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2 similar compounds to monomer 50246599

Wt: 500.5
BDBM50241251
Wt: 562.6
BDBM50241252

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50241251,50241252   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Carbonic anhydrase 9


(Homo sapiens (human))
BDBM50241252
PNG
(2-[hydroxycarbamoylmethyl-(4-phenoxy-benzenesulfon...)
Show SMILES NS(=O)(=O)c1ccc(CCNC(=O)CN(CC(=O)NO)S(=O)(=O)c2ccc(Oc3ccccc3)cc2)cc1
Show InChI InChI=1S/C24H26N4O8S2/c25-37(32,33)21-10-6-18(7-11-21)14-15-26-23(29)16-28(17-24(30)27-31)38(34,35)22-12-8-20(9-13-22)36-19-4-2-1-3-5-19/h1-13,31H,14-17H2,(H,26,29)(H,27,30)(H2,25,32,33)
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12n/an/an/an/an/an/an/an/a



Instituto Superior Técnico

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CA9 catalytic domain by stopped-flow CO2 hydrase assay


J Med Chem 51: 7968-79 (2008)

More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (human))
BDBM50241251
PNG
(2-[hydroxycarbamoylmethyl-(4-methoxy-benzenesulfon...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(CC(=O)NO)CC(=O)NCCc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C19H24N4O8S2/c1-31-15-4-8-17(9-5-15)33(29,30)23(13-19(25)22-26)12-18(24)21-11-10-14-2-6-16(7-3-14)32(20,27)28/h2-9,26H,10-13H2,1H3,(H,21,24)(H,22,25)(H2,20,27,28)
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13n/an/an/an/an/an/an/an/a



Instituto Superior Técnico

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CA9 catalytic domain by stopped-flow CO2 hydrase assay


J Med Chem 51: 7968-79 (2008)

More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (human))
BDBM50241251
PNG
(2-[hydroxycarbamoylmethyl-(4-methoxy-benzenesulfon...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(CC(=O)NO)CC(=O)NCCc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C19H24N4O8S2/c1-31-15-4-8-17(9-5-15)33(29,30)23(13-19(25)22-26)12-18(24)21-11-10-14-2-6-16(7-3-14)32(20,27)28/h2-9,26H,10-13H2,1H3,(H,21,24)(H,22,25)(H2,20,27,28)
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57n/an/an/an/an/an/an/an/a



Instituto Superior Técnico

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CA2 by stopped-flow CO2 hydrase assay


J Med Chem 51: 7968-79 (2008)

More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (human))
BDBM50241252
PNG
(2-[hydroxycarbamoylmethyl-(4-phenoxy-benzenesulfon...)
Show SMILES NS(=O)(=O)c1ccc(CCNC(=O)CN(CC(=O)NO)S(=O)(=O)c2ccc(Oc3ccccc3)cc2)cc1
Show InChI InChI=1S/C24H26N4O8S2/c25-37(32,33)21-10-6-18(7-11-21)14-15-26-23(29)16-28(17-24(30)27-31)38(34,35)22-12-8-20(9-13-22)36-19-4-2-1-3-5-19/h1-13,31H,14-17H2,(H,26,29)(H,27,30)(H2,25,32,33)
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65n/an/an/an/an/an/an/an/a



Instituto Superior Técnico

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CA2 by stopped-flow CO2 hydrase assay


J Med Chem 51: 7968-79 (2008)

More data for this
Ligand-Target Pair
Carbonic anhydrase


(Homo sapiens (human))
BDBM50241252
PNG
(2-[hydroxycarbamoylmethyl-(4-phenoxy-benzenesulfon...)
Show SMILES NS(=O)(=O)c1ccc(CCNC(=O)CN(CC(=O)NO)S(=O)(=O)c2ccc(Oc3ccccc3)cc2)cc1
Show InChI InChI=1S/C24H26N4O8S2/c25-37(32,33)21-10-6-18(7-11-21)14-15-26-23(29)16-28(17-24(30)27-31)38(34,35)22-12-8-20(9-13-22)36-19-4-2-1-3-5-19/h1-13,31H,14-17H2,(H,26,29)(H,27,30)(H2,25,32,33)
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95n/an/an/an/an/an/an/an/a



Instituto Superior Técnico

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CA1 by stopped-flow CO2 hydrase assay


J Med Chem 51: 7968-79 (2008)

More data for this
Ligand-Target Pair
Carbonic anhydrase


(Homo sapiens (human))
BDBM50241251
PNG
(2-[hydroxycarbamoylmethyl-(4-methoxy-benzenesulfon...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(CC(=O)NO)CC(=O)NCCc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C19H24N4O8S2/c1-31-15-4-8-17(9-5-15)33(29,30)23(13-19(25)22-26)12-18(24)21-11-10-14-2-6-16(7-3-14)32(20,27)28/h2-9,26H,10-13H2,1H3,(H,21,24)(H,22,25)(H2,20,27,28)
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1.77E+3n/an/an/an/an/an/an/an/a



Instituto Superior Técnico

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CA1 by stopped-flow CO2 hydrase assay


