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5 similar compounds to monomer 50224221

Compile data set for download or QSAR
Wt: 270.2
BDBM50224200
Wt: 252.3
BDBM50224201
Wt: 292.3
BDBM50224202
Wt: 252.3
BDBM50224207
Wt: 270.2
BDBM50224217

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50224200,50224201,50224202,50224207,50224217   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224207
PNG
(2-(2-fluorophenylamino)-5-isopropylthiazol-4(5H)-o...)
Show SMILES CC(C)c1sc(Nc2ccccc2F)nc1O
Show InChI InChI=1S/C12H13FN2OS/c1-7(2)10-11(16)15-12(17-10)14-9-6-4-3-5-8(9)13/h3-7,16H,1-2H3,(H,14,15)
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7n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 by SPA


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224202
PNG
(5-cyclohexyl-2-(2-fluorophenylamino)thiazol-4(5H)-...)
Show SMILES Oc1nc(Nc2ccccc2F)sc1C1CCCCC1
Show InChI InChI=1S/C15H17FN2OS/c16-11-8-4-5-9-12(11)17-15-18-14(19)13(20-15)10-6-2-1-3-7-10/h4-5,8-10,19H,1-3,6-7H2,(H,17,18)
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7.20n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 by SPA


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224217
PNG
(2-(2,5-difluorophenylamino)-5-isopropylthiazol-4(5...)
Show SMILES CC(C)c1sc(Nc2cc(F)ccc2F)nc1O
Show InChI InChI=1S/C12H12F2N2OS/c1-6(2)10-11(17)16-12(18-10)15-9-5-7(13)3-4-8(9)14/h3-6,17H,1-2H3,(H,15,16)
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12n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 by SPA


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224207
PNG
(2-(2-fluorophenylamino)-5-isopropylthiazol-4(5H)-o...)
Show SMILES CC(C)c1sc(Nc2ccccc2F)nc1O
Show InChI InChI=1S/C12H13FN2OS/c1-7(2)10-11(16)15-12(17-10)14-9-6-4-3-5-8(9)13/h3-7,16H,1-2H3,(H,14,15)
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17n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 by SPA


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224200
PNG
(2-(2,4-difluorophenylamino)-5-isopropylthiazol-4(5...)
Show SMILES CC(C)c1sc(Nc2ccc(F)cc2F)nc1O
Show InChI InChI=1S/C12H12F2N2OS/c1-6(2)10-11(17)16-12(18-10)15-9-4-3-7(13)5-8(9)14/h3-6,17H,1-2H3,(H,15,16)
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26n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 by SPA


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224207
PNG
(2-(2-fluorophenylamino)-5-isopropylthiazol-4(5H)-o...)
Show SMILES CC(C)c1sc(Nc2ccccc2F)nc1O
Show InChI InChI=1S/C12H13FN2OS/c1-7(2)10-11(16)15-12(17-10)14-9-6-4-3-5-8(9)13/h3-7,16H,1-2H3,(H,14,15)
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140n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 by SPA


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224201
PNG
(2-(4-fluorophenylamino)-5-isopropylthiazol-4(5H)-o...)
Show SMILES CC(C)c1sc(Nc2ccc(F)cc2)nc1O
Show InChI InChI=1S/C12H13FN2OS/c1-7(2)10-11(16)15-12(17-10)14-9-5-3-8(13)4-6-9/h3-7,16H,1-2H3,(H,14,15)
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340n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 by SPA


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224201
PNG
(2-(4-fluorophenylamino)-5-isopropylthiazol-4(5H)-o...)
Show SMILES CC(C)c1sc(Nc2ccc(F)cc2)nc1O
Show InChI InChI=1S/C12H13FN2OS/c1-7(2)10-11(16)15-12(17-10)14-9-5-3-8(13)4-6-9/h3-7,16H,1-2H3,(H,14,15)
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n/an/a 230n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 in CHO cells assessed as conversion of cortisone to cortisol


