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15 molecules are shown

Wt: 411.4
BDBM50265866
Wt: 318.4
BDBM50266327
Wt: 329.3
BDBM50266328
Wt: 432.4
BDBM50266329
Wt: 441.2
BDBM50266330
Wt: 428.4
BDBM50265922
Wt: 427.4
BDBM50265923
Wt: 400.3
BDBM50266287
Wt: 304.3
BDBM50266289
Wt: 372.3
BDBM50266254
Wt: 317.3
BDBM50266257
Wt: 415.4
BDBM50265837
Wt: 388.3
BDBM50265838
Wt: 388.3
BDBM50265839
Wt: 417.3
BDBM50265840

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 50265866,50266327,50266328,50266329,50266330,50265922,50265923,50266287,50266289,50266254,50266257,50265837,50265838,50265839,50265840   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50266254
PNG
(2-(4-methylpiperazin-1-yl)-8-phenyl-6-(trifluorome...)
Show SMILES CN1CCN(CC1)c1cnc2cc(cc(-c3ccccc3)c2n1)C(F)(F)F
Show InChI InChI=1S/C20H19F3N4/c1-26-7-9-27(10-8-26)18-13-24-17-12-15(20(21,22)23)11-16(19(17)25-18)14-5-3-2-4-6-14/h2-6,11-13H,7-10H2,1H3
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n/an/a 1.30E+3n/an/an/an/an/an/a



UCB Celltech

Curated by ChEMBL


Assay Description
Inhibition of human recombinant his-tagged c-Met by TR-FRET assay


Bioorg Med Chem Lett 19: 397-400 (2008)


Article DOI: 10.1016/j.bmcl.2008.11.062
BindingDB Entry DOI: 10.7270/Q2ZC82QC
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50265922
PNG
(5-(3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)q...)
Show SMILES CN1CCN(CC1)c1cnc2cc(cc(-c3ccc4[nH]c(=O)[nH]c4c3)c2n1)C(F)(F)F
Show InChI InChI=1S/C21H19F3N6O/c1-29-4-6-30(7-5-29)18-11-25-17-10-13(21(22,23)24)9-14(19(17)28-18)12-2-3-15-16(8-12)27-20(31)26-15/h2-3,8-11H,4-7H2,1H3,(H2,26,27,31)
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n/an/a 390n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50266287
PNG
(1-(4-(8-phenyl-6-(trifluoromethyl)quinoxalin-2-yl)...)
Show SMILES CC(=O)N1CCN(CC1)c1cnc2cc(cc(-c3ccccc3)c2n1)C(F)(F)F
Show InChI InChI=1S/C21H19F3N4O/c1-14(29)27-7-9-28(10-8-27)19-13-25-18-12-16(21(22,23)24)11-17(20(18)26-19)15-5-3-2-4-6-15/h2-6,11-13H,7-10H2,1H3
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n/an/a 1.30E+3n/an/an/an/an/an/a



UCB Celltech

Curated by ChEMBL


Assay Description
Inhibition of human recombinant his-tagged c-Met by TR-FRET assay


Bioorg Med Chem Lett 19: 397-400 (2008)


Article DOI: 10.1016/j.bmcl.2008.11.062
BindingDB Entry DOI: 10.7270/Q2ZC82QC
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50266289
PNG
(2-(4-methylpiperazin-1-yl)-8-phenylquinoxaline | C...)
Show SMILES CN1CCN(CC1)c1cnc2cccc(-c3ccccc3)c2n1
Show InChI InChI=1S/C19H20N4/c1-22-10-12-23(13-11-22)18-14-20-17-9-5-8-16(19(17)21-18)15-6-3-2-4-7-15/h2-9,14H,10-13H2,1H3
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n/an/a 2.83E+4n/an/an/an/an/an/a



UCB Celltech

Curated by ChEMBL


Assay Description
Inhibition of human recombinant his-tagged c-Met by TR-FRET assay


Bioorg Med Chem Lett 19: 397-400 (2008)


Article DOI: 10.1016/j.bmcl.2008.11.062
BindingDB Entry DOI: 10.7270/Q2ZC82QC
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50266327
PNG
(6-methyl-2-(4-methylpiperazin-1-yl)-8-phenylquinox...)
Show SMILES CN1CCN(CC1)c1cnc2cc(C)cc(-c3ccccc3)c2n1
Show InChI InChI=1S/C20H22N4/c1-15-12-17(16-6-4-3-5-7-16)20-18(13-15)21-14-19(22-20)24-10-8-23(2)9-11-24/h3-7,12-14H,8-11H2,1-2H3
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n/an/a 5.00E+3n/an/an/an/an/an/a



UCB Celltech

Curated by ChEMBL


Assay Description
Inhibition of human recombinant his-tagged c-Met by TR-FRET assay


Bioorg Med Chem Lett 19: 397-400 (2008)


Article DOI: 10.1016/j.bmcl.2008.11.062
BindingDB Entry DOI: 10.7270/Q2ZC82QC
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50266328
PNG
(2-(4-methylpiperazin-1-yl)-8-phenylquinoxaline-6-c...)
Show SMILES CN1CCN(CC1)c1cnc2cc(cc(-c3ccccc3)c2n1)C#N
Show InChI InChI=1S/C20H19N5/c1-24-7-9-25(10-8-24)19-14-22-18-12-15(13-21)11-17(20(18)23-19)16-5-3-2-4-6-16/h2-6,11-12,14H,7-10H2,1H3
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n/an/a 6.02E+4n/an/an/an/an/an/a



