BindingDB logo
myBDB logout

17 similar compounds to monomer 50213511

Compile data set for download or QSAR
Wt: 538.6
BDBM50213533
Wt: 498.6
BDBM50213534
Wt: 520.6
BDBM50213536
Wt: 556.6
BDBM50213537
Wt: 534.6
BDBM50213539
Wt: 534.6
BDBM50213508
Wt: 538.6
BDBM50213523
Wt: 516.6
BDBM50213524
Wt: 556.6
BDBM50213525
Wt: 514.6
BDBM50213513
Wt: 554.6
BDBM50213516
Wt: 498.6
BDBM50213517
Wt: 520.6
BDBM50213519
Wt: 516.6
BDBM50213521
Wt: 554.6
BDBM50213527
Displayed 1 to 15 (of 17 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 96 hits for monomerid = 50213533,50213534,50213536,50213537,50213539,50213508,50213523,50213524,50213525,50213513,50213516,50213517,50213519,50213521,50213527   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Alpha-1D adrenergic receptor


(Homo sapiens (Human))
BDBM50213521
PNG
(CHEMBL390129 | N-((1s,4s)-4-(4-(2-isopropoxyphenyl...)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)N[C@H]1CC[C@H](CC1)N1CCC(CC1)c1ccccc1OC(C)C
Show InChI InChI=1S/C28H40N2O5S/c1-20(2)35-26-8-6-5-7-25(26)21-15-17-30(18-16-21)23-11-9-22(10-12-23)29-36(31,32)24-13-14-27(33-3)28(19-24)34-4/h5-8,13-14,19-23,29H,9-12,15-18H2,1-4H3/t22-,23+
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
0.770n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L.L.C.

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha1d receptor


Bioorg Med Chem Lett 17: 3930-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.098
BindingDB Entry DOI: 10.7270/Q2639PF1
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(Homo sapiens (Human))
BDBM50213521
PNG
(CHEMBL390129 | N-((1s,4s)-4-(4-(2-isopropoxyphenyl...)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)N[C@H]1CC[C@H](CC1)N1CCC(CC1)c1ccccc1OC(C)C
Show InChI InChI=1S/C28H40N2O5S/c1-20(2)35-26-8-6-5-7-25(26)21-15-17-30(18-16-21)23-11-9-22(10-12-23)29-36(31,32)24-13-14-27(33-3)28(19-24)34-4/h5-8,13-14,19-23,29H,9-12,15-18H2,1-4H3/t22-,23+
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
1.70n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L.L.C.

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha1d receptor


Bioorg Med Chem Lett 17: 6123-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.051
BindingDB Entry DOI: 10.7270/Q2C82925
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50213525
PNG
(3,4-dimethoxy-N-((1s,4s)-4-(4-(2-(2,2,2-trifluoroe...)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)N[C@H]1CC[C@H](CC1)N1CCC(CC1)c1ccccc1OCC(F)(F)F
Show InChI InChI=1S/C27H35F3N2O5S/c1-35-25-12-11-22(17-26(25)36-2)38(33,34)31-20-7-9-21(10-8-20)32-15-13-19(14-16-32)23-5-3-4-6-24(23)37-18-27(28,29)30/h3-6,11-12,17,19-21,31H,7-10,13-16,18H2,1-2H3/t20-,21+
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
1.80n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L.L.C.

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha1a receptor


Bioorg Med Chem Lett 17: 6123-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.051
BindingDB Entry DOI: 10.7270/Q2C82925
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50213525
PNG
(3,4-dimethoxy-N-((1s,4s)-4-(4-(2-(2,2,2-trifluoroe...)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)N[C@H]1CC[C@H](CC1)N1CCC(CC1)c1ccccc1OCC(F)(F)F
Show InChI InChI=1S/C27H35F3N2O5S/c1-35-25-12-11-22(17-26(25)36-2)38(33,34)31-20-7-9-21(10-8-20)32-15-13-19(14-16-32)23-5-3-4-6-24(23)37-18-27(28,29)30/h3-6,11-12,17,19-21,31H,7-10,13-16,18H2,1-2H3/t20-,21+
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
1.80n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L.L.C.

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha1a receptor


Bioorg Med Chem Lett 17: 3930-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.098
BindingDB Entry DOI: 10.7270/Q2639PF1
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50213521
PNG
(CHEMBL390129 | N-((1s,4s)-4-(4-(2-isopropoxyphenyl...)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)N[C@H]1CC[C@H](CC1)N1CCC(CC1)c1ccccc1OC(C)C
Show InChI InChI=1S/C28H40N2O5S/c1-20(2)35-26-8-6-5-7-25(26)21-15-17-30(18-16-21)23-11-9-22(10-12-23)29-36(31,32)24-13-14-27(33-3)28(19-24)34-4/h5-8,13-14,19-23,29H,9-12,15-18H2,1-4H3/t22-,23+
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
1.80n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L.L.C.

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha1a receptor


Bioorg Med Chem Lett 17: 6123-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.051
BindingDB Entry DOI: 10.7270/Q2C82925
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50213521
PNG
(CHEMBL390129 | N-((1s,4s)-4-(4-(2-isopropoxyphenyl...)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)N[C@H]1CC[C@H](CC1)N1CCC(CC1)c1ccccc1OC(C)C
Show InChI InChI=1S/C28H40N2O5S/c1-20(2)35-26-8-6-5-7-25(26)21-15-17-30(18-16-21)23-11-9-22(10-12-23)29-36(31,32)24-13-14-27(33-3)28(19-24)34-4/h5-8,13-14,19-23,29H,9-12,15-18H2,1-4H3/t22-,23+
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
2.20n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L.L.C.