J Med Chem 51: 7968-79 (2008)

More data for this
Ligand-Target Pair
Matrix Metalloproteinase-8 (MMP-8)


(Homo sapiens (human))
BDBM50241251
PNG
(2-[hydroxycarbamoylmethyl-(4-methoxy-benzenesulfon...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(CC(=O)NO)CC(=O)NCCc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C19H24N4O8S2/c1-31-15-4-8-17(9-5-15)33(29,30)23(13-19(25)22-26)12-18(24)21-11-10-14-2-6-16(7-3-14)32(20,27)28/h2-9,26H,10-13H2,1H3,(H,21,24)(H,22,25)(H2,20,27,28)
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n/an/a 59n/an/an/an/an/an/a



Instituto Superior Técnico

Curated by ChEMBL


Assay Description
Inhibition of MMP8


J Med Chem 51: 7968-79 (2008)

More data for this
Ligand-Target Pair
Matrix metalloproteinase 16


(Homo sapiens)
BDBM50241251
PNG
(2-[hydroxycarbamoylmethyl-(4-methoxy-benzenesulfon...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(CC(=O)NO)CC(=O)NCCc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C19H24N4O8S2/c1-31-15-4-8-17(9-5-15)33(29,30)23(13-19(25)22-26)12-18(24)21-11-10-14-2-6-16(7-3-14)32(20,27)28/h2-9,26H,10-13H2,1H3,(H,21,24)(H,22,25)(H2,20,27,28)
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n/an/a 44n/an/an/an/an/an/a



Instituto Superior Técnico

Curated by ChEMBL


Assay Description
Inhibition of MMP16


J Med Chem 51: 7968-79 (2008)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-14 (MMP14)


(Homo sapiens (Human))
BDBM50241251
PNG
(2-[hydroxycarbamoylmethyl-(4-methoxy-benzenesulfon...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(CC(=O)NO)CC(=O)NCCc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C19H24N4O8S2/c1-31-15-4-8-17(9-5-15)33(29,30)23(13-19(25)22-26)12-18(24)21-11-10-14-2-6-16(7-3-14)32(20,27)28/h2-9,26H,10-13H2,1H3,(H,21,24)(H,22,25)(H2,20,27,28)
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n/an/a 90n/an/an/an/an/an/a



Instituto Superior Técnico

Curated by ChEMBL


Assay Description
Inhibition of MMP14


J Med Chem 51: 7968-79 (2008)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-14 (MMP14)


(Homo sapiens (Human))
BDBM50241252
PNG
(2-[hydroxycarbamoylmethyl-(4-phenoxy-benzenesulfon...)
Show SMILES NS(=O)(=O)c1ccc(CCNC(=O)CN(CC(=O)NO)S(=O)(=O)c2ccc(Oc3ccccc3)cc2)cc1
Show InChI InChI=1S/C24H26N4O8S2/c25-37(32,33)21-10-6-18(7-11-21)14-15-26-23(29)16-28(17-24(30)27-31)38(34,35)22-12-8-20(9-13-22)36-19-4-2-1-3-5-19/h1-13,31H,14-17H2,(H,26,29)(H,27,30)(H2,25,32,33)
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n/an/a 2.10n/an/an/an/an/an/a



Instituto Superior Técnico

Curated by ChEMBL


Assay Description
Inhibition of MMP14


J Med Chem 51: 7968-79 (2008)

More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50241252
PNG
(2-[hydroxycarbamoylmethyl-(4-phenoxy-benzenesulfon...)
Show SMILES NS(=O)(=O)c1ccc(CCNC(=O)CN(CC(=O)NO)S(=O)(=O)c2ccc(Oc3ccccc3)cc2)cc1
Show InChI InChI=1S/C24H26N4O8S2/c25-37(32,33)21-10-6-18(7-11-21)14-15-26-23(29)16-28(17-24(30)27-31)38(34,35)22-12-8-20(9-13-22)36-19-4-2-1-3-5-19/h1-13,31H,14-17H2,(H,26,29)(H,27,30)(H2,25,32,33)
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n/an/a 0.510n/an/an/an/an/an/a



Instituto Superior Técnico

Curated by ChEMBL


Assay Description
Inhibition of MMP9


J Med Chem 51: 7968-79 (2008)

More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50241251
PNG
(2-[hydroxycarbamoylmethyl-(4-methoxy-benzenesulfon...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(CC(=O)NO)CC(=O)NCCc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C19H24N4O8S2/c1-31-15-4-8-17(9-5-15)33(29,30)23(13-19(25)22-26)12-18(24)21-11-10-14-2-6-16(7-3-14)32(20,27)28/h2-9,26H,10-13H2,1H3,(H,21,24)(H,22,25)(H2,20,27,28)
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n/an/a 25n/an/an/an/an/an/a



Instituto Superior Técnico

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 transfected in mouse melanoma cells


