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6 similar compounds to monomer 50222274

Compile data set for download or QSAR
Wt: 204.2
BDBM50222281
Wt: 218.2
BDBM50222282
Wt: 232.2
BDBM50222288
Wt: 218.2
BDBM50222312
Wt: 204.2
BDBM50222275
Wt: 190.1
BDBM50222298

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50222281,50222282,50222288,50222312,50222275,50222298   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
15-Lipoxygenase-2 (15-LOX-2)


(Homo sapiens (Human))
BDBM50222282
PNG
(3-hydroxy-2-t-butyl-4H-benzopyran-4-one | CHEMBL23...)
Show SMILES CC(C)(C)c1oc2ccccc2c(=O)c1O
Show InChI InChI=1S/C13H14O3/c1-13(2,3)12-11(15)10(14)8-6-4-5-7-9(8)16-12/h4-7,15H,1-3H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Universidad de Santiago de Chile

Curated by ChEMBL


Assay Description
Inhibition of 15-hLO2


Bioorg Med Chem 15: 7408-25 (2007)


Article DOI: 10.1016/j.bmc.2007.07.036
BindingDB Entry DOI: 10.7270/Q2RN37KN
More data for this
Ligand-Target Pair
12-Lipoxygenase (12-LOX)


(Homo sapiens (Human))
BDBM50222275
PNG
(2-isopropyl-3-hydroxy-4H-benzopyran-4-one | CHEMBL...)
Show SMILES CCCc1oc2ccccc2c(=O)c1O
Show InChI InChI=1S/C12H12O3/c1-2-5-10-12(14)11(13)8-6-3-4-7-9(8)15-10/h3-4,6-7,14H,2,5H2,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Universidad de Santiago de Chile

Curated by ChEMBL


Assay Description
Inhibition of 12-hLO


Bioorg Med Chem 15: 7408-25 (2007)


Article DOI: 10.1016/j.bmc.2007.07.036
BindingDB Entry DOI: 10.7270/Q2RN37KN
More data for this
Ligand-Target Pair
15-Lipoxygenase-2 (15-LOX-2)


(Homo sapiens (Human))
BDBM50222312
PNG
(6-hydroxy-2-isobutyl-4H-benzopyran-4-one | CHEMBL3...)
Show SMILES CC(C)Cc1cc(=O)c2cc(O)ccc2o1
Show InChI InChI=1S/C13H14O3/c1-8(2)5-10-7-12(15)11-6-9(14)3-4-13(11)16-10/h3-4,6-8,14H,5H2,1-2H3
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Universidad de Santiago de Chile

Curated by ChEMBL


Assay Description
Inhibition of 15-hLO2


Bioorg Med Chem 15: 7408-25 (2007)


Article DOI: 10.1016/j.bmc.2007.07.036
BindingDB Entry DOI: 10.7270/Q2RN37KN
More data for this
Ligand-Target Pair
15-Lipoxygenase-2 (15-LOX-2)


(Homo sapiens (Human))
BDBM50222298
PNG
(2-ethyl-3-hydroxy-4 H-benzopyran-4-one | CHEMBL238...)
Show SMILES CCc1oc2ccccc2c(=O)c1O
Show InChI InChI=1S/C11H10O3/c1-2-8-11(13)10(12)7-5-3-4-6-9(7)14-8/h3-6,13H,2H2,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Universidad de Santiago de Chile

Curated by ChEMBL


Assay Description
Inhibition of 15-hLO2


Bioorg Med Chem 15: 7408-25 (2007)


Article DOI: 10.1016/j.bmc.2007.07.036
BindingDB Entry DOI: 10.7270/Q2RN37KN
More data for this
Ligand-Target Pair
15-Lipoxygenase-2 (15-LOX-2)


(Homo sapiens (Human))
BDBM50222281
PNG
(3-hydroxy-2-propyl-4H-benzopyran-4-one | CHEMBL394...)
Show SMILES CC(C)c1oc2ccccc2c(=O)c1O
Show InChI InChI=1S/C12H12O3/c1-7(2)12-11(14)10(13)8-5-3-4-6-9(8)15-12/h3-7,14H,1-2H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Universidad de Santiago de Chile

Curated by ChEMBL


Assay Description
Inhibition of 15-hLO2


Bioorg Med Chem 15: 7408-25 (2007)


Article DOI: 10.1016/j.bmc.2007.07.036
BindingDB Entry DOI: 10.7270/Q2RN37KN
More data for this
Ligand-Target Pair
15-Lipoxygenase-2 (15-LOX-2)


