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12 molecules are shown

Wt: 428.4
BDBM50265368
Wt: 468.5
BDBM50265034
Wt: 439.5
BDBM50265156
Wt: 455.5
BDBM50265071
Wt: 470.5
BDBM50264957
Wt: 512.5
BDBM50265111
Wt: 423.5
BDBM50265260
Wt: 454.5
BDBM50264992
Wt: 439.5
BDBM50265198
Wt: 496.6
BDBM50264755
Wt: 427.4
BDBM50265323
Wt: 412.4
BDBM50265326

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 32 hits for monomerid = 50265368,50265034,50265156,50265071,50264957,50265111,50265260,50264992,50265198,50264755,50265323,50265326   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50264755
PNG
(4-methyl-N-(3-morpholin-4-ylphenyl)-3-(3-piperidin...)
Show SMILES Cc1ccc(cc1-c1ccc2c(noc2c1)C1CCNCC1)C(=O)Nc1cccc(c1)N1CCOCC1
Show InChI InChI=1S/C30H32N4O3/c1-20-5-6-23(30(35)32-24-3-2-4-25(19-24)34-13-15-36-16-14-34)17-27(20)22-7-8-26-28(18-22)37-33-29(26)21-9-11-31-12-10-21/h2-8,17-19,21,31H,9-16H2,1H3,(H,32,35)
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1.40n/an/an/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Displacement of fluorescent ATP competitive ligand from p38alpha


Bioorg Med Chem Lett 18: 5285-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.051
BindingDB Entry DOI: 10.7270/Q28K7B0R
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50265034
PNG
(2',6-dimethyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)-N...)
Show SMILES Cc1nnc(o1)-c1ccc(c(C)c1)-c1cc(ccc1C)C(=O)Nc1cccc(c1)N1CCOCC1
Show InChI InChI=1S/C28H28N4O3/c1-18-7-8-21(27(33)29-23-5-4-6-24(17-23)32-11-13-34-14-12-32)16-26(18)25-10-9-22(15-19(25)2)28-31-30-20(3)35-28/h4-10,15-17H,11-14H2,1-3H3,(H,29,33)
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2.80n/an/an/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Displacement of fluorescent ATP competitive ligand from p38alpha


Bioorg Med Chem Lett 18: 5285-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.051
BindingDB Entry DOI: 10.7270/Q28K7B0R
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50265260
PNG
(3-(isoquinolin-7-yl)-4-methyl-N-(3-morpholinopheny...)
Show SMILES Cc1ccc(cc1-c1ccc2ccncc2c1)C(=O)Nc1cccc(c1)N1CCOCC1
Show InChI InChI=1S/C27H25N3O2/c1-19-5-6-22(16-26(19)21-8-7-20-9-10-28-18-23(20)15-21)27(31)29-24-3-2-4-25(17-24)30-11-13-32-14-12-30/h2-10,15-18H,11-14H2,1H3,(H,29,31)
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4.5n/an/an/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Displacement of fluorescent ATP competitive ligand from p38alpha


Bioorg Med Chem Lett 18: 5285-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.051
BindingDB Entry DOI: 10.7270/Q28K7B0R
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50265071
PNG
(3-(2-amino-4-oxo-3,4-dihydroquinazolin-6-yl)-4-met...)
Show SMILES Cc1ccc(cc1-c1ccc2nc(N)[nH]c(=O)c2c1)C(=O)Nc1cccc(c1)N1CCOCC1
Show InChI InChI=1S/C26H25N5O3/c1-16-5-6-18(14-21(16)17-7-8-23-22(13-17)25(33)30-26(27)29-23)24(32)28-19-3-2-4-20(15-19)31-9-11-34-12-10-31/h2-8,13-15H,9-12H2,1H3,(H,28,32)(H3,27,29,30,33)
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4.70n/an/an/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Displacement of fluorescent ATP competitive ligand from p38alpha


Bioorg Med Chem Lett 18: 5285-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.051
BindingDB Entry DOI: 10.7270/Q28K7B0R
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50264992
PNG
(6-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-N-(3-m...)
Show SMILES Cc1nc(no1)-c1ccc(cc1)-c1cc(ccc1C)C(=O)Nc1cccc(c1)N1CCOCC1
Show InChI InChI=1S/C27H26N4O3/c1-18-6-7-22(16-25(18)20-8-10-21(11-9-20)26-28-19(2)34-30-26)27(32)29-23-4-3-5-24(17-23)31-12-14-33-15-13-31/h3-11,16-17H,12-15H2,1-2H3,(H,29,32)
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17n/an/an/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Displacement of fluorescent ATP competitive ligand from p38alpha


