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9 similar compounds to monomer 50231900

Compile data set for download or QSAR
Wt: 394.4
BDBM50231890
Wt: 3461.7
BDBM50231896
Wt: 3430.7
BDBM50231901
Wt: 3449.8
BDBM50231894
Wt: 3380.6
BDBM50231895
Wt: 3420.7
BDBM50231897
Wt: 3422.7
BDBM50231898
Wt: 3394.7
BDBM50231899
Wt: 3539.8
BDBM50231902

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 29 hits for monomerid = 50231890,50231896,50231901,50231894,50231895,50231897,50231898,50231899,50231902   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM50231894
PNG
(CHEMBL4100325)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O
Show InChI InChI=1S/C157H238N42O46/c1-17-81(10)126(154(243)176-85(14)132(221)186-111(66-91-69-168-96-38-25-24-37-94(91)96)145(234)188-107(62-78(4)5)146(235)196-124(79(6)7)152(241)185-98(39-26-29-57-158)135(224)170-72-118(208)177-97(42-32-60-167-157(163)164)134(223)169-71-116(162)206)198-147(236)109(63-88-33-20-18-21-34-88)190-142(231)105(51-56-122(214)215)182-138(227)99(40-27-30-58-159)178-130(219)83(12)173-129(218)82(11)175-137(226)102(47-52-115(161)205)181-139(228)100-41-28-31-59-166-117(207)53-48-103(141(230)189-108(65-90-43-45-93(204)46-44-90)144(233)187-106(61-77(2)3)143(232)183-104(140(229)180-100)50-55-121(212)213)184-150(239)113(74-200)193-153(242)125(80(8)9)197-149(238)112(68-123(216)217)191-151(240)114(75-201)194-156(245)128(87(16)203)199-148(237)110(64-89-35-22-19-23-36-89)192-155(244)127(86(15)202)195-119(209)73-171-136(225)101(49-54-120(210)211)179-131(220)84(13)174-133(222)95(160)67-92-70-165-76-172-92/h18-25,33-38,43-46,69-70,76-87,95,97-114,124-128,168,200-204H,17,26-32,39-42,47-68,71-75,158-160H2,1-16H3,(H2,161,205)(H2,162,206)(H,165,172)(H,166,207)(H,169,223)(H,170,224)(H,171,225)(H,173,218)(H,174,222)(H,175,226)(H,176,243)(H,177,208)(H,178,219)(H,179,220)(H,180,229)(H,181,228)(H,182,227)(H,183,232)(H,184,239)(H,185,241)(H,186,221)(H,187,233)(H,188,234)(H,189,230)(H,190,231)(H,191,240)(H,192,244)(H,193,242)(H,194,245)(H,195,209)(H,196,235)(H,197,238)(H,198,236)(H,199,237)(H,210,211)(H,212,213)(H,214,215)(H,216,217)(H4,163,164,167)/t81-,82-,83-,84-,85-,86+,87+,95-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,124-,125-,126-,127-,128-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.800n/an/an/an/an/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Displacement of [125I]-GLP (7 to 36 residues) from human GLP1R expressed in CHO cell membranes incubated for 30 mins measured after 10 hrs by scintil...


Eur J Med Chem 127: 703-714 (2017)


Article DOI: 10.1016/j.ejmech.2016.10.044
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM50231902
PNG
(CHEMBL4096416)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N1)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O)C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O
Show InChI InChI=1S/C162H236N42O48/c1-14-83(8)131(159(250)189-103-38-25-28-60-171-123(214)70-116(140(231)176-75-124(215)181-100(39-29-61-172-162(167)168)138(229)174-74-121(166)212)198-158(249)130(82(6)7)202-153(244)110(63-81(4)5)191-151(242)115(195-144(103)235)68-93-72-173-99-35-22-21-34-97(93)99)203-154(245)113(64-89-30-17-15-18-31-89)193-147(238)108(52-57-128(221)222)187-142(233)101(36-23-26-58-163)182-135(226)85(10)178-134(225)84(9)180-141(232)105(48-53-120(165)211)185-145(236)106-49-54-122(213)170-59-27-24-37-102(143(234)192-111(66-91-40-44-95(209)45-41-91)149(240)190-109(62-80(2)3)148(239)188-107(146(237)186-106)51-56-127(219)220)184-156(247)118(77-205)199-150(241)112(67-92-42-46-96(210)47-43-92)194-152(243)117(71-129(223)224)196-157(248)119(78-206)200-161(252)133(88(13)208)204-155(246)114(65-90-32-19-16-20-33-90)197-160(251)132(87(12)207)201-125(216)76-175-139(230)104(50-55-126(217)218)183-136(227)86(11)179-137(228)98(164)69-94-73-169-79-177-94/h15-22,30-35,40-47,72-73,79-88,98,100-119,130-133,173,205-210H,14,23-29,36-39,48-71,74-78,163-164H2,1-13H3,(H2,165,211)(H2,166,212)(H,169,177)(H,170,213)(H,171,214)(H,174,229)(H,175,230)(H,176,231)(H,178,225)(H,179,228)(H,180,232)(H,181,215)(H,182,226)(H,183,227)(H,184,247)(H,185,236)(H,186,237)(H,187,233)(H,188,239)(H,189,250)(H,190,240)(H,191,242)(H,192,234)(H,193,238)(H,194,243)(H,195,235)(H,196,248)(H,197,251)(H,198,249)(H,199,241)(H,200,252)(H,201,216)(H,202,244)(H,203,245)(H,204,246)(H,217,218)(H,219,220)(H,221,222)(H,223,224)(H4,167,168,172)/t83-,84-,85-,86-,87+,88+,98-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,130-,131-,132-,133-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.820n/an/an/an/an/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Displacement of [125I]-GLP (7 to 36 residues) from human GLP1R expressed in CHO cell membranes incubated for 30 mins measured after 10 hrs by scintil...


Eur J Med Chem 127: 703-714 (2017)


Article DOI: 10.1016/j.ejmech.2016.10.044
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM50231896
PNG
(CHEMBL4084829)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N1)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O)C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O
Show InChI InChI=1S/C157H234N42O47/c1-16-80(10)126(154(244)183-98-40-27-30-55-165-116(207)65-109(135(225)171-71-118(209)176-95(41-31-57-167-157(162)163)133(223)169-70-115(161)206)192-152(242)124(78(6)7)196-146(236)104(59-77(4)5)185-144(234)108(188-139(98)229)63-89-68-168-94-37-24-23-36-92(89)94)198-147(237)106(60-86-32-19-17-20-33-86)187-140(230)101(48-52-121(213)214)180-137(227)96(38-25-28-54-158)177-130(220)82(12)173-129(219)81(11)175-136(226)100(46-50-114(160)205)181-145(235)110-66-117(208)166-56-29-26-39-97(138(228)186-105(62-88-42-44-91(204)45-43-88)143(233)184-103(58-76(2)3)142(232)182-102(141(231)189-110)49-53-122(215)216)179-150(240)112(73-200)193-153(243)125(79(8)9)197-149(239)111(67-123(217)218)190-151(241)113(74-201)194-156(246)128(85(15)203)199-148(238)107(61-87-34-21-18-22-35-87)191-155(245)127(84(14)202)195-119(210)72-170-134(224)99(47-51-120(211)212)178-131(221)83(13)174-132(222)93(159)64-90-69-164-75-172-90/h17-24,32-37,42-45,68-69,75-85,93,95-113,124-128,168,200-204H,16,25-31,38-41,46-67,70-74,158-159H2,1-15H3,(H2,160,205)(H2,161,206)(H,164,172)(H,165,207)(H,166,208)(H,169,223)(H,170,224)(H,171,225)(H,173,219)(H,174,222)(H,175,226)(H,176,209)(H,177,220)(H,178,221)(H,179,240)(H,180,227)(H,181,235)(H,182,232)(H,183,244)(H,184,233)(H,185,234)(H,186,228)(H,187,230)(H,188,229)(H,189,231)(H,190,241)(H,191,245)(H,192,242)(H,193,243)(H,194,246)(H,195,210)(H,196,236)(H,197,239)(H,198,237)(H,199,238)(H,211,212)(H,213,214)(H,215,216)(H,217,218)(H4,162,163,167)/t80-,81-,82-,83-,84+,85+,93-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,124-,125-,126-,127-,128-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.940n/an/an/an/an/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Displacement of [125I]-GLP (7 to 36 residues) from human GLP1R expressed in CHO cell membranes incubated for 30 mins measured after 10 hrs by scintil...


