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28 molecules are shown

Compile data set for download or QSAR
Wt: 462.4
BDBM50222759
Wt: 555.9
BDBM50144613
Wt: 435.5
BDBM50159125
Wt: 405.5
BDBM50159126
Wt: 377.4
BDBM50159127
Wt: 369.4
BDBM50159128
Wt: 389.4
BDBM50159132
Wt: 437.4
BDBM50159133
Wt: 435.5
BDBM50159134
Wt: 343.3
BDBM50159135
Wt: 471.5
BDBM50159136
Wt: 341.4
BDBM50159138
Wt: 448.5
BDBM50159141
<<  First   |  Previous   |  Displayed 16 to 28 (of 28 total )

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 23 hits for monomerid = 50222759,50144613,50159125,50159126,50159127,50159128,50159132,50159133,50159134,50159135,50159136,50159138,50159141   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50144613
PNG
(CHEMBL3758753)
Show SMILES CCS(=O)(=O)N1CCC(CC1)NC(=O)c1nn(c(c1C)-c1ccc(Cl)cc1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C24H25Cl3N4O3S/c1-3-35(33,34)30-12-10-19(11-13-30)28-24(32)22-15(2)23(16-4-6-17(25)7-5-16)31(29-22)21-9-8-18(26)14-20(21)27/h4-9,14,19H,3,10-13H2,1-2H3,(H,28,32)
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44n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB1 receptor expressed in CHO cell membranes


Bioorg Med Chem 24: 1063-70 (2016)


Article DOI: 10.1016/j.bmc.2016.01.033
BindingDB Entry DOI: 10.7270/Q2GB25WW
More data for this
Ligand-Target Pair
Equilibrative Nucleoside Transporter 1 (ENT1)


(Homo sapiens (Human))
BDBM50222759
PNG
(2-dimethylamino-6-(4-nitrobenzylthio)-9-beta-D-rib...)
Show SMILES CN(C)c1nc(SCc2ccc(cc2)[N+]([O-])=O)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1
Show InChI InChI=1S/C19H22N6O6S/c1-23(2)19-21-16-13(20-9-24(16)18-15(28)14(27)12(7-26)31-18)17(22-19)32-8-10-3-5-11(6-4-10)25(29)30/h3-6,9,12,14-15,18,26-28H,7-8H2,1-2H3/t12-,14-,15-,18-/m1/s1
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429n/an/an/an/an/an/an/an/a



University of Tennessee Health Sciences Center

Curated by ChEMBL


Assay Description
Displacement of SAENTA-fluorescein from human ENT1 in K562 cells after 45 mins by flow cytometry


Bioorg Med Chem 15: 7726-37 (2007)


Article DOI: 10.1016/j.bmc.2007.08.058
BindingDB Entry DOI: 10.7270/Q26Q1WZD
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50144613
PNG
(CHEMBL3758753)
Show SMILES CCS(=O)(=O)N1CCC(CC1)NC(=O)c1nn(c(c1C)-c1ccc(Cl)cc1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C24H25Cl3N4O3S/c1-3-35(33,34)30-12-10-19(11-13-30)28-24(32)22-15(2)23(16-4-6-17(25)7-5-16)31(29-22)21-9-8-18(26)14-20(21)27/h4-9,14,19H,3,10-13H2,1-2H3,(H,28,32)
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4.41E+3n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB2 receptor expressed in CHO cell membranes


Bioorg Med Chem 24: 1063-70 (2016)


Article DOI: 10.1016/j.bmc.2016.01.033
BindingDB Entry DOI: 10.7270/Q2GB25WW
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM50159128
PNG
(CHEMBL3785545)
Show SMILES CCN(CC)C(=O)c1cccc(NC(=O)c2[nH]c(C)c(C(C)=O)c2CC)c1
Show InChI InChI=1S/C21H27N3O3/c1-6-17-18(14(5)25)13(4)22-19(17)20(26)23-16-11-9-10-15(12-16)21(27)24(7-2)8-3/h9-12,22H,6-8H2,1-5H3,(H,23,26)
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n/an/an/a 6.80E+3n/an/an/an/an/a



Albert-Ludwigs-Universit£t Freiburg

Curated by ChEMBL


Assay Description
Binding affinity to partial length human BRD4 bromodomain 1 by isothermal titration calorimetry