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224202
PNG
(5-cyclohexyl-2-(2-fluorophenylamino)thiazol-4(5H)-...)
Show SMILES Oc1nc(Nc2ccccc2F)sc1C1CCCCC1
Show InChI InChI=1S/C15H17FN2OS/c16-11-8-4-5-9-12(11)17-15-18-14(19)13(20-15)10-6-2-1-3-7-10/h4-5,8-10,19H,1-3,6-7H2,(H,17,18)
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n/an/a 43n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 in CHO cells assessed as conversion of cortisone to cortisol


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224217
PNG
(2-(2,5-difluorophenylamino)-5-isopropylthiazol-4(5...)
Show SMILES CC(C)c1sc(Nc2cc(F)ccc2F)nc1O
Show InChI InChI=1S/C12H12F2N2OS/c1-6(2)10-11(17)16-12(18-10)15-9-5-7(13)3-4-8(9)14/h3-6,17H,1-2H3,(H,15,16)
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n/an/a 28n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 in CHO cells assessed as conversion of cortisone to cortisol


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224207
PNG
(2-(2-fluorophenylamino)-5-isopropylthiazol-4(5H)-o...)
Show SMILES CC(C)c1sc(Nc2ccccc2F)nc1O
Show InChI InChI=1S/C12H13FN2OS/c1-7(2)10-11(16)15-12(17-10)14-9-6-4-3-5-8(9)13/h3-7,16H,1-2H3,(H,14,15)
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n/an/a 50n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 in CHO cells assessed as conversion of cortisone to cortisol


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224207
PNG
(2-(2-fluorophenylamino)-5-isopropylthiazol-4(5H)-o...)
Show SMILES CC(C)c1sc(Nc2ccccc2F)nc1O
Show InChI InChI=1S/C12H13FN2OS/c1-7(2)10-11(16)15-12(17-10)14-9-6-4-3-5-8(9)13/h3-7,16H,1-2H3,(H,14,15)
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n/an/a>10n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 in presence of 3% HSA by cell based assay


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 2


(Homo sapiens (Human))
BDBM50224202
PNG
(5-cyclohexyl-2-(2-fluorophenylamino)thiazol-4(5H)-...)
Show SMILES Oc1nc(Nc2ccccc2F)sc1C1CCCCC1
Show InChI InChI=1S/C15H17FN2OS/c16-11-8-4-5-9-12(11)17-15-18-14(19)13(20-15)10-6-2-1-3-7-10/h4-5,8-10,19H,1-3,6-7H2,(H,17,18)
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n/an/a 530n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD2 by SPA


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224200
PNG
(2-(2,4-difluorophenylamino)-5-isopropylthiazol-4(5...)
Show SMILES CC(C)c1sc(Nc2ccc(F)cc2F)nc1O
Show InChI InChI=1S/C12H12F2N2OS/c1-6(2)10-11(17)16-12(18-10)15-9-4-3-7(13)5-8(9)14/h3-6,17H,1-2H3,(H,15,16)
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n/an/a 45n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 in CHO cells assessed as conversion of cortisone to cortisol


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224207
PNG
(2-(2-fluorophenylamino)-5-isopropylthiazol-4(5H)-o...)
Show SMILES CC(C)c1sc(Nc2ccccc2F)nc1O
Show InChI InChI=1S/C12H13FN2OS/c1-7(2)10-11(16)15-12(17-10)14-9-6-4-3-5-8(9)13/h3-7,16H,1-2H3,(H,14,15)
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n/an/a 97n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 in CHO cells assessed as conversion of cortisone to cortisol


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224207
PNG
(2-(2-fluorophenylamino)-5-isopropylthiazol-4(5H)-o...)
Show SMILES CC(C)c1sc(Nc2ccccc2F)nc1O
Show InChI InChI=1S/C12H13FN2OS/c1-7(2)10-11(16)15-12(17-10)14-9-6-4-3-5-8(9)13/h3-7,16H,1-2H3,(H,14,15)
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n/an/a 15n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 in CHO cells assessed as conversion of cortisone to cortisol


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair