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35 similar compounds to monomer 50214527

Compile data set for download or QSAR
Wt: 355.3
BDBM50214528
Wt: 385.3
BDBM50214529
Purchase
Wt: 431.4
BDBM50214530
Wt: 431.4
BDBM50214531
Wt: 389.4
BDBM50214532
Wt: 355.3
BDBM50214533
Wt: 413.4
BDBM50214534
Wt: 389.4
BDBM50214535
Wt: 445.4
BDBM50214536
Wt: 463.4
BDBM50322699
Wt: 493.5
BDBM50322700
Wt: 463.4
BDBM50322701
Purchase
Wt: 531.6
BDBM50322702
Wt: 520.5
BDBM50322703
Wt: 493.5
BDBM50322708
Purchase
Displayed 1 to 15 (of 35 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 48 hits for monomerid = 50214528,50214529,50214530,50214531,50214532,50214533,50214534,50214535,50214536,50322699,50322700,50322701,50322702,50322703,50322708   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2


(Homo sapiens (Human))
BDBM50322708
PNG
(4-[(4-{[3-(4-Fluorobenzyl)-2,4-dioxo-1,3-thiazolan...)
Show SMILES COc1cc(\C=C2/SC(=O)N(Cc3ccc(F)cc3)C2=O)ccc1OCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C26H20FNO6S/c1-33-22-12-18(6-11-21(22)34-15-17-2-7-19(8-3-17)25(30)31)13-23-24(29)28(26(32)35-23)14-16-4-9-20(27)10-5-16/h2-13H,14-15H2,1H3,(H,30,31)/b23-13-
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n/an/a 56n/an/an/an/an/an/a



Institute

Curated by ChEMBL


Assay Description
Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells using bisP-nitrophenyl phosphate as a substrate


J Med Chem 53: 4958-67 (2010)


Article DOI: 10.1021/jm1005012
BindingDB Entry DOI: 10.7270/Q2G73DXK
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (Human))
BDBM50214530
PNG
(4-[2,4-dioxo-5-(4-phenoxybenzylidene)thiazolidin-3...)
Show SMILES OC(=O)c1ccc(CN2C(=O)S\C(=C/c3ccc(Oc4ccccc4)cc3)C2=O)cc1
Show InChI InChI=1S/C24H17NO5S/c26-22-21(14-16-8-12-20(13-9-16)30-19-4-2-1-3-5-19)31-24(29)25(22)15-17-6-10-18(11-7-17)23(27)28/h1-14H,15H2,(H,27,28)/b21-14-
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n/an/a 2.80E+3n/an/an/an/an/an/a



Universit£ di Messina

Curated by ChEMBL


Assay Description
Inhibition of human protein-tyrosine phosphatase 1B


Bioorg Med Chem 15: 5137-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.027
BindingDB Entry DOI: 10.7270/Q2QR4XXH
More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2


(Homo sapiens (Human))
BDBM50322703
PNG
(4-((2-methoxy-4-((3-(4-nitrobenzyl)-2,4-dioxothiaz...)
Show SMILES COc1cc(\C=C2/SC(=O)N(Cc3ccc(cc3)[N+]([O-])=O)C2=O)ccc1OCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C26H20N2O8S/c1-35-22-12-18(6-11-21(22)36-15-17-2-7-19(8-3-17)25(30)31)13-23-24(29)27(26(32)37-23)14-16-4-9-20(10-5-16)28(33)34/h2-13H,14-15H2,1H3,(H,30,31)/b23-13-
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n/an/a 442n/an/an/an/an/an/a



Institute

Curated by ChEMBL


Assay Description
Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells using bisP-nitrophenyl phosphate as a substrate


J Med Chem 53: 4958-67 (2010)


Article DOI: 10.1021/jm1005012
BindingDB Entry DOI: 10.7270/Q2G73DXK
More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2


(Homo sapiens (Human))
BDBM50322703
PNG
(4-((2-methoxy-4-((3-(4-nitrobenzyl)-2,4-dioxothiaz...)
Show SMILES COc1cc(\C=C2/SC(=O)N(Cc3ccc(cc3)[N+]([O-])=O)C2=O)ccc1OCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C26H20N2O8S/c1-35-22-12-18(6-11-21(22)36-15-17-2-7-19(8-3-17)25(30)31)13-23-24(29)27(26(32)37-23)14-16-4-9-20(10-5-16)28(33)34/h2-13H,14-15H2,1H3,(H,30,31)/b23-13-
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n/an/a>5.00E+3n/an/an/an/an/an/a



Institute

Curated by ChEMBL


Assay Description
Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells assessed as lysophosphatidulcholine release


J Med Chem 53: 4958-67 (2010)


Article DOI: 10.1021/jm1005012
BindingDB Entry DOI: 10.7270/Q2G73DXK
More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2


(Homo sapiens (Human))
BDBM50322701
PNG
(4-((4-((3-(4-fluorobenzyl)-2,4-dioxothiazolidin-5-...)
Show SMILES OC(=O)c1ccc(COc2ccc(\C=C3/SC(=O)N(Cc4ccc(F)cc4)C3=O)cc2)cc1
Show InChI InChI=1S/C25H18FNO5S/c26-20-9-3-17(4-10-20)14-27-23(28)22(33-25(27)31)13-16-5-11-21(12-6-16)32-15-18-1-7-19(8-2-18)24(29)30/h1-13H,14-15H2,(H,29,30)/b22-13-
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n/an/a 1.63E+3n/an/an/an/an/an/a



Institute

Curated by ChEMBL


Assay Description
Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells assessed as lysophosphatidulcholine release


J Med Chem 53: 4958-67 (2010)


Article DOI: 10.1021/jm1005012
BindingDB Entry DOI: 10.7270/Q2G73DXK
More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2


(Homo sapiens (Human))
BDBM50322702
PNG
(4-((4-((3-(4-tert-butylbenzyl)-2,4-dioxothiazolidi...)
Show SMILES COc1cc(\C=C2/SC(=O)N(Cc3ccc(cc3)C(C)(C)C)C2=O)ccc1OCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C30H29NO6S/c1-30(2,3)23-12-7-19(8-13-23)17-31-27(32)26(38-29(31)35)16-21-9-14-24(25(15-21)36-4)37-18-20-5-10-22(11-6-20)28(33)34/h5-16H,17-18H2,1-4H3,(H,33,34)/b26-16-
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n/an/a 1.82E+4n/an/an/an/an/an/a



Institute

Curated by ChEMBL


Assay Description
Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells using bisP-nitrophenyl phosphate as a substrate


J Med Chem 53: 4958-67 (2010)


Article DOI: 10.1021/jm1005012
BindingDB Entry DOI: 10.7270/Q2G73DXK
More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2


(Homo sapiens (Human))
BDBM50322702
PNG
(4-((4-((3-(4-tert-butylbenzyl)-2,4-dioxothiazolidi...)
Show SMILES COc1cc(\C=C2/SC(=O)N(Cc3ccc(cc3)C(C)(C)C)C2=O)ccc1OCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C30H29NO6S/c1-30(2,3)23-12-7-19(8-13-23)17-31-27(32)26(38-29(31)35)16-21-9-14-24(25(15-21)36-4)37-18-20-5-10-22(11-6-20)28(33)34/h5-16H,17-18H2,1-4H3,(H,33,34)/b26-16-
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n/an/a 1.36E+4n/an/an/an/an/an/a



Institute

Curated by ChEMBL


Assay Description
Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells assessed as lysophosphatidulcholine release


J Med Chem 53: 4958-67 (2010)


Article DOI: 10.1021/jm1005012
BindingDB Entry DOI: 10.7270/Q2G73DXK
More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2


(Homo sapiens (Human))
BDBM50322699
PNG
(3-((4-((3-(4-fluorobenzyl)-2,4-dioxothiazolidin-5-...)
Show SMILES OC(=O)c1cccc(COc2ccc(\C=C3/SC(=O)N(Cc4ccc(F)cc4)C3=O)cc2)c1
Show InChI InChI=1S/C25H18FNO5S/c26-20-8-4-17(5-9-20)14-27-23(28)22(33-25(27)31)13-16-6-10-21(11-7-16)32-15-18-2-1-3-19(12-18)24(29)30/h1-13H,14-15H2,(H,29,30)/b22-13-
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n/an/a 1.07E+3n/an/an/an/an/an/a



Institute

Curated by ChEMBL


Assay Description
Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells assessed as lysophosphatidulcholine release


J Med Chem 53: 4958-67 (2010)


Article DOI: 10.1021/jm1005012
BindingDB Entry DOI: 10.7270/Q2G73DXK
More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2


(Homo sapiens (Human))
BDBM50322700
PNG
(3-((4-((3-(4-fluorobenzyl)-2,4-dioxothiazolidin-5-...)
Show SMILES COc1cc(\C=C2/SC(=O)N(Cc3ccc(F)cc3)C2=O)ccc1OCc1cccc(c1)C(O)=O
Show InChI InChI=1S/C26H20FNO6S/c1-33-22-12-17(7-10-21(22)34-15-18-3-2-4-19(11-18)25(30)31)13-23-24(29)28(26(32)35-23)14-16-5-8-20(27)9-6-16/h2-13H,14-15H2,1H3,(H,30,31)/b23-13-
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n/an/a 2.05E+3n/an/an/an/an/an/a



Institute

Curated by ChEMBL


Assay Description
Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells assessed as lysophosphatidulcholine release


J Med Chem 53: 4958-67 (2010)


Article DOI: 10.1021/jm1005012
BindingDB Entry DOI: 10.7270/Q2G73DXK
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (Human))
BDBM50214528
PNG
(4-[5-(4-hydroxybenzylidene)-2,4-dioxothiazolidin-3...)
Show SMILES OC(=O)c1ccc(CN2C(=O)S\C(=C/c3ccc(O)cc3)C2=O)cc1
Show InChI InChI=1S/C18H13NO5S/c20-14-7-3-11(4-8-14)9-15-16(21)19(18(24)25-15)10-12-1-5-13(6-2-12)17(22)23/h1-9,20H,10H2,(H,22,23)/b15-9-
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n/an/a 1.00E+4n/an/an/an/an/an/a



Universit£ di Messina

Curated by ChEMBL


Assay Description
Inhibition of human protein-tyrosine phosphatase 1B


Bioorg Med Chem 15: 5137-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.027
BindingDB Entry DOI: 10.7270/Q2QR4XXH
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Saccharomyces cerevisiae)
BDBM50214529
PNG
(4-[5-(4-hydroxy-3-methoxybenzylidene)-2,4-dioxothi...)
Show SMILES COc1cc(\C=C2/SC(=O)N(Cc3ccc(cc3)C(O)=O)C2=O)ccc1O
Show InChI InChI=1S/C19H15NO6S/c1-26-15-8-12(4-7-14(15)21)9-16-17(22)20(19(25)27-16)10-11-2-5-13(6-3-11)18(23)24/h2-9,21H,10H2,1H3,(H,23,24)/b16-9-
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n/an/a 3.89E+5n/an/an/an/an/an/a