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha1a receptor


Bioorg Med Chem Lett 17: 3930-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.098
BindingDB Entry DOI: 10.7270/Q2639PF1
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(Homo sapiens (Human))
BDBM50213525
PNG
(3,4-dimethoxy-N-((1s,4s)-4-(4-(2-(2,2,2-trifluoroe...)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)N[C@H]1CC[C@H](CC1)N1CCC(CC1)c1ccccc1OCC(F)(F)F
Show InChI InChI=1S/C27H35F3N2O5S/c1-35-25-12-11-22(17-26(25)36-2)38(33,34)31-20-7-9-21(10-8-20)32-15-13-19(14-16-32)23-5-3-4-6-24(23)37-18-27(28,29)30/h3-6,11-12,17,19-21,31H,7-10,13-16,18H2,1-2H3/t20-,21+
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
2.20n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L.L.C.

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha1d receptor


Bioorg Med Chem Lett 17: 3930-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.098
BindingDB Entry DOI: 10.7270/Q2639PF1
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50213527
PNG
(CHEMBL228390 | N-((1r,4r)-4-(4-(2-(2,2,2-trifluoro...)
Show SMILES FC(F)(F)COc1ccccc1C1CCN(CC1)[C@H]1CC[C@@H](CC1)NS(=O)(=O)c1ccc2OCCOc2c1
Show InChI InChI=1S/C27H33F3N2O5S/c28-27(29,30)18-37-24-4-2-1-3-23(24)19-11-13-32(14-12-19)21-7-5-20(6-8-21)31-38(33,34)22-9-10-25-26(17-22)36-16-15-35-25/h1-4,9-10,17,19-21,31H,5-8,11-16,18H2/t20-,21-
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
2.20n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L.L.C.

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha1a receptor


Bioorg Med Chem Lett 17: 3930-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.098
BindingDB Entry DOI: 10.7270/Q2639PF1
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(Homo sapiens (Human))
BDBM50213525
PNG
(3,4-dimethoxy-N-((1s,4s)-4-(4-(2-(2,2,2-trifluoroe...)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)N[C@H]1CC[C@H](CC1)N1CCC(CC1)c1ccccc1OCC(F)(F)F
Show InChI InChI=1S/C27H35F3N2O5S/c1-35-25-12-11-22(17-26(25)36-2)38(33,34)31-20-7-9-21(10-8-20)32-15-13-19(14-16-32)23-5-3-4-6-24(23)37-18-27(28,29)30/h3-6,11-12,17,19-21,31H,7-10,13-16,18H2,1-2H3/t20-,21+
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
2.20n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L.L.C.

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha1d receptor


Bioorg Med Chem Lett 17: 6123-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.051
BindingDB Entry DOI: 10.7270/Q2C82925
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(Homo sapiens (Human))
BDBM50213516
PNG
(CHEMBL439197 | N-((1s,4s)-4-(4-(2-(2,2,2-trifluoro...)
Show SMILES FC(F)(F)COc1ccccc1C1CCN(CC1)[C@@H]1CC[C@@H](CC1)NS(=O)(=O)c1ccc2OCCOc2c1
Show InChI InChI=1S/C27H33F3N2O5S/c28-27(29,30)18-37-24-4-2-1-3-23(24)19-11-13-32(14-12-19)21-7-5-20(6-8-21)31-38(33,34)22-9-10-25-26(17-22)36-16-15-35-25/h1-4,9-10,17,19-21,31H,5-8,11-16,18H2/t20-,21+
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
3n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L.L.C.

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha1d receptor


Bioorg Med Chem Lett 17: 3930-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.098
BindingDB Entry DOI: 10.7270/Q2639PF1
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50213516
PNG
(CHEMBL439197 | N-((1s,4s)-4-(4-(2-(2,2,2-trifluoro...)
Show SMILES FC(F)(F)COc1ccccc1C1CCN(CC1)[C@@H]1CC[C@@H](CC1)NS(=O)(=O)c1ccc2OCCOc2c1
Show InChI InChI=1S/C27H33F3N2O5S/c28-27(29,30)18-37-24-4-2-1-3-23(24)19-11-13-32(14-12-19)21-7-5-20(6-8-21)31-38(33,34)22-9-10-25-26(17-22)36-16-15-35-25/h1-4,9-10,17,19-21,31H,5-8,11-16,18H2/t20-,21+
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
4n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L.L.C.

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha1a receptor


Bioorg Med Chem Lett 17: 3930-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.098
BindingDB Entry DOI: 10.7270/Q2639PF1
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(Homo sapiens (Human))
BDBM50213523
PNG
(CHEMBL387833 | N-((1s,4s)-4-(4-(2-(2,2-difluoroeth...)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)N[C@H]1CC[C@H](CC1)N1CCC(CC1)c1ccccc1OCC(F)F
Show InChI InChI=1S/C27H36F2N2O5S/c1-34-25-12-11-22(17-26(25)35-2)37(32,33)30-20-7-9-21(10-8-20)31-15-13-19(14-16-31)23-5-3-4-6-24(23)36-18-27(28)29/h3-6,11-12,17,19-21,27,30H,7-10,13-16,18H2,1-2H3/t20-,21+
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
4.10n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L.L.C.