(Homo sapiens (Human))
BDBM50222275
PNG
(2-isopropyl-3-hydroxy-4H-benzopyran-4-one | CHEMBL...)
Show SMILES CCCc1oc2ccccc2c(=O)c1O
Show InChI InChI=1S/C12H12O3/c1-2-5-10-12(14)11(13)8-6-3-4-7-9(8)15-10/h3-4,6-7,14H,2,5H2,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Universidad de Santiago de Chile

Curated by ChEMBL


Assay Description
Inhibition of 15-hLO2


Bioorg Med Chem 15: 7408-25 (2007)


Article DOI: 10.1016/j.bmc.2007.07.036
BindingDB Entry DOI: 10.7270/Q2RN37KN
More data for this
Ligand-Target Pair
12-Lipoxygenase (12-LOX)


(Homo sapiens (Human))
BDBM50222288
PNG
(3-hydroxy-2-pentyl-4H-benzopyran-4-one | CHEMBL241...)
Show SMILES CCCCCc1oc2ccccc2c(=O)c1O
Show InChI InChI=1S/C14H16O3/c1-2-3-4-9-12-14(16)13(15)10-7-5-6-8-11(10)17-12/h5-8,16H,2-4,9H2,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Universidad de Santiago de Chile

Curated by ChEMBL


Assay Description
Inhibition of 12-hLO


Bioorg Med Chem 15: 7408-25 (2007)


Article DOI: 10.1016/j.bmc.2007.07.036
BindingDB Entry DOI: 10.7270/Q2RN37KN
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50222298
PNG
(2-ethyl-3-hydroxy-4 H-benzopyran-4-one | CHEMBL238...)
Show SMILES CCc1oc2ccccc2c(=O)c1O
Show InChI InChI=1S/C11H10O3/c1-2-8-11(13)10(12)7-5-3-4-6-9(7)14-8/h3-6,13H,2H2,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Universidad de Santiago de Chile

Curated by ChEMBL


Assay Description
Inhibition of 15-hLO1


Bioorg Med Chem 15: 7408-25 (2007)


Article DOI: 10.1016/j.bmc.2007.07.036
BindingDB Entry DOI: 10.7270/Q2RN37KN
More data for this
Ligand-Target Pair
12-Lipoxygenase (12-LOX)


(Homo sapiens (Human))
BDBM50222298
PNG
(2-ethyl-3-hydroxy-4 H-benzopyran-4-one | CHEMBL238...)
Show SMILES CCc1oc2ccccc2c(=O)c1O
Show InChI InChI=1S/C11H10O3/c1-2-8-11(13)10(12)7-5-3-4-6-9(7)14-8/h3-6,13H,2H2,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Universidad de Santiago de Chile

Curated by ChEMBL


Assay Description
Inhibition of 12-hLO


Bioorg Med Chem 15: 7408-25 (2007)


Article DOI: 10.1016/j.bmc.2007.07.036
BindingDB Entry DOI: 10.7270/Q2RN37KN
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50222288
PNG
(3-hydroxy-2-pentyl-4H-benzopyran-4-one | CHEMBL241...)
Show SMILES CCCCCc1oc2ccccc2c(=O)c1O
Show InChI InChI=1S/C14H16O3/c1-2-3-4-9-12-14(16)13(15)10-7-5-6-8-11(10)17-12/h5-8,16H,2-4,9H2,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Universidad de Santiago de Chile

Curated by ChEMBL


Assay Description
Inhibition of 15-hLO1


Bioorg Med Chem 15: 7408-25 (2007)


Article DOI: 10.1016/j.bmc.2007.07.036
BindingDB Entry DOI: 10.7270/Q2RN37KN
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50222282
PNG
(3-hydroxy-2-t-butyl-4H-benzopyran-4-one | CHEMBL23...)
Show SMILES CC(C)(C)c1oc2ccccc2c(=O)c1O
Show InChI InChI=1S/C13H14O3/c1-13(2,3)12-11(15)10(14)8-6-4-5-7-9(8)16-12/h4-7,15H,1-3H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Universidad de Santiago de Chile

Curated by ChEMBL


Assay Description
Inhibition of 15-hLO1


Bioorg Med Chem 15: 7408-25 (2007)


Article DOI: 10.1016/j.bmc.2007.07.036
BindingDB Entry DOI: 10.7270/Q2RN37KN
More data for this
Ligand-Target Pair
12-Lipoxygenase (12-LOX)


(Homo sapiens (Human))
BDBM50222282
PNG
(3-hydroxy-2-t-butyl-4H-benzopyran-4-one | CHEMBL23...)
Show SMILES CC(C)(C)c1oc2ccccc2c(=O)c1O
Show InChI InChI=1S/C13H14O3/c1-13(2,3)12-11(15)10(14)8-6-4-5-7-9(8)16-12/h4-7,15H,1-3H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Universidad de Santiago de Chile