Universit£ di Messina

Curated by ChEMBL


Assay Description
Inhibition of Saccharomyces cerevisiae low molecular weight Protein-tyrosine phosphatase Ltp1


Bioorg Med Chem 15: 5137-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.027
BindingDB Entry DOI: 10.7270/Q2QR4XXH
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM50214530
PNG
(4-[2,4-dioxo-5-(4-phenoxybenzylidene)thiazolidin-3...)
Show SMILES OC(=O)c1ccc(CN2C(=O)S\C(=C/c3ccc(Oc4ccccc4)cc3)C2=O)cc1
Show InChI InChI=1S/C24H17NO5S/c26-22-21(14-16-8-12-20(13-9-16)30-19-4-2-1-3-5-19)31-24(29)25(22)15-17-6-10-18(11-7-17)23(27)28/h1-14H,15H2,(H,27,28)/b21-14-
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n/an/a 1.30E+4n/an/an/an/an/an/a



Universit£ di Messina

Curated by ChEMBL


Assay Description
Inhibition of human low molecular weight Protein-tyrosine phosphatase IF2


Bioorg Med Chem 15: 5137-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.027
BindingDB Entry DOI: 10.7270/Q2QR4XXH
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Saccharomyces cerevisiae)
BDBM50214531
PNG
(4-[2,4-dioxo-5-(3-phenoxybenzylidene)thiazolidin-3...)
Show SMILES OC(=O)c1ccc(CN2C(=O)S\C(=C/c3cccc(Oc4ccccc4)c3)C2=O)cc1
Show InChI InChI=1S/C24H17NO5S/c26-22-21(14-17-5-4-8-20(13-17)30-19-6-2-1-3-7-19)31-24(29)25(22)15-16-9-11-18(12-10-16)23(27)28/h1-14H,15H2,(H,27,28)/b21-14-
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n/an/a 4.83E+5n/an/an/an/an/an/a



Universit£ di Messina

Curated by ChEMBL


Assay Description
Inhibition of Saccharomyces cerevisiae low molecular weight Protein-tyrosine phosphatase Ltp1


Bioorg Med Chem 15: 5137-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.027
BindingDB Entry DOI: 10.7270/Q2QR4XXH
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (Human))
BDBM50214532
PNG
(4-(5-naphthalen-2ylmethylene-2,4-dioxothiazolidin-...)
Show SMILES OC(=O)c1ccc(CN2C(=O)S\C(=C/c3ccc4ccccc4c3)C2=O)cc1
Show InChI InChI=1S/C22H15NO4S/c24-20-19(12-15-7-8-16-3-1-2-4-18(16)11-15)28-22(27)23(20)13-14-5-9-17(10-6-14)21(25)26/h1-12H,13H2,(H,25,26)/b19-12-
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n/an/a 6.50E+3n/an/an/an/an/an/a



Universit£ di Messina

Curated by ChEMBL


Assay Description
Inhibition of human protein-tyrosine phosphatase 1B


Bioorg Med Chem 15: 5137-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.027
BindingDB Entry DOI: 10.7270/Q2QR4XXH
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (LAR)


(Homo sapiens (Human))
BDBM50214530
PNG
(4-[2,4-dioxo-5-(4-phenoxybenzylidene)thiazolidin-3...)
Show SMILES OC(=O)c1ccc(CN2C(=O)S\C(=C/c3ccc(Oc4ccccc4)cc3)C2=O)cc1
Show InChI InChI=1S/C24H17NO5S/c26-22-21(14-16-8-12-20(13-9-16)30-19-4-2-1-3-5-19)31-24(29)25(22)15-17-6-10-18(11-7-17)23(27)28/h1-14H,15H2,(H,27,28)/b21-14-
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n/an/a 2.46E+4n/an/an/an/an/an/a



Universit£ di Messina

Curated by ChEMBL


Assay Description
Inhibition of human leukocyte antigen related protein-tyrosine phosphatase


Bioorg Med Chem 15: 5137-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.027
BindingDB Entry DOI: 10.7270/Q2QR4XXH
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Saccharomyces cerevisiae)
BDBM50214528
PNG
(4-[5-(4-hydroxybenzylidene)-2,4-dioxothiazolidin-3...)
Show SMILES OC(=O)c1ccc(CN2C(=O)S\C(=C/c3ccc(O)cc3)C2=O)cc1
Show InChI InChI=1S/C18H13NO5S/c20-14-7-3-11(4-8-14)9-15-16(21)19(18(24)25-15)10-12-1-5-13(6-2-12)17(22)23/h1-9,20H,10H2,(H,22,23)/b15-9-
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n/an/a 1.88E+5n/an/an/an/an/an/a



Universit£ di Messina

Curated by ChEMBL


Assay Description
Inhibition of Saccharomyces cerevisiae low molecular weight Protein-tyrosine phosphatase Ltp1


Bioorg Med Chem 15: 5137-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.027
BindingDB Entry DOI: 10.7270/Q2QR4XXH
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (Human))
BDBM50214531
PNG
(4-[2,4-dioxo-5-(3-phenoxybenzylidene)thiazolidin-3...)
Show SMILES OC(=O)c1ccc(CN2C(=O)S\C(=C/c3cccc(Oc4ccccc4)c3)C2=O)cc1
Show InChI InChI=1S/C24H17NO5S/c26-22-21(14-17-5-4-8-20(13-17)30-19-6-2-1-3-7-19)31-24(29)25(22)15-16-9-11-18(12-10-16)23(27)28/h1-14H,15H2,(H,27,28)/b21-14-
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n/an/a 1.80E+4n/an/an/an/an/an/a



