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19 similar compounds to monomer 50436117

Compile data set for download or QSAR
Wt: 358.4
BDBM50244421
Wt: 358.4
BDBM50244422
Wt: 358.4
BDBM50244423
Wt: 372.4
BDBM50244424
Wt: 372.4
BDBM50244425
Wt: 344.4
BDBM50245105
Wt: 344.4
BDBM50245106
Wt: 330.3
BDBM50245134
Wt: 344.4
BDBM50245138
Wt: 372.4
BDBM50313364
Wt: 372.4
BDBM50313380
Wt: 372.4
BDBM50313382
Wt: 358.4
BDBM50381537
Wt: 380.4
BDBM50436108
Wt: 380.4
BDBM50436111
Displayed 1 to 15 (of 19 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50244421,50244422,50244423,50244424,50244425,50245105,50245106,50245134,50245138,50313364,50313380,50313382,50381537,50436108,50436111   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50245105
PNG
((2R,3S,4R,5R,6S)-2-(hydroxymethyl)-6-(3-(4-methylb...)
Show SMILES Cc1ccc(Cc2cccc(c2)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1/C20H24O5/c1-12-5-7-13(8-6-12)9-14-3-2-4-15(10-14)20-19(24)18(23)17(22)16(11-21)25-20/h2-8,10,16-24H,9,11H2,1H3/t16-,17-,18+,19-,20+/s2
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n/an/an/an/a 22n/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as intracellular accumulation of [14C]-alpha-methyl glucopyranoside


Bioorg Med Chem Lett 18: 4770-3 (2008)


Article DOI: 10.1016/j.bmcl.2008.07.109
BindingDB Entry DOI: 10.7270/Q2NP248D
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50381537
PNG
(CHEMBL2017954)
Show SMILES CCc1ccc(Cc2cccc(c2)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1/C21H26O5/c1-2-13-6-8-14(9-7-13)10-15-4-3-5-16(11-15)21-20(25)19(24)18(23)17(12-22)26-21/h3-9,11,17-25H,2,10,12H2,1H3/t17-,18-,19+,20-,21+/s2
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n/an/a 10n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG accumulation after 2 hrs by scintillation counting


Bioorg Med Chem 20: 3263-79 (2012)


Article DOI: 10.1016/j.bmc.2012.03.051
BindingDB Entry DOI: 10.7270/Q2W66MSS
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50244424
PNG
((2R,3S,4R,5R,6S)-2-Hydroxymethyl-6-[3-(3-m-tolyl-p...)
Show SMILES Cc1cccc(CCCc2cccc(c2)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1
Show InChI InChI=1/C22H28O5/c1-14-5-2-6-15(11-14)7-3-8-16-9-4-10-17(12-16)22-21(26)20(25)19(24)18(13-23)27-22/h2,4-6,9-12,18-26H,3,7-8,13H2,1H3/t18-,19-,20+,21-,22+/s2
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n/an/an/an/a 1.20E+3n/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as intracellular accumulation of [14C]-alpha-methyl glucopyranoside


Bioorg Med Chem Lett 18: 4770-3 (2008)


Article DOI: 10.1016/j.bmcl.2008.07.109
BindingDB Entry DOI: 10.7270/Q2NP248D
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50244423
PNG
((2R,3S,4R,5R,6S)-2-(hydroxymethyl)-6-(3-(3-phenylp...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cccc(CCCc2ccccc2)c1
Show InChI InChI=1/C21H26O5/c22-13-17-18(23)19(24)20(25)21(26-17)16-11-5-10-15(12-16)9-4-8-14-6-2-1-3-7-14/h1-3,5-7,10-12,17-25H,4,8-9,13H2/t17-,18-,19+,20-,21+/s2
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Princ

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as intracellular accumulation of [14C]-alpha-methyl glucopyranoside


Bioorg Med Chem Lett 18: 4770-3 (2008)


Article DOI: 10.1016/j.bmcl.2008.07.109
BindingDB Entry DOI: 10.7270/Q2NP248D
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50244422
PNG
((2R,3S,4R,5R,6S)-2-Hydroxymethyl-6-[3-(2-p-tolyl-e...)
Show SMILES Cc1ccc(CCc2cccc(c2)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1/C21H26O5/c1-13-5-7-14(8-6-13)9-10-15-3-2-4-16(11-15)21-20(25)19(24)18(23)17(12-22)26-21/h2-8,11,17-25H,9-10,12H2,1H3/t17-,18-,19+,20-,21+/s2
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n/an/an/an/a 430n/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as intracellular accumulation of [14C]-alpha-methyl glucopyranoside


Bioorg Med Chem Lett 18: 4770-3 (2008)


Article DOI: 10.1016/j.bmcl.2008.07.109
BindingDB Entry DOI: 10.7270/Q2NP248D
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50244421
PNG
((2R,3S,4R,5R,6S)-2-Hydroxymethyl-6-[3-(2-m-tolyl-e...)
Show SMILES Cc1cccc(CCc2cccc(c2)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1
Show InChI InChI=1/C21H26O5/c1-13-4-2-5-14(10-13)8-9-15-6-3-7-16(11-15)21-20(25)19(24)18(23)17(12-22)26-21/h2-7,10-11,17-25H,8-9,12H2,1H3/t17-,18-,19+,20-,21+/s2
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n/an/an/an/a 970n/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as intracellular accumulation of [14C]-alpha-methyl glucopyranoside


Bioorg Med Chem Lett 18: 4770-3 (2008)


Article DOI: 10.1016/j.bmcl.2008.07.109
BindingDB Entry DOI: 10.7270/Q2NP248D
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50245138
PNG
((2R,3S,4R,5R,6S)-2-(hydroxymethyl)-6-(3-phenethylp...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cccc(CCc2ccccc2)c1
Show InChI InChI=1/C20H24O5/c21-12-16-17(22)18(23)19(24)20(25-16)15-8-4-7-14(11-15)10-9-13-5-2-1-3-6-13/h1-8,11,16-24H,9-10,12H2/t16-,17-,18+,19-,20+/s2
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Princ

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as intracellular accumulation of [14C]-alpha-methyl glucopyranoside


Bioorg Med Chem Lett 18: 4770-3 (2008)


Article DOI: 10.1016/j.bmcl.2008.07.109
BindingDB Entry DOI: 10.7270/Q2NP248D
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50245134
PNG
((2S,3R,4R,5S,6R)-2-(3-benzylphenyl)-6-(hydroxymeth...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cccc(Cc2ccccc2)c1
Show InChI InChI=1/C19H22O5/c20-11-15-16(21)17(22)18(23)19(24-15)14-8-4-7-13(10-14)9-12-5-2-1-3-6-12/h1-8,10,15-23H,9,11H2/t15-,16-,17+,18-,19+/s2
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n/an/an/an/a 190n/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as intracellular accumulation of [14C]-alpha-methyl glucopyranoside


Bioorg Med Chem Lett 18: 4770-3 (2008)


Article DOI: 10.1016/j.bmcl.2008.07.109
BindingDB Entry DOI: 10.7270/Q2NP248D
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50245106
PNG
((2R,3S,4R,5R,6S)-2-Hydroxymethyl-6-[3-(3-methyl-be...)
Show SMILES Cc1cccc(Cc2cccc(c2)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1
Show InChI InChI=1/C20H24O5/c1-12-4-2-5-13(8-12)9-14-6-3-7-15(10-14)20-19(24)18(23)17(22)16(11-21)25-20/h2-8,10,16-24H,9,11H2,1H3/t16-,17-,18+,19-,20+/s2
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n/an/an/an/a 510n/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as intracellular accumulation of [14C]-alpha-methyl glucopyranoside


Bioorg Med Chem Lett 18: 4770-3 (2008)


