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10 similar compounds to monomer 50233832

Compile data set for download or QSAR
Wt: 487.5
BDBM50233818
Wt: 526.5
BDBM50233819
Wt: 275.3
BDBM50233839
Wt: 549.6
BDBM50233836
Wt: 507.6
BDBM50233837
Wt: 521.6
BDBM50233831
Wt: 521.6
BDBM50233834
Wt: 549.6
BDBM50233829
Wt: 512.5
BDBM50233822
Wt: 502.2
BDBM50233823

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50233818,50233819,50233839,50233836,50233837,50233831,50233834,50233829,50233822,50233823   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Xanthine dehydrogenase/oxidase


(Homo sapiens (Human))
BDBM50233818
PNG
(CHEMBL4092465)
Show SMILES COC(=O)[C@H](Cc1ccccc1)NC(=O)\C=C\c1ccc(OC)c2oc(cc12)-c1ccc(O)c(O)c1
Show InChI InChI=1S/C28H25NO7/c1-34-24-12-9-18(20-16-25(36-27(20)24)19-8-11-22(30)23(31)15-19)10-13-26(32)29-21(28(33)35-2)14-17-6-4-3-5-7-17/h3-13,15-16,21,30-31H,14H2,1-2H3,(H,29,32)/b13-10+/t21-/m0/s1
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PubMed
n/an/a>6.00E+4n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Xanthine oxidase (unknown origin) using xanthine as substrate preincubated for 3 mins followed by substrate addition measured every 15 ...


Eur J Med Chem 124: 637-648 (2016)


Article DOI: 10.1016/j.ejmech.2016.08.019
More data for this
Ligand-Target Pair
Xanthine dehydrogenase/oxidase


(Homo sapiens (Human))
BDBM50233819
PNG
(CHEMBL4094442)
Show SMILES COC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)\C=C\c1ccc(OC)c2oc(cc12)-c1ccc(O)c(O)c1
Show InChI InChI=1S/C30H26N2O7/c1-37-26-11-8-17(21-15-27(39-29(21)26)18-7-10-24(33)25(34)14-18)9-12-28(35)32-23(30(36)38-2)13-19-16-31-22-6-4-3-5-20(19)22/h3-12,14-16,23,31,33-34H,13H2,1-2H3,(H,32,35)/b12-9+/t23-/m1/s1
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PubMed
n/an/a>6.00E+4n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Xanthine oxidase (unknown origin) using xanthine as substrate preincubated for 3 mins followed by substrate addition measured every 15 ...


Eur J Med Chem 124: 637-648 (2016)


Article DOI: 10.1016/j.ejmech.2016.08.019
More data for this
Ligand-Target Pair
Xanthine dehydrogenase/oxidase


(Homo sapiens (Human))
BDBM50233822
PNG
(CHEMBL4098091)
Show SMILES COc1ccc(\C=C\C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(O)=O)c2cc(oc12)-c1ccc(O)c(O)c1
Show InChI InChI=1S/C29H24N2O7/c1-37-25-10-7-16(20-14-26(38-28(20)25)17-6-9-23(32)24(33)13-17)8-11-27(34)31-22(29(35)36)12-18-15-30-21-5-3-2-4-19(18)21/h2-11,13-15,22,30,32-33H,12H2,1H3,(H,31,34)(H,35,36)/b11-8+/t22-/m1/s1
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PubMed
n/an/a>6.00E+4n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Xanthine oxidase (unknown origin) using xanthine as substrate preincubated for 3 mins followed by substrate addition measured every 15 ...


Eur J Med Chem 124: 637-648 (2016)


Article DOI: 10.1016/j.ejmech.2016.08.019
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50233823
PNG
(CHEMBL4097807)
Show SMILES Oc1cccc(C(=O)Nc2cc([123I])cc(NC(=O)c3cccc(O)c3O)c2)c1O
Show InChI InChI=1S/C20H15IN2O6/c21-10-7-11(22-19(28)13-3-1-5-15(24)17(13)26)9-12(8-10)23-20(29)14-4-2-6-16(25)18(14)27/h1-9,24-27H,(H,22,28)(H,23,29)/i21-4
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Article
PubMed
n/an/a 1.58E+3n/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of telomerase activity in human U2OS cell lysate measured after 24 hrs by TRAP assay


Eur J Med Chem 125: 117-129 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.028
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50233823
PNG
(CHEMBL4097807)
Show SMILES Oc1cccc(C(=O)Nc2cc([123I])cc(NC(=O)c3cccc(O)c3O)c2)c1O
Show InChI InChI=1S/C20H15IN2O6/c21-10-7-11(22-19(28)13-3-1-5-15(24)17(13)26)9-12(8-10)23-20(29)14-4-2-6-16(25)18(14)27/h1-9,24-27H,(H,22,28)(H,23,29)/i21-4
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PubMed
n/an/a 1.58E+3n/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of telomerase activity in human MDA-MB-435 cell lysate measured after 24 hrs by TRAP assay


Eur J Med Chem 125: 117-129 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.028
More data for this
Ligand-Target Pair
Cytosolic phospholipase A2


(Homo sapiens (Human))
BDBM50233829
PNG
(CHEMBL1801026)
Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2cc(C(=O)CCCCC(O)=O)c3cc(ccc23)C(O)=O)cc1
Show InChI InChI=1S/C32H39NO7/c1-2-3-4-5-6-7-10-23-13-16-26(17-14-23)40-22-25(34)20-33-21-28(30(35)11-8-9-12-31(36)37)27-19-24(32(38)39)15-18-29(27)33/h13-19,21H,2-12,20,22H2,1H3,(H,36,37)(H,38,39)
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n/an/a 22n/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Inhibition of human platelet cytosolic phospholipase alpha-2 using 1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine/1,2-dioleoyl-sn-glycerol as ...


