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10 similar compounds to monomer 50292792

Compile data set for download or QSAR
Wt: 746.1
BDBM50226792
Purchase
Wt: 705.3
BDBM50226793
Wt: 691.2
BDBM50247699
Wt: 789.4
BDBM50292789
Wt: 775.3
BDBM50292790
Wt: 817.4
BDBM50292791
Wt: 707.2
BDBM50292793
Wt: 762.3
BDBM50292794
Wt: 705.2
BDBM50292795
Wt: 700.2
BDBM50292797

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50226792,50226793,50247699,50292789,50292790,50292791,50292793,50292794,50292795,50292797   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cPLA2 C2


(Homo sapiens (Human))
BDBM50226793
PNG
(4-(3-(1-benzhydryl-5-chloro-2-(2-((2,6-dimethylphe...)
Show SMILES Cc1cccc(C)c1CS(=O)(=O)NCCc1c(CCCc2ccc(cc2)C(O)=O)c2cc(Cl)ccc2n1C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C42H41ClN2O4S/c1-29-11-9-12-30(2)38(29)28-50(48,49)44-26-25-40-36(18-10-13-31-19-21-34(22-20-31)42(46)47)37-27-35(43)23-24-39(37)45(40)41(32-14-5-3-6-15-32)33-16-7-4-8-17-33/h3-9,11-12,14-17,19-24,27,41,44H,10,13,18,25-26,28H2,1-2H3,(H,46,47)
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n/an/a 10n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human cytosolic PLA2alpha by GLU micelle assay


J Med Chem 52: 1156-71 (2009)


Article DOI: 10.1021/jm8009876
BindingDB Entry DOI: 10.7270/Q20C4VSK
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (Human))
BDBM50292790
PNG
(4-(3-{5-Chloro-1-(diphenylmethyl)-2-[2-({[2-(piper...)
Show SMILES OC(=O)c1ccc(CCCc2c(CCNS(=O)(=O)Cc3ccccc3CN3CCNCC3)n(C(c3ccccc3)c3ccccc3)c3ccc(Cl)cc23)cc1
Show InChI InChI=1S/C45H47ClN4O4S/c46-39-22-23-42-41(30-39)40(17-9-10-33-18-20-36(21-19-33)45(51)52)43(50(42)44(34-11-3-1-4-12-34)35-13-5-2-6-14-35)24-25-48-55(53,54)32-38-16-8-7-15-37(38)31-49-28-26-47-27-29-49/h1-8,11-16,18-23,30,44,47-48H,9-10,17,24-29,31-32H2,(H,51,52)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human cytosolic PLA2alpha by GLU micelle assay


J Med Chem 52: 1156-71 (2009)


Article DOI: 10.1021/jm8009876
BindingDB Entry DOI: 10.7270/Q20C4VSK
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (Human))
BDBM50292789
PNG
(4-[3-(5-Chloro-1-(diphenylmethyl)-2-{2-[({2-[(4-me...)
Show SMILES CN1CCN(Cc2ccccc2CS(=O)(=O)NCCc2c(CCCc3ccc(cc3)C(O)=O)c3cc(Cl)ccc3n2C(c2ccccc2)c2ccccc2)CC1
Show InChI InChI=1S/C46H49ClN4O4S/c1-49-27-29-50(30-28-49)32-38-16-8-9-17-39(38)33-56(54,55)48-26-25-44-41(18-10-11-34-19-21-37(22-20-34)46(52)53)42-31-40(47)23-24-43(42)51(44)45(35-12-4-2-5-13-35)36-14-6-3-7-15-36/h2-9,12-17,19-24,31,45,48H,10-11,18,25-30,32-33H2,1H3,(H,52,53)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human cytosolic PLA2alpha by GLU micelle assay


J Med Chem 52: 1156-71 (2009)


Article DOI: 10.1021/jm8009876
BindingDB Entry DOI: 10.7270/Q20C4VSK
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (Human))
BDBM50226792
PNG
(4-(3-(1-benzhydryl-5-chloro-2-(2-((3,4-dichlorophe...)
Show SMILES OC(=O)c1ccc(CCCc2c(CCNS(=O)(=O)Cc3ccc(Cl)c(Cl)c3)n(C(c3ccccc3)c3ccccc3)c3ccc(Cl)cc23)cc1
Show InChI InChI=1S/C40H35Cl3N2O4S/c41-32-19-21-37-34(25-32)33(13-7-8-27-14-17-31(18-15-27)40(46)47)38(22-23-44-50(48,49)26-28-16-20-35(42)36(43)24-28)45(37)39(29-9-3-1-4-10-29)30-11-5-2-6-12-30/h1-6,9-12,14-21,24-25,39,44H,7-8,13,22-23,26H2,(H,46,47)
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n/an/a 40n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human cytosolic PLA2alpha by GLU micelle assay


J Med Chem 52: 1156-71 (2009)


Article DOI: 10.1021/jm8009876
BindingDB Entry DOI: 10.7270/Q20C4VSK
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (Human))
BDBM50292797
PNG
(4-(3-{1-Benzhydryl-5-chloro-2-[2-({[2-(4-morpholin...)
Show SMILES OC(=O)c1ccc(CCCc2c(CCNS(=O)(=O)CCN3CCOCC3)n(C(c3ccccc3)c3ccccc3)c3ccc(Cl)cc23)cc1
Show InChI InChI=1S/C39H42ClN3O5S/c40-33-18-19-36-35(28-33)34(13-7-8-29-14-16-32(17-15-29)39(44)45)37(20-21-41-49(46,47)27-24-42-22-25-48-26-23-42)43(36)38(30-9-3-1-4-10-30)31-11-5-2-6-12-31/h1-6,9-12,14-19,28,38,41H,7-8,13,20-27H2,(H,44,45)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human cytosolic PLA2alpha by GLU micelle assay


J Med Chem 52: 1156-71 (2009)


Article DOI: 10.1021/jm8009876
BindingDB Entry DOI: 10.7270/Q20C4VSK
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (Human))
BDBM50226792
PNG
(4-(3-(1-benzhydryl-5-chloro-2-(2-((3,4-dichlorophe...)
Show SMILES OC(=O)c1ccc(CCCc2c(CCNS(=O)(=O)Cc3ccc(Cl)c(Cl)c3)n(C(c3ccccc3)c3ccccc3)c3ccc(Cl)cc23)cc1
Show InChI InChI=1S/C40H35Cl3N2O4S/c41-32-19-21-37-34(25-32)33(13-7-8-27-14-17-31(18-15-27)40(46)47)38(22-23-44-50(48,49)26-28-16-20-35(42)36(43)24-28)45(37)39(29-9-3-1-4-10-29)30-11-5-2-6-12-30/h1-6,9-12,14-21,24-25,39,44H,7-8,13,22-23,26H2,(H,46,47)
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n/an/a 0.540n/an/an/an/an/an/a



Asubio Pharma Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cPLA2alpha isolated from human U937 cell cytoplasm assessed as suppression of [14C]arachidonic acid release from L-alpha-1-palmitoyl-2-...


J Med Chem 57: 7244-62 (2014)


Article DOI: 10.1021/jm500494y
BindingDB Entry DOI: 10.7270/Q2F47QSP
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (Human))
BDBM50292795
PNG
(4-{3-[5-Chloro-1-(diphenylmethyl)-2-(2-{[(2-formyl...)
Show SMILES OC(=O)c1ccc(CCCc2c(CCNS(=O)(=O)Cc3ccccc3C=O)n(C(c3ccccc3)c3ccccc3)c3ccc(Cl)cc23)cc1
Show InChI InChI=1S/C41H37ClN2O5S/c42-35-22-23-38-37(26-35)36(17-9-10-29-18-20-32(21-19-29)41(46)47)39(24-25-43-50(48,49)28-34-16-8-7-15-33(34)27-45)44(38)40(30-11-3-1-4-12-30)31-13-5-2-6-14-31/h1-8,11-16,18-23,26-27,40,43H,9-10,17,24-25,28H2,(H,46,47)
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n/an/a 200n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human cytosolic PLA2alpha by GLU micelle assay


J Med Chem 52: 1156-71 (2009)