Universit£ di Messina

Curated by ChEMBL


Assay Description
Inhibition of human protein-tyrosine phosphatase 1B


Bioorg Med Chem 15: 5137-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.027
BindingDB Entry DOI: 10.7270/Q2QR4XXH
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM50214529
PNG
(4-[5-(4-hydroxy-3-methoxybenzylidene)-2,4-dioxothi...)
Show SMILES COc1cc(\C=C2/SC(=O)N(Cc3ccc(cc3)C(O)=O)C2=O)ccc1O
Show InChI InChI=1S/C19H15NO6S/c1-26-15-8-12(4-7-14(15)21)9-16-17(22)20(19(25)27-16)10-11-2-5-13(6-3-11)18(23)24/h2-9,21H,10H2,1H3,(H,23,24)/b16-9-
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n/an/a 2.66E+4n/an/an/an/an/an/a



Universit£ di Messina

Curated by ChEMBL


Assay Description
Inhibition of human low molecular weight Protein-tyrosine phosphatase IF2


Bioorg Med Chem 15: 5137-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.027
BindingDB Entry DOI: 10.7270/Q2QR4XXH
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM50214533
PNG
(4-[5-(3-hydroxybenzylidene)-2,4-dioxothiazolidin-3...)
Show SMILES OC(=O)c1ccc(CN2C(=O)S\C(=C/c3cccc(O)c3)C2=O)cc1
Show InChI InChI=1S/C18H13NO5S/c20-14-3-1-2-12(8-14)9-15-16(21)19(18(24)25-15)10-11-4-6-13(7-5-11)17(22)23/h1-9,20H,10H2,(H,22,23)/b15-9-
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n/an/a 1.12E+5n/an/an/an/an/an/a



Universit£ di Messina

Curated by ChEMBL


Assay Description
Inhibition of human low molecular weight Protein-tyrosine phosphatase IF2


Bioorg Med Chem 15: 5137-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.027
BindingDB Entry DOI: 10.7270/Q2QR4XXH
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM50214529
PNG
(4-[5-(4-hydroxy-3-methoxybenzylidene)-2,4-dioxothi...)
Show SMILES COc1cc(\C=C2/SC(=O)N(Cc3ccc(cc3)C(O)=O)C2=O)ccc1O
Show InChI InChI=1S/C19H15NO6S/c1-26-15-8-12(4-7-14(15)21)9-16-17(22)20(19(25)27-16)10-11-2-5-13(6-3-11)18(23)24/h2-9,21H,10H2,1H3,(H,23,24)/b16-9-
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n/an/a 9.10E+3n/an/an/an/an/an/a



Universit£ di Messina

Curated by ChEMBL


Assay Description
Inhibition of human low molecular weight Protein-tyrosine phosphatase IF1


Bioorg Med Chem 15: 5137-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.027
BindingDB Entry DOI: 10.7270/Q2QR4XXH
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Saccharomyces cerevisiae)
BDBM50214532
PNG
(4-(5-naphthalen-2ylmethylene-2,4-dioxothiazolidin-...)
Show SMILES OC(=O)c1ccc(CN2C(=O)S\C(=C/c3ccc4ccccc4c3)C2=O)cc1
Show InChI InChI=1S/C22H15NO4S/c24-20-19(12-15-7-8-16-3-1-2-4-18(16)11-15)28-22(27)23(20)13-14-5-9-17(10-6-14)21(25)26/h1-12H,13H2,(H,25,26)/b19-12-
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n/an/a 1.49E+5n/an/an/an/an/an/a



Universit£ di Messina

Curated by ChEMBL


Assay Description
Inhibition of Saccharomyces cerevisiae low molecular weight Protein-tyrosine phosphatase Ltp1


Bioorg Med Chem 15: 5137-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.027
BindingDB Entry DOI: 10.7270/Q2QR4XXH
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM50214528
PNG
(4-[5-(4-hydroxybenzylidene)-2,4-dioxothiazolidin-3...)
Show SMILES OC(=O)c1ccc(CN2C(=O)S\C(=C/c3ccc(O)cc3)C2=O)cc1
Show InChI InChI=1S/C18H13NO5S/c20-14-7-3-11(4-8-14)9-15-16(21)19(18(24)25-15)10-12-1-5-13(6-2-12)17(22)23/h1-9,20H,10H2,(H,22,23)/b15-9-
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n/an/a 8.50E+4n/an/an/an/an/an/a



Universit£ di Messina

Curated by ChEMBL


Assay Description
Inhibition of human low molecular weight Protein-tyrosine phosphatase IF2


Bioorg Med Chem 15: 5137-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.027
BindingDB Entry DOI: 10.7270/Q2QR4XXH
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Saccharomyces cerevisiae)
BDBM50214533
PNG
(4-[5-(3-hydroxybenzylidene)-2,4-dioxothiazolidin-3...)
Show SMILES OC(=O)c1ccc(CN2C(=O)S\C(=C/c3cccc(O)c3)C2=O)cc1
Show InChI InChI=1S/C18H13NO5S/c20-14-3-1-2-12(8-14)9-15-16(21)19(18(24)25-15)10-11-4-6-13(7-5-11)17(22)23/h1-9,20H,10H2,(H,22,23)/b15-9-
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n/an/a 1.40E+6n/an/an/an/an/an/a



Universit£ di Messina

Curated by ChEMBL


Assay Description
Inhibition of Saccharomyces cerevisiae low molecular weight Protein-tyrosine phosphatase Ltp1