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha1d receptor


Bioorg Med Chem Lett 17: 3930-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.098
BindingDB Entry DOI: 10.7270/Q2639PF1
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(Homo sapiens (Human))
BDBM50213536
PNG
(CHEMBL538397 | N-((1s,4s)-4-(4-(2-(2-fluoroethoxy)...)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)N[C@H]1CC[C@H](CC1)N1CCC(CC1)c1ccccc1OCCF
Show InChI InChI=1S/C27H37FN2O5S/c1-33-26-12-11-23(19-27(26)34-2)36(31,32)29-21-7-9-22(10-8-21)30-16-13-20(14-17-30)24-5-3-4-6-25(24)35-18-15-28/h3-6,11-12,19-22,29H,7-10,13-18H2,1-2H3/t21-,22+
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
5.5n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L.L.C.

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha1d receptor


Bioorg Med Chem Lett 17: 3930-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.098
BindingDB Entry DOI: 10.7270/Q2639PF1
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50213536
PNG
(CHEMBL538397 | N-((1s,4s)-4-(4-(2-(2-fluoroethoxy)...)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)N[C@H]1CC[C@H](CC1)N1CCC(CC1)c1ccccc1OCCF
Show InChI InChI=1S/C27H37FN2O5S/c1-33-26-12-11-23(19-27(26)34-2)36(31,32)29-21-7-9-22(10-8-21)30-16-13-20(14-17-30)24-5-3-4-6-25(24)35-18-15-28/h3-6,11-12,19-22,29H,7-10,13-18H2,1-2H3/t21-,22+
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
8.5n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L.L.C.

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha1a receptor


Bioorg Med Chem Lett 17: 3930-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.098
BindingDB Entry DOI: 10.7270/Q2639PF1
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(Homo sapiens (Human))
BDBM50213523
PNG
(CHEMBL387833 | N-((1s,4s)-4-(4-(2-(2,2-difluoroeth...)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)N[C@H]1CC[C@H](CC1)N1CCC(CC1)c1ccccc1OCC(F)F
Show InChI InChI=1S/C27H36F2N2O5S/c1-34-25-12-11-22(17-26(25)35-2)37(32,33)30-20-7-9-21(10-8-20)31-15-13-19(14-16-31)23-5-3-4-6-24(23)36-18-27(28)29/h3-6,11-12,17,19-21,27,30H,7-10,13-16,18H2,1-2H3/t20-,21+
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
8.60n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L.L.C.

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha1d receptor


Bioorg Med Chem Lett 17: 6123-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.051
BindingDB Entry DOI: 10.7270/Q2C82925
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(Homo sapiens (Human))
BDBM50213536
PNG
(CHEMBL538397 | N-((1s,4s)-4-(4-(2-(2-fluoroethoxy)...)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)N[C@H]1CC[C@H](CC1)N1CCC(CC1)c1ccccc1OCCF
Show InChI InChI=1S/C27H37FN2O5S/c1-33-26-12-11-23(19-27(26)34-2)36(31,32)29-21-7-9-22(10-8-21)30-16-13-20(14-17-30)24-5-3-4-6-25(24)35-18-15-28/h3-6,11-12,19-22,29H,7-10,13-18H2,1-2H3/t21-,22+
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
8.80n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L.L.C.

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha1d receptor


Bioorg Med Chem Lett 17: 6123-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.051
BindingDB Entry DOI: 10.7270/Q2C82925
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50213536
PNG
(CHEMBL538397 | N-((1s,4s)-4-(4-(2-(2-fluoroethoxy)...)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)N[C@H]1CC[C@H](CC1)N1CCC(CC1)c1ccccc1OCCF
Show InChI InChI=1S/C27H37FN2O5S/c1-33-26-12-11-23(19-27(26)34-2)36(31,32)29-21-7-9-22(10-8-21)30-16-13-20(14-17-30)24-5-3-4-6-25(24)35-18-15-28/h3-6,11-12,19-22,29H,7-10,13-18H2,1-2H3/t21-,22+
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
11n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L.L.C.

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha1a receptor


Bioorg Med Chem Lett 17: 6123-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.051
BindingDB Entry DOI: 10.7270/Q2C82925
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50213513
PNG
(CHEMBL228278 | N-((1r,4r)-4-(4-(2-cyclopropoxyphen...)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)N[C@H]1CC[C@@H](CC1)N1CCC(CC1)c1ccccc1OC1CC1
Show InChI InChI=1S/C28H38N2O5S/c1-33-27-14-13-24(19-28(27)34-2)36(31,32)29-21-7-9-22(10-8-21)30-17-15-20(16-18-30)25-5-3-4-6-26(25)35-23-11-12-23/h3-6,13-14,19-23,29H,7-12,15-18H2,1-2H3/t21-,22-
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
11n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L.L.C.