J Med Chem 59: 1518-30 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01267
BindingDB Entry DOI: 10.7270/Q27H1MHH
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM50159132
PNG
(CHEMBL3785971)
Show SMILES CCc1c([nH]c(C)c1C(C)=O)C(=O)N1CCc2ccc(cc12)S(=O)(=O)NC
Show InChI InChI=1S/C19H23N3O4S/c1-5-15-17(12(3)23)11(2)21-18(15)19(24)22-9-8-13-6-7-14(10-16(13)22)27(25,26)20-4/h6-7,10,20-21H,5,8-9H2,1-4H3
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n/an/an/a 7.40E+3n/an/an/an/an/a



Albert-Ludwigs-Universit£t Freiburg

Curated by ChEMBL


Assay Description
Binding affinity to partial length human BRD4 bromodomain 1 by isothermal titration calorimetry


J Med Chem 59: 1518-30 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01267
BindingDB Entry DOI: 10.7270/Q27H1MHH
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM50159133
PNG
(CHEMBL3786180)
Show SMILES CCc1c([nH]c(C)c1C(C)=O)C(=O)Nc1ccc(F)c(c1)S(=O)(=O)N1CCOCC1
Show InChI InChI=1S/C20H24FN3O5S/c1-4-15-18(13(3)25)12(2)22-19(15)20(26)23-14-5-6-16(21)17(11-14)30(27,28)24-7-9-29-10-8-24/h5-6,11,22H,4,7-10H2,1-3H3,(H,23,26)
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n/an/an/a 1.30E+3n/an/an/an/an/a



Albert-Ludwigs-Universit£t Freiburg

Curated by ChEMBL


Assay Description
Binding affinity to partial length human BRD4 bromodomain 1 by isothermal titration calorimetry


J Med Chem 59: 1518-30 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01267
BindingDB Entry DOI: 10.7270/Q27H1MHH
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM50159134
PNG
(CHEMBL3786700)
Show SMILES CCN(CC)S(=O)(=O)c1cc(NC(=O)c2[nH]c(C)c(C(C)=O)c2CC)c(O)cc1C
Show InChI InChI=1S/C21H29N3O5S/c1-7-15-19(14(6)25)13(5)22-20(15)21(27)23-16-11-18(12(4)10-17(16)26)30(28,29)24(8-2)9-3/h10-11,22,26H,7-9H2,1-6H3,(H,23,27)
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n/an/an/a 880n/an/an/an/an/a



Albert-Ludwigs-Universit£t Freiburg

Curated by ChEMBL


Assay Description
Binding affinity to partial length human BRD4 bromodomain 1 by isothermal titration calorimetry


J Med Chem 59: 1518-30 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01267
BindingDB Entry DOI: 10.7270/Q27H1MHH
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM50159135
PNG
(CHEMBL3786260)
Show SMILES CCc1c([nH]c(C)c1C(C)=O)C(=O)Nc1cccc(OCC(N)=O)c1
Show InChI InChI=1S/C18H21N3O4/c1-4-14-16(11(3)22)10(2)20-17(14)18(24)21-12-6-5-7-13(8-12)25-9-15(19)23/h5-8,20H,4,9H2,1-3H3,(H2,19,23)(H,21,24)
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n/an/an/a 5.80E+3n/an/an/an/an/a



Albert-Ludwigs-Universit£t Freiburg

Curated by ChEMBL


Assay Description
Binding affinity to partial length human BRD4 bromodomain 1 by isothermal titration calorimetry


J Med Chem 59: 1518-30 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01267
BindingDB Entry DOI: 10.7270/Q27H1MHH
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Melanin-concentrating hormone receptor 1


(Mus musculus)
BDBM50159141
PNG
(CHEMBL3785343)
Show SMILES CN(Cc1ccc(OC2CN(C2)C(=O)c2nnc(o2)-c2ccccc2)cc1)CC1(C)COC1
Show InChI InChI=1S/C25H28N4O4/c1-25(16-31-17-25)15-28(2)12-18-8-10-20(11-9-18)32-21-13-29(14-21)24(30)23-27-26-22(33-23)19-6-4-3-5-7-19/h3-11,21H,12-17H2,1-2H3
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n/an/a 14n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr13-MCH from mouse MCHR1 after 60 mins by microbeta scintillation counting analysis


