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8 similar compounds to monomer 50212607

Compile data set for download or QSAR
Wt: 607.6
BDBM50219000
Wt: 183.1
BDBM50212606
Wt: 116.1
BDBM50212605
Wt: 347.7
BDBM50219008
Wt: 536.0
BDBM50231463

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50219000,50212606,50212605,50219008,50231463   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 4


(Homo sapiens (Human))
BDBM50219008
PNG
(CHEMBL149612)
Show SMILES CCc1cc2c(cnc(OC)c2o1)C(=O)Nc1cc[n+]([O-])cc1Cl
Show InChI InChI=1S/C16H14ClN3O4/c1-3-9-6-10-11(7-18-16(23-2)14(10)24-9)15(21)19-13-4-5-20(22)8-12(13)17/h4-8H,3H2,1-2H3,(H,19,21)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 120n/an/an/an/an/an/a



Celltech R& D

Curated by ChEMBL


Assay Description
Inhibition of human phosphodiesterase 4 from U937 cells


Bioorg Med Chem Lett 12: 509-12 (2002)


Article DOI: 10.1016/s0960-894x(01)00786-7
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219008
PNG
(CHEMBL149612)
Show SMILES CCc1cc2c(cnc(OC)c2o1)C(=O)Nc1cc[n+]([O-])cc1Cl
Show InChI InChI=1S/C16H14ClN3O4/c1-3-9-6-10-11(7-18-16(23-2)14(10)24-9)15(21)19-13-4-5-20(22)8-12(13)17/h4-8H,3H2,1-2H3,(H,19,21)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 280n/an/an/an/an/an/a



Celltech R& D

Curated by ChEMBL


Assay Description
Inhibition of rolipram binding to rat brain


Bioorg Med Chem Lett 12: 509-12 (2002)


Article DOI: 10.1016/s0960-894x(01)00786-7
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50231463
PNG
(CHEMBL1203091)
Show SMILES Cl.Oc1nc2cc3cc(OCCCS(=O)(=O)N4CCN(Cc5ccc(F)cc5)CC4)ccc3[nH]c2n1
Show InChI InChI=1S/C24H26FN5O4S.ClH/c25-19-4-2-17(3-5-19)16-29-8-10-30(11-9-29)35(32,33)13-1-12-34-20-6-7-21-18(14-20)15-22-23(26-21)28-24(31)27-22;/h2-7,14-15H,1,8-13,16H2,(H2,26,27,28,31);1H
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/a 5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet aggregation cAMP PDE in vitro


J Med Chem 36: 3251-64 (1993)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50212605
PNG
(CHEMBL351464)
Show SMILES NC1CCN(O)C1=O
Show InChI InChI=1S/C4H8N2O2/c5-3-1-2-6(8)4(3)7/h3,8H,1-2,5H2
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
n/an/a 3.39E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]glycine binding to rat cortical membranes


Bioorg Med Chem Lett 3: 71-76 (1993)


Article DOI: 10.1016/S0960-894X(00)80094-3
BindingDB Entry DOI: 10.7270/Q2RB74HX
More data for this
Ligand-Target Pair
Glutamate NMDA receptor; Grin1/Grin2c


(Rattus norvegicus (Rat))
BDBM50212606
PNG
(CHEMBL176910 | LY-301900)
Show SMILES OC(=O)[C@H]1C[C@@H](CN1)c1nnn[nH]1
Show InChI InChI=1S/C6H9N5O2/c12-6(13)4-1-3(2-7-4)5-8-10-11-9-5/h3-4,7H,1-2H2,(H,12,13)(H,8,9,10,11)/t3-,4+/m0/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

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Article
n/an/a<1.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for the ability to displace [3H]CGS-19,755 (10 nM) binding in rat forebrain membranes for NMDA receptor


Bioorg Med Chem Lett 3: 95-98 (1993)


Article DOI: 10.1016/S0960-894X(00)80099-2
BindingDB Entry DOI: 10.7270/Q2C24WCX
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))
BDBM50219000
PNG
(CHEMBL291681)
Show SMILES CCCCN(C)C(=O)[C@H](CC1CCCCC1)NC(=O)[C@H](CC(C)C)NC(=O)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C30H43F6N3O3/c1-5-6-12-39(4)28(42)25(16-20-10-8-7-9-11-20)38-27(41)24(13-19(2)3)37-26(40)17-21-14-22(29(31,32)33)18-23(15-21)30(34,35)36/h14-15,18-20,24-25H,5-13,16-17H2,1-4H3,(H,37,40)(H,38,41)/t24-,25-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 408n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of gamma-secretase activity in H4 human neuroglioma cells by measuring amyloid beta production


Bioorg Med Chem Lett 14: 1917-21 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.086
More data for this
Ligand-Target Pair