Bioorg Med Chem Lett 18: 5285-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.051
BindingDB Entry DOI: 10.7270/Q28K7B0R
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50265198
PNG
(4-methyl-N-(3-morpholinophenyl)-3-(1-oxo-1,2-dihyd...)
Show SMILES Cc1ccc(cc1-c1ccc2cc[nH]c(=O)c2c1)C(=O)Nc1cccc(c1)N1CCOCC1
Show InChI InChI=1S/C27H25N3O3/c1-18-5-6-21(16-24(18)20-8-7-19-9-10-28-27(32)25(19)15-20)26(31)29-22-3-2-4-23(17-22)30-11-13-33-14-12-30/h2-10,15-17H,11-14H2,1H3,(H,28,32)(H,29,31)
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18n/an/an/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Displacement of fluorescent ATP competitive ligand from p38alpha


Bioorg Med Chem Lett 18: 5285-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.051
BindingDB Entry DOI: 10.7270/Q28K7B0R
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50265368
PNG
(3-(3-aminobenzo[d]isoxazol-6-yl)-4-methyl-N-(3-mor...)
Show SMILES Cc1ccc(cc1-c1ccc2c(N)noc2c1)C(=O)Nc1cccc(c1)N1CCOCC1
Show InChI InChI=1S/C25H24N4O3/c1-16-5-6-18(13-22(16)17-7-8-21-23(14-17)32-28-24(21)26)25(30)27-19-3-2-4-20(15-19)29-9-11-31-12-10-29/h2-8,13-15H,9-12H2,1H3,(H2,26,28)(H,27,30)
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19n/an/an/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Displacement of fluorescent ATP competitive ligand from p38alpha


Bioorg Med Chem Lett 18: 5285-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.051
BindingDB Entry DOI: 10.7270/Q28K7B0R
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50265111
PNG
(3-(3-butyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-...)
Show SMILES CCCCn1c(=O)[nH]c2cc(ccc2c1=O)-c1cc(ccc1C)C(=O)Nc1cccc(c1)N1CCOCC1
Show InChI InChI=1S/C30H32N4O4/c1-3-4-12-34-29(36)25-11-10-21(18-27(25)32-30(34)37)26-17-22(9-8-20(26)2)28(35)31-23-6-5-7-24(19-23)33-13-15-38-16-14-33/h5-11,17-19H,3-4,12-16H2,1-2H3,(H,31,35)(H,32,37)
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19n/an/an/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Displacement of fluorescent ATP competitive ligand from p38alpha


Bioorg Med Chem Lett 18: 5285-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.051
BindingDB Entry DOI: 10.7270/Q28K7B0R
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50264957
PNG
(4'-(2-aminothiazol-4-yl)-6-methyl-N-(3-morpholinop...)
Show SMILES Cc1ccc(cc1-c1ccc(cc1)-c1csc(N)n1)C(=O)Nc1cccc(c1)N1CCOCC1
Show InChI InChI=1S/C27H26N4O2S/c1-18-5-6-21(15-24(18)19-7-9-20(10-8-19)25-17-34-27(28)30-25)26(32)29-22-3-2-4-23(16-22)31-11-13-33-14-12-31/h2-10,15-17H,11-14H2,1H3,(H2,28,30)(H,29,32)
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20n/an/an/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Displacement of fluorescent ATP competitive ligand from p38alpha


Bioorg Med Chem Lett 18: 5285-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.051
BindingDB Entry DOI: 10.7270/Q28K7B0R
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50265326
PNG
(3-(1H-indazol-5-yl)-4-methyl-N-(3-morpholinophenyl...)
Show SMILES Cc1ccc(cc1-c1ccc2[nH]ncc2c1)C(=O)Nc1cccc(c1)N1CCOCC1
Show InChI InChI=1S/C25H24N4O2/c1-17-5-6-19(14-23(17)18-7-8-24-20(13-18)16-26-28-24)25(30)27-21-3-2-4-22(15-21)29-9-11-31-12-10-29/h2-8,13-16H,9-12H2,1H3,(H,26,28)(H,27,30)
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110n/an/an/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Displacement of fluorescent ATP competitive ligand from p38alpha