J Med Chem 59: 2497-511 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01654
BindingDB Entry DOI: 10.7270/Q23R0VSS
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM50159138
PNG
(CHEMBL3785707)
Show SMILES CCc1c([nH]c(C)c1C(C)=O)C(=O)N(C)Cc1cccc(c1)C(N)=O
Show InChI InChI=1S/C19H23N3O3/c1-5-15-16(12(3)23)11(2)21-17(15)19(25)22(4)10-13-7-6-8-14(9-13)18(20)24/h6-9,21H,5,10H2,1-4H3,(H2,20,24)
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n/an/an/a 1.20E+4n/an/an/an/an/a



Albert-Ludwigs-Universit£t Freiburg

Curated by ChEMBL


Assay Description
Binding affinity to partial length human BRD4 bromodomain 1 by isothermal titration calorimetry


J Med Chem 59: 1518-30 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01267
BindingDB Entry DOI: 10.7270/Q27H1MHH
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Bromodomain-containing protein 3


(Homo sapiens (Human))
BDBM50159133
PNG
(CHEMBL3786180)
Show SMILES CCc1c([nH]c(C)c1C(C)=O)C(=O)Nc1ccc(F)c(c1)S(=O)(=O)N1CCOCC1
Show InChI InChI=1S/C20H24FN3O5S/c1-4-15-18(13(3)25)12(2)22-19(15)20(26)23-14-5-6-16(21)17(11-14)30(27,28)24-7-9-29-10-8-24/h5-6,11,22H,4,7-10H2,1-3H3,(H,23,26)
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n/an/an/a 6.10E+3n/an/an/an/an/a



Albert-Ludwigs-Universit£t Freiburg

Curated by ChEMBL


Assay Description
Binding affinity to partial length human BRD3 bromodomain 1 by isothermal titration calorimetry


J Med Chem 59: 1518-30 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01267
BindingDB Entry DOI: 10.7270/Q27H1MHH
More data for this
Ligand-Target Pair
Bromodomain-containing protein 3


(Homo sapiens (Human))
BDBM50159135
PNG
(CHEMBL3786260)
Show SMILES CCc1c([nH]c(C)c1C(C)=O)C(=O)Nc1cccc(OCC(N)=O)c1
Show InChI InChI=1S/C18H21N3O4/c1-4-14-16(11(3)22)10(2)20-17(14)18(24)21-12-6-5-7-13(8-12)25-9-15(19)23/h5-8,20H,4,9H2,1-3H3,(H2,19,23)(H,21,24)
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n/an/an/a 4.10E+4n/an/an/an/an/a



Albert-Ludwigs-Universit£t Freiburg

Curated by ChEMBL


Assay Description
Binding affinity to partial length human BRD3 bromodomain 1 by isothermal titration calorimetry


J Med Chem 59: 1518-30 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01267
BindingDB Entry DOI: 10.7270/Q27H1MHH
More data for this
Ligand-Target Pair
Bromodomain-containing protein 3


(Homo sapiens (Human))
BDBM50159138
PNG
(CHEMBL3785707)
Show SMILES CCc1c([nH]c(C)c1C(C)=O)C(=O)N(C)Cc1cccc(c1)C(N)=O
Show InChI InChI=1S/C19H23N3O3/c1-5-15-16(12(3)23)11(2)21-17(15)19(25)22(4)10-13-7-6-8-14(9-13)18(20)24/h6-9,21H,5,10H2,1-4H3,(H2,20,24)
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n/an/an/a 5.00E+4n/an/an/an/an/a



Albert-Ludwigs-Universit£t Freiburg

Curated by ChEMBL


Assay Description
Binding affinity to partial length human BRD3 bromodomain 1 by isothermal titration calorimetry


J Med Chem 59: 1518-30 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01267
BindingDB Entry DOI: 10.7270/Q27H1MHH
More data for this
Ligand-Target Pair
Bromodomain-containing protein 3


(Homo sapiens (Human))
BDBM50159133
PNG
(CHEMBL3786180)
Show SMILES CCc1c([nH]c(C)c1C(C)=O)C(=O)Nc1ccc(F)c(c1)S(=O)(=O)N1CCOCC1
Show InChI InChI=1S/C20H24FN3O5S/c1-4-15-18(13(3)25)12(2)22-19(15)20(26)23-14-5-6-16(21)17(11-14)30(27,28)24-7-9-29-10-8-24/h5-6,11,22H,4,7-10H2,1-3H3,(H,23,26)
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n/an/an/a 1.80E+4n/an/an/an/an/a



Albert-Ludwigs-Universit£t Freiburg

Curated by ChEMBL


Assay Description
Binding affinity to partial length human BRD3 bromodomain 2 by isothermal titration calorimetry


J Med Chem 59: 1518-30 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01267
BindingDB Entry DOI: 10.7270/Q27H1MHH
More data for this
Ligand-Target Pair
Bromodomain-containing protein 3


(Homo sapiens (Human))
BDBM50159135
PNG
(CHEMBL3786260)
Show SMILES CCc1c([nH]c(C)c1C(C)=O)C(=O)Nc1cccc(OCC(N)=O)c1
Show InChI InChI=1S/C18H21N3O4/c1-4-14-16(11(3)22)10(2)20-17(14)18(24)21-12-6-5-7-13(8-12)25-9-15(19)23/h5-8,20H,4,9H2,1-3H3,(H2,19,23)(H,21,24)
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n/an/an/a 2.30E+4n/an/an/an/an/a



Albert-Ludwigs-Universit£t Freiburg

Curated by ChEMBL


Assay Description
Binding affinity to partial length human BRD3 bromodomain 2 by isothermal titration calorimetry


J Med Chem 59: 1518-30 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01267
BindingDB Entry DOI: 10.7270/Q27H1MHH
More data for this
Ligand-Target Pair
Bromodomain-containing protein 3


(Homo sapiens (Human))
BDBM50159138
PNG
(CHEMBL3785707)
Show SMILES CCc1c([nH]c(C)c1C(C)=O)C(=O)N(C)Cc1cccc(c1)C(N)=O
Show InChI InChI=1S/C19H23N3O3/c1-5-15-16(12(3)23)11(2)21-17(15)19(25)22(4)10-13-7-6-8-14(9-13)18(20)24/h6-9,21H,5,10H2,1-4H3,(H2,20,24)
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n/an/an/a 1.90E+4n/an/an/an/an/a



Albert-Ludwigs-Universit£t Freiburg

Curated by ChEMBL


Assay Description
Binding affinity to partial length human BRD3 bromodomain 2 by isothermal titration calorimetry


J Med Chem 59: 1518-30 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01267
BindingDB Entry DOI: 10.7270/Q27H1MHH
More data for this
Ligand-Target Pair
Peregrin


(Homo sapiens (Human))
BDBM50159125
PNG
(CHEMBL3786807)
Show SMILES CCN(CC)S(=O)(=O)c1ccc(O)c(NC(=O)c2[nH]c(C)c(C(C)=O)c2C(C)C)c1
Show InChI InChI=1S/C21H29N3O5S/c1-7-24(8-2)30(28,29)15-9-10-17(26)16(11-15)23-21(27)20-18(12(3)4)19(14(6)25)13(5)22-20/h9-12,22,26H,7-8H2,1-6H3,(H,23,27)
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n/an/an/a 3.60E+4n/an/an/an/an/a



Albert-Ludwigs-Universit£t Freiburg

Curated by ChEMBL


Assay Description
Binding affinity to partial length human BRPF1 by isothermal titration calorimetry


J Med Chem 59: 1518-30 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01267
BindingDB Entry DOI: 10.7270/Q27H1MHH
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50159141
PNG
(CHEMBL3785343)
Show SMILES CN(Cc1ccc(OC2CN(C2)C(=O)c2nnc(o2)-c2ccccc2)cc1)CC1(C)COC1
Show InChI InChI=1S/C25H28N4O4/c1-25(16-31-17-25)15-28(2)12-18-8-10-20(11-9-18)32-21-13-29(14-21)24(30)23-27-26-22(33-23)19-6-4-3-5-7-19/h3-11,21H,12-17H2,1-2H3
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n/an/a 35n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Antagonist activity at human MCHR1 expressed in CHO cell membranes preincubated for 5 mins followed by addition of MCH peptide measured after 45 mins...


