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11 similar compounds to monomer 50251614

Compile data set for download or QSAR
Wt: 329.3
BDBM50251685
Wt: 344.3
BDBM50251543
Wt: 331.3
BDBM50251644
Wt: 344.3
BDBM50251646
Wt: 330.3
BDBM50251648
Wt: 372.4
BDBM50251610
Wt: 358.3
BDBM50251611
Wt: 374.3
BDBM50251612
Wt: 358.3
BDBM50251613
Wt: 358.3
BDBM50251574
Wt: 358.3
BDBM50251575

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 39 hits for monomerid = 50251685,50251543,50251644,50251646,50251648,50251610,50251611,50251612,50251613,50251574,50251575   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50251685
PNG
(CHEMBL481289 | N-(6-phenoxypyridin-3-yl)-1H-indole...)
Show SMILES O=C(Nc1ccc(Oc2ccccc2)nc1)c1c[nH]c2ccccc12
Show InChI InChI=1S/C20H15N3O2/c24-20(17-13-21-18-9-5-4-8-16(17)18)23-14-10-11-19(22-12-14)25-15-6-2-1-3-7-15/h1-13,21H,(H,23,24)
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n/an/a 542n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]mesulergine at human cloned 5HT2C receptor expressed in CHOK1 cell


Bioorg Med Chem Lett 18: 3844-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.064
BindingDB Entry DOI: 10.7270/Q2P84BQN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50251646
PNG
(CHEMBL479764 | N-(6-(6-methylpyridin-3-yloxy)pyrid...)
Show SMILES Cc1ccc(Oc2ccc(NC(=O)c3c[nH]c4ccccc34)cn2)cn1
Show InChI InChI=1S/C20H16N4O2/c1-13-6-8-15(11-21-13)26-19-9-7-14(10-23-19)24-20(25)17-12-22-18-5-3-2-4-16(17)18/h2-12,22H,1H3,(H,24,25)
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n/an/a 2.25E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]mesulergine at human cloned 5HT2C receptor expressed in CHOK1 cell


Bioorg Med Chem Lett 18: 3844-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.064
BindingDB Entry DOI: 10.7270/Q2P84BQN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50251644
PNG
(CHEMBL517692 | N-(6-(pyrimidin-5-yloxy)pyridin-3-y...)
Show SMILES O=C(Nc1ccc(Oc2cncnc2)nc1)c1c[nH]c2ccccc12
Show InChI InChI=1S/C18H13N5O2/c24-18(15-10-21-16-4-2-1-3-14(15)16)23-12-5-6-17(22-7-12)25-13-8-19-11-20-9-13/h1-11,21H,(H,23,24)
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n/an/a 50n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]mesulergine at human cloned 5HT2C receptor expressed in CHOK1 cell


Bioorg Med Chem Lett 18: 3844-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.064
BindingDB Entry DOI: 10.7270/Q2P84BQN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50251613
PNG
(6-methyl-N-(6-(2-methylpyridin-3-yloxy)pyridin-3-y...)
Show SMILES Cc1ccc2c(c[nH]c2c1)C(=O)Nc1ccc(Oc2cccnc2C)nc1
Show InChI InChI=1S/C21H18N4O2/c1-13-5-7-16-17(12-23-18(16)10-13)21(26)25-15-6-8-20(24-11-15)27-19-4-3-9-22-14(19)2/h3-12,23H,1-2H3,(H,25,26)
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n/an/a 1.90n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]mesulergine at human cloned 5HT2C receptor expressed in CHOK1 cell


Bioorg Med Chem Lett 18: 3844-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.064
BindingDB Entry DOI: 10.7270/Q2P84BQN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50251612
PNG
(5-methoxy-N-(6-(2-methylpyridin-3-yloxy)pyridin-3-...)
Show SMILES COc1ccc2[nH]cc(C(=O)Nc3ccc(Oc4cccnc4C)nc3)c2c1
Show InChI InChI=1S/C21H18N4O3/c1-13-19(4-3-9-22-13)28-20-8-5-14(11-24-20)25-21(26)17-12-23-18-7-6-15(27-2)10-16(17)18/h3-12,23H,1-2H3,(H,25,26)
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n/an/a 10.7n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]mesulergine at human cloned 5HT2C receptor expressed in CHOK1 cell