Eur J Med Chem 127: 703-714 (2017)


Article DOI: 10.1016/j.ejmech.2016.10.044
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM50231895
PNG
(CHEMBL4073486)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O)C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O
Show InChI InChI=1S/C152H227N41O47/c1-16-77(10)122(149(238)177-94-37-26-28-52-160-112(202)61-105(132(221)166-67-113(203)171-92(38-29-53-161-152(157)158)129(218)163-65-111(156)201)185-147(236)120(75(6)7)190-140(229)100(55-74(4)5)179-139(228)104(182-135(94)224)59-86-63-162-91-35-24-23-34-89(86)91)192-141(230)102(56-83-30-19-17-20-31-83)180-136(225)98(46-50-118(210)211)176-134(223)93(36-25-27-51-153)173-126(215)79(12)168-125(214)78(11)170-133(222)97(43-47-110(155)200)172-114(204)66-164-131(220)96(45-49-117(208)209)175-137(226)99(54-73(2)3)178-138(227)101(58-85-39-41-88(199)42-40-85)181-144(233)107(69-194)186-146(235)109(71-196)187-148(237)121(76(8)9)191-143(232)106(62-119(212)213)183-145(234)108(70-195)188-151(240)124(82(15)198)193-142(231)103(57-84-32-21-18-22-33-84)184-150(239)123(81(14)197)189-115(205)68-165-130(219)95(44-48-116(206)207)174-127(216)80(13)169-128(217)90(154)60-87-64-159-72-167-87/h17-24,30-35,39-42,63-64,72-82,90,92-109,120-124,162,194-199H,16,25-29,36-38,43-62,65-71,153-154H2,1-15H3,(H2,155,200)(H2,156,201)(H,159,167)(H,160,202)(H,163,218)(H,164,220)(H,165,219)(H,166,221)(H,168,214)(H,169,217)(H,170,222)(H,171,203)(H,172,204)(H,173,215)(H,174,216)(H,175,226)(H,176,223)(H,177,238)(H,178,227)(H,179,228)(H,180,225)(H,181,233)(H,182,224)(H,183,234)(H,184,239)(H,185,236)(H,186,235)(H,187,237)(H,188,240)(H,189,205)(H,190,229)(H,191,232)(H,192,230)(H,193,231)(H,206,207)(H,208,209)(H,210,211)(H,212,213)(H4,157,158,161)/t77-,78-,79-,80-,81+,82+,90-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,120-,121-,122-,123-,124-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.10n/an/an/an/an/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Agonist activity at human GLP1R expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by LANCE assay


Eur J Med Chem 127: 703-714 (2017)


Article DOI: 10.1016/j.ejmech.2016.10.044
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM50231898
PNG
(CHEMBL4079909)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(C)C)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O)C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O
Show InChI InChI=1S/C155H233N41O47/c1-18-79(12)124(152(241)178-96-39-28-30-54-163-114(205)63-107(133(222)168-68-115(206)173-94(40-31-55-164-155(160)161)131(220)166-67-113(159)204)187-150(239)122(77(8)9)193-142(231)102(57-75(4)5)181-141(230)106(184-136(96)225)61-88-65-165-93-37-26-25-36-91(88)93)195-143(232)104(58-85-32-21-19-22-33-85)182-137(226)99(47-51-118(210)211)176-135(224)95(38-27-29-53-156)174-128(217)81(14)170-127(216)80(13)172-134(223)98(45-49-112(158)203)179-149(238)121(76(6)7)192-138(227)100(48-52-119(212)213)177-139(228)101(56-74(2)3)180-140(229)103(60-87-41-43-90(202)44-42-87)183-146(235)109(70-197)188-148(237)111(72-199)189-151(240)123(78(10)11)194-145(234)108(64-120(214)215)185-147(236)110(71-198)190-154(243)126(84(17)201)196-144(233)105(59-86-34-23-20-24-35-86)186-153(242)125(83(16)200)191-116(207)69-167-132(221)97(46-50-117(208)209)175-129(218)82(15)171-130(219)92(157)62-89-66-162-73-169-89/h19-26,32-37,41-44,65-66,73-84,92,94-111,121-126,165,197-202H,18,27-31,38-40,45-64,67-72,156-157H2,1-17H3,(H2,158,203)(H2,159,204)(H,162,169)(H,163,205)(H,166,220)(H,167,221)(H,168,222)(H,170,216)(H,171,219)(H,172,223)(H,173,206)(H,174,217)(H,175,218)(H,176,224)(H,177,228)(H,178,241)(H,179,238)(H,180,229)(H,181,230)(H,182,226)(H,183,235)(H,184,225)(H,185,236)(H,186,242)(H,187,239)(H,188,237)(H,189,240)(H,190,243)(H,191,207)(H,192,227)(H,193,231)(H,194,234)(H,195,232)(H,196,233)(H,208,209)(H,210,211)(H,212,213)(H,214,215)(H4,160,161,164)/t79-,80-,81-,82-,83+,84+,92-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,121-,122-,123-,124-,125-,126-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.5n/an/an/an/an/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Displacement of [125I]-GLP (7 to 36 residues) from human GLP1R expressed in CHO cell membranes incubated for 30 mins measured after 10 hrs by scintil...


Eur J Med Chem 127: 703-714 (2017)


Article DOI: 10.1016/j.ejmech.2016.10.044
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM50231899
PNG
(CHEMBL4087789)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O)C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O
Show InChI InChI=1S/C153H229N41O47/c1-17-77(10)122(150(239)178-95-38-27-29-53-161-113(203)62-106(132(221)166-67-114(204)172-93(39-30-54-162-153(158)159)130(219)164-66-112(157)202)186-148(237)120(75(6)7)191-141(230)101(56-74(4)5)180-140(229)105(183-136(95)225)60-87-64-163-92-36-25-24-35-90(87)92)193-142(231)103(57-84-31-20-18-21-32-84)181-137(226)99(47-51-118(210)211)176-135(224)94(37-26-28-52-154)173-126(215)79(12)168-125(214)78(11)170-133(222)97(44-48-111(156)201)175-128(217)81(14)171-134(223)98(46-50-117(208)209)177-138(227)100(55-73(2)3)179-139(228)102(59-86-40-42-89(200)43-41-86)182-145(234)108(69-195)187-147(236)110(71-197)188-149(238)121(76(8)9)192-144(233)107(63-119(212)213)184-146(235)109(70-196)189-152(241)124(83(16)199)194-143(232)104(58-85-33-22-19-23-34-85)185-151(240)123(82(15)198)190-115(205)68-165-131(220)96(45-49-116(206)207)174-127(216)80(13)169-129(218)91(155)61-88-65-160-72-167-88/h18-25,31-36,40-43,64-65,72-83,91,93-110,120-124,163,195-200H,17,26-30,37-39,44-63,66-71,154-155H2,1-16H3,(H2,156,201)(H2,157,202)(H,160,167)(H,161,203)(H,164,219)(H,165,220)(H,166,221)(H,168,214)(H,169,218)(H,170,222)(H,171,223)(H,172,204)(H,173,215)(H,174,216)(H,175,217)(H,176,224)(H,177,227)(H,178,239)(H,179,228)(H,180,229)(H,181,226)(H,182,234)(H,183,225)(H,184,235)(H,185,240)(H,186,237)(H,187,236)(H,188,238)(H,189,241)(H,190,205)(H,191,230)(H,192,233)(H,193,231)(H,194,232)(H,206,207)(H,208,209)(H,210,211)(H,212,213)(H4,158,159,162)/t77-,78-,79-,80-,81-,82+,83+,91-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,120-,121-,122-,123-,124-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.70n/an/an/an/an/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Agonist activity at human GLP1R expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by LANCE assay


Eur J Med Chem 127: 703-714 (2017)


