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48 similar compounds to monomer 50230622

Compile data set for download or QSAR
Wt: 626.7
BDBM50230683
Wt: 531.6
BDBM50230688
Wt: 576.6
BDBM50230689
Wt: 285.3
BDBM50230663
Wt: 374.2
BDBM50230664
Wt: 543.6
BDBM50230674
Wt: 499.6
BDBM50230675
Wt: 588.6
BDBM50230676
Wt: 515.6
BDBM50230668
Wt: 298.3
BDBM50230634
Wt: 290.3
BDBM50230623
Wt: 286.3
BDBM50230624
Wt: 300.3
BDBM50230625
Wt: 286.3
BDBM50230626
Wt: 434.5
BDBM50230695
Displayed 1 to 15 (of 48 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50230683,50230688,50230689,50230663,50230664,50230674,50230675,50230676,50230668,50230634,50230623,50230624,50230625,50230626,50230695   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cholecystokinin receptor


(MOUSE)
BDBM50230683
PNG
(CHEMBL3351024)
Show SMILES C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CNC(=O)\C=C\C(O)=O)Cc1ccccc1
Show InChI InChI=1S/C36H42N4O6/c1-36(19-27-20-37-30-10-6-5-9-29(27)30,40-35(45)46-33-25-14-23-13-24(16-25)17-26(33)15-23)34(44)39-28(18-22-7-3-2-4-8-22)21-38-31(41)11-12-32(42)43/h2-12,20,23-26,28,33,37H,13-19,21H2,1H3,(H,38,41)(H,39,44)(H,40,45)(H,42,43)/b12-11+/t23?,24?,25?,26?,28-,33?,36+/m0/s1
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0.708n/an/an/an/an/an/an/an/a



Parke-Davis Neuroscience Research Centre

Curated by ChEMBL


Assay Description
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse


J Med Chem 35: 1572-7 (1992)


Article DOI: 10.1021/jm00087a011
BindingDB Entry DOI: 10.7270/Q26H4KM8
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(MOUSE)
BDBM50230676
PNG
(CHEMBL3351013)
Show SMILES C[C@@H]1CCCC[C@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CNC(=O)\C=C\C(O)=O)Cc1ccccc1
Show InChI InChI=1S/C33H40N4O6/c1-22-10-6-9-15-28(22)43-32(42)37-33(2,19-24-20-34-27-14-8-7-13-26(24)27)31(41)36-25(18-23-11-4-3-5-12-23)21-35-29(38)16-17-30(39)40/h3-5,7-8,11-14,16-17,20,22,25,28,34H,6,9-10,15,18-19,21H2,1-2H3,(H,35,38)(H,36,41)(H,37,42)(H,39,40)/b17-16+/t22-,25+,28-,33-/m1/s1
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1.10n/an/an/an/an/an/an/an/a



Parke-Davis Neuroscience Research Centre

Curated by ChEMBL


Assay Description
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse


J Med Chem 35: 1572-7 (1992)


Article DOI: 10.1021/jm00087a011
BindingDB Entry DOI: 10.7270/Q26H4KM8
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50230695
PNG
(CHEMBL43258)
Show SMILES CN(C)CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc23)CC1
Show InChI InChI=1S/C26H34N4O2/c1-28(2)16-8-7-9-20-14-17-29(18-15-20)19-25(31)30-23-12-5-3-10-21(23)26(32)27-22-11-4-6-13-24(22)30/h3-6,10-13,20H,7-9,14-19H2,1-2H3,(H,27,32)
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3.70n/an/an/an/an/an/an/an/a



George Washington University Medical Center

Curated by ChEMBL


Assay Description
Binding affinity by the displacement of [3H]NMS binding to muscarinic M2 receptor of rat heart


J Med Chem 36: 162-5 (1993)