Article DOI: 10.1021/jm8009876
BindingDB Entry DOI: 10.7270/Q20C4VSK
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (Human))
BDBM50292794
PNG
(4-{3-[5-Chloro-2-{2-[({2-[(diethylamino)methyl]ben...)
Show SMILES CCN(CC)Cc1ccccc1CS(=O)(=O)NCCc1c(CCCc2ccc(cc2)C(O)=O)c2cc(Cl)ccc2n1C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C45H48ClN3O4S/c1-3-48(4-2)31-37-19-11-12-20-38(37)32-54(52,53)47-29-28-43-40(21-13-14-33-22-24-36(25-23-33)45(50)51)41-30-39(46)26-27-42(41)49(43)44(34-15-7-5-8-16-34)35-17-9-6-10-18-35/h5-12,15-20,22-27,30,44,47H,3-4,13-14,21,28-29,31-32H2,1-2H3,(H,50,51)
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n/an/a 30n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human cytosolic PLA2alpha by GLU micelle assay


J Med Chem 52: 1156-71 (2009)


Article DOI: 10.1021/jm8009876
BindingDB Entry DOI: 10.7270/Q20C4VSK
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (Human))
BDBM50292793
PNG
(4-(3-{5-Chloro-1-(diphenylmethyl)-2-[2-({[2-(hydro...)
Show SMILES OCc1ccccc1CS(=O)(=O)NCCc1c(CCCc2ccc(cc2)C(O)=O)c2cc(Cl)ccc2n1C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C41H39ClN2O5S/c42-35-22-23-38-37(26-35)36(17-9-10-29-18-20-32(21-19-29)41(46)47)39(24-25-43-50(48,49)28-34-16-8-7-15-33(34)27-45)44(38)40(30-11-3-1-4-12-30)31-13-5-2-6-14-31/h1-8,11-16,18-23,26,40,43,45H,9-10,17,24-25,27-28H2,(H,46,47)
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n/an/a 22n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human cytosolic PLA2alpha by GLU micelle assay


J Med Chem 52: 1156-71 (2009)


Article DOI: 10.1021/jm8009876
BindingDB Entry DOI: 10.7270/Q20C4VSK
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (Human))
BDBM50292791
PNG
(4-{3-[2-{2-[({2-[(4-Acetylpiperazin-1-yl)methyl]be...)
Show SMILES CC(=O)N1CCN(Cc2ccccc2CS(=O)(=O)NCCc2c(CCCc3ccc(cc3)C(O)=O)c3cc(Cl)ccc3n2C(c2ccccc2)c2ccccc2)CC1
Show InChI InChI=1S/C47H49ClN4O5S/c1-34(53)51-29-27-50(28-30-51)32-39-16-8-9-17-40(39)33-58(56,57)49-26-25-45-42(18-10-11-35-19-21-38(22-20-35)47(54)55)43-31-41(48)23-24-44(43)52(45)46(36-12-4-2-5-13-36)37-14-6-3-7-15-37/h2-9,12-17,19-24,31,46,49H,10-11,18,25-30,32-33H2,1H3,(H,54,55)
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n/an/a 6n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human cytosolic PLA2alpha by GLU micelle assay


J Med Chem 52: 1156-71 (2009)


Article DOI: 10.1021/jm8009876
BindingDB Entry DOI: 10.7270/Q20C4VSK
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (Human))
BDBM50247699
PNG
(4-(3-(1-benzhydryl-5-chloro-2-(2-(o-tolylmethylsul...)
Show SMILES Cc1ccccc1CS(=O)(=O)NCCc1c(CCCc2ccc(cc2)C(O)=O)c2cc(Cl)ccc2n1C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C41H39ClN2O4S/c1-29-11-8-9-17-34(29)28-49(47,48)43-26-25-39-36(18-10-12-30-19-21-33(22-20-30)41(45)46)37-27-35(42)23-24-38(37)44(39)40(31-13-4-2-5-14-31)32-15-6-3-7-16-32/h2-9,11,13-17,19-24,27,40,43H,10,12,18,25-26,28H2,1H3,(H,45,46)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human cytosolic PLA2alpha by GLU micelle assay


J Med Chem 52: 1156-71 (2009)


Article DOI: 10.1021/jm8009876
BindingDB Entry DOI: 10.7270/Q20C4VSK
More data for this
Ligand-Target Pair