BindingDB logo
myBDB logout

17 molecules are shown

Compile data set for download or QSAR
Wt: 369.2
BDBM50243798
Wt: 496.0
BDBM50245741
<<  First   |  Previous   |  Displayed 16 to 17 (of 17 total )

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50243798,50245741   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Chitotriosidase-1


(Mus musculus)
BDBM50243798
PNG
(CHEMBL4084148)
Show SMILES CN(CCc1ccc(Cl)cc1Cl)C1CCN(CC1)c1nc(N)n[nH]1
Show InChI InChI=1S/C16H22Cl2N6/c1-23(7-4-11-2-3-12(17)10-14(11)18)13-5-8-24(9-6-13)16-20-15(19)21-22-16/h2-3,10,13H,4-9H2,1H3,(H3,19,20,21,22)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.76E+4n/an/an/an/an/an/a



OncoArendi Therapeutics SA

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant full length C-terminal His-tagged chitotriosidase expressed in CHO-K1 cells using 4-methylumbelliferyl-beta-D-N,N',N\...


J Med Chem 61: 695-710 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01051
More data for this
Ligand-Target Pair
Acidic mammalian chitinase


(Mus musculus)
BDBM50243798
PNG
(CHEMBL4084148)
Show SMILES CN(CCc1ccc(Cl)cc1Cl)C1CCN(CC1)c1nc(N)n[nH]1
Show InChI InChI=1S/C16H22Cl2N6/c1-23(7-4-11-2-3-12(17)10-14(11)18)13-5-8-24(9-6-13)16-20-15(19)21-22-16/h2-3,10,13H,4-9H2,1H3,(H3,19,20,21,22)
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 333n/an/an/an/an/an/a



OncoArendi Therapeutics SA

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant full length C-terminal His-tagged acidic mammalian chitinase expressed in CHO-K1 cells using 4-methylumbelliferyl-bet...


J Med Chem 61: 695-710 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01051
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50245741
PNG
(CHEMBL4105442)
Show SMILES Cc1ccc(\C=C\c2ccc(Nc3ncc(Cl)c(Nc4cccc(NC(=O)C=C)c4)n3)cc2)c(C)c1
Show InChI InChI=1S/C29H26ClN5O/c1-4-27(36)32-24-6-5-7-25(17-24)33-28-26(30)18-31-29(35-28)34-23-14-10-21(11-15-23)9-13-22-12-8-19(2)16-20(22)3/h4-18H,1H2,2-3H3,(H,32,36)(H2,31,33,34,35)/b13-9+
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 996n/an/an/an/an/an/a



Dalian Medical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant wild type human EGFR (695 to end residues) using Poly (4:1 Glu, Tyr) as substrate after 1 hr by ADP-Glo assay


Bioorg Med Chem 25: 2724-2729 (2017)


Article DOI: 10.1016/j.bmc.2017.03.032
More data for this
Ligand-Target Pair
Chitinase 1


(Homo sapiens (Human))
BDBM50243798
PNG
(CHEMBL4084148)
Show SMILES CN(CCc1ccc(Cl)cc1Cl)C1CCN(CC1)c1nc(N)n[nH]1
Show InChI InChI=1S/C16H22Cl2N6/c1-23(7-4-11-2-3-12(17)10-14(11)18)13-5-8-24(9-6-13)16-20-15(19)21-22-16/h2-3,10,13H,4-9H2,1H3,(H3,19,20,21,22)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.26E+3n/an/an/an/an/an/a



OncoArendi Therapeutics SA

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full length C-terminal His-tagged chitotriosidase expressed in CHO-K1 cells using 4-methylumbelliferyl-beta-D-N,N',N\...


J Med Chem 61: 695-710 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01051
More data for this
Ligand-Target Pair
Acidic mammalian chitinase (AMCase)


(Homo sapiens (Human))
BDBM50243798
PNG
(CHEMBL4084148)
Show SMILES CN(CCc1ccc(Cl)cc1Cl)C1CCN(CC1)c1nc(N)n[nH]1
Show InChI InChI=1S/C16H22Cl2N6/c1-23(7-4-11-2-3-12(17)10-14(11)18)13-5-8-24(9-6-13)16-20-15(19)21-22-16/h2-3,10,13H,4-9H2,1H3,(H3,19,20,21,22)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.03E+3n/an/an/an/an/an/a



OncoArendi Therapeutics SA

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full length C-terminal His-tagged acidic mammalian chitinase expressed in CHO-K1 cells using 4-methylumbelliferyl-bet...


J Med Chem 61: 695-710 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01051
More data for this
Ligand-Target Pair