Article DOI: 10.1016/j.bmcl.2008.07.109
BindingDB Entry DOI: 10.7270/Q2NP248D
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50313364
PNG
((2S,3R,4R,5S,6R)-2-(3-(4-ethylbenzyl)-4-methylphen...)
Show SMILES CCc1ccc(Cc2cc(ccc2C)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1/C22H28O5/c1-3-14-5-7-15(8-6-14)10-17-11-16(9-4-13(17)2)22-21(26)20(25)19(24)18(12-23)27-22/h4-9,11,18-26H,3,10,12H2,1-2H3/t18-,19-,20+,21-,22+/s2
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n/an/a 1.5n/an/an/an/an/an/a



Pfizer Global Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrs


Bioorg Med Chem Lett 20: 1569-72 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.075
BindingDB Entry DOI: 10.7270/Q2DF6RBP
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50313380
PNG
((2S,3R,4S,5S,6R)-2-(3-(4-ethylbenzyl)-4-methylphen...)
Show SMILES CCc1ccc(Cc2cc(ccc2C)[C@@H]2O[C@H](CO)[C@@H](O)[C@@H](O)[C@H]2O)cc1
Show InChI InChI=1/C22H28O5/c1-3-14-5-7-15(8-6-14)10-17-11-16(9-4-13(17)2)22-21(26)20(25)19(24)18(12-23)27-22/h4-9,11,18-26H,3,10,12H2,1-2H3/t18-,19-,20-,21-,22+/s2
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n/an/a 3.70E+3n/an/an/an/an/an/a



Pfizer Global Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrs


Bioorg Med Chem Lett 20: 1569-72 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.075
BindingDB Entry DOI: 10.7270/Q2DF6RBP
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50313382
PNG
((2S,3R,4R,5R,6R)-2-(3-(4-ethylbenzyl)-4-methylphen...)
Show SMILES CCc1ccc(Cc2cc(ccc2C)[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1/C22H28O5/c1-3-14-5-7-15(8-6-14)10-17-11-16(9-4-13(17)2)22-21(26)20(25)19(24)18(12-23)27-22/h4-9,11,18-26H,3,10,12H2,1-2H3/t18-,19+,20+,21-,22+/s2
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n/an/a 139n/an/an/an/an/an/a



Pfizer Global Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrs


Bioorg Med Chem Lett 20: 1569-72 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.075
BindingDB Entry DOI: 10.7270/Q2DF6RBP
More data for this
Ligand-Target Pair
Bcl-2-related protein A1


(Homo sapiens (Human))
BDBM50313364
PNG
((2S,3R,4R,5S,6R)-2-(3-(4-ethylbenzyl)-4-methylphen...)
Show SMILES CCc1ccc(Cc2cc(ccc2C)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1/C22H28O5/c1-3-14-5-7-15(8-6-14)10-17-11-16(9-4-13(17)2)22-21(26)20(25)19(24)18(12-23)27-22/h4-9,11,18-26H,3,10,12H2,1-2H3/t18-,19-,20+,21-,22+/s2
PDB
MMDB

NCI pathway
KEGG

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B.MOAD
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n/an/a 250n/an/an/an/an/an/a



Human BioMolecular Research Institute

Curated by ChEMBL


Assay Description
Inhibition of N-terminal FITC BH3 peptide binding to GST-tagged Bfl1 by fluorescence polarization assay


Bioorg Med Chem Lett 20: 6560-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.046
BindingDB Entry DOI: 10.7270/Q27D2VCZ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50313364
PNG
((2S,3R,4R,5S,6R)-2-(3-(4-ethylbenzyl)-4-methylphen...)
Show SMILES CCc1ccc(Cc2cc(ccc2C)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1/C22H28O5/c1-3-14-5-7-15(8-6-14)10-17-11-16(9-4-13(17)2)22-21(26)20(25)19(24)18(12-23)27-22/h4-9,11,18-26H,3,10,12H2,1-2H3/t18-,19-,20+,21-,22+/s2
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n/an/an/an/a 12n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as reduction in [14C]-alpha-methylglucopyranoside uptake after 2 hrs by liquid scintilla...