Article DOI: 10.1021/jm00053a021
BindingDB Entry DOI: 10.7270/Q22R3TWJ
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(MOUSE)
BDBM50230689
PNG
(CHEMBL3351018)
Show SMILES C[C@@H]1CCCC[C@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)NC[C@H](NC(=O)CCC(O)=O)c1ccccc1
Show InChI InChI=1S/C32H40N4O6/c1-21-10-6-9-15-27(21)42-31(41)36-32(2,18-23-19-33-25-14-8-7-13-24(23)25)30(40)34-20-26(22-11-4-3-5-12-22)35-28(37)16-17-29(38)39/h3-5,7-8,11-14,19,21,26-27,33H,6,9-10,15-18,20H2,1-2H3,(H,34,40)(H,35,37)(H,36,41)(H,38,39)/t21-,26+,27-,32-/m1/s1
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3.70n/an/an/an/an/an/an/an/a



Parke-Davis Neuroscience Research Centre

Curated by ChEMBL


Assay Description
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse


J Med Chem 35: 1572-7 (1992)


Article DOI: 10.1021/jm00087a011
BindingDB Entry DOI: 10.7270/Q26H4KM8
More data for this
Ligand-Target Pair
Muscarinic receptor M1 and M2


(RAT)
BDBM50230695
PNG
(CHEMBL43258)
Show SMILES CN(C)CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc23)CC1
Show InChI InChI=1S/C26H34N4O2/c1-28(2)16-8-7-9-20-14-17-29(18-15-20)19-25(31)30-23-12-5-3-10-21(23)26(32)27-22-11-4-6-13-24(22)30/h3-6,10-13,20H,7-9,14-19H2,1-2H3,(H,27,32)
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11n/an/an/an/an/an/an/an/a



George Washington University Medical Center

Curated by ChEMBL


Assay Description
Binding affinity by the displacement of [3H]NMS binding to A9 L cells transfected with muscarinic M1 receptor of rat brain


J Med Chem 36: 162-5 (1993)


Article DOI: 10.1021/jm00053a021
BindingDB Entry DOI: 10.7270/Q22R3TWJ
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(MOUSE)
BDBM50230688
PNG
(CHEMBL3351019)
Show SMILES C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CC2CCC1(C)C2(C)C)C(=O)N[C@H](CO)Cc1ccccc1
Show InChI InChI=1S/C32H41N3O4/c1-30(2)23-14-15-31(30,3)27(17-23)39-29(38)35-32(4,18-22-19-33-26-13-9-8-12-25(22)26)28(37)34-24(20-36)16-21-10-6-5-7-11-21/h5-13,19,23-24,27,33,36H,14-18,20H2,1-4H3,(H,34,37)(H,35,38)/t23?,24-,27?,31?,32+/m0/s1
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15n/an/an/an/an/an/an/an/a



Parke-Davis Neuroscience Research Centre

Curated by ChEMBL


Assay Description
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse


J Med Chem 35: 1572-7 (1992)


Article DOI: 10.1021/jm00087a011
BindingDB Entry DOI: 10.7270/Q26H4KM8
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(MOUSE)
BDBM50230674
PNG
(CHEMBL3351014)
Show SMILES OC(=O)C[C@@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3
Show InChI InChI=1S/C32H37N3O5/c36-29(37)17-25(15-19-6-2-1-3-7-19)34-31(38)28(16-24-18-33-27-9-5-4-8-26(24)27)35-32(39)40-30-22-11-20-10-21(13-22)14-23(30)12-20/h1-9,18,20-23,25,28,30,33H,10-17H2,(H,34,38)(H,35,39)(H,36,37)/t20?,21?,22?,23?,25-,28-,30?/m1/s1
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138n/an/an/an/an/an/an/an/a



Parke-Davis Neuroscience Research Centre

Curated by ChEMBL


Assay Description
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse


J Med Chem 35: 1572-7 (1992)


Article DOI: 10.1021/jm00087a011
BindingDB Entry DOI: 10.7270/Q26H4KM8
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(MOUSE)
BDBM50230675
PNG
(CHEMBL40352)
Show SMILES CC(Cc1c[nH]c2ccccc12)(NC(=O)OC12CC3CC(CC(C3)C1)C2)C(=O)NCCc1ccccc1
Show InChI InChI=1/C31H37N3O3/c1-30(19-25-20-33-27-10-6-5-9-26(25)27,28(35)32-12-11-21-7-3-2-4-8-21)34-29(36)37-31-16-22-13-23(17-31)15-24(14-22)18-31/h2-10,20,22-24,33H,11-19H2,1H3,(H,32,35)(H,34,36)
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191n/an/an/an/an/an/an/an/a