Article DOI: 10.1016/j.ejmech.2016.10.044
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM50231897
PNG
(CHEMBL4102787)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O)C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O
Show InChI InChI=1S/C155H231N41O47/c1-16-79(10)124(151(240)178-96-38-26-28-54-163-115(205)64-107(133(222)168-69-116(206)173-94(39-29-55-164-155(160)161)131(220)166-68-114(159)204)187-149(238)122(77(6)7)192-141(230)102(58-76(4)5)181-140(229)106(184-136(96)225)62-88-66-165-93-36-24-23-35-91(88)93)194-142(231)104(59-85-31-19-17-20-32-85)182-137(226)99(47-51-119(210)211)176-135(224)95(37-25-27-53-156)174-128(217)81(12)170-127(216)80(11)172-134(223)98(45-49-113(158)203)177-148(237)112-40-30-56-196(112)154(243)100(48-52-120(212)213)179-138(227)101(57-75(2)3)180-139(228)103(61-87-41-43-90(202)44-42-87)183-145(234)109(71-197)188-147(236)111(73-199)189-150(239)123(78(8)9)193-144(233)108(65-121(214)215)185-146(235)110(72-198)190-153(242)126(84(15)201)195-143(232)105(60-86-33-21-18-22-34-86)186-152(241)125(83(14)200)191-117(207)70-167-132(221)97(46-50-118(208)209)175-129(218)82(13)171-130(219)92(157)63-89-67-162-74-169-89/h17-24,31-36,41-44,66-67,74-84,92,94-112,122-126,165,197-202H,16,25-30,37-40,45-65,68-73,156-157H2,1-15H3,(H2,158,203)(H2,159,204)(H,162,169)(H,163,205)(H,166,220)(H,167,221)(H,168,222)(H,170,216)(H,171,219)(H,172,223)(H,173,206)(H,174,217)(H,175,218)(H,176,224)(H,177,237)(H,178,240)(H,179,227)(H,180,228)(H,181,229)(H,182,226)(H,183,234)(H,184,225)(H,185,235)(H,186,241)(H,187,238)(H,188,236)(H,189,239)(H,190,242)(H,191,207)(H,192,230)(H,193,233)(H,194,231)(H,195,232)(H,208,209)(H,210,211)(H,212,213)(H,214,215)(H4,160,161,164)/t79-,80-,81-,82-,83+,84+,92-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,122-,123-,124-,125-,126-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
18n/an/an/an/an/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Displacement of [125I]-GLP (7 to 36 residues) from human GLP1R expressed in CHO cell membranes incubated for 30 mins measured after 10 hrs by scintil...


Eur J Med Chem 127: 703-714 (2017)


Article DOI: 10.1016/j.ejmech.2016.10.044
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM50231901
PNG
(CHEMBL4088708)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O
Show InChI InChI=1S/C157H233N41O46/c1-17-81(10)127(154(242)176-85(14)133(221)184-112(65-92-68-167-98-36-25-24-35-96(92)98)145(233)186-107(60-78(4)5)146(234)195-125(79(6)7)152(240)183-100(37-26-28-56-158)136(224)169-71-118(207)177-99(39-30-58-166-157(163)164)135(223)168-70-117(162)206)197-147(235)110(61-88-31-20-18-21-32-88)187-141(229)105(51-55-123(214)215)182-140(228)101(38-27-29-57-159)179-131(219)83(12)173-130(218)82(11)175-139(227)104(48-52-116(161)205)178-119(208)72-170-138(226)103(50-54-122(212)213)181-142(230)106(59-77(2)3)185-143(231)108(63-90-40-44-94(203)45-41-90)188-150(238)114(74-199)192-144(232)109(64-91-42-46-95(204)47-43-91)190-153(241)126(80(8)9)196-149(237)113(67-124(216)217)189-151(239)115(75-200)193-156(244)129(87(16)202)198-148(236)111(62-89-33-22-19-23-34-89)191-155(243)128(86(15)201)194-120(209)73-171-137(225)102(49-53-121(210)211)180-132(220)84(13)174-134(222)97(160)66-93-69-165-76-172-93/h18-25,31-36,40-47,68-69,76-87,97,99-115,125-129,167,199-204H,17,26-30,37-39,48-67,70-75,158-160H2,1-16H3,(H2,161,205)(H2,162,206)(H,165,172)(H,168,223)(H,169,224)(H,170,226)(H,171,225)(H,173,218)(H,174,222)(H,175,227)(H,176,242)(H,177,207)(H,178,208)(H,179,219)(H,180,220)(H,181,230)(H,182,228)(H,183,240)(H,184,221)(H,185,231)(H,186,233)(H,187,229)(H,188,238)(H,189,239)(H,190,241)(H,191,243)(H,192,232)(H,193,244)(H,194,209)(H,195,234)(H,196,237)(H,197,235)(H,198,236)(H,210,211)(H,212,213)(H,214,215)(H,216,217)(H4,163,164,166)/t81-,82-,83-,84-,85-,86+,87+,97-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,125-,126-,127-,128-,129-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
26n/an/an/an/an/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Displacement of [125I]-GLP (7 to 36 residues) from human GLP1R expressed in CHO cell membranes incubated for 30 mins measured after 10 hrs by scintil...


Eur J Med Chem 127: 703-714 (2017)


Article DOI: 10.1016/j.ejmech.2016.10.044
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM50231894
PNG
(CHEMBL4100325)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O
Show InChI InChI=1S/C157H238N42O46/c1-17-81(10)126(154(243)176-85(14)132(221)186-111(66-91-69-168-96-38-25-24-37-94(91)96)145(234)188-107(62-78(4)5)146(235)196-124(79(6)7)152(241)185-98(39-26-29-57-158)135(224)170-72-118(208)177-97(42-32-60-167-157(163)164)134(223)169-71-116(162)206)198-147(236)109(63-88-33-20-18-21-34-88)190-142(231)105(51-56-122(214)215)182-138(227)99(40-27-30-58-159)178-130(219)83(12)173-129(218)82(11)175-137(226)102(47-52-115(161)205)181-139(228)100-41-28-31-59-166-117(207)53-48-103(141(230)189-108(65-90-43-45-93(204)46-44-90)144(233)187-106(61-77(2)3)143(232)183-104(140(229)180-100)50-55-121(212)213)184-150(239)113(74-200)193-153(242)125(80(8)9)197-149(238)112(68-123(216)217)191-151(240)114(75-201)194-156(245)128(87(16)203)199-148(237)110(64-89-35-22-19-23-36-89)192-155(244)127(86(15)202)195-119(209)73-171-136(225)101(49-54-120(210)211)179-131(220)84(13)174-133(222)95(160)67-92-70-165-76-172-92/h18-25,33-38,43-46,69-70,76-87,95,97-114,124-128,168,200-204H,17,26-32,39-42,47-68,71-75,158-160H2,1-16H3,(H2,161,205)(H2,162,206)(H,165,172)(H,166,207)(H,169,223)(H,170,224)(H,171,225)(H,173,218)(H,174,222)(H,175,226)(H,176,243)(H,177,208)(H,178,219)(H,179,220)(H,180,229)(H,181,228)(H,182,227)(H,183,232)(H,184,239)(H,185,241)(H,186,221)(H,187,233)(H,188,234)(H,189,230)(H,190,231)(H,191,240)(H,192,244)(H,193,242)(H,194,245)(H,195,209)(H,196,235)(H,197,238)(H,198,236)(H,199,237)(H,210,211)(H,212,213)(H,214,215)(H,216,217)(H4,163,164,167)/t81-,82-,83-,84-,85-,86+,87+,95-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,124-,125-,126-,127-,128-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 8.60n/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Agonist activity at human GLP1R expressed in CHOK1 cells assessed as induction of beta-galactosidase-tagged beta-arrestin2 recruitment incubated for ...


Eur J Med Chem 127: 703-714 (2017)


Article DOI: 10.1016/j.ejmech.2016.10.044
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM50231896
PNG
(CHEMBL4084829)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N1)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O)C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O
Show InChI InChI=1S/C157H234N42O47/c1-16-80(10)126(154(244)183-98-40-27-30-55-165-116(207)65-109(135(225)171-71-118(209)176-95(41-31-57-167-157(162)163)133(223)169-70-115(161)206)192-152(242)124(78(6)7)196-146(236)104(59-77(4)5)185-144(234)108(188-139(98)229)63-89-68-168-94-37-24-23-36-92(89)94)198-147(237)106(60-86-32-19-17-20-33-86)187-140(230)101(48-52-121(213)214)180-137(227)96(38-25-28-54-158)177-130(220)82(12)173-129(219)81(11)175-136(226)100(46-50-114(160)205)181-145(235)110-66-117(208)166-56-29-26-39-97(138(228)186-105(62-88-42-44-91(204)45-43-88)143(233)184-103(58-76(2)3)142(232)182-102(141(231)189-110)49-53-122(215)216)179-150(240)112(73-200)193-153(243)125(79(8)9)197-149(239)111(67-123(217)218)190-151(241)113(74-201)194-156(246)128(85(15)203)199-148(238)107(61-87-34-21-18-22-35-87)191-155(245)127(84(14)202)195-119(210)72-170-134(224)99(47-51-120(211)212)178-131(221)83(13)174-132(222)93(159)64-90-69-164-75-172-90/h17-24,32-37,42-45,68-69,75-85,93,95-113,124-128,168,200-204H,16,25-31,38-41,46-67,70-74,158-159H2,1-15H3,(H2,160,205)(H2,161,206)(H,164,172)(H,165,207)(H,166,208)(H,169,223)(H,170,224)(H,171,225)(H,173,219)(H,174,222)(H,175,226)(H,176,209)(H,177,220)(H,178,221)(H,179,240)(H,180,227)(H,181,235)(H,182,232)(H,183,244)(H,184,233)(H,185,234)(H,186,228)(H,187,230)(H,188,229)(H,189,231)(H,190,241)(H,191,245)(H,192,242)(H,193,243)(H,194,246)(H,195,210)(H,196,236)(H,197,239)(H,198,237)(H,199,238)(H,211,212)(H,213,214)(H,215,216)(H,217,218)(H4,162,163,167)/t80-,81-,82-,83-,84+,85+,93-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,124-,125-,126-,127-,128-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 6.70n/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Agonist activity at human GLP1R expressed in CHOK1 cells assessed as induction of beta-galactosidase-tagged beta-arrestin2 recruitment incubated for ...


