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10 similar compounds to monomer 50222296

Compile data set for download or QSAR
Wt: 286.2
BDBM50222309
Wt: 270.2
BDBM50222295
Wt: 224.2
BDBM50380162
Purchase
Wt: 238.2
BDBM50380164
Wt: 284.3
BDBM50380160
Wt: 254.2
BDBM50380169
Wt: 254.2
BDBM50380171
Wt: 254.2
BDBM50380172
Wt: 254.2
BDBM50380179
Wt: 240.2
BDBM50380180

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50222309,50222295,50380162,50380164,50380160,50380169,50380171,50380172,50380179,50380180   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
15-Lipoxygenase-2 (15-LOX-2)


(Homo sapiens (Human))
BDBM50222309
PNG
(6,7-dihydroxy-4'-methoxyisoflavanone | CHEMBL23903...)
Show SMILES COc1ccc(cc1)C1COc2cc(O)c(O)cc2C1=O
Show InChI InChI=1S/C16H14O5/c1-20-10-4-2-9(3-5-10)12-8-21-15-7-14(18)13(17)6-11(15)16(12)19/h2-7,12,17-18H,8H2,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Universidad de Santiago de Chile

Curated by ChEMBL


Assay Description
Inhibition of 15-hLO2


Bioorg Med Chem 15: 7408-25 (2007)


Article DOI: 10.1016/j.bmc.2007.07.036
BindingDB Entry DOI: 10.7270/Q2RN37KN
More data for this
Ligand-Target Pair
15-Lipoxygenase-2 (15-LOX-2)


(Homo sapiens (Human))
BDBM50222295
PNG
(6,7-dihydroxy-3-m-tolyl-2,3-dihydrochromen-4-one |...)
Show SMILES Cc1cccc(c1)C1COc2cc(O)c(O)cc2C1=O
Show InChI InChI=1S/C16H14O4/c1-9-3-2-4-10(5-9)12-8-20-15-7-14(18)13(17)6-11(15)16(12)19/h2-7,12,17-18H,8H2,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Universidad de Santiago de Chile

Curated by ChEMBL


Assay Description
Inhibition of 15-hLO2


Bioorg Med Chem 15: 7408-25 (2007)


Article DOI: 10.1016/j.bmc.2007.07.036
BindingDB Entry DOI: 10.7270/Q2RN37KN
More data for this
Ligand-Target Pair
12-Lipoxygenase (12-LOX)


(Homo sapiens (Human))
BDBM50222295
PNG
(6,7-dihydroxy-3-m-tolyl-2,3-dihydrochromen-4-one |...)
Show SMILES Cc1cccc(c1)C1COc2cc(O)c(O)cc2C1=O
Show InChI InChI=1S/C16H14O4/c1-9-3-2-4-10(5-9)12-8-20-15-7-14(18)13(17)6-11(15)16(12)19/h2-7,12,17-18H,8H2,1H3
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n/an/a 1.40E+4n/an/an/an/an/an/a



Universidad de Santiago de Chile

Curated by ChEMBL


Assay Description
Inhibition of 12-hLO


Bioorg Med Chem 15: 7408-25 (2007)


Article DOI: 10.1016/j.bmc.2007.07.036
BindingDB Entry DOI: 10.7270/Q2RN37KN
More data for this
Ligand-Target Pair
12-Lipoxygenase (12-LOX)


(Homo sapiens (Human))
BDBM50222309
PNG
(6,7-dihydroxy-4'-methoxyisoflavanone | CHEMBL23903...)
Show SMILES COc1ccc(cc1)C1COc2cc(O)c(O)cc2C1=O
Show InChI InChI=1S/C16H14O5/c1-20-10-4-2-9(3-5-10)12-8-21-15-7-14(18)13(17)6-11(15)16(12)19/h2-7,12,17-18H,8H2,1H3
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n/an/a 1.60E+3n/an/an/an/an/an/a



Universidad de Santiago de Chile

Curated by ChEMBL


Assay Description
Inhibition of 12-hLO


Bioorg Med Chem 15: 7408-25 (2007)


Article DOI: 10.1016/j.bmc.2007.07.036
BindingDB Entry DOI: 10.7270/Q2RN37KN
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50222309
PNG
(6,7-dihydroxy-4'-methoxyisoflavanone | CHEMBL23903...)
Show SMILES COc1ccc(cc1)C1COc2cc(O)c(O)cc2C1=O
Show InChI InChI=1S/C16H14O5/c1-20-10-4-2-9(3-5-10)12-8-21-15-7-14(18)13(17)6-11(15)16(12)19/h2-7,12,17-18H,8H2,1H3
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n/an/a 1.90E+4n/an/an/an/an/an/a



Universidad de Santiago de Chile

Curated by ChEMBL


Assay Description
Inhibition of 15-hLO1


Bioorg Med Chem 15: 7408-25 (2007)


Article DOI: 10.1016/j.bmc.2007.07.036
BindingDB Entry DOI: 10.7270/Q2RN37KN
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50222295
PNG
(6,7-dihydroxy-3-m-tolyl-2,3-dihydrochromen-4-one |...)
Show SMILES Cc1cccc(c1)C1COc2cc(O)c(O)cc2C1=O
Show InChI InChI=1S/C16H14O4/c1-9-3-2-4-10(5-9)12-8-20-15-7-14(18)13(17)6-11(15)16(12)19/h2-7,12,17-18H,8H2,1H3
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n/an/a 210n/an/an/an/an/an/a



Universidad de Santiago de Chile

Curated by ChEMBL


Assay Description
Inhibition of 15-hLO1


Bioorg Med Chem 15: 7408-25 (2007)


Article DOI: 10.1016/j.bmc.2007.07.036
BindingDB Entry DOI: 10.7270/Q2RN37KN
More data for this
Ligand-Target Pair
Aromatase (CYP19)


(Homo sapiens (Human))
BDBM50380180
PNG
(CHEMBL2011192)
Show SMILES Oc1ccc(cc1)C1COc2ccccc2C1=O
Show InChI InChI=1S/C15H12O3/c16-11-7-5-10(6-8-11)13-9-18-14-4-2-1-3-12(14)15(13)17/h1-8,13,16H,9H2
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n/an/a 1.60E+5n/an/an/an/an/an/a



Northern Kentucky University

Curated by ChEMBL


Assay Description
Inhibition of aromatase


Bioorg Med Chem 20: 2603-13 (2012)


Article DOI: 10.1016/j.bmc.2012.02.042
BindingDB Entry DOI: 10.7270/Q29S1S24
More data for this
Ligand-Target Pair
Aromatase (CYP19)


(Homo sapiens (Human))
BDBM50380162
PNG
(CHEMBL2011171)
Show SMILES O=C1C(COc2ccccc12)c1ccccc1
Show InChI InChI=1S/C15H12O2/c16-15-12-8-4-5-9-14(12)17-10-13(15)11-6-2-1-3-7-11/h1-9,13H,10H2
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n/an/a 2.90E+4n/an/an/an/an/an/a



Northern Kentucky University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant aromatase expressed in baculovirus/insect cells using 7-methoxy-trifluoromethylcoumarin as substrate after 30 mins by...


Bioorg Med Chem 20: 2603-13 (2012)


Article DOI: 10.1016/j.bmc.2012.02.042
BindingDB Entry DOI: 10.7270/Q29S1S24
More data for this
Ligand-Target Pair
Aromatase (CYP19)


(Homo sapiens (Human))
BDBM50380164
PNG
(CHEMBL2011173)
Show SMILES Cc1ccc2C(=O)C(COc2c1)c1ccccc1
Show InChI InChI=1S/C16H14O2/c1-11-7-8-13-15(9-11)18-10-14(16(13)17)12-5-3-2-4-6-12/h2-9,14H,10H2,1H3
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n/an/a 1.80E+4n/an/an/an/an/an/a



Northern Kentucky University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant aromatase expressed in baculovirus/insect cells using 7-methoxy-trifluoromethylcoumarin as substrate after 30 mins by...


Bioorg Med Chem 20: 2603-13 (2012)


Article DOI: 10.1016/j.bmc.2012.02.042
BindingDB Entry DOI: 10.7270/Q29S1S24
More data for this
Ligand-Target Pair
Aromatase (CYP19)


(Homo sapiens (Human))
BDBM50380169
PNG
(CHEMBL2011180)
Show SMILES COc1ccc2OCC(C(=O)c2c1)c1ccccc1
Show InChI InChI=1S/C16H14O3/c1-18-12-7-8-15-13(9-12)16(17)14(10-19-15)11-5-3-2-4-6-11/h2-9,14H,10H2,1H3
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n/an/a 260n/an/an/an/an/an/a



Northern Kentucky University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant aromatase expressed in baculovirus/insect cells using 7-methoxy-trifluoromethylcoumarin as substrate after 30 mins by...


Bioorg Med Chem 20: 2603-13 (2012)


Article DOI: 10.1016/j.bmc.2012.02.042
BindingDB Entry DOI: 10.7270/Q29S1S24
More data for this
Ligand-Target Pair
Aromatase (CYP19)


(Homo sapiens (Human))
BDBM50380171
PNG
(CHEMBL2011182)
Show SMILES COc1cccc(c1)C1COc2ccccc2C1=O
Show InChI InChI=1S/C16H14O3/c1-18-12-6-4-5-11(9-12)14-10-19-15-8-3-2-7-13(15)16(14)17/h2-9,14H,10H2,1H3
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n/an/a 9.90E+4n/an/an/an/an/an/a



Northern Kentucky University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant aromatase expressed in baculovirus/insect cells using 7-methoxy-trifluoromethylcoumarin as substrate after 30 mins by...


Bioorg Med Chem 20: 2603-13 (2012)


Article DOI: 10.1016/j.bmc.2012.02.042
BindingDB Entry DOI: 10.7270/Q29S1S24
More data for this
Ligand-Target Pair
Aromatase (CYP19)


(Homo sapiens (Human))
BDBM50380172
PNG
(CHEMBL2011183)
Show SMILES COc1ccc(cc1)C1COc2ccccc2C1=O
Show InChI InChI=1S/C16H14O3/c1-18-12-8-6-11(7-9-12)14-10-19-15-5-3-2-4-13(15)16(14)17/h2-9,14H,10H2,1H3
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n/an/a 2.40E+4n/an/an/an/an/an/a



Northern Kentucky University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant aromatase expressed in baculovirus/insect cells using 7-methoxy-trifluoromethylcoumarin as substrate after 30 mins by...


Bioorg Med Chem 20: 2603-13 (2012)


Article DOI: 10.1016/j.bmc.2012.02.042
BindingDB Entry DOI: 10.7270/Q29S1S24
More data for this
Ligand-Target Pair
Aromatase (CYP19)


(Homo sapiens (Human))
BDBM50380179
PNG
(CHEMBL1165711)
Show SMILES COc1ccc2C(=O)C(COc2c1)c1ccccc1
Show InChI InChI=1S/C16H14O3/c1-18-12-7-8-13-15(9-12)19-10-14(16(13)17)11-5-3-2-4-6-11/h2-9,14H,10H2,1H3
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n/an/a 4.10E+4n/an/an/an/an/an/a



Northern Kentucky University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant aromatase expressed in baculovirus/insect cells using 7-methoxy-trifluoromethylcoumarin as substrate after 30 mins by...


Bioorg Med Chem 20: 2603-13 (2012)


Article DOI: 10.1016/j.bmc.2012.02.042
BindingDB Entry DOI: 10.7270/Q29S1S24
More data for this
Ligand-Target Pair
Aromatase (CYP19)


(Homo sapiens (Human))
BDBM50380160
PNG
(CHEMBL2011184)
Show SMILES COc1cc(OC)cc(c1)C1COc2ccccc2C1=O
Show InChI InChI=1S/C17H16O4/c1-19-12-7-11(8-13(9-12)20-2)15-10-21-16-6-4-3-5-14(16)17(15)18/h3-9,15H,10H2,1-2H3
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n/an/a 1.10E+4n/an/an/an/an/an/a



Northern Kentucky University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant aromatase expressed in baculovirus/insect cells using 7-methoxy-trifluoromethylcoumarin as substrate after 30 mins by...


Bioorg Med Chem 20: 2603-13 (2012)


Article DOI: 10.1016/j.bmc.2012.02.042
BindingDB Entry DOI: 10.7270/Q29S1S24
More data for this
Ligand-Target Pair