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31 similar compounds to monomer 50220996

Compile data set for download or QSAR
Wt: 236.6
BDBM50221041
Wt: 277.3
BDBM50221003
Wt: 557
BDBM50220992
Wt: 347.4
BDBM50220981
Wt: 311.4
BDBM50220983
Wt: 559.0
BDBM50220984
Wt: 584.0
BDBM50220987
Wt: 560.0
BDBM50220988
Wt: 556.0
BDBM50220991
Wt: 276.3
BDBM50220994
Wt: 290.3
BDBM50220997
Wt: 304.3
BDBM50221005
Wt: 371.4
BDBM50221011
Wt: 218.2
BDBM50221029
Wt: 287.1
BDBM50221038
Displayed 1 to 15 (of 31 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 31 hits for monomerid = 50221041,50221003,50220992,50220981,50220983,50220984,50220987,50220988,50220991,50220994,50220997,50221005,50221011,50221029,50221038   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50221005
PNG
(CHEMBL75684)
Show SMILES CCC(=O)N\N=C(/C)c1ccc(OC)c(OC2CCCC2)c1
Show InChI InChI=1S/C17H24N2O3/c1-4-17(20)19-18-12(2)13-9-10-15(21-3)16(11-13)22-14-7-5-6-8-14/h9-11,14H,4-8H2,1-3H3,(H,19,20)/b18-12+
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0.0420n/an/an/an/an/an/an/an/a



LEAD GENE CO., LTD

Curated by ChEMBL


Assay Description
Binding affinity towards rolipram binding site on phosphodiesterase 4 using [3H]rolipram as radioligand in crude rat brain homogenate


Bioorg Med Chem Lett 13: 2355-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00405-0
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50221003
PNG
(CHEMBL432348)
Show SMILES COc1ccc(\C=N\NC(N)=O)cc1OC1CCCC1
Show InChI InChI=1S/C14H19N3O3/c1-19-12-7-6-10(9-16-17-14(15)18)8-13(12)20-11-4-2-3-5-11/h6-9,11H,2-5H2,1H3,(H3,15,17,18)/b16-9+
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0.0690n/an/an/an/an/an/an/an/a



LEAD GENE CO., LTD

Curated by ChEMBL


Assay Description
Binding affinity towards rolipram binding site on phosphodiesterase 4 using [3H]rolipram as radioligand in crude rat brain homogenate


Bioorg Med Chem Lett 13: 2355-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00405-0
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50220997
PNG
(CHEMBL78237)
Show SMILES COc1ccc(cc1OC1CCCC1)C(\C)=N\NC(C)=O
Show InChI InChI=1S/C16H22N2O3/c1-11(17-18-12(2)19)13-8-9-15(20-3)16(10-13)21-14-6-4-5-7-14/h8-10,14H,4-7H2,1-3H3,(H,18,19)/b17-11+
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0.0920n/an/an/an/an/an/an/an/a



LEAD GENE CO., LTD

Curated by ChEMBL


Assay Description
Binding affinity towards rolipram binding site on phosphodiesterase 4 using [3H]rolipram as radioligand in crude rat brain homogenate


Bioorg Med Chem Lett 13: 2355-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00405-0
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(Homo sapiens (Human))
BDBM50220984
PNG
(CHEMBL554636)
Show SMILES Cl.COc1cc2cc(CO)nc(-c3ccnc(c3)-n3nc(-c4cccs4)c4ccccc4c3=O)c2cc1OC
Show InChI InChI=1S/C29H22N4O4S.ClH/c1-36-23-13-18-12-19(16-34)31-27(22(18)15-24(23)37-2)17-9-10-30-26(14-17)33-29(35)21-7-4-3-6-20(21)28(32-33)25-8-5-11-38-25;/h3-15,34H,16H2,1-2H3;1H
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1.40n/an/an/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of rolipram binding to phosphodiesterase 4


Bioorg Med Chem Lett 13: 2347-50 (2003)