Bioorg Med Chem 15: 5137-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.027
BindingDB Entry DOI: 10.7270/Q2QR4XXH
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM50214534
PNG
(4-[5-(4-carboxymethoxybenzylidene)-2,4-dioxothiazo...)
Show SMILES OC(=O)COc1ccc(\C=C2/SC(=O)N(Cc3ccc(cc3)C(O)=O)C2=O)cc1
Show InChI InChI=1S/C20H15NO7S/c22-17(23)11-28-15-7-3-12(4-8-15)9-16-18(24)21(20(27)29-16)10-13-1-5-14(6-2-13)19(25)26/h1-9H,10-11H2,(H,22,23)(H,25,26)/b16-9-
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n/an/a 1.64E+6n/an/an/an/an/an/a



Universit£ di Messina

Curated by ChEMBL


Assay Description
Inhibition of human low molecular weight Protein-tyrosine phosphatase IF2


Bioorg Med Chem 15: 5137-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.027
BindingDB Entry DOI: 10.7270/Q2QR4XXH
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (Human))
BDBM50214535
PNG
((Z)-4-((5-(naphthalen-1-ylmethylene)-2,4-dioxothia...)
Show SMILES OC(=O)c1ccc(CN2C(=O)S\C(=C/c3cccc4ccccc34)C2=O)cc1
Show InChI InChI=1S/C22H15NO4S/c24-20-19(12-17-6-3-5-15-4-1-2-7-18(15)17)28-22(27)23(20)13-14-8-10-16(11-9-14)21(25)26/h1-12H,13H2,(H,25,26)/b19-12-
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n/an/a 5.50E+3n/an/an/an/an/an/a



Universit£ di Messina

Curated by ChEMBL


Assay Description
Inhibition of human protein-tyrosine phosphatase 1B


Bioorg Med Chem 15: 5137-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.027
BindingDB Entry DOI: 10.7270/Q2QR4XXH
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50214530
PNG
(4-[2,4-dioxo-5-(4-phenoxybenzylidene)thiazolidin-3...)
Show SMILES OC(=O)c1ccc(CN2C(=O)S\C(=C/c3ccc(Oc4ccccc4)cc3)C2=O)cc1
Show InChI InChI=1S/C24H17NO5S/c26-22-21(14-16-8-12-20(13-9-16)30-19-4-2-1-3-5-19)31-24(29)25(22)15-17-6-10-18(11-7-17)23(27)28/h1-14H,15H2,(H,27,28)/b21-14-
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n/an/a 1.10E+3n/an/an/an/an/an/a



Universit£ di Messina

Curated by ChEMBL


Assay Description
Inhibition of human protein-tyrosine phosphatase beta


Bioorg Med Chem 15: 5137-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.027
BindingDB Entry DOI: 10.7270/Q2QR4XXH
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (Human))
BDBM50214529
PNG
(4-[5-(4-hydroxy-3-methoxybenzylidene)-2,4-dioxothi...)
Show SMILES COc1cc(\C=C2/SC(=O)N(Cc3ccc(cc3)C(O)=O)C2=O)ccc1O
Show InChI InChI=1S/C19H15NO6S/c1-26-15-8-12(4-7-14(15)21)9-16-17(22)20(19(25)27-16)10-11-2-5-13(6-3-11)18(23)24/h2-9,21H,10H2,1H3,(H,23,24)/b16-9-
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n/an/a 2.60E+3n/an/an/an/an/an/a



Universit£ di Messina

Curated by ChEMBL


Assay Description
Inhibition of human protein-tyrosine phosphatase 1B


Bioorg Med Chem 15: 5137-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.027
BindingDB Entry DOI: 10.7270/Q2QR4XXH
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM50214532
PNG
(4-(5-naphthalen-2ylmethylene-2,4-dioxothiazolidin-...)
Show SMILES OC(=O)c1ccc(CN2C(=O)S\C(=C/c3ccc4ccccc4c3)C2=O)cc1
Show InChI InChI=1S/C22H15NO4S/c24-20-19(12-15-7-8-16-3-1-2-4-18(16)11-15)28-22(27)23(20)13-14-5-9-17(10-6-14)21(25)26/h1-12H,13H2,(H,25,26)/b19-12-
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n/an/a 9.20E+4n/an/an/an/an/an/a



Universit£ di Messina

Curated by ChEMBL


Assay Description
Inhibition of human low molecular weight Protein-tyrosine phosphatase IF2


Bioorg Med Chem 15: 5137-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.027
BindingDB Entry DOI: 10.7270/Q2QR4XXH
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (Human))
BDBM50214533
PNG
(4-[5-(3-hydroxybenzylidene)-2,4-dioxothiazolidin-3...)
Show SMILES OC(=O)c1ccc(CN2C(=O)S\C(=C/c3cccc(O)c3)C2=O)cc1
Show InChI InChI=1S/C18H13NO5S/c20-14-3-1-2-12(8-14)9-15-16(21)19(18(24)25-15)10-11-4-6-13(7-5-11)17(22)23/h1-9,20H,10H2,(H,22,23)/b15-9-
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n/an/a 1.02E+4n/an/an/an/an/an/a



Universit£ di Messina

Curated by ChEMBL


Assay Description
Inhibition of human protein-tyrosine phosphatase 1B


Bioorg Med Chem 15: 5137-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.027
BindingDB Entry DOI: 10.7270/Q2QR4XXH
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM50214533
PNG
(4-[5-(3-hydroxybenzylidene)-2,4-dioxothiazolidin-3...)
Show SMILES OC(=O)c1ccc(CN2C(=O)S\C(=C/c3cccc(O)c3)C2=O)cc1
Show InChI InChI=1S/C18H13NO5S/c20-14-3-1-2-12(8-14)9-15-16(21)19(18(24)25-15)10-11-4-6-13(7-5-11)17(22)23/h1-9,20H,10H2,(H,22,23)/b15-9-
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n/an/a 8.57E+4n/an/an/an/an/an/a