Bioorg Med Chem Lett 18: 3844-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.064
BindingDB Entry DOI: 10.7270/Q2P84BQN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50251611
PNG
(5-methyl-N-(6-(2-methylpyridin-3-yloxy)pyridin-3-y...)
Show SMILES Cc1ccc2[nH]cc(C(=O)Nc3ccc(Oc4cccnc4C)nc3)c2c1
Show InChI InChI=1S/C21H18N4O2/c1-13-5-7-18-16(10-13)17(12-23-18)21(26)25-15-6-8-20(24-11-15)27-19-4-3-9-22-14(19)2/h3-12,23H,1-2H3,(H,25,26)
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n/an/a 4.5n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]mesulergine at human cloned 5HT2C receptor expressed in CHOK1 cell


Bioorg Med Chem Lett 18: 3844-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.064
BindingDB Entry DOI: 10.7270/Q2P84BQN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50251610
PNG
(CHEMBL518154 | N,1-dimethyl-N-(6-(2-methylpyridin-...)
Show SMILES CN(C(=O)c1cn(C)c2ccccc12)c1ccc(Oc2cccnc2C)nc1
Show InChI InChI=1S/C22H20N4O2/c1-15-20(9-6-12-23-15)28-21-11-10-16(13-24-21)26(3)22(27)18-14-25(2)19-8-5-4-7-17(18)19/h4-14H,1-3H3
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n/an/a 6.37E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]mesulergine at human cloned 5HT2C receptor expressed in CHOK1 cell


Bioorg Med Chem Lett 18: 3844-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.064
BindingDB Entry DOI: 10.7270/Q2P84BQN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50251575
PNG
(CHEMBL518452 | N-methyl-N-(6-(2-methylpyridin-3-yl...)
Show SMILES CN(C(=O)c1c[nH]c2ccccc12)c1ccc(Oc2cccnc2C)nc1
Show InChI InChI=1S/C21H18N4O2/c1-14-19(8-5-11-22-14)27-20-10-9-15(12-24-20)25(2)21(26)17-13-23-18-7-4-3-6-16(17)18/h3-13,23H,1-2H3
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n/an/a 9.44E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]mesulergine at human cloned 5HT2C receptor expressed in CHOK1 cell


Bioorg Med Chem Lett 18: 3844-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.064
BindingDB Entry DOI: 10.7270/Q2P84BQN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50251574
PNG
(1-methyl-N-(6-(2-methylpyridin-3-yloxy)pyridin-3-y...)
Show SMILES Cc1ncccc1Oc1ccc(NC(=O)c2cn(C)c3ccccc23)cn1
Show InChI InChI=1S/C21H18N4O2/c1-14-19(8-5-11-22-14)27-20-10-9-15(12-23-20)24-21(26)17-13-25(2)18-7-4-3-6-16(17)18/h3-13H,1-2H3,(H,24,26)
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n/an/a 474n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]mesulergine at human cloned 5HT2C receptor expressed in CHOK1 cell


Bioorg Med Chem Lett 18: 3844-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.064
BindingDB Entry DOI: 10.7270/Q2P84BQN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50251543
PNG
(CHEMBL512900 | N-(6-(2-methylpyridin-3-yloxy)pyrid...)
Show SMILES Cc1ncccc1Oc1ccc(NC(=O)c2c[nH]c3ccccc23)cn1
Show InChI InChI=1S/C20H16N4O2/c1-13-18(7-4-10-21-13)26-19-9-8-14(11-23-19)24-20(25)16-12-22-17-6-3-2-5-15(16)17/h2-12,22H,1H3,(H,24,25)
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n/an/a 67n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]mesulergine at human cloned 5HT2C receptor expressed in CHOK1 cell