Article DOI: 10.1016/s0960-894x(03)00438-4
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(Homo sapiens (Human))
BDBM50220988
PNG
(CHEMBL544766)
Show SMILES Cl.COc1cc2cc(CO)nc(-c3ccnc(c3)-n3nc(-c4nccs4)c4ccccc4c3=O)c2cc1OC
Show InChI InChI=1S/C28H21N5O4S.ClH/c1-36-22-12-17-11-18(15-34)31-25(21(17)14-23(22)37-2)16-7-8-29-24(13-16)33-28(35)20-6-4-3-5-19(20)26(32-33)27-30-9-10-38-27;/h3-14,34H,15H2,1-2H3;1H
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1.70n/an/an/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of rolipram binding to phosphodiesterase 4


Bioorg Med Chem Lett 13: 2347-50 (2003)


Article DOI: 10.1016/s0960-894x(03)00438-4
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50220994
PNG
(CHEMBL77177)
Show SMILES COc1ccc(\C=N\N=C(N)N)cc1OC1CCCC1
Show InChI InChI=1S/C14H20N4O2/c1-19-12-7-6-10(9-17-18-14(15)16)8-13(12)20-11-4-2-3-5-11/h6-9,11H,2-5H2,1H3,(H4,15,16,18)/b17-9+
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>5n/an/an/an/an/an/an/an/a



LEAD GENE CO., LTD

Curated by ChEMBL


Assay Description
Binding affinity towards rolipram binding site on phosphodiesterase 4 using [3H]rolipram as radioligand in crude rat brain homogenate


Bioorg Med Chem Lett 13: 2355-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00405-0
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(Homo sapiens (Human))
BDBM50220992
PNG
(CHEMBL545700)
Show SMILES Cl.COc1cc2C[C@@H](CO)N=C(c3ccnc(c3)-n3nc(-c4cncnc4)c4ccccc4c3=O)c2cc1OC
Show InChI InChI=1S/C29H24N6O4.ClH/c1-38-24-10-18-9-20(15-36)33-27(23(18)12-25(24)39-2)17-7-8-32-26(11-17)35-29(37)22-6-4-3-5-21(22)28(34-35)19-13-30-16-31-14-19;/h3-8,10-14,16,20,36H,9,15H2,1-2H3;1H/t20-;/m0./s1
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5.40n/an/an/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of rolipram binding to phosphodiesterase 4


Bioorg Med Chem Lett 13: 2347-50 (2003)


Article DOI: 10.1016/s0960-894x(03)00438-4
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(Homo sapiens (Human))
BDBM50220991
PNG
(CHEMBL539265)
Show SMILES Cl.COc1cc2C[C@@H](CO)N=C(c3ccnc(c3)-n3nc(-c4cccnc4)c4ccccc4c3=O)c2cc1OC
Show InChI InChI=1S/C30H25N5O4.ClH/c1-38-25-13-20-12-21(17-36)33-28(24(20)15-26(25)39-2)18-9-11-32-27(14-18)35-30(37)23-8-4-3-7-22(23)29(34-35)19-6-5-10-31-16-19;/h3-11,13-16,21,36H,12,17H2,1-2H3;1H/t21-;/m0./s1
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6.5n/an/an/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of rolipram binding to phosphodiesterase 4


Bioorg Med Chem Lett 13: 2347-50 (2003)


Article DOI: 10.1016/s0960-894x(03)00438-4
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50220983
PNG
(CHEMBL291830)
Show SMILES CN(C)CCCCNc1c2CCCCCc2nc2ccccc12
Show InChI InChI=1S/C20H29N3/c1-23(2)15-9-8-14-21-20-16-10-4-3-5-12-18(16)22-19-13-7-6-11-17(19)20/h6-7,11,13H,3-5,8-10,12,14-15H2,1-2H3,(H,21,22)
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39n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards rat cortical Histamine H3 receptor


Bioorg Med Chem Lett 13: 2131-5 (2003)


Article DOI: 10.1016/s0960-894x(03)00356-1
BindingDB Entry DOI: 10.7270/Q2K073N9
More data for this
Ligand-Target Pair
Histamine receptor (H3 and H4)