Bioorg Med Chem Lett 18: 5285-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.051
BindingDB Entry DOI: 10.7270/Q28K7B0R
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50265156
PNG
(4-methyl-N-(3-morpholinophenyl)-3-(2-oxo-1,2-dihyd...)
Show SMILES Cc1ccc(cc1-c1ccc2[nH]c(=O)ccc2c1)C(=O)Nc1cccc(c1)N1CCOCC1
Show InChI InChI=1S/C27H25N3O3/c1-18-5-6-21(16-24(18)19-7-9-25-20(15-19)8-10-26(31)29-25)27(32)28-22-3-2-4-23(17-22)30-11-13-33-14-12-30/h2-10,15-17H,11-14H2,1H3,(H,28,32)(H,29,31)
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290n/an/an/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Displacement of fluorescent ATP competitive ligand from p38alpha


Bioorg Med Chem Lett 18: 5285-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.051
BindingDB Entry DOI: 10.7270/Q28K7B0R
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50265323
PNG
(4-methyl-3-(3-methylbenzo[d]isoxazol-5-yl)-N-(3-mo...)
Show SMILES Cc1noc2ccc(cc12)-c1cc(ccc1C)C(=O)Nc1cccc(c1)N1CCOCC1
Show InChI InChI=1S/C26H25N3O3/c1-17-6-7-20(15-23(17)19-8-9-25-24(14-19)18(2)28-32-25)26(30)27-21-4-3-5-22(16-21)29-10-12-31-13-11-29/h3-9,14-16H,10-13H2,1-2H3,(H,27,30)
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380n/an/an/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Displacement of fluorescent ATP competitive ligand from p38alpha


Bioorg Med Chem Lett 18: 5285-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.051
BindingDB Entry DOI: 10.7270/Q28K7B0R
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM50265034
PNG
(2',6-dimethyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)-N...)
Show SMILES Cc1nnc(o1)-c1ccc(c(C)c1)-c1cc(ccc1C)C(=O)Nc1cccc(c1)N1CCOCC1
Show InChI InChI=1S/C28H28N4O3/c1-18-7-8-21(27(33)29-23-5-4-6-24(17-23)32-11-13-34-14-12-32)16-26(18)25-10-9-22(15-19(25)2)28-31-30-20(3)35-28/h4-10,15-17H,11-14H2,1-3H3,(H,29,33)
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n/an/a 700n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of cFMS


Bioorg Med Chem Lett 18: 5285-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.051
BindingDB Entry DOI: 10.7270/Q28K7B0R
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50265034
PNG
(2',6-dimethyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)-N...)
Show SMILES Cc1nnc(o1)-c1ccc(c(C)c1)-c1cc(ccc1C)C(=O)Nc1cccc(c1)N1CCOCC1
Show InChI InChI=1S/C28H28N4O3/c1-18-7-8-21(27(33)29-23-5-4-6-24(17-23)32-11-13-34-14-12-32)16-26(18)25-10-9-22(15-19(25)2)28-31-30-20(3)35-28/h4-10,15-17H,11-14H2,1-3H3,(H,29,33)
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n/an/a>2.50E+4n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of EGFR


Bioorg Med Chem Lett 18: 5285-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.051
BindingDB Entry DOI: 10.7270/Q28K7B0R
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-4 (HER4)


(Homo sapiens (Human))
BDBM50265034
PNG
(2',6-dimethyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)-N...)
Show SMILES Cc1nnc(o1)-c1ccc(c(C)c1)-c1cc(ccc1C)C(=O)Nc1cccc(c1)N1CCOCC1
Show InChI InChI=1S/C28H28N4O3/c1-18-7-8-21(27(33)29-23-5-4-6-24(17-23)32-11-13-34-14-12-32)16-26(18)25-10-9-22(15-19(25)2)28-31-30-20(3)35-28/h4-10,15-17H,11-14H2,1-3H3,(H,29,33)
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n/an/a>2.50E+4n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of ErbB4


Bioorg Med Chem Lett 18: 5285-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.051
BindingDB Entry DOI: 10.7270/Q28K7B0R
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM50265034
PNG
(2',6-dimethyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)-N...)
Show SMILES Cc1nnc(o1)-c1ccc(c(C)c1)-c1cc(ccc1C)C(=O)Nc1cccc(c1)N1CCOCC1
Show InChI InChI=1S/C28H28N4O3/c1-18-7-8-21(27(33)29-23-5-4-6-24(17-23)32-11-13-34-14-12-32)16-26(18)25-10-9-22(15-19(25)2)28-31-30-20(3)35-28/h4-10,15-17H,11-14H2,1-3H3,(H,29,33)
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n/an/a>1.60E+4n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of JNK3