Universit£ di Messina

Curated by ChEMBL


Assay Description
Inhibition of human low molecular weight Protein-tyrosine phosphatase IF1


Bioorg Med Chem 15: 5137-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.027
BindingDB Entry DOI: 10.7270/Q2QR4XXH
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM50214536
PNG
(4-[5-(3-benzyloxybenzylidene)-2,4-dioxothiazolidin...)
Show SMILES OC(=O)c1ccc(CN2C(=O)S\C(=C/c3cccc(OCc4ccccc4)c3)C2=O)cc1
Show InChI InChI=1S/C25H19NO5S/c27-23-22(32-25(30)26(23)15-17-9-11-20(12-10-17)24(28)29)14-19-7-4-8-21(13-19)31-16-18-5-2-1-3-6-18/h1-14H,15-16H2,(H,28,29)/b22-14-
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n/an/a 1.84E+4n/an/an/an/an/an/a



Universit£ di Messina

Curated by ChEMBL


Assay Description
Inhibition of human low molecular weight Protein-tyrosine phosphatase IF2


Bioorg Med Chem 15: 5137-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.027
BindingDB Entry DOI: 10.7270/Q2QR4XXH
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM50214531
PNG
(4-[2,4-dioxo-5-(3-phenoxybenzylidene)thiazolidin-3...)
Show SMILES OC(=O)c1ccc(CN2C(=O)S\C(=C/c3cccc(Oc4ccccc4)c3)C2=O)cc1
Show InChI InChI=1S/C24H17NO5S/c26-22-21(14-17-5-4-8-20(13-17)30-19-6-2-1-3-7-19)31-24(29)25(22)15-16-9-11-18(12-10-16)23(27)28/h1-14H,15H2,(H,27,28)/b21-14-
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n/an/a 3.70E+4n/an/an/an/an/an/a



Universit£ di Messina

Curated by ChEMBL


Assay Description
Inhibition of human low molecular weight Protein-tyrosine phosphatase IF1


Bioorg Med Chem 15: 5137-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.027
BindingDB Entry DOI: 10.7270/Q2QR4XXH
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Saccharomyces cerevisiae)
BDBM50214535
PNG
((Z)-4-((5-(naphthalen-1-ylmethylene)-2,4-dioxothia...)
Show SMILES OC(=O)c1ccc(CN2C(=O)S\C(=C/c3cccc4ccccc34)C2=O)cc1
Show InChI InChI=1S/C22H15NO4S/c24-20-19(12-17-6-3-5-15-4-1-2-7-18(15)17)28-22(27)23(20)13-14-8-10-16(11-9-14)21(25)26/h1-12H,13H2,(H,25,26)/b19-12-
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n/an/a 9.90E+4n/an/an/an/an/an/a



Universit£ di Messina

Curated by ChEMBL


Assay Description
Inhibition of Saccharomyces cerevisiae low molecular weight Protein-tyrosine phosphatase Ltp1


Bioorg Med Chem 15: 5137-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.027
BindingDB Entry DOI: 10.7270/Q2QR4XXH
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM50214535
PNG
((Z)-4-((5-(naphthalen-1-ylmethylene)-2,4-dioxothia...)
Show SMILES OC(=O)c1ccc(CN2C(=O)S\C(=C/c3cccc4ccccc34)C2=O)cc1
Show InChI InChI=1S/C22H15NO4S/c24-20-19(12-17-6-3-5-15-4-1-2-7-18(15)17)28-22(27)23(20)13-14-8-10-16(11-9-14)21(25)26/h1-12H,13H2,(H,25,26)/b19-12-
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n/an/a 1.22E+5n/an/an/an/an/an/a



Universit£ di Messina

Curated by ChEMBL


Assay Description
Inhibition of human low molecular weight Protein-tyrosine phosphatase IF1


Bioorg Med Chem 15: 5137-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.027
BindingDB Entry DOI: 10.7270/Q2QR4XXH
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM50214531
PNG
(4-[2,4-dioxo-5-(3-phenoxybenzylidene)thiazolidin-3...)
Show SMILES OC(=O)c1ccc(CN2C(=O)S\C(=C/c3cccc(Oc4ccccc4)c3)C2=O)cc1
Show InChI InChI=1S/C24H17NO5S/c26-22-21(14-17-5-4-8-20(13-17)30-19-6-2-1-3-7-19)31-24(29)25(22)15-16-9-11-18(12-10-16)23(27)28/h1-14H,15H2,(H,27,28)/b21-14-
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n/an/a 1.30E+5n/an/an/an/an/an/a



Universit£ di Messina

Curated by ChEMBL


Assay Description
Inhibition of human low molecular weight Protein-tyrosine phosphatase IF2


Bioorg Med Chem 15: 5137-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.027
BindingDB Entry DOI: 10.7270/Q2QR4XXH
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (Human))
BDBM50214536
PNG
(4-[5-(3-benzyloxybenzylidene)-2,4-dioxothiazolidin...)
Show SMILES OC(=O)c1ccc(CN2C(=O)S\C(=C/c3cccc(OCc4ccccc4)c3)C2=O)cc1
Show InChI InChI=1S/C25H19NO5S/c27-23-22(32-25(30)26(23)15-17-9-11-20(12-10-17)24(28)29)14-19-7-4-8-21(13-19)31-16-18-5-2-1-3-6-18/h1-14H,15-16H2,(H,28,29)/b22-14-
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n/an/a 1.10E+3n/an/an/an/an/an/a