(Homo sapiens (Human))
BDBM50220983
PNG
(CHEMBL291830)
Show SMILES CN(C)CCCCNc1c2CCCCCc2nc2ccccc12
Show InChI InChI=1S/C20H29N3/c1-23(2)15-9-8-14-21-20-16-10-4-3-5-12-18(16)22-19-13-7-6-11-17(19)20/h6-7,11,13H,3-5,8-10,12,14-15H2,1-2H3,(H,21,22)
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44n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human H3L receptor


Bioorg Med Chem Lett 13: 2131-5 (2003)


Article DOI: 10.1016/s0960-894x(03)00356-1
BindingDB Entry DOI: 10.7270/Q2K073N9
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(Homo sapiens (Human))
BDBM50220987
PNG
(CHEMBL553278)
Show SMILES Cl.COc1cc2nc(CO)c(CO)c(-c3ccnc(c3)-n3nc(-c4cccnc4)c4ccccc4c3=O)c2cc1OC
Show InChI InChI=1S/C31H25N5O5.ClH/c1-40-26-13-22-24(14-27(26)41-2)34-25(17-38)23(16-37)29(22)18-9-11-33-28(12-18)36-31(39)21-8-4-3-7-20(21)30(35-36)19-6-5-10-32-15-19;/h3-15,37-38H,16-17H2,1-2H3;1H
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120n/an/an/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of rolipram binding to phosphodiesterase 4


Bioorg Med Chem Lett 13: 2347-50 (2003)


Article DOI: 10.1016/s0960-894x(03)00438-4
More data for this
Ligand-Target Pair
Histamine receptor (H3 and H4)


(Homo sapiens (Human))
BDBM50220981
PNG
(CHEMBL65797)
Show SMILES CN1CCN(CCC#Cc2c3CCCCCc3nc3ccccc23)CC1
Show InChI InChI=1S/C23H29N3/c1-25-15-17-26(18-16-25)14-8-7-9-19-20-10-3-2-4-12-22(20)24-23-13-6-5-11-21(19)23/h5-6,11,13H,2-4,8,10,12,14-18H2,1H3
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724n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human H3L receptor


Bioorg Med Chem Lett 13: 2131-5 (2003)


Article DOI: 10.1016/s0960-894x(03)00356-1
BindingDB Entry DOI: 10.7270/Q2K073N9
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50220981
PNG
(CHEMBL65797)
Show SMILES CN1CCN(CCC#Cc2c3CCCCCc3nc3ccccc23)CC1
Show InChI InChI=1S/C23H29N3/c1-25-15-17-26(18-16-25)14-8-7-9-19-20-10-3-2-4-12-22(20)24-23-13-6-5-11-21(19)23/h5-6,11,13H,2-4,8,10,12,14-18H2,1H3
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<1.00E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards rat cortical Histamine H3 receptor


Bioorg Med Chem Lett 13: 2131-5 (2003)


Article DOI: 10.1016/s0960-894x(03)00356-1
BindingDB Entry DOI: 10.7270/Q2K073N9
More data for this
Ligand-Target Pair
MurB (S. aureus)


(Staphylococcus aureus (Firmicutes))
BDBM50221038
PNG
(CHEMBL87521)
Show SMILES Oc1c2SCCc2nn1-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C11H8Cl2N2OS/c12-7-2-1-6(5-8(7)13)15-11(16)10-9(14-15)3-4-17-10/h1-2,5,16H,3-4H2
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n/an/a 3.83E+4n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Staphylococcus aureus UDP-N-acetylmuramate dehydrogenase


Bioorg Med Chem Lett 13: 2591-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00471-2
More data for this
Ligand-Target Pair
MurB (S. aureus)


(Staphylococcus aureus (Firmicutes))
BDBM50221029
PNG
(CHEMBL87821)
Show SMILES Oc1c2SCCc2nn1-c1ccccc1
Show InChI InChI=1S/C11H10N2OS/c14-11-10-9(6-7-15-10)12-13(11)8-4-2-1-3-5-8/h1-5,14H,6-7H2
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n/an/a>1.14E+5n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Staphylococcus aureus UDP-N-acetylmuramate dehydrogenase


