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13 similar compounds to monomer 50209193

Wt: 689.5
BDBM50209182
Wt: 649.5
BDBM50209183
Wt: 593.4
BDBM50209187
Wt: 649.4
BDBM50209190
Wt: 621.4
BDBM50209194
Wt: 608.4
BDBM50209198
Wt: 607.4
BDBM50209201
Wt: 564.3
BDBM50209202
Wt: 578.4
BDBM50209203
Wt: 609.4
BDBM50209204
Wt: 679.5
BDBM50209207
Wt: 621.4
BDBM50209208
Wt: 579.3
BDBM50209210

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50209182,50209183,50209187,50209190,50209194,50209198,50209201,50209202,50209203,50209204,50209207,50209208,50209210   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Baculoviral IAP repeat-containing protein 5


(Homo sapiens)
BDBM50209182
PNG
(CHEMBL234421 | N-(5-chloro-3-(4-(2-chloro-5-(trifl...)
Show SMILES CN(Cc1cc(Cl)cc(c1O)-c1cc(-c2cc(ccc2Cl)C(F)(F)F)c(C#N)c(=O)[nH]1)C(=O)C1CCN(CC1)C(=O)C1CCCCC1
Show InChI InChI=1S/C34H33Cl2F3N4O4/c1-42(32(46)20-9-11-43(12-10-20)33(47)19-5-3-2-4-6-19)18-21-13-23(35)15-26(30(21)44)29-16-24(27(17-40)31(45)41-29)25-14-22(34(37,38)39)7-8-28(25)36/h7-8,13-16,19-20,44H,2-6,9-12,18H2,1H3,(H,41,45)
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n/an/an/a 100n/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to human survivin expressed in Escherichia coli BL21 cells after 30 mins


Bioorg Med Chem Lett 17: 3122-9 (2007)

More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 5


(Homo sapiens)
BDBM50209208
PNG
(CHEMBL232404 | N-(5-chloro-3-(4-(2-chloro-5-(trifl...)
Show SMILES CN(Cc1cc(Cl)cc(c1O)-c1cc(-c2cc(ccc2Cl)C(F)(F)F)c(C#N)c(=O)[nH]1)C(=O)C1CCN(CC1)C(C)=O
Show InChI InChI=1S/C29H25Cl2F3N4O4/c1-15(39)38-7-5-16(6-8-38)28(42)37(2)14-17-9-19(30)11-22(26(17)40)25-12-20(23(13-35)27(41)36-25)21-10-18(29(32,33)34)3-4-24(21)31/h3-4,9-12,16,40H,5-8,14H2,1-2H3,(H,36,41)
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n/an/an/a 86n/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to human survivin expressed in Escherichia coli BL21 cells after 30 mins


Bioorg Med Chem Lett 17: 3122-9 (2007)

More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 5


(Homo sapiens)
BDBM50209190
PNG
(CHEMBL272921 | N-(5-chloro-3-(4-(2-chloro-5-(trifl...)
Show SMILES CCCC(=O)N1CCC(CC1)C(=O)N(C)Cc1cc(Cl)cc(c1O)-c1cc(-c2cc(ccc2Cl)C(F)(F)F)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C31H29Cl2F3N4O4/c1-3-4-27(41)40-9-7-17(8-10-40)30(44)39(2)16-18-11-20(32)13-23(28(18)42)26-14-21(24(15-37)29(43)38-26)22-12-19(31(34,35)36)5-6-25(22)33/h5-6,11-14,17,42H,3-4,7-10,16H2,1-2H3,(H,38,43)
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n/an/an/a 60n/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to human survivin expressed in Escherichia coli BL21 cells after 30 mins


Bioorg Med Chem Lett 17: 3122-9 (2007)

More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 5


(Homo sapiens)
BDBM50209202
PNG
(CHEMBL234608 | N-(5-chloro-3-(4-(2-chloro-5-(trifl...)
Show SMILES Oc1c(CNC(=O)C2CCCCC2)cc(Cl)cc1-c1cc(-c2cc(ccc2Cl)C(F)(F)F)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C27H22Cl2F3N3O3/c28-17-8-15(13-34-25(37)14-4-2-1-3-5-14)24(36)20(10-17)23-11-18(21(12-33)26(38)35-23)19-9-16(27(30,31)32)6-7-22(19)29/h6-11,14,36H,1-5,13H2,(H,34,37)(H,35,38)
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n/an/an/a 880n/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to human survivin expressed in Escherichia coli BL21 cells after 30 mins