Bioorg Med Chem Lett 18: 3844-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.064
BindingDB Entry DOI: 10.7270/Q2P84BQN
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50251648
PNG
(CHEMBL479952 | N-(6-(pyridin-3-yloxy)pyridin-3-yl)...)
Show SMILES O=C(Nc1ccc(Oc2cccnc2)nc1)c1c[nH]c2ccccc12
Show InChI InChI=1S/C19H14N4O2/c24-19(16-12-21-17-6-2-1-5-15(16)17)23-13-7-8-18(22-10-13)25-14-4-3-9-20-11-14/h1-12,21H,(H,23,24)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human cloned dopamine D4 receptor


Bioorg Med Chem Lett 18: 3844-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.064
BindingDB Entry DOI: 10.7270/Q2P84BQN
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50251613
PNG
(6-methyl-N-(6-(2-methylpyridin-3-yloxy)pyridin-3-y...)
Show SMILES Cc1ccc2c(c[nH]c2c1)C(=O)Nc1ccc(Oc2cccnc2C)nc1
Show InChI InChI=1S/C21H18N4O2/c1-13-5-7-16-17(12-23-18(16)10-13)21(26)25-15-6-8-20(24-11-15)27-19-4-3-9-22-14(19)2/h3-12,23H,1-2H3,(H,25,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human cloned dopamine D4 receptor


Bioorg Med Chem Lett 18: 3844-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.064
BindingDB Entry DOI: 10.7270/Q2P84BQN
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50251612
PNG
(5-methoxy-N-(6-(2-methylpyridin-3-yloxy)pyridin-3-...)
Show SMILES COc1ccc2[nH]cc(C(=O)Nc3ccc(Oc4cccnc4C)nc3)c2c1
Show InChI InChI=1S/C21H18N4O3/c1-13-19(4-3-9-22-13)28-20-8-5-14(11-24-20)25-21(26)17-12-23-18-7-6-15(27-2)10-16(17)18/h3-12,23H,1-2H3,(H,25,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human cloned dopamine D4 receptor


Bioorg Med Chem Lett 18: 3844-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.064
BindingDB Entry DOI: 10.7270/Q2P84BQN
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50251611
PNG
(5-methyl-N-(6-(2-methylpyridin-3-yloxy)pyridin-3-y...)
Show SMILES Cc1ccc2[nH]cc(C(=O)Nc3ccc(Oc4cccnc4C)nc3)c2c1
Show InChI InChI=1S/C21H18N4O2/c1-13-5-7-18-16(10-13)17(12-23-18)21(26)25-15-6-8-20(24-11-15)27-19-4-3-9-22-14(19)2/h3-12,23H,1-2H3,(H,25,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human cloned dopamine D4 receptor


Bioorg Med Chem Lett 18: 3844-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.064
BindingDB Entry DOI: 10.7270/Q2P84BQN
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50251648
PNG
(CHEMBL479952 | N-(6-(pyridin-3-yloxy)pyridin-3-yl)...)
Show SMILES O=C(Nc1ccc(Oc2cccnc2)nc1)c1c[nH]c2ccccc12
Show InChI InChI=1S/C19H14N4O2/c24-19(16-12-21-17-6-2-1-5-15(16)17)23-13-7-8-18(22-10-13)25-14-4-3-9-20-11-14/h1-12,21H,(H,23,24)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human cloned dopamine D3 receptor


Bioorg Med Chem Lett 18: 3844-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.064
BindingDB Entry DOI: 10.7270/Q2P84BQN
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50251613
PNG
(6-methyl-N-(6-(2-methylpyridin-3-yloxy)pyridin-3-y...)
Show SMILES Cc1ccc2c(c[nH]c2c1)C(=O)Nc1ccc(Oc2cccnc2C)nc1
Show InChI InChI=1S/C21H18N4O2/c1-13-5-7-16-17(12-23-18(16)10-13)21(26)25-15-6-8-20(24-11-15)27-19-4-3-9-22-14(19)2/h3-12,23H,1-2H3,(H,25,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human cloned dopamine D3 receptor