Bioorg Med Chem Lett 13: 2591-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00471-2
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50221003
PNG
(CHEMBL432348)
Show SMILES COc1ccc(\C=N\NC(N)=O)cc1OC1CCCC1
Show InChI InChI=1S/C14H19N3O3/c1-19-12-7-6-10(9-16-17-14(15)18)8-13(12)20-11-4-2-3-5-11/h6-9,11H,2-5H2,1H3,(H3,15,17,18)/b16-9+
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n/an/a 0.600n/an/an/an/an/an/a



LEAD GENE CO., LTD

Curated by ChEMBL


Assay Description
Inhibitory activity against purified rat liver phosphodiesterase 4


Bioorg Med Chem Lett 13: 2355-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00405-0
More data for this
Ligand-Target Pair
MurD (S. aureus)


(Staphylococcus aureus (Firmicutes))
BDBM50221029
PNG
(CHEMBL87821)
Show SMILES Oc1c2SCCc2nn1-c1ccccc1
Show InChI InChI=1S/C11H10N2OS/c14-11-10-9(6-7-15-10)12-13(11)8-4-2-1-3-5-8/h1-5,14H,6-7H2
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n/an/a 9.62E+4n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Staphylococcus aureus UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase


Bioorg Med Chem Lett 13: 2591-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00471-2
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(Homo sapiens (Human))
BDBM50220988
PNG
(CHEMBL544766)
Show SMILES Cl.COc1cc2cc(CO)nc(-c3ccnc(c3)-n3nc(-c4nccs4)c4ccccc4c3=O)c2cc1OC
Show InChI InChI=1S/C28H21N5O4S.ClH/c1-36-22-12-17-11-18(15-34)31-25(21(17)14-23(22)37-2)16-7-8-29-24(13-16)33-28(35)20-6-4-3-5-19(20)26(32-33)27-30-9-10-38-27;/h3-14,34H,15H2,1-2H3;1H
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n/an/a 0.300n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 4


Bioorg Med Chem Lett 13: 2347-50 (2003)


Article DOI: 10.1016/s0960-894x(03)00438-4
More data for this
Ligand-Target Pair
DNA topoisomerase II


(Homo sapiens (Human))
BDBM50221011
PNG
(CHEMBL76485)
Show SMILES C[C@H]1COc2c(ccc3c2n1cc(C(O)=O)c3=O)N1CC[C@H](C1)C(C)(C)N
Show InChI InChI=1S/C20H25N3O4/c1-11-10-27-18-15(22-7-6-12(8-22)20(2,3)21)5-4-13-16(18)23(11)9-14(17(13)24)19(25)26/h4-5,9,11-12H,6-8,10,21H2,1-3H3,(H,25,26)/t11-,12+/m0/s1
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n/an/a 4.03E+5n/an/an/an/an/an/a



Procter& Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against mammalian DNA topoisomerase II


Bioorg Med Chem Lett 13: 2373-5 (2003)


Article DOI: 10.1016/s0960-894x(03)00399-8
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(Homo sapiens (Human))
BDBM50220991
PNG
(CHEMBL539265)
Show SMILES Cl.COc1cc2C[C@@H](CO)N=C(c3ccnc(c3)-n3nc(-c4cccnc4)c4ccccc4c3=O)c2cc1OC
Show InChI InChI=1S/C30H25N5O4.ClH/c1-38-25-13-20-12-21(17-36)33-28(24(20)15-26(25)39-2)18-9-11-32-27(14-18)35-30(37)23-8-4-3-7-22(23)29(34-35)19-6-5-10-31-16-19;/h3-11,13-16,21,36H,12,17H2,1-2H3;1H/t21-;/m0./s1
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n/an/a 1n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 4


Bioorg Med Chem Lett 13: 2347-50 (2003)