Universit£ di Messina

Curated by ChEMBL


Assay Description
Inhibition of human protein-tyrosine phosphatase 1B


Bioorg Med Chem 15: 5137-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.027
BindingDB Entry DOI: 10.7270/Q2QR4XXH
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM50214536
PNG
(4-[5-(3-benzyloxybenzylidene)-2,4-dioxothiazolidin...)
Show SMILES OC(=O)c1ccc(CN2C(=O)S\C(=C/c3cccc(OCc4ccccc4)c3)C2=O)cc1
Show InChI InChI=1S/C25H19NO5S/c27-23-22(32-25(30)26(23)15-17-9-11-20(12-10-17)24(28)29)14-19-7-4-8-21(13-19)31-16-18-5-2-1-3-6-18/h1-14H,15-16H2,(H,28,29)/b22-14-
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n/an/a 7.10E+3n/an/an/an/an/an/a



Universit£ di Messina

Curated by ChEMBL


Assay Description
Inhibition of human low molecular weight Protein-tyrosine phosphatase IF1


Bioorg Med Chem 15: 5137-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.027
BindingDB Entry DOI: 10.7270/Q2QR4XXH
More data for this
Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 2


(Homo sapiens (Human))
BDBM50214530
PNG
(4-[2,4-dioxo-5-(4-phenoxybenzylidene)thiazolidin-3...)
Show SMILES OC(=O)c1ccc(CN2C(=O)S\C(=C/c3ccc(Oc4ccccc4)cc3)C2=O)cc1
Show InChI InChI=1S/C24H17NO5S/c26-22-21(14-16-8-12-20(13-9-16)30-19-4-2-1-3-5-19)31-24(29)25(22)15-17-6-10-18(11-7-17)23(27)28/h1-14H,15H2,(H,27,28)/b21-14-
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n/an/a 2.80E+3n/an/an/an/an/an/a



Universit£ di Messina

Curated by ChEMBL


Assay Description
Inhibition of human T cell protein-tyrosine phosphatase


Bioorg Med Chem 15: 5137-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.027
BindingDB Entry DOI: 10.7270/Q2QR4XXH
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Saccharomyces cerevisiae)
BDBM50214530
PNG
(4-[2,4-dioxo-5-(4-phenoxybenzylidene)thiazolidin-3...)
Show SMILES OC(=O)c1ccc(CN2C(=O)S\C(=C/c3ccc(Oc4ccccc4)cc3)C2=O)cc1
Show InChI InChI=1S/C24H17NO5S/c26-22-21(14-16-8-12-20(13-9-16)30-19-4-2-1-3-5-19)31-24(29)25(22)15-17-6-10-18(11-7-17)23(27)28/h1-14H,15H2,(H,27,28)/b21-14-
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n/an/a 3.40E+4n/an/an/an/an/an/a



Universit£ di Messina

Curated by ChEMBL


Assay Description
Inhibition of Saccharomyces cerevisiae low molecular weight Protein-tyrosine phosphatase Ltp1


Bioorg Med Chem 15: 5137-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.027
BindingDB Entry DOI: 10.7270/Q2QR4XXH
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Saccharomyces cerevisiae)
BDBM50214536
PNG
(4-[5-(3-benzyloxybenzylidene)-2,4-dioxothiazolidin...)
Show SMILES OC(=O)c1ccc(CN2C(=O)S\C(=C/c3cccc(OCc4ccccc4)c3)C2=O)cc1
Show InChI InChI=1S/C25H19NO5S/c27-23-22(32-25(30)26(23)15-17-9-11-20(12-10-17)24(28)29)14-19-7-4-8-21(13-19)31-16-18-5-2-1-3-6-18/h1-14H,15-16H2,(H,28,29)/b22-14-
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n/an/a 1.97E+4n/an/an/an/an/an/a



Universit£ di Messina

Curated by ChEMBL


Assay Description
Inhibition of Saccharomyces cerevisiae low molecular weight Protein-tyrosine phosphatase Ltp1


Bioorg Med Chem 15: 5137-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.027
BindingDB Entry DOI: 10.7270/Q2QR4XXH
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM50214528
PNG
(4-[5-(4-hydroxybenzylidene)-2,4-dioxothiazolidin-3...)
Show SMILES OC(=O)c1ccc(CN2C(=O)S\C(=C/c3ccc(O)cc3)C2=O)cc1
Show InChI InChI=1S/C18H13NO5S/c20-14-7-3-11(4-8-14)9-15-16(21)19(18(24)25-15)10-12-1-5-13(6-2-12)17(22)23/h1-9,20H,10H2,(H,22,23)/b15-9-
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n/an/a 3.00E+4n/an/an/an/an/an/a



Universit£ di Messina

Curated by ChEMBL


Assay Description
Inhibition of human low molecular weight Protein-tyrosine phosphatase IF1


Bioorg Med Chem 15: 5137-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.027
BindingDB Entry DOI: 10.7270/Q2QR4XXH
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (Human))
BDBM50214534
PNG
(4-[5-(4-carboxymethoxybenzylidene)-2,4-dioxothiazo...)
Show SMILES OC(=O)COc1ccc(\C=C2/SC(=O)N(Cc3ccc(cc3)C(O)=O)C2=O)cc1
Show InChI InChI=1S/C20H15NO7S/c22-17(23)11-28-15-7-3-12(4-8-15)9-16-18(24)21(20(27)29-16)10-13-1-5-14(6-2-13)19(25)26/h1-9H,10-11H2,(H,22,23)(H,25,26)/b16-9-
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n/an/a 8.50E+4n/an/an/an/an/an/a