J Med Chem 59: 2497-511 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01654
BindingDB Entry DOI: 10.7270/Q23R0VSS
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50159141
PNG
(CHEMBL3785343)
Show SMILES CN(Cc1ccc(OC2CN(C2)C(=O)c2nnc(o2)-c2ccccc2)cc1)CC1(C)COC1
Show InChI InChI=1S/C25H28N4O4/c1-25(16-31-17-25)15-28(2)12-18-8-10-20(11-9-18)32-21-13-29(14-21)24(30)23-27-26-22(33-23)19-6-4-3-5-7-19/h3-11,21H,12-17H2,1-2H3
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MMDB

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n/an/a 1.40E+4n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human ERG by IonWork assay


J Med Chem 59: 2497-511 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01654
BindingDB Entry DOI: 10.7270/Q23R0VSS
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM50159127
PNG
(CHEMBL3785242)
Show SMILES CCc1c([nH]c(C)c1C(C)=O)C(=O)Nc1cc(ccc1C)S(=O)(=O)NC
Show InChI InChI=1S/C18H23N3O4S/c1-6-14-16(12(4)22)11(3)20-17(14)18(23)21-15-9-13(8-7-10(15)2)26(24,25)19-5/h7-9,19-20H,6H2,1-5H3,(H,21,23)
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n/an/an/a 9.20E+3n/an/an/an/an/a



Albert-Ludwigs-Universit£t Freiburg

Curated by ChEMBL


Assay Description
Binding affinity to partial length human BRD4 bromodomain 1 by isothermal titration calorimetry


J Med Chem 59: 1518-30 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01267
BindingDB Entry DOI: 10.7270/Q27H1MHH
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM50159126
PNG
(CHEMBL3786456)
Show SMILES CCN(CC)S(=O)(=O)c1cccc(NC(=O)c2[nH]c(C)c(C(C)=O)c2CC)c1
Show InChI InChI=1S/C20H27N3O4S/c1-6-17-18(14(5)24)13(4)21-19(17)20(25)22-15-10-9-11-16(12-15)28(26,27)23(7-2)8-3/h9-12,21H,6-8H2,1-5H3,(H,22,25)
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n/an/an/a 5.70E+3n/an/an/an/an/a



Albert-Ludwigs-Universit£t Freiburg

Curated by ChEMBL


Assay Description
Binding affinity to partial length human BRD4 bromodomain 1 by isothermal titration calorimetry


J Med Chem 59: 1518-30 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01267
BindingDB Entry DOI: 10.7270/Q27H1MHH
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM50159125
PNG
(CHEMBL3786807)
Show SMILES CCN(CC)S(=O)(=O)c1ccc(O)c(NC(=O)c2[nH]c(C)c(C(C)=O)c2C(C)C)c1
Show InChI InChI=1S/C21H29N3O5S/c1-7-24(8-2)30(28,29)15-9-10-17(26)16(11-15)23-21(27)20-18(12(3)4)19(14(6)25)13(5)22-20/h9-12,22,26H,7-8H2,1-6H3,(H,23,27)
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n/an/an/a 7.20E+3n/an/an/an/an/a



Albert-Ludwigs-Universit£t Freiburg

Curated by ChEMBL


Assay Description
Binding affinity to partial length human BRD4 bromodomain 1 by isothermal titration calorimetry


J Med Chem 59: 1518-30 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01267
BindingDB Entry DOI: 10.7270/Q27H1MHH
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM50159136
PNG
(CHEMBL3786704)
Show SMILES CCc1c([nH]c(C)c1C(C)=O)C(=O)Nc1cc(ccc1O)S(=O)(=O)Nc1ccccc1OC
Show InChI InChI=1S/C23H25N3O6S/c1-5-16-21(14(3)27)13(2)24-22(16)23(29)25-18-12-15(10-11-19(18)28)33(30,31)26-17-8-6-7-9-20(17)32-4/h6-12,24,26,28H,5H2,1-4H3,(H,25,29)
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n/an/an/a 3.90E+3n/an/an/an/an/a



Albert-Ludwigs-Universit£t Freiburg

Curated by ChEMBL


Assay Description
Binding affinity to partial length human BRD4 bromodomain 1 by isothermal titration calorimetry


J Med Chem 59: 1518-30 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01267
BindingDB Entry DOI: 10.7270/Q27H1MHH
More data for this
Ligand-Target Pair