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha1a receptor


Bioorg Med Chem Lett 17: 3930-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.098
BindingDB Entry DOI: 10.7270/Q2639PF1
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50213513
PNG
(CHEMBL228278 | N-((1r,4r)-4-(4-(2-cyclopropoxyphen...)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)N[C@H]1CC[C@@H](CC1)N1CCC(CC1)c1ccccc1OC1CC1
Show InChI InChI=1S/C28H38N2O5S/c1-33-27-14-13-24(19-28(27)34-2)36(31,32)29-21-7-9-22(10-8-21)30-17-15-20(16-18-30)25-5-3-4-6-26(25)35-23-11-12-23/h3-6,13-14,19-23,29H,7-12,15-18H2,1-2H3/t21-,22-
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
11n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L.L.C.

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha1a receptor


Bioorg Med Chem Lett 17: 6123-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.051
BindingDB Entry DOI: 10.7270/Q2C82925
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50213523
PNG
(CHEMBL387833 | N-((1s,4s)-4-(4-(2-(2,2-difluoroeth...)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)N[C@H]1CC[C@H](CC1)N1CCC(CC1)c1ccccc1OCC(F)F
Show InChI InChI=1S/C27H36F2N2O5S/c1-34-25-12-11-22(17-26(25)35-2)37(32,33)30-20-7-9-21(10-8-20)31-15-13-19(14-16-31)23-5-3-4-6-24(23)36-18-27(28)29/h3-6,11-12,17,19-21,27,30H,7-10,13-16,18H2,1-2H3/t20-,21+
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
12n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L.L.C.

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha1a receptor


Bioorg Med Chem Lett 17: 6123-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.051
BindingDB Entry DOI: 10.7270/Q2C82925
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50213523
PNG
(CHEMBL387833 | N-((1s,4s)-4-(4-(2-(2,2-difluoroeth...)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)N[C@H]1CC[C@H](CC1)N1CCC(CC1)c1ccccc1OCC(F)F
Show InChI InChI=1S/C27H36F2N2O5S/c1-34-25-12-11-22(17-26(25)35-2)37(32,33)30-20-7-9-21(10-8-20)31-15-13-19(14-16-31)23-5-3-4-6-24(23)36-18-27(28)29/h3-6,11-12,17,19-21,27,30H,7-10,13-16,18H2,1-2H3/t20-,21+
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
12n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L.L.C.

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha1a receptor


Bioorg Med Chem Lett 17: 3930-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.098
BindingDB Entry DOI: 10.7270/Q2639PF1
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(Homo sapiens (Human))
BDBM50213517
PNG
(CHEMBL389104 | N-((1s,4s)-4-(4-(2-cyclopropoxyphen...)
Show SMILES O=S(=O)(N[C@H]1CC[C@H](CC1)N1CCC(CC1)c1ccccc1OC1CC1)c1ccc2OCOc2c1
Show InChI InChI=1S/C27H34N2O5S/c30-35(31,23-11-12-26-27(17-23)33-18-32-26)28-20-5-7-21(8-6-20)29-15-13-19(14-16-29)24-3-1-2-4-25(24)34-22-9-10-22/h1-4,11-12,17,19-22,28H,5-10,13-16,18H2/t20-,21+
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
13n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L.L.C.

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha1d receptor


Bioorg Med Chem Lett 17: 3930-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.098
BindingDB Entry DOI: 10.7270/Q2639PF1
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50213534
PNG
(CHEMBL228333 | N-((1r,4r)-4-(4-(2-cyclopropoxyphen...)
Show SMILES O=S(=O)(N[C@H]1CC[C@@H](CC1)N1CCC(CC1)c1ccccc1OC1CC1)c1ccc2OCOc2c1
Show InChI InChI=1S/C27H34N2O5S/c30-35(31,23-11-12-26-27(17-23)33-18-32-26)28-20-5-7-21(8-6-20)29-15-13-19(14-16-29)24-3-1-2-4-25(24)34-22-9-10-22/h1-4,11-12,17,19-22,28H,5-10,13-16,18H2/t20-,21-
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
14n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L.L.C.

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha1a receptor


Bioorg Med Chem Lett 17: 3930-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.098
BindingDB Entry DOI: 10.7270/Q2639PF1
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50213517
PNG
(CHEMBL389104 | N-((1s,4s)-4-(4-(2-cyclopropoxyphen...)
Show SMILES O=S(=O)(N[C@H]1CC[C@H](CC1)N1CCC(CC1)c1ccccc1OC1CC1)c1ccc2OCOc2c1
Show InChI InChI=1S/C27H34N2O5S/c30-35(31,23-11-12-26-27(17-23)33-18-32-26)28-20-5-7-21(8-6-20)29-15-13-19(14-16-29)24-3-1-2-4-25(24)34-22-9-10-22/h1-4,11-12,17,19-22,28H,5-10,13-16,18H2/t20-,21+
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
16n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L.L.C.

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha1a receptor


Bioorg Med Chem Lett 17: 3930-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.098
BindingDB Entry DOI: 10.7270/Q2639PF1
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50213537
PNG
(3,4-dimethoxy-N-((1r,4r)-4-(4-(2-(2,2,2-trifluoroe...)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)N[C@H]1CC[C@@H](CC1)N1CCC(CC1)c1ccccc1OCC(F)(F)F
Show InChI InChI=1S/C27H35F3N2O5S/c1-35-25-12-11-22(17-26(25)36-2)38(33,34)31-20-7-9-21(10-8-20)32-15-13-19(14-16-32)23-5-3-4-6-24(23)37-18-27(28,29)30/h3-6,11-12,17,19-21,31H,7-10,13-16,18H2,1-2H3/t20-,21-
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
21n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L.L.C.

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha1a receptor


Bioorg Med Chem Lett 17: 6123-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.051
BindingDB Entry DOI: 10.7270/Q2C82925
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50213537
PNG
(3,4-dimethoxy-N-((1r,4r)-4-(4-(2-(2,2,2-trifluoroe...)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)N[C@H]1CC[C@@H](CC1)N1CCC(CC1)c1ccccc1OCC(F)(F)F
Show InChI InChI=1S/C27H35F3N2O5S/c1-35-25-12-11-22(17-26(25)36-2)38(33,34)31-20-7-9-21(10-8-20)32-15-13-19(14-16-32)23-5-3-4-6-24(23)37-18-27(28,29)30/h3-6,11-12,17,19-21,31H,7-10,13-16,18H2,1-2H3/t20-,21-
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
21n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L.L.C.

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha1a receptor


Bioorg Med Chem Lett 17: 3930-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.098
BindingDB Entry DOI: 10.7270/Q2639PF1
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50213508
PNG
(CHEMBL228658 | N-((1r,4r)-4-(4-(4-fluoro-2-isoprop...)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)N[C@H]1CC[C@@H](CC1)N1CCC(CC1)c1ccc(F)cc1OC(C)C
Show InChI InChI=1S/C28H39FN2O5S/c1-19(2)36-27-17-21(29)5-11-25(27)20-13-15-31(16-14-20)23-8-6-22(7-9-23)30-37(32,33)24-10-12-26(34-3)28(18-24)35-4/h5,10-12,17-20,22-23,30H,6-9,13-16H2,1-4H3/t22-,23-
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
23n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L.L.C.

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha1a receptor


Bioorg Med Chem Lett 17: 3930-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.098
BindingDB Entry DOI: 10.7270/Q2639PF1
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50213527
PNG
(CHEMBL228390 | N-((1r,4r)-4-(4-(2-(2,2,2-trifluoro...)
Show SMILES FC(F)(F)COc1ccccc1C1CCN(CC1)[C@H]1CC[C@@H](CC1)NS(=O)(=O)c1ccc2OCCOc2c1
Show InChI InChI=1S/C27H33F3N2O5S/c28-27(29,30)18-37-24-4-2-1-3-23(24)19-11-13-32(14-12-19)21-7-5-20(6-8-21)31-38(33,34)22-9-10-25-26(17-22)36-16-15-35-25/h1-4,9-10,17,19-21,31H,5-8,11-16,18H2/t20-,21-
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
23n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L.L.C.

Curated by ChEMBL


Assay Description
Binding affinity for dopamine D2 receptor


Bioorg Med Chem Lett 17: 3930-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.098
BindingDB Entry DOI: 10.7270/Q2639PF1
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(Homo sapiens (Human))
BDBM50213537
PNG
(3,4-dimethoxy-N-((1r,4r)-4-(4-(2-(2,2,2-trifluoroe...)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)N[C@H]1CC[C@@H](CC1)N1CCC(CC1)c1ccccc1OCC(F)(F)F
Show InChI InChI=1S/C27H35F3N2O5S/c1-35-25-12-11-22(17-26(25)36-2)38(33,34)31-20-7-9-21(10-8-20)32-15-13-19(14-16-32)23-5-3-4-6-24(23)37-18-27(28,29)30/h3-6,11-12,17,19-21,31H,7-10,13-16,18H2,1-2H3/t20-,21-
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
23n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L.L.C.

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha1d receptor


Bioorg Med Chem Lett 17: 6123-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.051
BindingDB Entry DOI: 10.7270/Q2C82925
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(Homo sapiens (Human))
BDBM50213537
PNG
(3,4-dimethoxy-N-((1r,4r)-4-(4-(2-(2,2,2-trifluoroe...)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)N[C@H]1CC[C@@H](CC1)N1CCC(CC1)c1ccccc1OCC(F)(F)F
Show InChI InChI=1S/C27H35F3N2O5S/c1-35-25-12-11-22(17-26(25)36-2)38(33,34)31-20-7-9-21(10-8-20)32-15-13-19(14-16-32)23-5-3-4-6-24(23)37-18-27(28,29)30/h3-6,11-12,17,19-21,31H,7-10,13-16,18H2,1-2H3/t20-,21-
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
23n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L.L.C.

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha1d receptor


Bioorg Med Chem Lett 17: 3930-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.098
BindingDB Entry DOI: 10.7270/Q2639PF1
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(Homo sapiens (Human))
BDBM50213527
PNG
(CHEMBL228390 | N-((1r,4r)-4-(4-(2-(2,2,2-trifluoro...)
Show SMILES FC(F)(F)COc1ccccc1C1CCN(CC1)[C@H]1CC[C@@H](CC1)NS(=O)(=O)c1ccc2OCCOc2c1
Show InChI InChI=1S/C27H33F3N2O5S/c28-27(29,30)18-37-24-4-2-1-3-23(24)19-11-13-32(14-12-19)21-7-5-20(6-8-21)31-38(33,34)22-9-10-25-26(17-22)36-16-15-35-25/h1-4,9-10,17,19-21,31H,5-8,11-16,18H2/t20-,21-
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
26n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L.L.C.