Eur J Med Chem 127: 703-714 (2017)


Article DOI: 10.1016/j.ejmech.2016.10.044
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM50231895
PNG
(CHEMBL4073486)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O)C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O
Show InChI InChI=1S/C152H227N41O47/c1-16-77(10)122(149(238)177-94-37-26-28-52-160-112(202)61-105(132(221)166-67-113(203)171-92(38-29-53-161-152(157)158)129(218)163-65-111(156)201)185-147(236)120(75(6)7)190-140(229)100(55-74(4)5)179-139(228)104(182-135(94)224)59-86-63-162-91-35-24-23-34-89(86)91)192-141(230)102(56-83-30-19-17-20-31-83)180-136(225)98(46-50-118(210)211)176-134(223)93(36-25-27-51-153)173-126(215)79(12)168-125(214)78(11)170-133(222)97(43-47-110(155)200)172-114(204)66-164-131(220)96(45-49-117(208)209)175-137(226)99(54-73(2)3)178-138(227)101(58-85-39-41-88(199)42-40-85)181-144(233)107(69-194)186-146(235)109(71-196)187-148(237)121(76(8)9)191-143(232)106(62-119(212)213)183-145(234)108(70-195)188-151(240)124(82(15)198)193-142(231)103(57-84-32-21-18-22-33-84)184-150(239)123(81(14)197)189-115(205)68-165-130(219)95(44-48-116(206)207)174-127(216)80(13)169-128(217)90(154)60-87-64-159-72-167-87/h17-24,30-35,39-42,63-64,72-82,90,92-109,120-124,162,194-199H,16,25-29,36-38,43-62,65-71,153-154H2,1-15H3,(H2,155,200)(H2,156,201)(H,159,167)(H,160,202)(H,163,218)(H,164,220)(H,165,219)(H,166,221)(H,168,214)(H,169,217)(H,170,222)(H,171,203)(H,172,204)(H,173,215)(H,174,216)(H,175,226)(H,176,223)(H,177,238)(H,178,227)(H,179,228)(H,180,225)(H,181,233)(H,182,224)(H,183,234)(H,184,239)(H,185,236)(H,186,235)(H,187,237)(H,188,240)(H,189,205)(H,190,229)(H,191,232)(H,192,230)(H,193,231)(H,206,207)(H,208,209)(H,210,211)(H,212,213)(H4,157,158,161)/t77-,78-,79-,80-,81+,82+,90-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,120-,121-,122-,123-,124-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0740n/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Agonist activity at human GLP1R expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by LANCE assay


Eur J Med Chem 127: 703-714 (2017)


Article DOI: 10.1016/j.ejmech.2016.10.044
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM50231899
PNG
(CHEMBL4087789)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O)C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O
Show InChI InChI=1S/C153H229N41O47/c1-17-77(10)122(150(239)178-95-38-27-29-53-161-113(203)62-106(132(221)166-67-114(204)172-93(39-30-54-162-153(158)159)130(219)164-66-112(157)202)186-148(237)120(75(6)7)191-141(230)101(56-74(4)5)180-140(229)105(183-136(95)225)60-87-64-163-92-36-25-24-35-90(87)92)193-142(231)103(57-84-31-20-18-21-32-84)181-137(226)99(47-51-118(210)211)176-135(224)94(37-26-28-52-154)173-126(215)79(12)168-125(214)78(11)170-133(222)97(44-48-111(156)201)175-128(217)81(14)171-134(223)98(46-50-117(208)209)177-138(227)100(55-73(2)3)179-139(228)102(59-86-40-42-89(200)43-41-86)182-145(234)108(69-195)187-147(236)110(71-197)188-149(238)121(76(8)9)192-144(233)107(63-119(212)213)184-146(235)109(70-196)189-152(241)124(83(16)199)194-143(232)104(58-85-33-22-19-23-34-85)185-151(240)123(82(15)198)190-115(205)68-165-131(220)96(45-49-116(206)207)174-127(216)80(13)169-129(218)91(155)61-88-65-160-72-167-88/h18-25,31-36,40-43,64-65,72-83,91,93-110,120-124,163,195-200H,17,26-30,37-39,44-63,66-71,154-155H2,1-16H3,(H2,156,201)(H2,157,202)(H,160,167)(H,161,203)(H,164,219)(H,165,220)(H,166,221)(H,168,214)(H,169,218)(H,170,222)(H,171,223)(H,172,204)(H,173,215)(H,174,216)(H,175,217)(H,176,224)(H,177,227)(H,178,239)(H,179,228)(H,180,229)(H,181,226)(H,182,234)(H,183,225)(H,184,235)(H,185,240)(H,186,237)(H,187,236)(H,188,238)(H,189,241)(H,190,205)(H,191,230)(H,192,233)(H,193,231)(H,194,232)(H,206,207)(H,208,209)(H,210,211)(H,212,213)(H4,158,159,162)/t77-,78-,79-,80-,81-,82+,83+,91-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,120-,121-,122-,123-,124-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0200n/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Agonist activity at human GLP1R expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by LANCE assay


Eur J Med Chem 127: 703-714 (2017)


Article DOI: 10.1016/j.ejmech.2016.10.044
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM50231899
PNG
(CHEMBL4087789)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O)C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O
Show InChI InChI=1S/C153H229N41O47/c1-17-77(10)122(150(239)178-95-38-27-29-53-161-113(203)62-106(132(221)166-67-114(204)172-93(39-30-54-162-153(158)159)130(219)164-66-112(157)202)186-148(237)120(75(6)7)191-141(230)101(56-74(4)5)180-140(229)105(183-136(95)225)60-87-64-163-92-36-25-24-35-90(87)92)193-142(231)103(57-84-31-20-18-21-32-84)181-137(226)99(47-51-118(210)211)176-135(224)94(37-26-28-52-154)173-126(215)79(12)168-125(214)78(11)170-133(222)97(44-48-111(156)201)175-128(217)81(14)171-134(223)98(46-50-117(208)209)177-138(227)100(55-73(2)3)179-139(228)102(59-86-40-42-89(200)43-41-86)182-145(234)108(69-195)187-147(236)110(71-197)188-149(238)121(76(8)9)192-144(233)107(63-119(212)213)184-146(235)109(70-196)189-152(241)124(83(16)199)194-143(232)104(58-85-33-22-19-23-34-85)185-151(240)123(82(15)198)190-115(205)68-165-131(220)96(45-49-116(206)207)174-127(216)80(13)169-129(218)91(155)61-88-65-160-72-167-88/h18-25,31-36,40-43,64-65,72-83,91,93-110,120-124,163,195-200H,17,26-30,37-39,44-63,66-71,154-155H2,1-16H3,(H2,156,201)(H2,157,202)(H,160,167)(H,161,203)(H,164,219)(H,165,220)(H,166,221)(H,168,214)(H,169,218)(H,170,222)(H,171,223)(H,172,204)(H,173,215)(H,174,216)(H,175,217)(H,176,224)(H,177,227)(H,178,239)(H,179,228)(H,180,229)(H,181,226)(H,182,234)(H,183,225)(H,184,235)(H,185,240)(H,186,237)(H,187,236)(H,188,238)(H,189,241)(H,190,205)(H,191,230)(H,192,233)(H,193,231)(H,194,232)(H,206,207)(H,208,209)(H,210,211)(H,212,213)(H4,158,159,162)/t77-,78-,79-,80-,81-,82+,83+,91-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,120-,121-,122-,123-,124-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 11n/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Agonist activity at human GLP1R expressed in CHOK1 cells assessed as induction of beta-galactosidase-tagged beta-arrestin2 recruitment incubated for ...


Eur J Med Chem 127: 703-714 (2017)


Article DOI: 10.1016/j.ejmech.2016.10.044
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM50231902
PNG
(CHEMBL4096416)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N1)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O)C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O
Show InChI InChI=1S/C162H236N42O48/c1-14-83(8)131(159(250)189-103-38-25-28-60-171-123(214)70-116(140(231)176-75-124(215)181-100(39-29-61-172-162(167)168)138(229)174-74-121(166)212)198-158(249)130(82(6)7)202-153(244)110(63-81(4)5)191-151(242)115(195-144(103)235)68-93-72-173-99-35-22-21-34-97(93)99)203-154(245)113(64-89-30-17-15-18-31-89)193-147(238)108(52-57-128(221)222)187-142(233)101(36-23-26-58-163)182-135(226)85(10)178-134(225)84(9)180-141(232)105(48-53-120(165)211)185-145(236)106-49-54-122(213)170-59-27-24-37-102(143(234)192-111(66-91-40-44-95(209)45-41-91)149(240)190-109(62-80(2)3)148(239)188-107(146(237)186-106)51-56-127(219)220)184-156(247)118(77-205)199-150(241)112(67-92-42-46-96(210)47-43-92)194-152(243)117(71-129(223)224)196-157(248)119(78-206)200-161(252)133(88(13)208)204-155(246)114(65-90-32-19-16-20-33-90)197-160(251)132(87(12)207)201-125(216)76-175-139(230)104(50-55-126(217)218)183-136(227)86(11)179-137(228)98(164)69-94-73-169-79-177-94/h15-22,30-35,40-47,72-73,79-88,98,100-119,130-133,173,205-210H,14,23-29,36-39,48-71,74-78,163-164H2,1-13H3,(H2,165,211)(H2,166,212)(H,169,177)(H,170,213)(H,171,214)(H,174,229)(H,175,230)(H,176,231)(H,178,225)(H,179,228)(H,180,232)(H,181,215)(H,182,226)(H,183,227)(H,184,247)(H,185,236)(H,186,237)(H,187,233)(H,188,239)(H,189,250)(H,190,240)(H,191,242)(H,192,234)(H,193,238)(H,194,243)(H,195,235)(H,196,248)(H,197,251)(H,198,249)(H,199,241)(H,200,252)(H,201,216)(H,202,244)(H,203,245)(H,204,246)(H,217,218)(H,219,220)(H,221,222)(H,223,224)(H4,167,168,172)/t83-,84-,85-,86-,87+,88+,98-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,130-,131-,132-,133-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 8.80n/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Agonist activity at human GLP1R expressed in CHOK1 cells assessed as induction of beta-galactosidase-tagged beta-arrestin2 recruitment incubated for ...


Eur J Med Chem 127: 703-714 (2017)


Article DOI: 10.1016/j.ejmech.2016.10.044
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM50231894
PNG
(CHEMBL4100325)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O
Show InChI InChI=1S/C157H238N42O46/c1-17-81(10)126(154(243)176-85(14)132(221)186-111(66-91-69-168-96-38-25-24-37-94(91)96)145(234)188-107(62-78(4)5)146(235)196-124(79(6)7)152(241)185-98(39-26-29-57-158)135(224)170-72-118(208)177-97(42-32-60-167-157(163)164)134(223)169-71-116(162)206)198-147(236)109(63-88-33-20-18-21-34-88)190-142(231)105(51-56-122(214)215)182-138(227)99(40-27-30-58-159)178-130(219)83(12)173-129(218)82(11)175-137(226)102(47-52-115(161)205)181-139(228)100-41-28-31-59-166-117(207)53-48-103(141(230)189-108(65-90-43-45-93(204)46-44-90)144(233)187-106(61-77(2)3)143(232)183-104(140(229)180-100)50-55-121(212)213)184-150(239)113(74-200)193-153(242)125(80(8)9)197-149(238)112(68-123(216)217)191-151(240)114(75-201)194-156(245)128(87(16)203)199-148(237)110(64-89-35-22-19-23-36-89)192-155(244)127(86(15)202)195-119(209)73-171-136(225)101(49-54-120(210)211)179-131(220)84(13)174-133(222)95(160)67-92-70-165-76-172-92/h18-25,33-38,43-46,69-70,76-87,95,97-114,124-128,168,200-204H,17,26-32,39-42,47-68,71-75,158-160H2,1-16H3,(H2,161,205)(H2,162,206)(H,165,172)(H,166,207)(H,169,223)(H,170,224)(H,171,225)(H,173,218)(H,174,222)(H,175,226)(H,176,243)(H,177,208)(H,178,219)(H,179,220)(H,180,229)(H,181,228)(H,182,227)(H,183,232)(H,184,239)(H,185,241)(H,186,221)(H,187,233)(H,188,234)(H,189,230)(H,190,231)(H,191,240)(H,192,244)(H,193,242)(H,194,245)(H,195,209)(H,196,235)(H,197,238)(H,198,236)(H,199,237)(H,210,211)(H,212,213)(H,214,215)(H,216,217)(H4,163,164,167)/t81-,82-,83-,84-,85-,86+,87+,95-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,124-,125-,126-,127-,128-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0410n/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Agonist activity at human GLP1R expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by LANCE assay


Eur J Med Chem 127: 703-714 (2017)


Article DOI: 10.1016/j.ejmech.2016.10.044
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM50231896
PNG
(CHEMBL4084829)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N1)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O)C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O
Show InChI InChI=1S/C157H234N42O47/c1-16-80(10)126(154(244)183-98-40-27-30-55-165-116(207)65-109(135(225)171-71-118(209)176-95(41-31-57-167-157(162)163)133(223)169-70-115(161)206)192-152(242)124(78(6)7)196-146(236)104(59-77(4)5)185-144(234)108(188-139(98)229)63-89-68-168-94-37-24-23-36-92(89)94)198-147(237)106(60-86-32-19-17-20-33-86)187-140(230)101(48-52-121(213)214)180-137(227)96(38-25-28-54-158)177-130(220)82(12)173-129(219)81(11)175-136(226)100(46-50-114(160)205)181-145(235)110-66-117(208)166-56-29-26-39-97(138(228)186-105(62-88-42-44-91(204)45-43-88)143(233)184-103(58-76(2)3)142(232)182-102(141(231)189-110)49-53-122(215)216)179-150(240)112(73-200)193-153(243)125(79(8)9)197-149(239)111(67-123(217)218)190-151(241)113(74-201)194-156(246)128(85(15)203)199-148(238)107(61-87-34-21-18-22-35-87)191-155(245)127(84(14)202)195-119(210)72-170-134(224)99(47-51-120(211)212)178-131(221)83(13)174-132(222)93(159)64-90-69-164-75-172-90/h17-24,32-37,42-45,68-69,75-85,93,95-113,124-128,168,200-204H,16,25-31,38-41,46-67,70-74,158-159H2,1-15H3,(H2,160,205)(H2,161,206)(H,164,172)(H,165,207)(H,166,208)(H,169,223)(H,170,224)(H,171,225)(H,173,219)(H,174,222)(H,175,226)(H,176,209)(H,177,220)(H,178,221)(H,179,240)(H,180,227)(H,181,235)(H,182,232)(H,183,244)(H,184,233)(H,185,234)(H,186,228)(H,187,230)(H,188,229)(H,189,231)(H,190,241)(H,191,245)(H,192,242)(H,193,243)(H,194,246)(H,195,210)(H,196,236)(H,197,239)(H,198,237)(H,199,238)(H,211,212)(H,213,214)(H,215,216)(H,217,218)(H4,162,163,167)/t80-,81-,82-,83-,84+,85+,93-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,124-,125-,126-,127-,128-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0130n/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Agonist activity at human GLP1R expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by LANCE assay


Eur J Med Chem 127: 703-714 (2017)


Article DOI: 10.1016/j.ejmech.2016.10.044
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM50231897
PNG
(CHEMBL4102787)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O)C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O
Show InChI InChI=1S/C155H231N41O47/c1-16-79(10)124(151(240)178-96-38-26-28-54-163-115(205)64-107(133(222)168-69-116(206)173-94(39-29-55-164-155(160)161)131(220)166-68-114(159)204)187-149(238)122(77(6)7)192-141(230)102(58-76(4)5)181-140(229)106(184-136(96)225)62-88-66-165-93-36-24-23-35-91(88)93)194-142(231)104(59-85-31-19-17-20-32-85)182-137(226)99(47-51-119(210)211)176-135(224)95(37-25-27-53-156)174-128(217)81(12)170-127(216)80(11)172-134(223)98(45-49-113(158)203)177-148(237)112-40-30-56-196(112)154(243)100(48-52-120(212)213)179-138(227)101(57-75(2)3)180-139(228)103(61-87-41-43-90(202)44-42-87)183-145(234)109(71-197)188-147(236)111(73-199)189-150(239)123(78(8)9)193-144(233)108(65-121(214)215)185-146(235)110(72-198)190-153(242)126(84(15)201)195-143(232)105(60-86-33-21-18-22-34-86)186-152(241)125(83(14)200)191-117(207)70-167-132(221)97(46-50-118(208)209)175-129(218)82(13)171-130(219)92(157)63-89-67-162-74-169-89/h17-24,31-36,41-44,66-67,74-84,92,94-112,122-126,165,197-202H,16,25-30,37-40,45-65,68-73,156-157H2,1-15H3,(H2,158,203)(H2,159,204)(H,162,169)(H,163,205)(H,166,220)(H,167,221)(H,168,222)(H,170,216)(H,171,219)(H,172,223)(H,173,206)(H,174,217)(H,175,218)(H,176,224)(H,177,237)(H,178,240)(H,179,227)(H,180,228)(H,181,229)(H,182,226)(H,183,234)(H,184,225)(H,185,235)(H,186,241)(H,187,238)(H,188,236)(H,189,239)(H,190,242)(H,191,207)(H,192,230)(H,193,233)(H,194,231)(H,195,232)(H,208,209)(H,210,211)(H,212,213)(H,214,215)(H4,160,161,164)/t79-,80-,81-,82-,83+,84+,92-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,122-,123-,124-,125-,126-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.350n/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Agonist activity at human GLP1R expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by LANCE assay