Bioorg Med Chem Lett 18: 5285-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.051
BindingDB Entry DOI: 10.7270/Q28K7B0R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (human))
BDBM50265034
PNG
(2',6-dimethyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)-N...)
Show SMILES Cc1nnc(o1)-c1ccc(c(C)c1)-c1cc(ccc1C)C(=O)Nc1cccc(c1)N1CCOCC1
Show InChI InChI=1S/C28H28N4O3/c1-18-7-8-21(27(33)29-23-5-4-6-24(17-23)32-11-13-34-14-12-32)16-26(18)25-10-9-22(15-19(25)2)28-31-30-20(3)35-28/h4-10,15-17H,11-14H2,1-3H3,(H,29,33)
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n/an/a 8.00E+3n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of LCK


Bioorg Med Chem Lett 18: 5285-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.051
BindingDB Entry DOI: 10.7270/Q28K7B0R
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM50265034
PNG
(2',6-dimethyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)-N...)
Show SMILES Cc1nnc(o1)-c1ccc(c(C)c1)-c1cc(ccc1C)C(=O)Nc1cccc(c1)N1CCOCC1
Show InChI InChI=1S/C28H28N4O3/c1-18-7-8-21(27(33)29-23-5-4-6-24(17-23)32-11-13-34-14-12-32)16-26(18)25-10-9-22(15-19(25)2)28-31-30-20(3)35-28/h4-10,15-17H,11-14H2,1-3H3,(H,29,33)
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n/an/a>2.50E+4n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of PLK1


Bioorg Med Chem Lett 18: 5285-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.051
BindingDB Entry DOI: 10.7270/Q28K7B0R
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (human))
BDBM50265034
PNG
(2',6-dimethyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)-N...)
Show SMILES Cc1nnc(o1)-c1ccc(c(C)c1)-c1cc(ccc1C)C(=O)Nc1cccc(c1)N1CCOCC1
Show InChI InChI=1S/C28H28N4O3/c1-18-7-8-21(27(33)29-23-5-4-6-24(17-23)32-11-13-34-14-12-32)16-26(18)25-10-9-22(15-19(25)2)28-31-30-20(3)35-28/h4-10,15-17H,11-14H2,1-3H3,(H,29,33)
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n/an/a>3.30E+4n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of SGK1


Bioorg Med Chem Lett 18: 5285-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.051
BindingDB Entry DOI: 10.7270/Q28K7B0R
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (human))
BDBM50265034
PNG
(2',6-dimethyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)-N...)
Show SMILES Cc1nnc(o1)-c1ccc(c(C)c1)-c1cc(ccc1C)C(=O)Nc1cccc(c1)N1CCOCC1
Show InChI InChI=1S/C28H28N4O3/c1-18-7-8-21(27(33)29-23-5-4-6-24(17-23)32-11-13-34-14-12-32)16-26(18)25-10-9-22(15-19(25)2)28-31-30-20(3)35-28/h4-10,15-17H,11-14H2,1-3H3,(H,29,33)
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n/an/a>2.00E+4n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of CDK2


Bioorg Med Chem Lett 18: 5285-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.051
BindingDB Entry DOI: 10.7270/Q28K7B0R
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (human))
BDBM50265034
PNG
(2',6-dimethyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)-N...)
Show SMILES Cc1nnc(o1)-c1ccc(c(C)c1)-c1cc(ccc1C)C(=O)Nc1cccc(c1)N1CCOCC1
Show InChI InChI=1S/C28H28N4O3/c1-18-7-8-21(27(33)29-23-5-4-6-24(17-23)32-11-13-34-14-12-32)16-26(18)25-10-9-22(15-19(25)2)28-31-30-20(3)35-28/h4-10,15-17H,11-14H2,1-3H3,(H,29,33)
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n/an/a 400n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of MEK1 by cRaf/mek/Erk cascade assay