J Med Chem 51: 7968-79 (2008)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM50241251
PNG
(2-[hydroxycarbamoylmethyl-(4-methoxy-benzenesulfon...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(CC(=O)NO)CC(=O)NCCc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C19H24N4O8S2/c1-31-15-4-8-17(9-5-15)33(29,30)23(13-19(25)22-26)12-18(24)21-11-10-14-2-6-16(7-3-14)32(20,27)28/h2-9,26H,10-13H2,1H3,(H,21,24)(H,22,25)(H2,20,27,28)
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n/an/a 532n/an/an/an/an/an/a



Instituto Superior Técnico

Curated by ChEMBL


Assay Description
Inhibition of MMP1


J Med Chem 51: 7968-79 (2008)

More data for this
Ligand-Target Pair
Matrix metalloproteinase 16


(Homo sapiens)
BDBM50241252
PNG
(2-[hydroxycarbamoylmethyl-(4-phenoxy-benzenesulfon...)
Show SMILES NS(=O)(=O)c1ccc(CCNC(=O)CN(CC(=O)NO)S(=O)(=O)c2ccc(Oc3ccccc3)cc2)cc1
Show InChI InChI=1S/C24H26N4O8S2/c25-37(32,33)21-10-6-18(7-11-21)14-15-26-23(29)16-28(17-24(30)27-31)38(34,35)22-12-8-20(9-13-22)36-19-4-2-1-3-5-19/h1-13,31H,14-17H2,(H,26,29)(H,27,30)(H2,25,32,33)
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n/an/a 1n/an/an/an/an/an/a



Instituto Superior Técnico

Curated by ChEMBL


Assay Description
Inhibition of MMP16


J Med Chem 51: 7968-79 (2008)

More data for this
Ligand-Target Pair
Matrix Metalloproteinase-8 (MMP-8)


(Homo sapiens (human))
BDBM50241252
PNG
(2-[hydroxycarbamoylmethyl-(4-phenoxy-benzenesulfon...)
Show SMILES NS(=O)(=O)c1ccc(CCNC(=O)CN(CC(=O)NO)S(=O)(=O)c2ccc(Oc3ccccc3)cc2)cc1
Show InChI InChI=1S/C24H26N4O8S2/c25-37(32,33)21-10-6-18(7-11-21)14-15-26-23(29)16-28(17-24(30)27-31)38(34,35)22-12-8-20(9-13-22)36-19-4-2-1-3-5-19/h1-13,31H,14-17H2,(H,26,29)(H,27,30)(H2,25,32,33)
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n/an/a 0.740n/an/an/an/an/an/a



Instituto Superior Técnico

Curated by ChEMBL


Assay Description
Inhibition of MMP8


J Med Chem 51: 7968-79 (2008)

More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50241251
PNG
(2-[hydroxycarbamoylmethyl-(4-methoxy-benzenesulfon...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(CC(=O)NO)CC(=O)NCCc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C19H24N4O8S2/c1-31-15-4-8-17(9-5-15)33(29,30)23(13-19(25)22-26)12-18(24)21-11-10-14-2-6-16(7-3-14)32(20,27)28/h2-9,26H,10-13H2,1H3,(H,21,24)(H,22,25)(H2,20,27,28)
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n/an/a 54n/an/an/an/an/an/a



Instituto Superior Técnico

Curated by ChEMBL


Assay Description
Inhibition of MMP9


J Med Chem 51: 7968-79 (2008)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM50241252
PNG
(2-[hydroxycarbamoylmethyl-(4-phenoxy-benzenesulfon...)
Show SMILES NS(=O)(=O)c1ccc(CCNC(=O)CN(CC(=O)NO)S(=O)(=O)c2ccc(Oc3ccccc3)cc2)cc1
Show InChI InChI=1S/C24H26N4O8S2/c25-37(32,33)21-10-6-18(7-11-21)14-15-26-23(29)16-28(17-24(30)27-31)38(34,35)22-12-8-20(9-13-22)36-19-4-2-1-3-5-19/h1-13,31H,14-17H2,(H,26,29)(H,27,30)(H2,25,32,33)
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n/an/a 143n/an/an/an/an/an/a



Instituto Superior Técnico

Curated by ChEMBL


Assay Description
Inhibition of MMP1


J Med Chem 51: 7968-79 (2008)

More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50241252
PNG
(2-[hydroxycarbamoylmethyl-(4-phenoxy-benzenesulfon...)
Show SMILES NS(=O)(=O)c1ccc(CCNC(=O)CN(CC(=O)NO)S(=O)(=O)c2ccc(Oc3ccccc3)cc2)cc1
Show InChI InChI=1S/C24H26N4O8S2/c25-37(32,33)21-10-6-18(7-11-21)14-15-26-23(29)16-28(17-24(30)27-31)38(34,35)22-12-8-20(9-13-22)36-19-4-2-1-3-5-19/h1-13,31H,14-17H2,(H,26,29)(H,27,30)(H2,25,32,33)
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n/an/a 1.60n/an/an/an/an/an/a



Instituto Superior Técnico

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 transfected in mouse melanoma cells


J Med Chem 51: 7968-79 (2008)

More data for this
Ligand-Target Pair