Parke-Davis Neuroscience Research Centre

Curated by ChEMBL


Assay Description
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse


J Med Chem 35: 1572-7 (1992)


Article DOI: 10.1021/jm00087a011
BindingDB Entry DOI: 10.7270/Q26H4KM8
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(MOUSE)
BDBM50230668
PNG
(CHEMBL3350393)
Show SMILES OC[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3
Show InChI InChI=1S/C31H37N3O4/c35-18-25(15-19-6-2-1-3-7-19)33-30(36)28(16-24-17-32-27-9-5-4-8-26(24)27)34-31(37)38-29-22-11-20-10-21(13-22)14-23(29)12-20/h1-9,17,20-23,25,28-29,32,35H,10-16,18H2,(H,33,36)(H,34,37)/t20?,21?,22?,23?,25-,28+,29?/m0/s1
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813n/an/an/an/an/an/an/an/a



Parke-Davis Neuroscience Research Centre

Curated by ChEMBL


Assay Description
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse


J Med Chem 35: 1572-7 (1992)


Article DOI: 10.1021/jm00087a011
BindingDB Entry DOI: 10.7270/Q26H4KM8
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(MOUSE)
BDBM50230668
PNG
(CHEMBL3350393)
Show SMILES OC[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3
Show InChI InChI=1S/C31H37N3O4/c35-18-25(15-19-6-2-1-3-7-19)33-30(36)28(16-24-17-32-27-9-5-4-8-26(24)27)34-31(37)38-29-22-11-20-10-21(13-22)14-23(29)12-20/h1-9,17,20-23,25,28-29,32,35H,10-16,18H2,(H,33,36)(H,34,37)/t20?,21?,22?,23?,25-,28+,29?/m0/s1
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2.09E+3n/an/an/an/an/an/an/an/a



Parke-Davis Neuroscience Research Centre

Curated by ChEMBL


Assay Description
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse


J Med Chem 35: 1572-7 (1992)


Article DOI: 10.1021/jm00087a011
BindingDB Entry DOI: 10.7270/Q26H4KM8
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50230623
PNG
(CHEMBL10255)
Show SMILES COc1ccc(cc1O)-c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C16H18O5/c1-18-13-6-5-10(7-12(13)17)11-8-14(19-2)16(21-4)15(9-11)20-3/h5-9,17H,1-4H3
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n/an/a>4.00E+4n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit the extent of glutamate-dependent tubulin polymerization by 50% at 37 degrees C(1.0 mM MgCl2)


J Med Chem 35: 1058-67 (1992)


Article DOI: 10.1021/jm00084a011
BindingDB Entry DOI: 10.7270/Q2KS6TSB
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50230634
PNG
(CHEMBL10653)
Show SMILES CCOc1cc2OCOc2cc1\C=C/c1ccc(OC)cc1
Show InChI InChI=1S/C18H18O4/c1-3-20-16-11-18-17(21-12-22-18)10-14(16)7-4-13-5-8-15(19-2)9-6-13/h4-11H,3,12H2,1-2H3/b7-4-
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n/an/a>4.00E+4n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Inhibition of glutamate-dependent tubulin polymerization at 30 degrees C(0.25 mM MgCl2)


J Med Chem 35: 1058-67 (1992)


Article DOI: 10.1021/jm00084a011
BindingDB Entry DOI: 10.7270/Q2KS6TSB
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50230623
PNG
(CHEMBL10255)
Show SMILES COc1ccc(cc1O)-c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C16H18O5/c1-18-13-6-5-10(7-12(13)17)11-8-14(19-2)16(21-4)15(9-11)20-3/h5-9,17H,1-4H3
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n/an/a>4.00E+4n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Inhibition of glutamate-dependent tubulin polymerization at 30 degrees C(0.25 mM MgCl2)


J Med Chem 35: 1058-67 (1992)