Article DOI: 10.1016/s0960-894x(03)00438-4
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(Homo sapiens (Human))
BDBM50220992
PNG
(CHEMBL545700)
Show SMILES Cl.COc1cc2C[C@@H](CO)N=C(c3ccnc(c3)-n3nc(-c4cncnc4)c4ccccc4c3=O)c2cc1OC
Show InChI InChI=1S/C29H24N6O4.ClH/c1-38-24-10-18-9-20(15-36)33-27(23(18)12-25(24)39-2)17-7-8-32-26(11-17)35-29(37)22-6-4-3-5-21(22)28(34-35)19-13-30-16-31-14-19;/h3-8,10-14,16,20,36H,9,15H2,1-2H3;1H/t20-;/m0./s1
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n/an/a 3n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 4


Bioorg Med Chem Lett 13: 2347-50 (2003)


Article DOI: 10.1016/s0960-894x(03)00438-4
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(Homo sapiens (Human))
BDBM50220984
PNG
(CHEMBL554636)
Show SMILES Cl.COc1cc2cc(CO)nc(-c3ccnc(c3)-n3nc(-c4cccs4)c4ccccc4c3=O)c2cc1OC
Show InChI InChI=1S/C29H22N4O4S.ClH/c1-36-23-13-18-12-19(16-34)31-27(22(18)15-24(23)37-2)17-9-10-30-26(14-17)33-29(35)21-7-4-3-6-20(21)28(32-33)25-8-5-11-38-25;/h3-15,34H,16H2,1-2H3;1H
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n/an/a 0.300n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 4


Bioorg Med Chem Lett 13: 2347-50 (2003)


Article DOI: 10.1016/s0960-894x(03)00438-4
More data for this
Ligand-Target Pair
DNA topoisomerase II


(Homo sapiens (Human))
BDBM50221011
PNG
(CHEMBL76485)
Show SMILES C[C@H]1COc2c(ccc3c2n1cc(C(O)=O)c3=O)N1CC[C@H](C1)C(C)(C)N
Show InChI InChI=1S/C20H25N3O4/c1-11-10-27-18-15(22-7-6-12(8-22)20(2,3)21)5-4-13-16(18)23(11)9-14(17(13)24)19(25)26/h4-5,9,11-12H,6-8,10,21H2,1-3H3,(H,25,26)/t11-,12+/m0/s1
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n/an/a 8.61E+3n/an/an/an/an/an/a



Procter& Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against wild type gyrase in Escherichia coli


Bioorg Med Chem Lett 13: 2373-5 (2003)


Article DOI: 10.1016/s0960-894x(03)00399-8
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(Homo sapiens (Human))
BDBM50220987
PNG
(CHEMBL553278)
Show SMILES Cl.COc1cc2nc(CO)c(CO)c(-c3ccnc(c3)-n3nc(-c4cccnc4)c4ccccc4c3=O)c2cc1OC
Show InChI InChI=1S/C31H25N5O5.ClH/c1-40-26-13-22-24(14-27(26)41-2)34-25(17-38)23(16-37)29(22)18-9-11-33-28(12-18)36-31(39)21-8-4-3-7-20(21)30(35-36)19-6-5-10-32-15-19;/h3-15,37-38H,16-17H2,1-2H3;1H
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n/an/a 70n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 4


Bioorg Med Chem Lett 13: 2347-50 (2003)


Article DOI: 10.1016/s0960-894x(03)00438-4
More data for this
Ligand-Target Pair
DNA topoisomerase II


(Homo sapiens (Human))
BDBM50221011
PNG
(CHEMBL76485)
Show SMILES C[C@H]1COc2c(ccc3c2n1cc(C(O)=O)c3=O)N1CC[C@H](C1)C(C)(C)N
Show InChI InChI=1S/C20H25N3O4/c1-11-10-27-18-15(22-7-6-12(8-22)20(2,3)21)5-4-13-16(18)23(11)9-14(17(13)24)19(25)26/h4-5,9,11-12H,6-8,10,21H2,1-3H3,(H,25,26)/t11-,12+/m0/s1
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n/an/a>2.74E+5n/an/an/an/an/an/a



Procter& Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against quinolone resistant gyrase in Escherichia coli


Bioorg Med Chem Lett 13: 2373-5 (2003)


Article DOI: 10.1016/s0960-894x(03)00399-8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50220994
PNG
(CHEMBL77177)
Show SMILES COc1ccc(\C=N\N=C(N)N)cc1OC1CCCC1
Show InChI InChI=1S/C14H20N4O2/c1-19-12-7-6-10(9-17-18-14(15)16)8-13(12)20-11-4-2-3-5-11/h6-9,11H,2-5H2,1H3,(H4,15,16,18)/b17-9+
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n/an/a>10n/an/an/an/an/an/a



LEAD GENE CO., LTD

Curated by ChEMBL


Assay Description
Inhibitory activity against purified rat liver phosphodiesterase 4


Bioorg Med Chem Lett 13: 2355-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00405-0
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50221005
PNG
(CHEMBL75684)
Show SMILES CCC(=O)N\N=C(/C)c1ccc(OC)c(OC2CCCC2)c1
Show InChI InChI=1S/C17H24N2O3/c1-4-17(20)19-18-12(2)13-9-10-15(21-3)16(11-13)22-14-7-5-6-8-14/h9-11,14H,4-8H2,1-3H3,(H,19,20)/b18-12+
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n/an/a>10n/an/an/an/an/an/a



LEAD GENE CO., LTD

Curated by ChEMBL


Assay Description
Inhibitory activity against purified rat liver phosphodiesterase 4


Bioorg Med Chem Lett 13: 2355-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00405-0
More data for this
Ligand-Target Pair
MurB (S. aureus)


(Staphylococcus aureus (Firmicutes))
BDBM50221041
PNG
(CHEMBL83458)
Show SMILES Oc1c2COCc2nn1-c1ccc(Cl)cc1
Show InChI InChI=1S/C11H9ClN2O2/c12-7-1-3-8(4-2-7)14-11(15)9-5-16-6-10(9)13-14/h1-4,15H,5-6H2
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n/an/a>1.05E+5n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Staphylococcus aureus UDP-N-acetylmuramate dehydrogenase


Bioorg Med Chem Lett 13: 2591-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00471-2
More data for this
Ligand-Target Pair
MurC (S. aureus)


(Staphylococcus aureus (Firmicutes))
BDBM50221029
PNG
(CHEMBL87821)
Show SMILES Oc1c2SCCc2nn1-c1ccccc1
Show InChI InChI=1S/C11H10N2OS/c14-11-10-9(6-7-15-10)12-13(11)8-4-2-1-3-5-8/h1-5,14H,6-7H2
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n/an/a>1.14E+5n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Staphylococcus aureus UDP-N-acetylmuramoyl-L-alanine synthetase


Bioorg Med Chem Lett 13: 2591-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00471-2
More data for this
Ligand-Target Pair
MurC (S. aureus)


(Staphylococcus aureus (Firmicutes))
BDBM50221038
PNG
(CHEMBL87521)
Show SMILES Oc1c2SCCc2nn1-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C11H8Cl2N2OS/c12-7-2-1-6(5-8(7)13)15-11(16)10-9(14-15)3-4-17-10/h1-2,5,16H,3-4H2
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n/an/a 2.43E+4n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Staphylococcus aureus UDP-N-acetylmuramoyl-L-alanine synthetase


Bioorg Med Chem Lett 13: 2591-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00471-2
More data for this
Ligand-Target Pair
MurD (S. aureus)


(Staphylococcus aureus (Firmicutes))
BDBM50221038
PNG
(CHEMBL87521)
Show SMILES Oc1c2SCCc2nn1-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C11H8Cl2N2OS/c12-7-2-1-6(5-8(7)13)15-11(16)10-9(14-15)3-4-17-10/h1-2,5,16H,3-4H2
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n/an/a 4.87E+4n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Staphylococcus aureus UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase


Bioorg Med Chem Lett 13: 2591-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00471-2
More data for this
Ligand-Target Pair