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1 similar compounds to monomer 50232697

Compile data set for download or QSAR
Wt: 503.5
BDBM50232677

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50232677   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Proteasome subunit beta type-10


(Homo sapiens (Human))
BDBM50232677
PNG
(CHEMBL4074528)
Show SMILES COc1ccc(C[C@H](NC(=O)c2cccc(=O)[nH]2)C(=O)N[C@@H](Cc2ccccc2)C(=O)[C@@]2(C)CO2)cc1
Show InChI InChI=1S/C28H29N3O6/c1-28(17-37-28)25(33)22(15-18-7-4-3-5-8-18)30-27(35)23(16-19-11-13-20(36-2)14-12-19)31-26(34)21-9-6-10-24(32)29-21/h3-14,22-23H,15-17H2,1-2H3,(H,29,32)(H,30,35)(H,31,34)/t22-,23-,28+/m0/s1
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n/an/a>2.50E+5n/an/an/an/an/an/a



Kezar Life Sciences

Curated by ChEMBL


Assay Description
Inhibition of MECL1 in human MOLT4 cell lysate after 1 hr by ELISA


ACS Med Chem Lett 8: 413-417 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00496
More data for this
Ligand-Target Pair
20S proteasome chymotrypsin-like


(Homo sapiens (Human))
BDBM50232677
PNG
(CHEMBL4074528)
Show SMILES COc1ccc(C[C@H](NC(=O)c2cccc(=O)[nH]2)C(=O)N[C@@H](Cc2ccccc2)C(=O)[C@@]2(C)CO2)cc1
Show InChI InChI=1S/C28H29N3O6/c1-28(17-37-28)25(33)22(15-18-7-4-3-5-8-18)30-27(35)23(16-19-11-13-20(36-2)14-12-19)31-26(34)21-9-6-10-24(32)29-21/h3-14,22-23H,15-17H2,1-2H3,(H,29,32)(H,30,35)(H,31,34)/t22-,23-,28+/m0/s1
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PubMed
n/an/a 1.82E+4n/an/an/an/an/an/a



Kezar Life Sciences

Curated by ChEMBL


Assay Description
Inhibition of proteasome beta5 in human MOLT4 cell lysate after 1 hr by ELISA


ACS Med Chem Lett 8: 413-417 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00496
More data for this
Ligand-Target Pair
Proteasome component C5


(Homo sapiens (Human))
BDBM50232677
PNG
(CHEMBL4074528)
Show SMILES COc1ccc(C[C@H](NC(=O)c2cccc(=O)[nH]2)C(=O)N[C@@H](Cc2ccccc2)C(=O)[C@@]2(C)CO2)cc1
Show InChI InChI=1S/C28H29N3O6/c1-28(17-37-28)25(33)22(15-18-7-4-3-5-8-18)30-27(35)23(16-19-11-13-20(36-2)14-12-19)31-26(34)21-9-6-10-24(32)29-21/h3-14,22-23H,15-17H2,1-2H3,(H,29,32)(H,30,35)(H,31,34)/t22-,23-,28+/m0/s1
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n/an/a 9.11E+4n/an/an/an/an/an/a



Kezar Life Sciences

Curated by ChEMBL


Assay Description
Inhibition of proteasome beta1 in human MOLT4 cell lysate after 1 hr by ELISA


ACS Med Chem Lett 8: 413-417 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00496
More data for this
Ligand-Target Pair
Proteasome subunit beta type-9


(Homo sapiens (Human))
BDBM50232677
PNG
(CHEMBL4074528)
Show SMILES COc1ccc(C[C@H](NC(=O)c2cccc(=O)[nH]2)C(=O)N[C@@H](Cc2ccccc2)C(=O)[C@@]2(C)CO2)cc1
Show InChI InChI=1S/C28H29N3O6/c1-28(17-37-28)25(33)22(15-18-7-4-3-5-8-18)30-27(35)23(16-19-11-13-20(36-2)14-12-19)31-26(34)21-9-6-10-24(32)29-21/h3-14,22-23H,15-17H2,1-2H3,(H,29,32)(H,30,35)(H,31,34)/t22-,23-,28+/m0/s1
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PubMed
n/an/a 140n/an/an/an/an/an/a



Kezar Life Sciences

Curated by ChEMBL


Assay Description
Inhibition of LMP2 in human MOLT4 cell lysate after 1 hr by ELISA


ACS Med Chem Lett 8: 413-417 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00496
More data for this
Ligand-Target Pair
Proteasome Macropain subunit


(Homo sapiens (Human))
BDBM50232677
PNG
(CHEMBL4074528)
Show SMILES COc1ccc(C[C@H](NC(=O)c2cccc(=O)[nH]2)C(=O)N[C@@H](Cc2ccccc2)C(=O)[C@@]2(C)CO2)cc1
Show InChI InChI=1S/C28H29N3O6/c1-28(17-37-28)25(33)22(15-18-7-4-3-5-8-18)30-27(35)23(16-19-11-13-20(36-2)14-12-19)31-26(34)21-9-6-10-24(32)29-21/h3-14,22-23H,15-17H2,1-2H3,(H,29,32)(H,30,35)(H,31,34)/t22-,23-,28+/m0/s1
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n/an/a>2.50E+5n/an/an/an/an/an/a



Kezar Life Sciences

Curated by ChEMBL


Assay Description
Inhibition of proteasome beta2 in human MOLT4 cell lysate after 1 hr by ELISA


ACS Med Chem Lett 8: 413-417 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00496
More data for this
Ligand-Target Pair
26S proteosome


(Homo sapiens (Human))
BDBM50232677
PNG
(CHEMBL4074528)
Show SMILES COc1ccc(C[C@H](NC(=O)c2cccc(=O)[nH]2)C(=O)N[C@@H](Cc2ccccc2)C(=O)[C@@]2(C)CO2)cc1
Show InChI InChI=1S/C28H29N3O6/c1-28(17-37-28)25(33)22(15-18-7-4-3-5-8-18)30-27(35)23(16-19-11-13-20(36-2)14-12-19)31-26(34)21-9-6-10-24(32)29-21/h3-14,22-23H,15-17H2,1-2H3,(H,29,32)(H,30,35)(H,31,34)/t22-,23-,28+/m0/s1
PDB

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Article
PubMed
n/an/a 4.81E+3n/an/an/an/an/an/a



Kezar Life Sciences

Curated by ChEMBL


Assay Description
Inhibition of LMP7 in human MOLT4 cell lysate after 1 hr by ELISA


ACS Med Chem Lett 8: 413-417 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00496
More data for this
Ligand-Target Pair