Article DOI: 10.1021/jm00084a011
BindingDB Entry DOI: 10.7270/Q2KS6TSB
More data for this
Ligand-Target Pair
Melatonin receptor


(Homo sapiens (Human))
BDBM50230663
PNG
(CHEMBL34349)
Show SMILES CCCCC(=O)NCCc1cccc2ccc(OC)cc12
Show InChI InChI=1S/C18H23NO2/c1-3-4-8-18(20)19-12-11-15-7-5-6-14-9-10-16(21-2)13-17(14)15/h5-7,9-10,13H,3-4,8,11-12H2,1-2H3,(H,19,20)
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n/an/an/a 3.40n/an/an/an/an/a



Universite de Lille

Curated by ChEMBL


Assay Description
Binding affinity against Melatonin receptor using ovine pars tuberalis membranes of the pituitary.


J Med Chem 35: 1484-6 (1992)


Article DOI: 10.1021/jm00086a018
BindingDB Entry DOI: 10.7270/Q2B85BB0
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50230626
PNG
(CHEMBL10703)
Show SMILES COc1ccc(cc1)C(C)c1cc2OCOc2cc1OC
Show InChI InChI=1/C17H18O4/c1-11(12-4-6-13(18-2)7-5-12)14-8-16-17(21-10-20-16)9-15(14)19-3/h4-9,11H,10H2,1-3H3
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n/an/a 2.50E+3n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Inhibition of glutamate-dependent tubulin polymerization at 30 degrees C(0.25 mM MgCl2)


J Med Chem 35: 1058-67 (1992)


Article DOI: 10.1021/jm00084a011
BindingDB Entry DOI: 10.7270/Q2KS6TSB
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50230625
PNG
(CHEMBL10686)
Show SMILES COc1ccc(CCCc2cc3OCOc3cc2OC)cc1
Show InChI InChI=1S/C18H20O4/c1-19-15-8-6-13(7-9-15)4-3-5-14-10-17-18(22-12-21-17)11-16(14)20-2/h6-11H,3-5,12H2,1-2H3
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n/an/a 3.80E+3n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Inhibition of glutamate-dependent tubulin polymerization at 30 degrees C(0.25 mM MgCl2)


J Med Chem 35: 1058-67 (1992)


Article DOI: 10.1021/jm00084a011
BindingDB Entry DOI: 10.7270/Q2KS6TSB
More data for this
Ligand-Target Pair
Similar to alpha-tubulin isoform 1


(Bos taurus)
BDBM50230624
PNG
(CHEMBL269215)
Show SMILES COc1ccc(CCc2cc3OCOc3cc2OC)cc1
Show InChI InChI=1S/C17H18O4/c1-18-14-7-4-12(5-8-14)3-6-13-9-16-17(21-11-20-16)10-15(13)19-2/h4-5,7-10H,3,6,11H2,1-2H3
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n/an/a 8.80E+3n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Inhibition of glutamate-dependent tubulin polymerization at 30 degrees C(0.25 mM MgCl2)


J Med Chem 35: 1058-67 (1992)


Article DOI: 10.1021/jm00084a011
BindingDB Entry DOI: 10.7270/Q2KS6TSB
More data for this
Ligand-Target Pair
Melatonin receptor


(Homo sapiens (Human))
BDBM50230664
PNG
(CHEMBL290568)
Show SMILES COc1ccc2cccc(CCNC(=O)c3cc(Cl)cc(Cl)c3)c2c1
Show InChI InChI=1S/C20H17Cl2NO2/c1-25-18-6-5-13-3-2-4-14(19(13)12-18)7-8-23-20(24)15-9-16(21)11-17(22)10-15/h2-6,9-12H,7-8H2,1H3,(H,23,24)
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n/an/an/a 1.10n/an/an/an/an/a



Universite de Lille

Curated by ChEMBL


Assay Description
Binding affinity against Melatonin receptor using ovine pars tuberalis membranes of the pituitary.


J Med Chem 35: 1484-6 (1992)


Article DOI: 10.1021/jm00086a018
BindingDB Entry DOI: 10.7270/Q2B85BB0
More data for this
Ligand-Target Pair