Bioorg Med Chem Lett 17: 3122-9 (2007)

More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 5


(Homo sapiens)
BDBM50209203
PNG
(CHEMBL392285 | N-(5-chloro-3-(4-(2-chloro-5-(trifl...)
Show SMILES CN(Cc1cc(Cl)cc(c1O)-c1cc(-c2cc(ccc2Cl)C(F)(F)F)c(C#N)c(=O)[nH]1)C(=O)C1CCCCC1
Show InChI InChI=1S/C28H24Cl2F3N3O3/c1-36(27(39)15-5-3-2-4-6-15)14-16-9-18(29)11-21(25(16)37)24-12-19(22(13-34)26(38)35-24)20-10-17(28(31,32)33)7-8-23(20)30/h7-12,15,37H,2-6,14H2,1H3,(H,35,38)
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n/an/an/a 620n/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to human survivin expressed in Escherichia coli BL21 cells after 30 mins


Bioorg Med Chem Lett 17: 3122-9 (2007)

More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 5


(Homo sapiens)
BDBM50209210
PNG
(CHEMBL392286 | N-(5-chloro-3-(4-(2-chloro-5-(trifl...)
Show SMILES CN(Cc1cc(Cl)cc(c1O)-c1cc(-c2cc(ccc2Cl)C(F)(F)F)c(C#N)c(=O)[nH]1)C(=O)C1CCNCC1
Show InChI InChI=1S/C27H23Cl2F3N4O3/c1-36(26(39)14-4-6-34-7-5-14)13-15-8-17(28)10-20(24(15)37)23-11-18(21(12-33)25(38)35-23)19-9-16(27(30,31)32)2-3-22(19)29/h2-3,8-11,14,34,37H,4-7,13H2,1H3,(H,35,38)
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n/an/an/a 530n/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to human survivin expressed in Escherichia coli BL21 cells after 30 mins


Bioorg Med Chem Lett 17: 3122-9 (2007)

More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 5


(Homo sapiens)
BDBM50209194
PNG
(CHEMBL234358 | N-(5-chloro-3-(4-(2-chloro-5-(trifl...)
Show SMILES CCCN1CCC(CC1)C(=O)N(C)Cc1cc(Cl)cc(c1O)-c1cc(-c2cc(ccc2Cl)C(F)(F)F)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C30H29Cl2F3N4O3/c1-3-8-39-9-6-17(7-10-39)29(42)38(2)16-18-11-20(31)13-23(27(18)40)26-14-21(24(15-36)28(41)37-26)22-12-19(30(33,34)35)4-5-25(22)32/h4-5,11-14,17,40H,3,6-10,16H2,1-2H3,(H,37,41)
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n/an/an/a 37n/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to human survivin expressed in Escherichia coli BL21 cells after 30 mins


Bioorg Med Chem Lett 17: 3122-9 (2007)

More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 5


(Homo sapiens)
BDBM50209198
PNG
(CHEMBL234041 | N-(5-chloro-3-(4-(2-chloro-5-(trifl...)
Show SMILES COC1CCC(CC1)C(=O)N(C)Cc1cc(Cl)cc(c1O)-c1cc(-c2cc(ccc2Cl)C(F)(F)F)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C29H26Cl2F3N3O4/c1-37(28(40)15-3-6-19(41-2)7-4-15)14-16-9-18(30)11-22(26(16)38)25-12-20(23(13-35)27(39)36-25)21-10-17(29(32,33)34)5-8-24(21)31/h5,8-12,15,19,38H,3-4,6-7,14H2,1-2H3,(H,36,39)
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n/an/an/a 200n/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to human survivin expressed in Escherichia coli BL21 cells after 30 mins


Bioorg Med Chem Lett 17: 3122-9 (2007)

More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 5


(Homo sapiens)
BDBM50209183
PNG
(CHEMBL396856 | N-(5-chloro-3-(4-(2-chloro-5-(trifl...)
Show SMILES CCCCCN1CCC(CC1)C(=O)N(C)Cc1cc(Cl)cc(c1O)-c1cc(-c2cc(ccc2Cl)C(F)(F)F)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C32H33Cl2F3N4O3/c1-3-4-5-10-41-11-8-19(9-12-41)31(44)40(2)18-20-13-22(33)15-25(29(20)42)28-16-23(26(17-38)30(43)39-28)24-14-21(32(35,36)37)6-7-27(24)34/h6-7,13-16,19,42H,3-5,8-12,18H2,1-2H3,(H,39,43)
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n/an/an/a 220n/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to human survivin expressed in Escherichia coli BL21 cells after 30 mins


Bioorg Med Chem Lett 17: 3122-9 (2007)

More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 5


(Homo sapiens)
BDBM50209204
PNG
(CHEMBL234040 | N-(5-chloro-3-(4-(2-chloro-5-(trifl...)
Show SMILES CN(Cc1cc(Cl)cc(c1O)-c1cc(-c2cc(ccc2Cl)C(F)(F)F)c(C#N)c(=O)[nH]1)C(=O)CCN1CCOCC1
Show InChI InChI=1S/C28H25Cl2F3N4O4/c1-36(25(38)4-5-37-6-8-41-9-7-37)15-16-10-18(29)12-21(26(16)39)24-13-19(22(14-34)27(40)35-24)20-11-17(28(31,32)33)2-3-23(20)30/h2-3,10-13,39H,4-9,15H2,1H3,(H,35,40)
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n/an/an/a 76n/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to human survivin expressed in Escherichia coli BL21 cells after 30 mins


Bioorg Med Chem Lett 17: 3122-9 (2007)

More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 5


(Homo sapiens)
BDBM50209201
PNG
(CHEMBL233848 | N-(5-chloro-3-(4-(2-chloro-5-(trifl...)
Show SMILES CC(=O)N1CCC(CC1)C(=O)NCc1cc(Cl)cc(c1O)-c1cc(-c2cc(ccc2Cl)C(F)(F)F)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C28H23Cl2F3N4O4/c1-14(38)37-6-4-15(5-7-37)26(40)35-13-16-8-18(29)10-21(25(16)39)24-11-19(22(12-34)27(41)36-24)20-9-17(28(31,32)33)2-3-23(20)30/h2-3,8-11,15,39H,4-7,13H2,1H3,(H,35,40)(H,36,41)
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n/an/an/a 48n/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to human survivin expressed in Escherichia coli BL21 cells after 30 mins


Bioorg Med Chem Lett 17: 3122-9 (2007)

More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 5


(Homo sapiens)
BDBM50209187
PNG
(CHEMBL428195 | N-(5-chloro-3-(4-(2-chloro-5-(trifl...)
Show SMILES CN(Cc1cc(Cl)cc(c1O)-c1cc(-c2cc(ccc2Cl)C(F)(F)F)c(C#N)c(=O)[nH]1)C(=O)CCN1CCCC1
Show InChI InChI=1S/C28H25Cl2F3N4O3/c1-36(25(38)6-9-37-7-2-3-8-37)15-16-10-18(29)12-21(26(16)39)24-13-19(22(14-34)27(40)35-24)20-11-17(28(31,32)33)4-5-23(20)30/h4-5,10-13,39H,2-3,6-9,15H2,1H3,(H,35,40)
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n/an/an/a 440n/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to human survivin expressed in Escherichia coli BL21 cells after 30 mins


Bioorg Med Chem Lett 17: 3122-9 (2007)

More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 5


(Homo sapiens)
BDBM50209207
PNG
(CHEMBL394046 | tert-butyl 4-((5-chloro-3-(4-(2-chl...)
Show SMILES CN(Cc1cc(Cl)cc(c1O)-c1cc(-c2cc(ccc2Cl)C(F)(F)F)c(C#N)c(=O)[nH]1)C(=O)C1CCN(CC1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C32H31Cl2F3N4O5/c1-31(2,3)46-30(45)41-9-7-17(8-10-41)29(44)40(4)16-18-11-20(33)13-23(27(18)42)26-14-21(24(15-38)28(43)39-26)22-12-19(32(35,36)37)5-6-25(22)34/h5-6,11-14,17,42H,7-10,16H2,1-4H3,(H,39,43)
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n/an/an/a 260n/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to human survivin expressed in Escherichia coli BL21 cells after 30 mins


Bioorg Med Chem Lett 17: 3122-9 (2007)

More data for this
Ligand-Target Pair