Eur J Med Chem 127: 703-714 (2017)


Article DOI: 10.1016/j.ejmech.2016.10.044
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM50231898
PNG
(CHEMBL4079909)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(C)C)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O)C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O
Show InChI InChI=1S/C155H233N41O47/c1-18-79(12)124(152(241)178-96-39-28-30-54-163-114(205)63-107(133(222)168-68-115(206)173-94(40-31-55-164-155(160)161)131(220)166-67-113(159)204)187-150(239)122(77(8)9)193-142(231)102(57-75(4)5)181-141(230)106(184-136(96)225)61-88-65-165-93-37-26-25-36-91(88)93)195-143(232)104(58-85-32-21-19-22-33-85)182-137(226)99(47-51-118(210)211)176-135(224)95(38-27-29-53-156)174-128(217)81(14)170-127(216)80(13)172-134(223)98(45-49-112(158)203)179-149(238)121(76(6)7)192-138(227)100(48-52-119(212)213)177-139(228)101(56-74(2)3)180-140(229)103(60-87-41-43-90(202)44-42-87)183-146(235)109(70-197)188-148(237)111(72-199)189-151(240)123(78(10)11)194-145(234)108(64-120(214)215)185-147(236)110(71-198)190-154(243)126(84(17)201)196-144(233)105(59-86-34-23-20-24-35-86)186-153(242)125(83(16)200)191-116(207)69-167-132(221)97(46-50-117(208)209)175-129(218)82(15)171-130(219)92(157)62-89-66-162-73-169-89/h19-26,32-37,41-44,65-66,73-84,92,94-111,121-126,165,197-202H,18,27-31,38-40,45-64,67-72,156-157H2,1-17H3,(H2,158,203)(H2,159,204)(H,162,169)(H,163,205)(H,166,220)(H,167,221)(H,168,222)(H,170,216)(H,171,219)(H,172,223)(H,173,206)(H,174,217)(H,175,218)(H,176,224)(H,177,228)(H,178,241)(H,179,238)(H,180,229)(H,181,230)(H,182,226)(H,183,235)(H,184,225)(H,185,236)(H,186,242)(H,187,239)(H,188,237)(H,189,240)(H,190,243)(H,191,207)(H,192,227)(H,193,231)(H,194,234)(H,195,232)(H,196,233)(H,208,209)(H,210,211)(H,212,213)(H,214,215)(H4,160,161,164)/t79-,80-,81-,82-,83+,84+,92-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,121-,122-,123-,124-,125-,126-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.100n/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Agonist activity at human GLP1R expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by LANCE assay


Eur J Med Chem 127: 703-714 (2017)


Article DOI: 10.1016/j.ejmech.2016.10.044
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM50231901
PNG
(CHEMBL4088708)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O
Show InChI InChI=1S/C157H233N41O46/c1-17-81(10)127(154(242)176-85(14)133(221)184-112(65-92-68-167-98-36-25-24-35-96(92)98)145(233)186-107(60-78(4)5)146(234)195-125(79(6)7)152(240)183-100(37-26-28-56-158)136(224)169-71-118(207)177-99(39-30-58-166-157(163)164)135(223)168-70-117(162)206)197-147(235)110(61-88-31-20-18-21-32-88)187-141(229)105(51-55-123(214)215)182-140(228)101(38-27-29-57-159)179-131(219)83(12)173-130(218)82(11)175-139(227)104(48-52-116(161)205)178-119(208)72-170-138(226)103(50-54-122(212)213)181-142(230)106(59-77(2)3)185-143(231)108(63-90-40-44-94(203)45-41-90)188-150(238)114(74-199)192-144(232)109(64-91-42-46-95(204)47-43-91)190-153(241)126(80(8)9)196-149(237)113(67-124(216)217)189-151(239)115(75-200)193-156(244)129(87(16)202)198-148(236)111(62-89-33-22-19-23-34-89)191-155(243)128(86(15)201)194-120(209)73-171-137(225)102(49-53-121(210)211)180-132(220)84(13)174-134(222)97(160)66-93-69-165-76-172-93/h18-25,31-36,40-47,68-69,76-87,97,99-115,125-129,167,199-204H,17,26-30,37-39,48-67,70-75,158-160H2,1-16H3,(H2,161,205)(H2,162,206)(H,165,172)(H,168,223)(H,169,224)(H,170,226)(H,171,225)(H,173,218)(H,174,222)(H,175,227)(H,176,242)(H,177,207)(H,178,208)(H,179,219)(H,180,220)(H,181,230)(H,182,228)(H,183,240)(H,184,221)(H,185,231)(H,186,233)(H,187,229)(H,188,238)(H,189,239)(H,190,241)(H,191,243)(H,192,232)(H,193,244)(H,194,209)(H,195,234)(H,196,237)(H,197,235)(H,198,236)(H,210,211)(H,212,213)(H,214,215)(H,216,217)(H4,163,164,166)/t81-,82-,83-,84-,85-,86+,87+,97-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,125-,126-,127-,128-,129-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.90n/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Agonist activity at human GLP1R expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by LANCE assay


Eur J Med Chem 127: 703-714 (2017)


Article DOI: 10.1016/j.ejmech.2016.10.044
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM50231902
PNG
(CHEMBL4096416)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N1)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O)C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O
Show InChI InChI=1S/C162H236N42O48/c1-14-83(8)131(159(250)189-103-38-25-28-60-171-123(214)70-116(140(231)176-75-124(215)181-100(39-29-61-172-162(167)168)138(229)174-74-121(166)212)198-158(249)130(82(6)7)202-153(244)110(63-81(4)5)191-151(242)115(195-144(103)235)68-93-72-173-99-35-22-21-34-97(93)99)203-154(245)113(64-89-30-17-15-18-31-89)193-147(238)108(52-57-128(221)222)187-142(233)101(36-23-26-58-163)182-135(226)85(10)178-134(225)84(9)180-141(232)105(48-53-120(165)211)185-145(236)106-49-54-122(213)170-59-27-24-37-102(143(234)192-111(66-91-40-44-95(209)45-41-91)149(240)190-109(62-80(2)3)148(239)188-107(146(237)186-106)51-56-127(219)220)184-156(247)118(77-205)199-150(241)112(67-92-42-46-96(210)47-43-92)194-152(243)117(71-129(223)224)196-157(248)119(78-206)200-161(252)133(88(13)208)204-155(246)114(65-90-32-19-16-20-33-90)197-160(251)132(87(12)207)201-125(216)76-175-139(230)104(50-55-126(217)218)183-136(227)86(11)179-137(228)98(164)69-94-73-169-79-177-94/h15-22,30-35,40-47,72-73,79-88,98,100-119,130-133,173,205-210H,14,23-29,36-39,48-71,74-78,163-164H2,1-13H3,(H2,165,211)(H2,166,212)(H,169,177)(H,170,213)(H,171,214)(H,174,229)(H,175,230)(H,176,231)(H,178,225)(H,179,228)(H,180,232)(H,181,215)(H,182,226)(H,183,227)(H,184,247)(H,185,236)(H,186,237)(H,187,233)(H,188,239)(H,189,250)(H,190,240)(H,191,242)(H,192,234)(H,193,238)(H,194,243)(H,195,235)(H,196,248)(H,197,251)(H,198,249)(H,199,241)(H,200,252)(H,201,216)(H,202,244)(H,203,245)(H,204,246)(H,217,218)(H,219,220)(H,221,222)(H,223,224)(H4,167,168,172)/t83-,84-,85-,86-,87+,88+,98-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,130-,131-,132-,133-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.00900n/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Agonist activity at human GLP1R expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by LANCE assay


Eur J Med Chem 127: 703-714 (2017)


Article DOI: 10.1016/j.ejmech.2016.10.044
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM50231897
PNG
(CHEMBL4102787)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O)C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O
Show InChI InChI=1S/C155H231N41O47/c1-16-79(10)124(151(240)178-96-38-26-28-54-163-115(205)64-107(133(222)168-69-116(206)173-94(39-29-55-164-155(160)161)131(220)166-68-114(159)204)187-149(238)122(77(6)7)192-141(230)102(58-76(4)5)181-140(229)106(184-136(96)225)62-88-66-165-93-36-24-23-35-91(88)93)194-142(231)104(59-85-31-19-17-20-32-85)182-137(226)99(47-51-119(210)211)176-135(224)95(37-25-27-53-156)174-128(217)81(12)170-127(216)80(11)172-134(223)98(45-49-113(158)203)177-148(237)112-40-30-56-196(112)154(243)100(48-52-120(212)213)179-138(227)101(57-75(2)3)180-139(228)103(61-87-41-43-90(202)44-42-87)183-145(234)109(71-197)188-147(236)111(73-199)189-150(239)123(78(8)9)193-144(233)108(65-121(214)215)185-146(235)110(72-198)190-153(242)126(84(15)201)195-143(232)105(60-86-33-21-18-22-34-86)186-152(241)125(83(14)200)191-117(207)70-167-132(221)97(46-50-118(208)209)175-129(218)82(13)171-130(219)92(157)63-89-67-162-74-169-89/h17-24,31-36,41-44,66-67,74-84,92,94-112,122-126,165,197-202H,16,25-30,37-40,45-65,68-73,156-157H2,1-15H3,(H2,158,203)(H2,159,204)(H,162,169)(H,163,205)(H,166,220)(H,167,221)(H,168,222)(H,170,216)(H,171,219)(H,172,223)(H,173,206)(H,174,217)(H,175,218)(H,176,224)(H,177,237)(H,178,240)(H,179,227)(H,180,228)(H,181,229)(H,182,226)(H,183,234)(H,184,225)(H,185,235)(H,186,241)(H,187,238)(H,188,236)(H,189,239)(H,190,242)(H,191,207)(H,192,230)(H,193,233)(H,194,231)(H,195,232)(H,208,209)(H,210,211)(H,212,213)(H,214,215)(H4,160,161,164)/t79-,80-,81-,82-,83+,84+,92-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,122-,123-,124-,125-,126-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 33n/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Agonist activity at human GLP1R expressed in CHOK1 cells assessed as induction of beta-galactosidase-tagged beta-arrestin2 recruitment incubated for ...


Eur J Med Chem 127: 703-714 (2017)


Article DOI: 10.1016/j.ejmech.2016.10.044
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM50231898
PNG
(CHEMBL4079909)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(C)C)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O)C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O
Show InChI InChI=1S/C155H233N41O47/c1-18-79(12)124(152(241)178-96-39-28-30-54-163-114(205)63-107(133(222)168-68-115(206)173-94(40-31-55-164-155(160)161)131(220)166-67-113(159)204)187-150(239)122(77(8)9)193-142(231)102(57-75(4)5)181-141(230)106(184-136(96)225)61-88-65-165-93-37-26-25-36-91(88)93)195-143(232)104(58-85-32-21-19-22-33-85)182-137(226)99(47-51-118(210)211)176-135(224)95(38-27-29-53-156)174-128(217)81(14)170-127(216)80(13)172-134(223)98(45-49-112(158)203)179-149(238)121(76(6)7)192-138(227)100(48-52-119(212)213)177-139(228)101(56-74(2)3)180-140(229)103(60-87-41-43-90(202)44-42-87)183-146(235)109(70-197)188-148(237)111(72-199)189-151(240)123(78(10)11)194-145(234)108(64-120(214)215)185-147(236)110(71-198)190-154(243)126(84(17)201)196-144(233)105(59-86-34-23-20-24-35-86)186-153(242)125(83(16)200)191-116(207)69-167-132(221)97(46-50-117(208)209)175-129(218)82(15)171-130(219)92(157)62-89-66-162-73-169-89/h19-26,32-37,41-44,65-66,73-84,92,94-111,121-126,165,197-202H,18,27-31,38-40,45-64,67-72,156-157H2,1-17H3,(H2,158,203)(H2,159,204)(H,162,169)(H,163,205)(H,166,220)(H,167,221)(H,168,222)(H,170,216)(H,171,219)(H,172,223)(H,173,206)(H,174,217)(H,175,218)(H,176,224)(H,177,228)(H,178,241)(H,179,238)(H,180,229)(H,181,230)(H,182,226)(H,183,235)(H,184,225)(H,185,236)(H,186,242)(H,187,239)(H,188,237)(H,189,240)(H,190,243)(H,191,207)(H,192,227)(H,193,231)(H,194,234)(H,195,232)(H,196,233)(H,208,209)(H,210,211)(H,212,213)(H,214,215)(H4,160,161,164)/t79-,80-,81-,82-,83+,84+,92-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,121-,122-,123-,124-,125-,126-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 9n/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Agonist activity at human GLP1R expressed in CHOK1 cells assessed as induction of beta-galactosidase-tagged beta-arrestin2 recruitment incubated for ...


Eur J Med Chem 127: 703-714 (2017)


Article DOI: 10.1016/j.ejmech.2016.10.044
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM50231901
PNG
(CHEMBL4088708)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O
Show InChI InChI=1S/C157H233N41O46/c1-17-81(10)127(154(242)176-85(14)133(221)184-112(65-92-68-167-98-36-25-24-35-96(92)98)145(233)186-107(60-78(4)5)146(234)195-125(79(6)7)152(240)183-100(37-26-28-56-158)136(224)169-71-118(207)177-99(39-30-58-166-157(163)164)135(223)168-70-117(162)206)197-147(235)110(61-88-31-20-18-21-32-88)187-141(229)105(51-55-123(214)215)182-140(228)101(38-27-29-57-159)179-131(219)83(12)173-130(218)82(11)175-139(227)104(48-52-116(161)205)178-119(208)72-170-138(226)103(50-54-122(212)213)181-142(230)106(59-77(2)3)185-143(231)108(63-90-40-44-94(203)45-41-90)188-150(238)114(74-199)192-144(232)109(64-91-42-46-95(204)47-43-91)190-153(241)126(80(8)9)196-149(237)113(67-124(216)217)189-151(239)115(75-200)193-156(244)129(87(16)202)198-148(236)111(62-89-33-22-19-23-34-89)191-155(243)128(86(15)201)194-120(209)73-171-137(225)102(49-53-121(210)211)180-132(220)84(13)174-134(222)97(160)66-93-69-165-76-172-93/h18-25,31-36,40-47,68-69,76-87,97,99-115,125-129,167,199-204H,17,26-30,37-39,48-67,70-75,158-160H2,1-16H3,(H2,161,205)(H2,162,206)(H,165,172)(H,168,223)(H,169,224)(H,170,226)(H,171,225)(H,173,218)(H,174,222)(H,175,227)(H,176,242)(H,177,207)(H,178,208)(H,179,219)(H,180,220)(H,181,230)(H,182,228)(H,183,240)(H,184,221)(H,185,231)(H,186,233)(H,187,229)(H,188,238)(H,189,239)(H,190,241)(H,191,243)(H,192,232)(H,193,244)(H,194,209)(H,195,234)(H,196,237)(H,197,235)(H,198,236)(H,210,211)(H,212,213)(H,214,215)(H,216,217)(H4,163,164,166)/t81-,82-,83-,84-,85-,86+,87+,97-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,125-,126-,127-,128-,129-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 58n/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Agonist activity at human GLP1R expressed in CHOK1 cells assessed as induction of beta-galactosidase-tagged beta-arrestin2 recruitment incubated for ...