Bioorg Med Chem Lett 18: 3844-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.064
BindingDB Entry DOI: 10.7270/Q2P84BQN
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50251612
PNG
(5-methoxy-N-(6-(2-methylpyridin-3-yloxy)pyridin-3-...)
Show SMILES COc1ccc2[nH]cc(C(=O)Nc3ccc(Oc4cccnc4C)nc3)c2c1
Show InChI InChI=1S/C21H18N4O3/c1-13-19(4-3-9-22-13)28-20-8-5-14(11-24-20)25-21(26)17-12-23-18-7-6-15(27-2)10-16(17)18/h3-12,23H,1-2H3,(H,25,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human cloned dopamine D3 receptor


Bioorg Med Chem Lett 18: 3844-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.064
BindingDB Entry DOI: 10.7270/Q2P84BQN
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50251611
PNG
(5-methyl-N-(6-(2-methylpyridin-3-yloxy)pyridin-3-y...)
Show SMILES Cc1ccc2[nH]cc(C(=O)Nc3ccc(Oc4cccnc4C)nc3)c2c1
Show InChI InChI=1S/C21H18N4O2/c1-13-5-7-18-16(10-13)17(12-23-18)21(26)25-15-6-8-20(24-11-15)27-19-4-3-9-22-14(19)2/h3-12,23H,1-2H3,(H,25,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human cloned dopamine D3 receptor


Bioorg Med Chem Lett 18: 3844-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.064
BindingDB Entry DOI: 10.7270/Q2P84BQN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50251648
PNG
(CHEMBL479952 | N-(6-(pyridin-3-yloxy)pyridin-3-yl)...)
Show SMILES O=C(Nc1ccc(Oc2cccnc2)nc1)c1c[nH]c2ccccc12
Show InChI InChI=1S/C19H14N4O2/c24-19(16-12-21-17-6-2-1-5-15(16)17)23-13-7-8-18(22-10-13)25-14-4-3-9-20-11-14/h1-12,21H,(H,23,24)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human cloned dopamine D2 receptor


Bioorg Med Chem Lett 18: 3844-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.064
BindingDB Entry DOI: 10.7270/Q2P84BQN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50251613
PNG
(6-methyl-N-(6-(2-methylpyridin-3-yloxy)pyridin-3-y...)
Show SMILES Cc1ccc2c(c[nH]c2c1)C(=O)Nc1ccc(Oc2cccnc2C)nc1
Show InChI InChI=1S/C21H18N4O2/c1-13-5-7-16-17(12-23-18(16)10-13)21(26)25-15-6-8-20(24-11-15)27-19-4-3-9-22-14(19)2/h3-12,23H,1-2H3,(H,25,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human cloned dopamine D2 receptor


Bioorg Med Chem Lett 18: 3844-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.064
BindingDB Entry DOI: 10.7270/Q2P84BQN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50251612
PNG
(5-methoxy-N-(6-(2-methylpyridin-3-yloxy)pyridin-3-...)
Show SMILES COc1ccc2[nH]cc(C(=O)Nc3ccc(Oc4cccnc4C)nc3)c2c1
Show InChI InChI=1S/C21H18N4O3/c1-13-19(4-3-9-22-13)28-20-8-5-14(11-24-20)25-21(26)17-12-23-18-7-6-15(27-2)10-16(17)18/h3-12,23H,1-2H3,(H,25,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human cloned dopamine D2 receptor


Bioorg Med Chem Lett 18: 3844-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.064
BindingDB Entry DOI: 10.7270/Q2P84BQN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50251611
PNG
(5-methyl-N-(6-(2-methylpyridin-3-yloxy)pyridin-3-y...)
Show SMILES Cc1ccc2[nH]cc(C(=O)Nc3ccc(Oc4cccnc4C)nc3)c2c1
Show InChI InChI=1S/C21H18N4O2/c1-13-5-7-18-16(10-13)17(12-23-18)21(26)25-15-6-8-20(24-11-15)27-19-4-3-9-22-14(19)2/h3-12,23H,1-2H3,(H,25,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human cloned dopamine D2 receptor