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha1d receptor


Bioorg Med Chem Lett 17: 3930-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.098
BindingDB Entry DOI: 10.7270/Q2639PF1
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50213524
PNG
(CHEMBL388361 | N-((1r,4r)-4-(4-(2-isopropoxyphenyl...)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)N[C@H]1CC[C@@H](CC1)N1CCC(CC1)c1ccccc1OC(C)C
Show InChI InChI=1S/C28H40N2O5S/c1-20(2)35-26-8-6-5-7-25(26)21-15-17-30(18-16-21)23-11-9-22(10-12-23)29-36(31,32)24-13-14-27(33-3)28(19-24)34-4/h5-8,13-14,19-23,29H,9-12,15-18H2,1-4H3/t22-,23-
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
28n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L.L.C.

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha1a receptor


Bioorg Med Chem Lett 17: 6123-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.051
BindingDB Entry DOI: 10.7270/Q2C82925
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50213524
PNG
(CHEMBL388361 | N-((1r,4r)-4-(4-(2-isopropoxyphenyl...)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)N[C@H]1CC[C@@H](CC1)N1CCC(CC1)c1ccccc1OC(C)C
Show InChI InChI=1S/C28H40N2O5S/c1-20(2)35-26-8-6-5-7-25(26)21-15-17-30(18-16-21)23-11-9-22(10-12-23)29-36(31,32)24-13-14-27(33-3)28(19-24)34-4/h5-8,13-14,19-23,29H,9-12,15-18H2,1-4H3/t22-,23-
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
28n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L.L.C.

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha1a receptor


Bioorg Med Chem Lett 17: 3930-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.098
BindingDB Entry DOI: 10.7270/Q2639PF1
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50213533
PNG
(CHEMBL228607 | N-((1r,4r)-4-(4-(2-(2,2-difluoroeth...)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)N[C@H]1CC[C@@H](CC1)N1CCC(CC1)c1ccccc1OCC(F)F
Show InChI InChI=1S/C27H36F2N2O5S/c1-34-25-12-11-22(17-26(25)35-2)37(32,33)30-20-7-9-21(10-8-20)31-15-13-19(14-16-31)23-5-3-4-6-24(23)36-18-27(28)29/h3-6,11-12,17,19-21,27,30H,7-10,13-16,18H2,1-2H3/t20-,21-
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
31n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L.L.C.

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha1a receptor


Bioorg Med Chem Lett 17: 6123-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.051
BindingDB Entry DOI: 10.7270/Q2C82925
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50213533
PNG
(CHEMBL228607 | N-((1r,4r)-4-(4-(2-(2,2-difluoroeth...)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)N[C@H]1CC[C@@H](CC1)N1CCC(CC1)c1ccccc1OCC(F)F
Show InChI InChI=1S/C27H36F2N2O5S/c1-34-25-12-11-22(17-26(25)35-2)37(32,33)30-20-7-9-21(10-8-20)31-15-13-19(14-16-31)23-5-3-4-6-24(23)36-18-27(28)29/h3-6,11-12,17,19-21,27,30H,7-10,13-16,18H2,1-2H3/t20-,21-
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
31n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L.L.C.

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha1a receptor


Bioorg Med Chem Lett 17: 3930-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.098
BindingDB Entry DOI: 10.7270/Q2639PF1
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(Homo sapiens (Human))
BDBM50213513
PNG
(CHEMBL228278 | N-((1r,4r)-4-(4-(2-cyclopropoxyphen...)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)N[C@H]1CC[C@@H](CC1)N1CCC(CC1)c1ccccc1OC1CC1
Show InChI InChI=1S/C28H38N2O5S/c1-33-27-14-13-24(19-28(27)34-2)36(31,32)29-21-7-9-22(10-8-21)30-17-15-20(16-18-30)25-5-3-4-6-26(25)35-23-11-12-23/h3-6,13-14,19-23,29H,7-12,15-18H2,1-2H3/t21-,22-
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
34n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L.L.C.

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha1d receptor


Bioorg Med Chem Lett 17: 3930-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.098
BindingDB Entry DOI: 10.7270/Q2639PF1
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(Homo sapiens (Human))
BDBM50213513
PNG
(CHEMBL228278 | N-((1r,4r)-4-(4-(2-cyclopropoxyphen...)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)N[C@H]1CC[C@@H](CC1)N1CCC(CC1)c1ccccc1OC1CC1
Show InChI InChI=1S/C28H38N2O5S/c1-33-27-14-13-24(19-28(27)34-2)36(31,32)29-21-7-9-22(10-8-21)30-17-15-20(16-18-30)25-5-3-4-6-26(25)35-23-11-12-23/h3-6,13-14,19-23,29H,7-12,15-18H2,1-2H3/t21-,22-
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
34n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L.L.C.

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha1d receptor


Bioorg Med Chem Lett 17: 6123-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.051
BindingDB Entry DOI: 10.7270/Q2C82925
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(Homo sapiens (Human))
BDBM50213524
PNG
(CHEMBL388361 | N-((1r,4r)-4-(4-(2-isopropoxyphenyl...)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)N[C@H]1CC[C@@H](CC1)N1CCC(CC1)c1ccccc1OC(C)C
Show InChI InChI=1S/C28H40N2O5S/c1-20(2)35-26-8-6-5-7-25(26)21-15-17-30(18-16-21)23-11-9-22(10-12-23)29-36(31,32)24-13-14-27(33-3)28(19-24)34-4/h5-8,13-14,19-23,29H,9-12,15-18H2,1-4H3/t22-,23-
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
40n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L.L.C.