Universit£ di Messina

Curated by ChEMBL


Assay Description
Inhibition of human protein-tyrosine phosphatase 1B


Bioorg Med Chem 15: 5137-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.027
BindingDB Entry DOI: 10.7270/Q2QR4XXH
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM50214534
PNG
(4-[5-(4-carboxymethoxybenzylidene)-2,4-dioxothiazo...)
Show SMILES OC(=O)COc1ccc(\C=C2/SC(=O)N(Cc3ccc(cc3)C(O)=O)C2=O)cc1
Show InChI InChI=1S/C20H15NO7S/c22-17(23)11-28-15-7-3-12(4-8-15)9-16-18(24)21(20(27)29-16)10-13-1-5-14(6-2-13)19(25)26/h1-9H,10-11H2,(H,22,23)(H,25,26)/b16-9-
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n/an/a 2.19E+5n/an/an/an/an/an/a



Universit£ di Messina

Curated by ChEMBL


Assay Description
Inhibition of human low molecular weight Protein-tyrosine phosphatase IF1


Bioorg Med Chem 15: 5137-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.027
BindingDB Entry DOI: 10.7270/Q2QR4XXH
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM50214532
PNG
(4-(5-naphthalen-2ylmethylene-2,4-dioxothiazolidin-...)
Show SMILES OC(=O)c1ccc(CN2C(=O)S\C(=C/c3ccc4ccccc4c3)C2=O)cc1
Show InChI InChI=1S/C22H15NO4S/c24-20-19(12-15-7-8-16-3-1-2-4-18(16)11-15)28-22(27)23(20)13-14-5-9-17(10-6-14)21(25)26/h1-12H,13H2,(H,25,26)/b19-12-
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n/an/a 1.20E+4n/an/an/an/an/an/a



Universit£ di Messina

Curated by ChEMBL


Assay Description
Inhibition of human low molecular weight Protein-tyrosine phosphatase IF1


Bioorg Med Chem 15: 5137-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.027
BindingDB Entry DOI: 10.7270/Q2QR4XXH
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM50214535
PNG
((Z)-4-((5-(naphthalen-1-ylmethylene)-2,4-dioxothia...)
Show SMILES OC(=O)c1ccc(CN2C(=O)S\C(=C/c3cccc4ccccc34)C2=O)cc1
Show InChI InChI=1S/C22H15NO4S/c24-20-19(12-17-6-3-5-15-4-1-2-7-18(15)17)28-22(27)23(20)13-14-8-10-16(11-9-14)21(25)26/h1-12H,13H2,(H,25,26)/b19-12-
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n/an/a 1.38E+5n/an/an/an/an/an/a



Universit£ di Messina

Curated by ChEMBL


Assay Description
Inhibition of human low molecular weight Protein-tyrosine phosphatase IF2


Bioorg Med Chem 15: 5137-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.027
BindingDB Entry DOI: 10.7270/Q2QR4XXH
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM50214530
PNG
(4-[2,4-dioxo-5-(4-phenoxybenzylidene)thiazolidin-3...)
Show SMILES OC(=O)c1ccc(CN2C(=O)S\C(=C/c3ccc(Oc4ccccc4)cc3)C2=O)cc1
Show InChI InChI=1S/C24H17NO5S/c26-22-21(14-16-8-12-20(13-9-16)30-19-4-2-1-3-5-19)31-24(29)25(22)15-17-6-10-18(11-7-17)23(27)28/h1-14H,15H2,(H,27,28)/b21-14-
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n/an/a 900n/an/an/an/an/an/a



Universit£ di Messina

Curated by ChEMBL


Assay Description
Inhibition of human low molecular weight Protein-tyrosine phosphatase IF1


Bioorg Med Chem 15: 5137-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.027
BindingDB Entry DOI: 10.7270/Q2QR4XXH
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Saccharomyces cerevisiae)
BDBM50214534
PNG
(4-[5-(4-carboxymethoxybenzylidene)-2,4-dioxothiazo...)
Show SMILES OC(=O)COc1ccc(\C=C2/SC(=O)N(Cc3ccc(cc3)C(O)=O)C2=O)cc1
Show InChI InChI=1S/C20H15NO7S/c22-17(23)11-28-15-7-3-12(4-8-15)9-16-18(24)21(20(27)29-16)10-13-1-5-14(6-2-13)19(25)26/h1-9H,10-11H2,(H,22,23)(H,25,26)/b16-9-
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n/an/a>4.50E+5n/an/an/an/an/an/a



Universit£ di Messina

Curated by ChEMBL


Assay Description
Inhibition of Saccharomyces cerevisiae low molecular weight Protein-tyrosine phosphatase Ltp1


Bioorg Med Chem 15: 5137-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.027
BindingDB Entry DOI: 10.7270/Q2QR4XXH
More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2


(Homo sapiens (Human))
BDBM50322708
PNG
(4-[(4-{[3-(4-Fluorobenzyl)-2,4-dioxo-1,3-thiazolan...)
Show SMILES COc1cc(\C=C2/SC(=O)N(Cc3ccc(F)cc3)C2=O)ccc1OCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C26H20FNO6S/c1-33-22-12-18(6-11-21(22)34-15-17-2-7-19(8-3-17)25(30)31)13-23-24(29)28(26(32)35-23)14-16-4-9-20(27)10-5-16/h2-13H,14-15H2,1H3,(H,30,31)/b23-13-
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n/an/a 2.50E+3n/an/an/an/an/an/a



Institute

Curated by ChEMBL


Assay Description
Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells assessed as lysophosphatidulcholine release


J Med Chem 53: 4958-67 (2010)


Article DOI: 10.1021/jm1005012
BindingDB Entry DOI: 10.7270/Q2G73DXK
More data for this
Ligand-Target Pair