-((2-methylquinolin-4-yl)methoxy)-N-(2-((2-oxo-2,...)
Show SMILES Cc1cc(COc2ccc(cc2)C(=O)Nc2ccccc2Cc2c[nH]c(=O)[nH]2)c2ccccc2n1
Show InChI InChI=1S/C28H24N4O3/c1-18-14-21(24-7-3-5-9-26(24)30-18)17-35-23-12-10-19(11-13-23)27(33)32-25-8-4-2-6-20(25)15-22-16-29-28(34)31-22/h2-14,16H,15,17H2,1H3,(H,32,33)(H2,29,31,34)
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Article
PubMed
>6.02E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to MMP12


Bioorg Med Chem Lett 17: 2769-74 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.076
BindingDB Entry DOI: 10.7270/Q2ZC82J4
More data for this
Ligand-Target Pair
Matrix metalloproteinase-7 (MMP7)


(Homo sapiens (Human))
BDBM50208344
PNG
(4-((2-methylquinolin-4-yl)methoxy)-N-(2-((2-oxo-2,...)
Show SMILES Cc1cc(COc2ccc(cc2)C(=O)Nc2ccccc2Cc2c[nH]c(=O)[nH]2)c2ccccc2n1
Show InChI InChI=1S/C28H24N4O3/c1-18-14-21(24-7-3-5-9-26(24)30-18)17-35-23-12-10-19(11-13-23)27(33)32-25-8-4-2-6-20(25)15-22-16-29-28(34)31-22/h2-14,16H,15,17H2,1H3,(H,32,33)(H2,29,31,34)
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Article
PubMed
>6.37E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to MMP7


Bioorg Med Chem Lett 17: 2769-74 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.076
BindingDB Entry DOI: 10.7270/Q2ZC82J4
More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM50208344
PNG
(4-((2-methylquinolin-4-yl)methoxy)-N-(2-((2-oxo-2,...)
Show SMILES Cc1cc(COc2ccc(cc2)C(=O)Nc2ccccc2Cc2c[nH]c(=O)[nH]2)c2ccccc2n1
Show InChI InChI=1S/C28H24N4O3/c1-18-14-21(24-7-3-5-9-26(24)30-18)17-35-23-12-10-19(11-13-23)27(33)32-25-8-4-2-6-20(25)15-22-16-29-28(34)31-22/h2-14,16H,15,17H2,1H3,(H,32,33)(H2,29,31,34)
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Article
PubMed
n/an/a 1.60E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of pTACE


Bioorg Med Chem Lett 17: 2769-74 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.076
BindingDB Entry DOI: 10.7270/Q2ZC82J4
More data for this
Ligand-Target Pair