Curated by ChEMBL


Assay Description
Inhibition of 12-hLO


Bioorg Med Chem 15: 7408-25 (2007)


Article DOI: 10.1016/j.bmc.2007.07.036
BindingDB Entry DOI: 10.7270/Q2RN37KN
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50222275
PNG
(2-isopropyl-3-hydroxy-4H-benzopyran-4-one | CHEMBL...)
Show SMILES CCCc1oc2ccccc2c(=O)c1O
Show InChI InChI=1S/C12H12O3/c1-2-5-10-12(14)11(13)8-6-3-4-7-9(8)15-10/h3-4,6-7,14H,2,5H2,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Universidad de Santiago de Chile

Curated by ChEMBL


Assay Description
Inhibition of 15-hLO1


Bioorg Med Chem 15: 7408-25 (2007)


Article DOI: 10.1016/j.bmc.2007.07.036
BindingDB Entry DOI: 10.7270/Q2RN37KN
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50222312
PNG
(6-hydroxy-2-isobutyl-4H-benzopyran-4-one | CHEMBL3...)
Show SMILES CC(C)Cc1cc(=O)c2cc(O)ccc2o1
Show InChI InChI=1S/C13H14O3/c1-8(2)5-10-7-12(15)11-6-9(14)3-4-13(11)16-10/h3-4,6-8,14H,5H2,1-2H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Universidad de Santiago de Chile

Curated by ChEMBL


Assay Description
Inhibition of 15-hLO1


Bioorg Med Chem 15: 7408-25 (2007)


Article DOI: 10.1016/j.bmc.2007.07.036
BindingDB Entry DOI: 10.7270/Q2RN37KN
More data for this
Ligand-Target Pair
12-Lipoxygenase (12-LOX)


(Homo sapiens (Human))
BDBM50222312
PNG
(6-hydroxy-2-isobutyl-4H-benzopyran-4-one | CHEMBL3...)
Show SMILES CC(C)Cc1cc(=O)c2cc(O)ccc2o1
Show InChI InChI=1S/C13H14O3/c1-8(2)5-10-7-12(15)11-6-9(14)3-4-13(11)16-10/h3-4,6-8,14H,5H2,1-2H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Universidad de Santiago de Chile

Curated by ChEMBL


Assay Description
Inhibition of 12-hLO


Bioorg Med Chem 15: 7408-25 (2007)


Article DOI: 10.1016/j.bmc.2007.07.036
BindingDB Entry DOI: 10.7270/Q2RN37KN
More data for this
Ligand-Target Pair
12-Lipoxygenase (12-LOX)


(Homo sapiens (Human))
BDBM50222281
PNG
(3-hydroxy-2-propyl-4H-benzopyran-4-one | CHEMBL394...)
Show SMILES CC(C)c1oc2ccccc2c(=O)c1O
Show InChI InChI=1S/C12H12O3/c1-7(2)12-11(14)10(13)8-5-3-4-6-9(8)15-12/h3-7,14H,1-2H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Universidad de Santiago de Chile

Curated by ChEMBL


Assay Description
Inhibition of 12-hLO


Bioorg Med Chem 15: 7408-25 (2007)


Article DOI: 10.1016/j.bmc.2007.07.036
BindingDB Entry DOI: 10.7270/Q2RN37KN
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50222281
PNG
(3-hydroxy-2-propyl-4H-benzopyran-4-one | CHEMBL394...)
Show SMILES CC(C)c1oc2ccccc2c(=O)c1O
Show InChI InChI=1S/C12H12O3/c1-7(2)12-11(14)10(13)8-5-3-4-6-9(8)15-12/h3-7,14H,1-2H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Universidad de Santiago de Chile

Curated by ChEMBL


Assay Description
Inhibition of 15-hLO1


Bioorg Med Chem 15: 7408-25 (2007)


Article DOI: 10.1016/j.bmc.2007.07.036
BindingDB Entry DOI: 10.7270/Q2RN37KN
More data for this
Ligand-Target Pair
15-Lipoxygenase-2 (15-LOX-2)


(Homo sapiens (Human))
BDBM50222288
PNG
(3-hydroxy-2-pentyl-4H-benzopyran-4-one | CHEMBL241...)
Show SMILES CCCCCc1oc2ccccc2c(=O)c1O
Show InChI InChI=1S/C14H16O3/c1-2-3-4-9-12-14(16)13(15)10-7-5-6-8-11(10)17-12/h5-8,16H,2-4,9H2,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Universidad de Santiago de Chile

Curated by ChEMBL


Assay Description
Inhibition of 15-hLO2


Bioorg Med Chem 15: 7408-25 (2007)


Article DOI: 10.1016/j.bmc.2007.07.036
BindingDB Entry DOI: 10.7270/Q2RN37KN
More data for this
Ligand-Target Pair