Bioorg Med Chem Lett 18: 5285-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.051
BindingDB Entry DOI: 10.7270/Q28K7B0R
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50264755
PNG
(4-methyl-N-(3-morpholin-4-ylphenyl)-3-(3-piperidin...)
Show SMILES Cc1ccc(cc1-c1ccc2c(noc2c1)C1CCNCC1)C(=O)Nc1cccc(c1)N1CCOCC1
Show InChI InChI=1S/C30H32N4O3/c1-20-5-6-23(30(35)32-24-3-2-4-25(19-24)34-13-15-36-16-14-34)17-27(20)22-7-8-26-28(18-22)37-33-29(26)21-9-11-31-12-10-21/h2-8,17-19,21,31H,9-16H2,1H3,(H,32,35)
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n/an/a>2.00E+4n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 18: 5285-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.051
BindingDB Entry DOI: 10.7270/Q28K7B0R
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (human))
BDBM50264755
PNG
(4-methyl-N-(3-morpholin-4-ylphenyl)-3-(3-piperidin...)
Show SMILES Cc1ccc(cc1-c1ccc2c(noc2c1)C1CCNCC1)C(=O)Nc1cccc(c1)N1CCOCC1
Show InChI InChI=1S/C30H32N4O3/c1-20-5-6-23(30(35)32-24-3-2-4-25(19-24)34-13-15-36-16-14-34)17-27(20)22-7-8-26-28(18-22)37-33-29(26)21-9-11-31-12-10-21/h2-8,17-19,21,31H,9-16H2,1H3,(H,32,35)
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n/an/a>3.30E+4n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of SGK1


Bioorg Med Chem Lett 18: 5285-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.051
BindingDB Entry DOI: 10.7270/Q28K7B0R
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM50264755
PNG
(4-methyl-N-(3-morpholin-4-ylphenyl)-3-(3-piperidin...)
Show SMILES Cc1ccc(cc1-c1ccc2c(noc2c1)C1CCNCC1)C(=O)Nc1cccc(c1)N1CCOCC1
Show InChI InChI=1S/C30H32N4O3/c1-20-5-6-23(30(35)32-24-3-2-4-25(19-24)34-13-15-36-16-14-34)17-27(20)22-7-8-26-28(18-22)37-33-29(26)21-9-11-31-12-10-21/h2-8,17-19,21,31H,9-16H2,1H3,(H,32,35)
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n/an/a>2.50E+4n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of PLK1


Bioorg Med Chem Lett 18: 5285-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.051
BindingDB Entry DOI: 10.7270/Q28K7B0R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (human))
BDBM50264755
PNG
(4-methyl-N-(3-morpholin-4-ylphenyl)-3-(3-piperidin...)
Show SMILES Cc1ccc(cc1-c1ccc2c(noc2c1)C1CCNCC1)C(=O)Nc1cccc(c1)N1CCOCC1
Show InChI InChI=1S/C30H32N4O3/c1-20-5-6-23(30(35)32-24-3-2-4-25(19-24)34-13-15-36-16-14-34)17-27(20)22-7-8-26-28(18-22)37-33-29(26)21-9-11-31-12-10-21/h2-8,17-19,21,31H,9-16H2,1H3,(H,32,35)
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n/an/a 8.00E+3n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of LCK


Bioorg Med Chem Lett 18: 5285-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.051
BindingDB Entry DOI: 10.7270/Q28K7B0R
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM50264755
PNG
(4-methyl-N-(3-morpholin-4-ylphenyl)-3-(3-piperidin...)
Show SMILES Cc1ccc(cc1-c1ccc2c(noc2c1)C1CCNCC1)C(=O)Nc1cccc(c1)N1CCOCC1
Show InChI InChI=1S/C30H32N4O3/c1-20-5-6-23(30(35)32-24-3-2-4-25(19-24)34-13-15-36-16-14-34)17-27(20)22-7-8-26-28(18-22)37-33-29(26)21-9-11-31-12-10-21/h2-8,17-19,21,31H,9-16H2,1H3,(H,32,35)
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n/an/a>1.60E+4n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of JNK3


Bioorg Med Chem Lett 18: 5285-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.051
BindingDB Entry DOI: 10.7270/Q28K7B0R
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-4 (HER4)


(Homo sapiens (Human))
BDBM50264755
PNG
(4-methyl-N-(3-morpholin-4-ylphenyl)-3-(3-piperidin...)
Show SMILES Cc1ccc(cc1-c1ccc2c(noc2c1)C1CCNCC1)C(=O)Nc1cccc(c1)N1CCOCC1
Show InChI InChI=1S/C30H32N4O3/c1-20-5-6-23(30(35)32-24-3-2-4-25(19-24)34-13-15-36-16-14-34)17-27(20)22-7-8-26-28(18-22)37-33-29(26)21-9-11-31-12-10-21/h2-8,17-19,21,31H,9-16H2,1H3,(H,32,35)
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n/an/a>2.50E+4n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of ErbB4


Bioorg Med Chem Lett 18: 5285-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.051
BindingDB Entry DOI: 10.7270/Q28K7B0R
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50265034
PNG
(2',6-dimethyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)-N...)
Show SMILES Cc1nnc(o1)-c1ccc(c(C)c1)-c1cc(ccc1C)C(=O)Nc1cccc(c1)N1CCOCC1
Show InChI InChI=1S/C28H28N4O3/c1-18-7-8-21(27(33)29-23-5-4-6-24(17-23)32-11-13-34-14-12-32)16-26(18)25-10-9-22(15-19(25)2)28-31-30-20(3)35-28/h4-10,15-17H,11-14H2,1-3H3,(H,29,33)
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n/an/a 6.00E+3n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 18: 5285-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.051
BindingDB Entry DOI: 10.7270/Q28K7B0R
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM50264755
PNG
(4-methyl-N-(3-morpholin-4-ylphenyl)-3-(3-piperidin...)
Show SMILES Cc1ccc(cc1-c1ccc2c(noc2c1)C1CCNCC1)C(=O)Nc1cccc(c1)N1CCOCC1
Show InChI InChI=1S/C30H32N4O3/c1-20-5-6-23(30(35)32-24-3-2-4-25(19-24)34-13-15-36-16-14-34)17-27(20)22-7-8-26-28(18-22)37-33-29(26)21-9-11-31-12-10-21/h2-8,17-19,21,31H,9-16H2,1H3,(H,32,35)
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n/an/a>2.00E+4n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of cFMS


Bioorg Med Chem Lett 18: 5285-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.051
BindingDB Entry DOI: 10.7270/Q28K7B0R
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (human))
BDBM50264755
PNG
(4-methyl-N-(3-morpholin-4-ylphenyl)-3-(3-piperidin...)
Show SMILES Cc1ccc(cc1-c1ccc2c(noc2c1)C1CCNCC1)C(=O)Nc1cccc(c1)N1CCOCC1
Show InChI InChI=1S/C30H32N4O3/c1-20-5-6-23(30(35)32-24-3-2-4-25(19-24)34-13-15-36-16-14-34)17-27(20)22-7-8-26-28(18-22)37-33-29(26)21-9-11-31-12-10-21/h2-8,17-19,21,31H,9-16H2,1H3,(H,32,35)
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GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of CDK2


Bioorg Med Chem Lett 18: 5285-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.051
BindingDB Entry DOI: 10.7270/Q28K7B0R
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (human))
BDBM50264755
PNG
(4-methyl-N-(3-morpholin-4-ylphenyl)-3-(3-piperidin...)
Show SMILES Cc1ccc(cc1-c1ccc2c(noc2c1)C1CCNCC1)C(=O)Nc1cccc(c1)N1CCOCC1
Show InChI InChI=1S/C30H32N4O3/c1-20-5-6-23(30(35)32-24-3-2-4-25(19-24)34-13-15-36-16-14-34)17-27(20)22-7-8-26-28(18-22)37-33-29(26)21-9-11-31-12-10-21/h2-8,17-19,21,31H,9-16H2,1H3,(H,32,35)
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n/an/a 40n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of MEK1 by cRaf/mek/Erk cascade assay


Bioorg Med Chem Lett 18: 5285-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.051
BindingDB Entry DOI: 10.7270/Q28K7B0R
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50264755
PNG
(4-methyl-N-(3-morpholin-4-ylphenyl)-3-(3-piperidin...)
Show SMILES Cc1ccc(cc1-c1ccc2c(noc2c1)C1CCNCC1)C(=O)Nc1cccc(c1)N1CCOCC1
Show InChI InChI=1S/C30H32N4O3/c1-20-5-6-23(30(35)32-24-3-2-4-25(19-24)34-13-15-36-16-14-34)17-27(20)22-7-8-26-28(18-22)37-33-29(26)21-9-11-31-12-10-21/h2-8,17-19,21,31H,9-16H2,1H3,(H,32,35)
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n/an/a>2.50E+4n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of EGFR


Bioorg Med Chem Lett 18: 5285-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.051
BindingDB Entry DOI: 10.7270/Q28K7B0R
More data for this
Ligand-Target Pair