Eur J Med Chem 125: 1107-1114 (2017)


Article DOI: 10.1016/j.ejmech.2016.10.039
More data for this
Ligand-Target Pair
Cytosolic phospholipase A2


(Homo sapiens (Human))
BDBM50233836
PNG
(CHEMBL4100466)
Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2cc(C(=O)CCCCCOC)c3cc(ccc23)C(O)=O)cc1
Show InChI InChI=1S/C33H43NO6/c1-3-4-5-6-7-9-12-25-14-17-28(18-15-25)40-24-27(35)22-34-23-30(32(36)13-10-8-11-20-39-2)29-21-26(33(37)38)16-19-31(29)34/h14-19,21,23H,3-13,20,22,24H2,1-2H3,(H,37,38)
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n/an/a 49n/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Inhibition of human platelet cytosolic phospholipase alpha-2 using 1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine/1,2-dioleoyl-sn-glycerol as ...


Eur J Med Chem 125: 1107-1114 (2017)


Article DOI: 10.1016/j.ejmech.2016.10.039
More data for this
Ligand-Target Pair
Cytosolic phospholipase A2


(Homo sapiens (Human))
BDBM50233831
PNG
(CHEMBL1801024)
Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2cc(C(=O)CCC(O)=O)c3cc(ccc23)C(O)=O)cc1
Show InChI InChI=1S/C30H35NO7/c1-2-3-4-5-6-7-8-21-9-12-24(13-10-21)38-20-23(32)18-31-19-26(28(33)15-16-29(34)35)25-17-22(30(36)37)11-14-27(25)31/h9-14,17,19H,2-8,15-16,18,20H2,1H3,(H,34,35)(H,36,37)
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n/an/a 210n/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Inhibition of human platelet cytosolic phospholipase alpha-2 using 1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine/1,2-dioleoyl-sn-glycerol as ...


Eur J Med Chem 125: 1107-1114 (2017)


Article DOI: 10.1016/j.ejmech.2016.10.039
More data for this
Ligand-Target Pair
Cytosolic phospholipase A2


(Homo sapiens (Human))
BDBM50233837
PNG
(CHEMBL4086908)
Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2cc(C(=O)CCCO)c3cc(ccc23)C(O)=O)cc1
Show InChI InChI=1S/C30H37NO6/c1-2-3-4-5-6-7-9-22-11-14-25(15-12-22)37-21-24(33)19-31-20-27(29(34)10-8-17-32)26-18-23(30(35)36)13-16-28(26)31/h11-16,18,20,32H,2-10,17,19,21H2,1H3,(H,35,36)
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n/an/a 23n/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Inhibition of human platelet cytosolic phospholipase alpha-2 using 1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine/1,2-dioleoyl-sn-glycerol as ...


Eur J Med Chem 125: 1107-1114 (2017)


Article DOI: 10.1016/j.ejmech.2016.10.039
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM50233839
PNG
(CHEMBL4090213)
Show SMILES CC(C)n1nc(-c2cc(on2)C2CC2)c(C(N)=O)c1N
Show InChI InChI=1S/C13H17N5O2/c1-6(2)18-12(14)10(13(15)19)11(16-18)8-5-9(20-17-8)7-3-4-7/h5-7H,3-4,14H2,1-2H3,(H2,15,19)
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n/an/a 44n/an/an/an/an/an/a



Korea Institute of Science and Technology (KIST)

Curated by ChEMBL


Assay Description
Inhibition of human RET using KKKSPGEYVNIEFG as peptide substrate in presence of [gamma33P]ATP by radiometric assay


Eur J Med Chem 125: 1145-1155 (2017)


Article DOI: 10.1016/j.ejmech.2016.10.050
More data for this
Ligand-Target Pair
Cytosolic phospholipase A2


(Homo sapiens (Human))
BDBM50233834
PNG
(CHEMBL4079052)
Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2cc(C(=O)CCCOC)c3cc(ccc23)C(O)=O)cc1
Show InChI InChI=1S/C31H39NO6/c1-3-4-5-6-7-8-10-23-12-15-26(16-13-23)38-22-25(33)20-32-21-28(30(34)11-9-18-37-2)27-19-24(31(35)36)14-17-29(27)32/h12-17,19,21H,3-11,18,20,22H2,1-2H3,(H,35,36)
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n/an/a 15n/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Inhibition of human platelet cytosolic phospholipase alpha-2 using 1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine/1,2-dioleoyl-sn-glycerol as ...


Eur J Med Chem 125: 1107-1114 (2017)


Article DOI: 10.1016/j.ejmech.2016.10.039
More data for this
Ligand-Target Pair