Bioorg Med Chem Lett 18: 3844-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.064
BindingDB Entry DOI: 10.7270/Q2P84BQN
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 7 (5-HT7)


(Homo sapiens (Human))
BDBM50251648
PNG
(CHEMBL479952 | N-(6-(pyridin-3-yloxy)pyridin-3-yl)...)
Show SMILES O=C(Nc1ccc(Oc2cccnc2)nc1)c1c[nH]c2ccccc12
Show InChI InChI=1S/C19H14N4O2/c24-19(16-12-21-17-6-2-1-5-15(16)17)23-13-7-8-18(22-10-13)25-14-4-3-9-20-11-14/h1-12,21H,(H,23,24)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human cloned 5HT7 receptor


Bioorg Med Chem Lett 18: 3844-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.064
BindingDB Entry DOI: 10.7270/Q2P84BQN
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 7 (5-HT7)


(Homo sapiens (Human))
BDBM50251613
PNG
(6-methyl-N-(6-(2-methylpyridin-3-yloxy)pyridin-3-y...)
Show SMILES Cc1ccc2c(c[nH]c2c1)C(=O)Nc1ccc(Oc2cccnc2C)nc1
Show InChI InChI=1S/C21H18N4O2/c1-13-5-7-16-17(12-23-18(16)10-13)21(26)25-15-6-8-20(24-11-15)27-19-4-3-9-22-14(19)2/h3-12,23H,1-2H3,(H,25,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human cloned 5HT7 receptor


Bioorg Med Chem Lett 18: 3844-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.064
BindingDB Entry DOI: 10.7270/Q2P84BQN
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 7 (5-HT7)


(Homo sapiens (Human))
BDBM50251612
PNG
(5-methoxy-N-(6-(2-methylpyridin-3-yloxy)pyridin-3-...)
Show SMILES COc1ccc2[nH]cc(C(=O)Nc3ccc(Oc4cccnc4C)nc3)c2c1
Show InChI InChI=1S/C21H18N4O3/c1-13-19(4-3-9-22-13)28-20-8-5-14(11-24-20)25-21(26)17-12-23-18-7-6-15(27-2)10-16(17)18/h3-12,23H,1-2H3,(H,25,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human cloned 5HT7 receptor


Bioorg Med Chem Lett 18: 3844-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.064
BindingDB Entry DOI: 10.7270/Q2P84BQN
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 7 (5-HT7)


(Homo sapiens (Human))
BDBM50251611
PNG
(5-methyl-N-(6-(2-methylpyridin-3-yloxy)pyridin-3-y...)
Show SMILES Cc1ccc2[nH]cc(C(=O)Nc3ccc(Oc4cccnc4C)nc3)c2c1
Show InChI InChI=1S/C21H18N4O2/c1-13-5-7-18-16(10-13)17(12-23-18)21(26)25-15-6-8-20(24-11-15)27-19-4-3-9-22-14(19)2/h3-12,23H,1-2H3,(H,25,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human cloned 5HT7 receptor


Bioorg Med Chem Lett 18: 3844-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.064
BindingDB Entry DOI: 10.7270/Q2P84BQN
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50251648
PNG
(CHEMBL479952 | N-(6-(pyridin-3-yloxy)pyridin-3-yl)...)
Show SMILES O=C(Nc1ccc(Oc2cccnc2)nc1)c1c[nH]c2ccccc12
Show InChI InChI=1S/C19H14N4O2/c24-19(16-12-21-17-6-2-1-5-15(16)17)23-13-7-8-18(22-10-13)25-14-4-3-9-20-11-14/h1-12,21H,(H,23,24)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human cloned 5HT6 receptor


Bioorg Med Chem Lett 18: 3844-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.064
BindingDB Entry DOI: 10.7270/Q2P84BQN
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50251613
PNG
(6-methyl-N-(6-(2-methylpyridin-3-yloxy)pyridin-3-y...)
Show SMILES Cc1ccc2c(c[nH]c2c1)C(=O)Nc1ccc(Oc2cccnc2C)nc1
Show InChI InChI=1S/C21H18N4O2/c1-13-5-7-16-17(12-23-18(16)10-13)21(26)25-15-6-8-20(24-11-15)27-19-4-3-9-22-14(19)2/h3-12,23H,1-2H3,(H,25,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human cloned 5HT6 receptor


Bioorg Med Chem Lett 18: 3844-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.064
BindingDB Entry DOI: 10.7270/Q2P84BQN
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50251612
PNG
(5-methoxy-N-(6-(2-methylpyridin-3-yloxy)pyridin-3-...)
Show SMILES COc1ccc2[nH]cc(C(=O)Nc3ccc(Oc4cccnc4C)nc3)c2c1
Show InChI InChI=1S/C21H18N4O3/c1-13-19(4-3-9-22-13)28-20-8-5-14(11-24-20)25-21(26)17-12-23-18-7-6-15(27-2)10-16(17)18/h3-12,23H,1-2H3,(H,25,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human cloned 5HT6 receptor


Bioorg Med Chem Lett 18: 3844-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.064
BindingDB Entry DOI: 10.7270/Q2P84BQN
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50251611
PNG
(5-methyl-N-(6-(2-methylpyridin-3-yloxy)pyridin-3-y...)
Show SMILES Cc1ccc2[nH]cc(C(=O)Nc3ccc(Oc4cccnc4C)nc3)c2c1
Show InChI InChI=1S/C21H18N4O2/c1-13-5-7-18-16(10-13)17(12-23-18)21(26)25-15-6-8-20(24-11-15)27-19-4-3-9-22-14(19)2/h3-12,23H,1-2H3,(H,25,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human cloned 5HT6 receptor


Bioorg Med Chem Lett 18: 3844-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.064
BindingDB Entry DOI: 10.7270/Q2P84BQN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50251648
PNG
(CHEMBL479952 | N-(6-(pyridin-3-yloxy)pyridin-3-yl)...)
Show SMILES O=C(Nc1ccc(Oc2cccnc2)nc1)c1c[nH]c2ccccc12
Show InChI InChI=1S/C19H14N4O2/c24-19(16-12-21-17-6-2-1-5-15(16)17)23-13-7-8-18(22-10-13)25-14-4-3-9-20-11-14/h1-12,21H,(H,23,24)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human cloned 5HT2A receptor


Bioorg Med Chem Lett 18: 3844-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.064
BindingDB Entry DOI: 10.7270/Q2P84BQN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50251613
PNG
(6-methyl-N-(6-(2-methylpyridin-3-yloxy)pyridin-3-y...)
Show SMILES Cc1ccc2c(c[nH]c2c1)C(=O)Nc1ccc(Oc2cccnc2C)nc1
Show InChI InChI=1S/C21H18N4O2/c1-13-5-7-16-17(12-23-18(16)10-13)21(26)25-15-6-8-20(24-11-15)27-19-4-3-9-22-14(19)2/h3-12,23H,1-2H3,(H,25,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human cloned 5HT2A receptor


Bioorg Med Chem Lett 18: 3844-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.064
BindingDB Entry DOI: 10.7270/Q2P84BQN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50251612
PNG
(5-methoxy-N-(6-(2-methylpyridin-3-yloxy)pyridin-3-...)
Show SMILES COc1ccc2[nH]cc(C(=O)Nc3ccc(Oc4cccnc4C)nc3)c2c1
Show InChI InChI=1S/C21H18N4O3/c1-13-19(4-3-9-22-13)28-20-8-5-14(11-24-20)25-21(26)17-12-23-18-7-6-15(27-2)10-16(17)18/h3-12,23H,1-2H3,(H,25,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human cloned 5HT2A receptor