J Med Chem 53: 8770-4 (2010)


Article DOI: 10.1021/jm101080v
BindingDB Entry DOI: 10.7270/Q2N29X9T
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50381537
PNG
(CHEMBL2017954)
Show SMILES CCc1ccc(Cc2cccc(c2)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1/C21H26O5/c1-2-13-6-8-14(9-7-13)10-15-4-3-5-16(11-15)21-20(25)19(24)18(23)17(12-22)26-21/h3-9,11,17-25H,2,10,12H2,1H3/t17-,18-,19+,20-,21+/s2
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n/an/a 5.10n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHOK cells assessed as [14-C]AMG uptake preincubated for 10 mins followed by [14-C]AMG addition measured after...


Bioorg Med Chem Lett 23: 5641-5 (2013)


Article DOI: 10.1016/j.bmcl.2013.08.042
BindingDB Entry DOI: 10.7270/Q2TX3GSM
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50436108
PNG
(CHEMBL2397441)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cccc(Cc2ccc3cccc3cc2)c1
Show InChI InChI=1/C23H24O5/c24-13-19-20(25)21(26)22(27)23(28-19)18-6-1-3-15(12-18)11-14-7-9-16-4-2-5-17(16)10-8-14/h1-10,12,19-27H,11,13H2/t19-,20-,21+,22-,23+/s2
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n/an/a 99n/an/an/an/an/an/a



Astellas Pharmaceutical Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-methyl-alpha-D-glucopyranoside accumulation


Bioorg Med Chem 21: 3934-48 (2013)


Article DOI: 10.1016/j.bmc.2013.03.067
BindingDB Entry DOI: 10.7270/Q2ZC848C
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50436111
PNG
(CHEMBL2397442)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cccc(Cc2cc3cccccc3c2)c1
Show InChI InChI=1/C23H24O5/c24-13-19-20(25)21(26)22(27)23(28-19)18-8-4-5-14(10-18)9-15-11-16-6-2-1-3-7-17(16)12-15/h1-8,10-12,19-27H,9,13H2/t19-,20-,21+,22-,23+/s2
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n/an/a 22n/an/an/an/an/an/a



Astellas Pharmaceutical Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-methyl-alpha-D-glucopyranoside accumulation


Bioorg Med Chem 21: 3934-48 (2013)


Article DOI: 10.1016/j.bmc.2013.03.067
BindingDB Entry DOI: 10.7270/Q2ZC848C
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50245105
PNG
((2R,3S,4R,5R,6S)-2-(hydroxymethyl)-6-(3-(4-methylb...)
Show SMILES Cc1ccc(Cc2cccc(c2)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1/C20H24O5/c1-12-5-7-13(8-6-12)9-14-3-2-4-15(10-14)20-19(24)18(23)17(22)16(11-21)25-20/h2-8,10,16-24H,9,11H2,1H3/t16-,17-,18+,19-,20+/s2
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n/an/an/an/a 22n/an/an/an/a



Bristol-Myers Squibb Co

Curated by ChEMBL


Assay Description
Inhibition of human kidney SGLT2 assessed as renal glucose reabsorption


J Med Chem 52: 1785-94 (2009)


Article DOI: 10.1021/jm8013019
BindingDB Entry DOI: 10.7270/Q2F47Q1T
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50244425
PNG
((2R,3S,4R,5R,6S)-2-Hydroxymethyl-6-[3-(3-p-tolyl-p...)
Show SMILES Cc1ccc(CCCc2cccc(c2)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1/C22H28O5/c1-14-8-10-15(11-9-14)4-2-5-16-6-3-7-17(12-16)22-21(26)20(25)19(24)18(13-23)27-22/h3,6-12,18-26H,2,4-5,13H2,1H3/t18-,19-,20+,21-,22+/s2
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n/an/an/an/a 630n/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as intracellular accumulation of [14C]-alpha-methyl glucopyranoside


Bioorg Med Chem Lett 18: 4770-3 (2008)


Article DOI: 10.1016/j.bmcl.2008.07.109
BindingDB Entry DOI: 10.7270/Q2NP248D
More data for this
Ligand-Target Pair