Eur J Med Chem 127: 703-714 (2017)


Article DOI: 10.1016/j.ejmech.2016.10.044
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM50231895
PNG
(CHEMBL4073486)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O)C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O
Show InChI InChI=1S/C152H227N41O47/c1-16-77(10)122(149(238)177-94-37-26-28-52-160-112(202)61-105(132(221)166-67-113(203)171-92(38-29-53-161-152(157)158)129(218)163-65-111(156)201)185-147(236)120(75(6)7)190-140(229)100(55-74(4)5)179-139(228)104(182-135(94)224)59-86-63-162-91-35-24-23-34-89(86)91)192-141(230)102(56-83-30-19-17-20-31-83)180-136(225)98(46-50-118(210)211)176-134(223)93(36-25-27-51-153)173-126(215)79(12)168-125(214)78(11)170-133(222)97(43-47-110(155)200)172-114(204)66-164-131(220)96(45-49-117(208)209)175-137(226)99(54-73(2)3)178-138(227)101(58-85-39-41-88(199)42-40-85)181-144(233)107(69-194)186-146(235)109(71-196)187-148(237)121(76(8)9)191-143(232)106(62-119(212)213)183-145(234)108(70-195)188-151(240)124(82(15)198)193-142(231)103(57-84-32-21-18-22-33-84)184-150(239)123(81(14)197)189-115(205)68-165-130(219)95(44-48-116(206)207)174-127(216)80(13)169-128(217)90(154)60-87-64-159-72-167-87/h17-24,30-35,39-42,63-64,72-82,90,92-109,120-124,162,194-199H,16,25-29,36-38,43-62,65-71,153-154H2,1-15H3,(H2,155,200)(H2,156,201)(H,159,167)(H,160,202)(H,163,218)(H,164,220)(H,165,219)(H,166,221)(H,168,214)(H,169,217)(H,170,222)(H,171,203)(H,172,204)(H,173,215)(H,174,216)(H,175,226)(H,176,223)(H,177,238)(H,178,227)(H,179,228)(H,180,225)(H,181,233)(H,182,224)(H,183,234)(H,184,239)(H,185,236)(H,186,235)(H,187,237)(H,188,240)(H,189,205)(H,190,229)(H,191,232)(H,192,230)(H,193,231)(H,206,207)(H,208,209)(H,210,211)(H,212,213)(H4,157,158,161)/t77-,78-,79-,80-,81+,82+,90-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,120-,121-,122-,123-,124-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 9.20n/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Agonist activity at human GLP1R expressed in CHOK1 cells assessed as induction of beta-galactosidase-tagged beta-arrestin2 recruitment incubated for ...


Eur J Med Chem 127: 703-714 (2017)


Article DOI: 10.1016/j.ejmech.2016.10.044
More data for this
Ligand-Target Pair
Segment polarity protein dishevelled homolog DVL-3


(Homo sapiens (Human))
BDBM50231890
PNG
(2-((2-carboxyethyl)carbamoyl)-6-methyl-3-phenethyl...)
Show SMILES Cc1cc2[nH]c(C(=O)NCCC(O)=O)c(CCc3ccccc3)c2cc1C(O)=O
Show InChI InChI=1S/C22H22N2O5/c1-13-11-18-17(12-16(13)22(28)29)15(8-7-14-5-3-2-4-6-14)20(24-18)21(27)23-10-9-19(25)26/h2-6,11-12,24H,7-10H2,1H3,(H,23,27)(H,25,26)(H,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+5n/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Antagonist activity at human Dvl3 assessed as inhibition of interaction between Dvl3 PDZ domain and Fz7 PDZ domain by alphaScreen assay


Bioorg Med Chem Lett 18: 946-9 (2008)


Article DOI: 10.1016/j.bmcl.2007.12.039
BindingDB Entry DOI: 10.7270/Q25D8SPT
More data for this
Ligand-Target Pair
Segment polarity protein dishevelled homolog DVL-1


(Homo sapiens (Human))
BDBM50231890
PNG
(2-((2-carboxyethyl)carbamoyl)-6-methyl-3-phenethyl...)
Show SMILES Cc1cc2[nH]c(C(=O)NCCC(O)=O)c(CCc3ccccc3)c2cc1C(O)=O
Show InChI InChI=1S/C22H22N2O5/c1-13-11-18-17(12-16(13)22(28)29)15(8-7-14-5-3-2-4-6-14)20(24-18)21(27)23-10-9-19(25)26/h2-6,11-12,24H,7-10H2,1H3,(H,23,27)(H,25,26)(H,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+5n/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Antagonist activity at human Dvl1 assessed as inhibition of interaction between Dvl1 PDZ domain and Fz7 PDZ domain by alphaScreen assay


Bioorg Med Chem Lett 18: 946-9 (2008)


Article DOI: 10.1016/j.bmcl.2007.12.039
BindingDB Entry DOI: 10.7270/Q25D8SPT
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Rattus norvegicus)
BDBM50231901
PNG
(CHEMBL4088708)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O
Show InChI InChI=1S/C157H233N41O46/c1-17-81(10)127(154(242)176-85(14)133(221)184-112(65-92-68-167-98-36-25-24-35-96(92)98)145(233)186-107(60-78(4)5)146(234)195-125(79(6)7)152(240)183-100(37-26-28-56-158)136(224)169-71-118(207)177-99(39-30-58-166-157(163)164)135(223)168-70-117(162)206)197-147(235)110(61-88-31-20-18-21-32-88)187-141(229)105(51-55-123(214)215)182-140(228)101(38-27-29-57-159)179-131(219)83(12)173-130(218)82(11)175-139(227)104(48-52-116(161)205)178-119(208)72-170-138(226)103(50-54-122(212)213)181-142(230)106(59-77(2)3)185-143(231)108(63-90-40-44-94(203)45-41-90)188-150(238)114(74-199)192-144(232)109(64-91-42-46-95(204)47-43-91)190-153(241)126(80(8)9)196-149(237)113(67-124(216)217)189-151(239)115(75-200)193-156(244)129(87(16)202)198-148(236)111(62-89-33-22-19-23-34-89)191-155(243)128(86(15)201)194-120(209)73-171-137(225)102(49-53-121(210)211)180-132(220)84(13)174-134(222)97(160)66-93-69-165-76-172-93/h18-25,31-36,40-47,68-69,76-87,97,99-115,125-129,167,199-204H,17,26-30,37-39,48-67,70-75,158-160H2,1-16H3,(H2,161,205)(H2,162,206)(H,165,172)(H,168,223)(H,169,224)(H,170,226)(H,171,225)(H,173,218)(H,174,222)(H,175,227)(H,176,242)(H,177,207)(H,178,208)(H,179,219)(H,180,220)(H,181,230)(H,182,228)(H,183,240)(H,184,221)(H,185,231)(H,186,233)(H,187,229)(H,188,238)(H,189,239)(H,190,241)(H,191,243)(H,192,232)(H,193,244)(H,194,209)(H,195,234)(H,196,237)(H,197,235)(H,198,236)(H,210,211)(H,212,213)(H,214,215)(H,216,217)(H4,163,164,166)/t81-,82-,83-,84-,85-,86+,87+,97-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,125-,126-,127-,128-,129-/m0/s1
PDB
MMDB

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KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

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Article
PubMed
n/an/an/an/a 16n/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Agonist activity at GLP1R in rat INS-1 cells assessed as increase in glucose-stimulated insulin secretion after 1 hr by HTRF assay


Eur J Med Chem 127: 703-714 (2017)


Article DOI: 10.1016/j.ejmech.2016.10.044
More data for this
Ligand-Target Pair
Beta-2 adrenergic receptor and beta-3 adrenergic receptor


(Homo sapiens (Human))
BDBM50231890
PNG
(2-((2-carboxyethyl)carbamoyl)-6-methyl-3-phenethyl...)
Show SMILES Cc1cc2[nH]c(C(=O)NCCC(O)=O)c(CCc3ccccc3)c2cc1C(O)=O
Show InChI InChI=1S/C22H22N2O5/c1-13-11-18-17(12-16(13)22(28)29)15(8-7-14-5-3-2-4-6-14)20(24-18)21(27)23-10-9-19(25)26/h2-6,11-12,24H,7-10H2,1H3,(H,23,27)(H,25,26)(H,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 8.20E+5n/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Binding affinity to GST tagged human beta 2 adrenergic receptor PDZ1 domain


Bioorg Med Chem Lett 18: 942-5 (2008)


Article DOI: 10.1016/j.bmcl.2007.12.038
BindingDB Entry DOI: 10.7270/Q2DJ5FC2
More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator


(Homo sapiens (Human))
BDBM50231890
PNG
(2-((2-carboxyethyl)carbamoyl)-6-methyl-3-phenethyl...)
Show SMILES Cc1cc2[nH]c(C(=O)NCCC(O)=O)c(CCc3ccccc3)c2cc1C(O)=O
Show InChI InChI=1S/C22H22N2O5/c1-13-11-18-17(12-16(13)22(28)29)15(8-7-14-5-3-2-4-6-14)20(24-18)21(27)23-10-9-19(25)26/h2-6,11-12,24H,7-10H2,1H3,(H,23,27)(H,25,26)(H,28,29)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.90E+5n/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Binding affinity to GST tagged human CFTR PDZ2 domain


Bioorg Med Chem Lett 18: 942-5 (2008)


Article DOI: 10.1016/j.bmcl.2007.12.038
BindingDB Entry DOI: 10.7270/Q2DJ5FC2
More data for this
Ligand-Target Pair