Bioorg Med Chem Lett 18: 3844-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.064
BindingDB Entry DOI: 10.7270/Q2P84BQN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50251611
PNG
(5-methyl-N-(6-(2-methylpyridin-3-yloxy)pyridin-3-y...)
Show SMILES Cc1ccc2[nH]cc(C(=O)Nc3ccc(Oc4cccnc4C)nc3)c2c1
Show InChI InChI=1S/C21H18N4O2/c1-13-5-7-18-16(10-13)17(12-23-18)21(26)25-15-6-8-20(24-11-15)27-19-4-3-9-22-14(19)2/h3-12,23H,1-2H3,(H,25,26)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human cloned 5HT2A receptor


Bioorg Med Chem Lett 18: 3844-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.064
BindingDB Entry DOI: 10.7270/Q2P84BQN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50251648
PNG
(CHEMBL479952 | N-(6-(pyridin-3-yloxy)pyridin-3-yl)...)
Show SMILES O=C(Nc1ccc(Oc2cccnc2)nc1)c1c[nH]c2ccccc12
Show InChI InChI=1S/C19H14N4O2/c24-19(16-12-21-17-6-2-1-5-15(16)17)23-13-7-8-18(22-10-13)25-14-4-3-9-20-11-14/h1-12,21H,(H,23,24)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor


Bioorg Med Chem Lett 18: 3844-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.064
BindingDB Entry DOI: 10.7270/Q2P84BQN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50251613
PNG
(6-methyl-N-(6-(2-methylpyridin-3-yloxy)pyridin-3-y...)
Show SMILES Cc1ccc2c(c[nH]c2c1)C(=O)Nc1ccc(Oc2cccnc2C)nc1
Show InChI InChI=1S/C21H18N4O2/c1-13-5-7-16-17(12-23-18(16)10-13)21(26)25-15-6-8-20(24-11-15)27-19-4-3-9-22-14(19)2/h3-12,23H,1-2H3,(H,25,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor


Bioorg Med Chem Lett 18: 3844-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.064
BindingDB Entry DOI: 10.7270/Q2P84BQN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50251612
PNG
(5-methoxy-N-(6-(2-methylpyridin-3-yloxy)pyridin-3-...)
Show SMILES COc1ccc2[nH]cc(C(=O)Nc3ccc(Oc4cccnc4C)nc3)c2c1
Show InChI InChI=1S/C21H18N4O3/c1-13-19(4-3-9-22-13)28-20-8-5-14(11-24-20)25-21(26)17-12-23-18-7-6-15(27-2)10-16(17)18/h3-12,23H,1-2H3,(H,25,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor


Bioorg Med Chem Lett 18: 3844-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.064
BindingDB Entry DOI: 10.7270/Q2P84BQN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50251611
PNG
(5-methyl-N-(6-(2-methylpyridin-3-yloxy)pyridin-3-y...)
Show SMILES Cc1ccc2[nH]cc(C(=O)Nc3ccc(Oc4cccnc4C)nc3)c2c1
Show InChI InChI=1S/C21H18N4O2/c1-13-5-7-18-16(10-13)17(12-23-18)21(26)25-15-6-8-20(24-11-15)27-19-4-3-9-22-14(19)2/h3-12,23H,1-2H3,(H,25,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor


Bioorg Med Chem Lett 18: 3844-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.064
BindingDB Entry DOI: 10.7270/Q2P84BQN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50251648
PNG
(CHEMBL479952 | N-(6-(pyridin-3-yloxy)pyridin-3-yl)...)
Show SMILES O=C(Nc1ccc(Oc2cccnc2)nc1)c1c[nH]c2ccccc12
Show InChI InChI=1S/C19H14N4O2/c24-19(16-12-21-17-6-2-1-5-15(16)17)23-13-7-8-18(22-10-13)25-14-4-3-9-20-11-14/h1-12,21H,(H,23,24)
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n/an/a 1.60n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]mesulergine at human cloned 5HT2C receptor expressed in CHOK1 cell


Bioorg Med Chem Lett 18: 3844-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.064
BindingDB Entry DOI: 10.7270/Q2P84BQN
More data for this
Ligand-Target Pair