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha1d receptor


Bioorg Med Chem Lett 17: 6123-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.051
BindingDB Entry DOI: 10.7270/Q2C82925
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(Homo sapiens (Human))
BDBM50213524
PNG
(CHEMBL388361 | N-((1r,4r)-4-(4-(2-isopropoxyphenyl...)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)N[C@H]1CC[C@@H](CC1)N1CCC(CC1)c1ccccc1OC(C)C
Show InChI InChI=1S/C28H40N2O5S/c1-20(2)35-26-8-6-5-7-25(26)21-15-17-30(18-16-21)23-11-9-22(10-12-23)29-36(31,32)24-13-14-27(33-3)28(19-24)34-4/h5-8,13-14,19-23,29H,9-12,15-18H2,1-4H3/t22-,23-
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
40n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L.L.C.

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha1d receptor


Bioorg Med Chem Lett 17: 3930-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.098
BindingDB Entry DOI: 10.7270/Q2639PF1
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50213539
PNG
(CHEMBL390473 | N-((1r,4r)-4-(4-(5-fluoro-2-isoprop...)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)N[C@H]1CC[C@@H](CC1)N1CCC(CC1)c1cc(F)ccc1OC(C)C
Show InChI InChI=1S/C28H39FN2O5S/c1-19(2)36-26-11-5-21(29)17-25(26)20-13-15-31(16-14-20)23-8-6-22(7-9-23)30-37(32,33)24-10-12-27(34-3)28(18-24)35-4/h5,10-12,17-20,22-23,30H,6-9,13-16H2,1-4H3/t22-,23-
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
43n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L.L.C.

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha1a receptor


Bioorg Med Chem Lett 17: 3930-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.098
BindingDB Entry DOI: 10.7270/Q2639PF1
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(Homo sapiens (Human))
BDBM50213519
PNG
(CHEMBL228606 | N-((1r,4r)-4-(4-(2-(2-fluoroethoxy)...)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)N[C@H]1CC[C@@H](CC1)N1CCC(CC1)c1ccccc1OCCF
Show InChI InChI=1S/C27H37FN2O5S/c1-33-26-12-11-23(19-27(26)34-2)36(31,32)29-21-7-9-22(10-8-21)30-16-13-20(14-17-30)24-5-3-4-6-25(24)35-18-15-28/h3-6,11-12,19-22,29H,7-10,13-18H2,1-2H3/t21-,22-
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
49n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L.L.C.

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha1d receptor


Bioorg Med Chem Lett 17: 3930-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.098
BindingDB Entry DOI: 10.7270/Q2639PF1
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(Homo sapiens (Human))
BDBM50213519
PNG
(CHEMBL228606 | N-((1r,4r)-4-(4-(2-(2-fluoroethoxy)...)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)N[C@H]1CC[C@@H](CC1)N1CCC(CC1)c1ccccc1OCCF
Show InChI InChI=1S/C27H37FN2O5S/c1-33-26-12-11-23(19-27(26)34-2)36(31,32)29-21-7-9-22(10-8-21)30-16-13-20(14-17-30)24-5-3-4-6-25(24)35-18-15-28/h3-6,11-12,19-22,29H,7-10,13-18H2,1-2H3/t21-,22-
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
49n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L.L.C.

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha1d receptor


Bioorg Med Chem Lett 17: 6123-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.051
BindingDB Entry DOI: 10.7270/Q2C82925
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(Homo sapiens (Human))
BDBM50213539
PNG
(CHEMBL390473 | N-((1r,4r)-4-(4-(5-fluoro-2-isoprop...)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)N[C@H]1CC[C@@H](CC1)N1CCC(CC1)c1cc(F)ccc1OC(C)C
Show InChI InChI=1S/C28H39FN2O5S/c1-19(2)36-26-11-5-21(29)17-25(26)20-13-15-31(16-14-20)23-8-6-22(7-9-23)30-37(32,33)24-10-12-27(34-3)28(18-24)35-4/h5,10-12,17-20,22-23,30H,6-9,13-16H2,1-4H3/t22-,23-
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
53n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L.L.C.

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha1d receptor


Bioorg Med Chem Lett 17: 3930-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.098
BindingDB Entry DOI: 10.7270/Q2639PF1
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50213524
PNG
(CHEMBL388361 | N-((1r,4r)-4-(4-(2-isopropoxyphenyl...)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)N[C@H]1CC[C@@H](CC1)N1CCC(CC1)c1ccccc1OC(C)C
Show InChI InChI=1S/C28H40N2O5S/c1-20(2)35-26-8-6-5-7-25(26)21-15-17-30(18-16-21)23-11-9-22(10-12-23)29-36(31,32)24-13-14-27(33-3)28(19-24)34-4/h5-8,13-14,19-23,29H,9-12,15-18H2,1-4H3/t22-,23-
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
55n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L.L.C.

Curated by ChEMBL


Assay Description
Binding affinity for dopamine D2 receptor


Bioorg Med Chem Lett 17: 3930-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.098
BindingDB Entry DOI: 10.7270/Q2639PF1
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50213524
PNG
(CHEMBL388361 | N-((1r,4r)-4-(4-(2-isopropoxyphenyl...)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)N[C@H]1CC[C@@H](CC1)N1CCC(CC1)c1ccccc1OC(C)C
Show InChI InChI=1S/C28H40N2O5S/c1-20(2)35-26-8-6-5-7-25(26)21-15-17-30(18-16-21)23-11-9-22(10-12-23)29-36(31,32)24-13-14-27(33-3)28(19-24)34-4/h5-8,13-14,19-23,29H,9-12,15-18H2,1-4H3/t22-,23-
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
55n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L.L.C.

Curated by ChEMBL


Assay Description
Binding affinity to human cloned dopamine D2 receptor


Bioorg Med Chem Lett 17: 6123-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.051
BindingDB Entry DOI: 10.7270/Q2C82925
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(Homo sapiens (Human))
BDBM50213534
PNG
(CHEMBL228333 | N-((1r,4r)-4-(4-(2-cyclopropoxyphen...)
Show SMILES O=S(=O)(N[C@H]1CC[C@@H](CC1)N1CCC(CC1)c1ccccc1OC1CC1)c1ccc2OCOc2c1
Show InChI InChI=1S/C27H34N2O5S/c30-35(31,23-11-12-26-27(17-23)33-18-32-26)28-20-5-7-21(8-6-20)29-15-13-19(14-16-29)24-3-1-2-4-25(24)34-22-9-10-22/h1-4,11-12,17,19-22,28H,5-10,13-16,18H2/t20-,21-
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
57n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L.L.C.

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha1d receptor


Bioorg Med Chem Lett 17: 3930-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.098
BindingDB Entry DOI: 10.7270/Q2639PF1
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50213516
PNG
(CHEMBL439197 | N-((1s,4s)-4-(4-(2-(2,2,2-trifluoro...)
Show SMILES FC(F)(F)COc1ccccc1C1CCN(CC1)[C@@H]1CC[C@@H](CC1)NS(=O)(=O)c1ccc2OCCOc2c1
Show InChI InChI=1S/C27H33F3N2O5S/c28-27(29,30)18-37-24-4-2-1-3-23(24)19-11-13-32(14-12-19)21-7-5-20(6-8-21)31-38(33,34)22-9-10-25-26(17-22)36-16-15-35-25/h1-4,9-10,17,19-21,31H,5-8,11-16,18H2/t20-,21+
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
57n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L.L.C.

Curated by ChEMBL


Assay Description
Binding affinity for dopamine D2 receptor


Bioorg Med Chem Lett 17: 3930-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.098
BindingDB Entry DOI: 10.7270/Q2639PF1
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(Homo sapiens (Human))
BDBM50213508
PNG
(CHEMBL228658 | N-((1r,4r)-4-(4-(4-fluoro-2-isoprop...)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)N[C@H]1CC[C@@H](CC1)N1CCC(CC1)c1ccc(F)cc1OC(C)C
Show InChI InChI=1S/C28H39FN2O5S/c1-19(2)36-27-17-21(29)5-11-25(27)20-13-15-31(16-14-20)23-8-6-22(7-9-23)30-37(32,33)24-10-12-26(34-3)28(18-24)35-4/h5,10-12,17-20,22-23,30H,6-9,13-16H2,1-4H3/t22-,23-
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
60n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L.L.C.

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha1d receptor


Bioorg Med Chem Lett 17: 3930-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.098
BindingDB Entry DOI: 10.7270/Q2639PF1
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50213517
PNG
(CHEMBL389104 | N-((1s,4s)-4-(4-(2-cyclopropoxyphen...)
Show SMILES O=S(=O)(N[C@H]1CC[C@H](CC1)N1CCC(CC1)c1ccccc1OC1CC1)c1ccc2OCOc2c1
Show InChI InChI=1S/C27H34N2O5S/c30-35(31,23-11-12-26-27(17-23)33-18-32-26)28-20-5-7-21(8-6-20)29-15-13-19(14-16-29)24-3-1-2-4-25(24)34-22-9-10-22/h1-4,11-12,17,19-22,28H,5-10,13-16,18H2/t20-,21+
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
66n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L.L.C.

Curated by ChEMBL


Assay Description
Binding affinity for dopamine D2 receptor


Bioorg Med Chem Lett 17: 3930-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.098
BindingDB Entry DOI: 10.7270/Q2639PF1
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50213519
PNG
(CHEMBL228606 | N-((1r,4r)-4-(4-(2-(2-fluoroethoxy)...)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)N[C@H]1CC[C@@H](CC1)N1CCC(CC1)c1ccccc1OCCF
Show InChI InChI=1S/C27H37FN2O5S/c1-33-26-12-11-23(19-27(26)34-2)36(31,32)29-21-7-9-22(10-8-21)30-16-13-20(14-17-30)24-5-3-4-6-25(24)35-18-15-28/h3-6,11-12,19-22,29H,7-10,13-18H2,1-2H3/t21-,22-
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
69n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L.L.C.

Curated by ChEMBL


Assay Description
Binding affinity to human cloned adrenergic alpha1a receptor


Bioorg Med Chem Lett 17: 3930-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.098
BindingDB Entry DOI: 10.7270/Q2639PF1
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 96 total )  |  Next  |  Last  >>