UCB Celltech

Curated by ChEMBL


Assay Description
Inhibition of human recombinant his-tagged c-Met by TR-FRET assay


Bioorg Med Chem Lett 19: 397-400 (2008)


Article DOI: 10.1016/j.bmcl.2008.11.062
BindingDB Entry DOI: 10.7270/Q2ZC82QC
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50266329
PNG
(8-(3,4-dimethoxyphenyl)-2-(4-methylpiperazin-1-yl)...)
Show SMILES COc1ccc(cc1OC)-c1cc(cc2ncc(nc12)N1CCN(C)CC1)C(F)(F)F
Show InChI InChI=1S/C22H23F3N4O2/c1-28-6-8-29(9-7-28)20-13-26-17-12-15(22(23,24)25)11-16(21(17)27-20)14-4-5-18(30-2)19(10-14)31-3/h4-5,10-13H,6-9H2,1-3H3
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n/an/a 1.50E+3n/an/an/an/an/an/a



UCB Celltech

Curated by ChEMBL


Assay Description
Inhibition of human recombinant his-tagged c-Met by TR-FRET assay


Bioorg Med Chem Lett 19: 397-400 (2008)


Article DOI: 10.1016/j.bmcl.2008.11.062
BindingDB Entry DOI: 10.7270/Q2ZC82QC
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50266330
PNG
(8-(2,3-dichlorophenyl)-2-(4-methylpiperazin-1-yl)-...)
Show SMILES CN1CCN(CC1)c1cnc2cc(cc(-c3cccc(Cl)c3Cl)c2n1)C(F)(F)F
Show InChI InChI=1S/C20H17Cl2F3N4/c1-28-5-7-29(8-6-28)17-11-26-16-10-12(20(23,24)25)9-14(19(16)27-17)13-3-2-4-15(21)18(13)22/h2-4,9-11H,5-8H2,1H3
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n/an/a 1.80E+3n/an/an/an/an/an/a



UCB Celltech

Curated by ChEMBL


Assay Description
Inhibition of human recombinant his-tagged c-Met by TR-FRET assay


Bioorg Med Chem Lett 19: 397-400 (2008)


Article DOI: 10.1016/j.bmcl.2008.11.062
BindingDB Entry DOI: 10.7270/Q2ZC82QC
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50265837
PNG
(3-(3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)q...)
Show SMILES CN1CCN(CC1)c1cnc2cc(cc(-c3cccc(c3)C(N)=O)c2n1)C(F)(F)F
Show InChI InChI=1S/C21H20F3N5O/c1-28-5-7-29(8-6-28)18-12-26-17-11-15(21(22,23)24)10-16(19(17)27-18)13-3-2-4-14(9-13)20(25)30/h2-4,9-12H,5-8H2,1H3,(H2,25,30)
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n/an/a 5.00E+3n/an/an/an/an/an/a



UCB Celltech

Curated by ChEMBL


Assay Description
Inhibition of human recombinant his-tagged c-Met by TR-FRET assay


Bioorg Med Chem Lett 19: 397-400 (2008)


Article DOI: 10.1016/j.bmcl.2008.11.062
BindingDB Entry DOI: 10.7270/Q2ZC82QC
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50265838
PNG
(3-(3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)q...)
Show SMILES CN1CCN(CC1)c1cnc2cc(cc(-c3cccc(O)c3)c2n1)C(F)(F)F
Show InChI InChI=1S/C20H19F3N4O/c1-26-5-7-27(8-6-26)18-12-24-17-11-14(20(21,22)23)10-16(19(17)25-18)13-3-2-4-15(28)9-13/h2-4,9-12,28H,5-8H2,1H3
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n/an/a 900n/an/an/an/an/an/a



UCB Celltech

Curated by ChEMBL


Assay Description
Inhibition of human recombinant his-tagged c-Met by TR-FRET assay


Bioorg Med Chem Lett 19: 397-400 (2008)


Article DOI: 10.1016/j.bmcl.2008.11.062
BindingDB Entry DOI: 10.7270/Q2ZC82QC
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50265839
PNG
(4-(3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)q...)
Show SMILES CN1CCN(CC1)c1cnc2cc(cc(-c3ccc(O)cc3)c2n1)C(F)(F)F
Show InChI InChI=1S/C20H19F3N4O/c1-26-6-8-27(9-7-26)18-12-24-17-11-14(20(21,22)23)10-16(19(17)25-18)13-2-4-15(28)5-3-13/h2-5,10-12,28H,6-9H2,1H3
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n/an/a 800n/an/an/an/an/an/a



UCB Celltech

Curated by ChEMBL


Assay Description
Inhibition of human recombinant his-tagged c-Met by TR-FRET assay


Bioorg Med Chem Lett 19: 397-400 (2008)


Article DOI: 10.1016/j.bmcl.2008.11.062
BindingDB Entry DOI: 10.7270/Q2ZC82QC
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50265840
PNG
(2-(4-methylpiperazin-1-yl)-8-(3-nitrophenyl)-6-(tr...)
Show SMILES CN1CCN(CC1)c1cnc2cc(cc(-c3cccc(c3)[N+]([O-])=O)c2n1)C(F)(F)F
Show InChI InChI=1S/C20H18F3N5O2/c1-26-5-7-27(8-6-26)18-12-24-17-11-14(20(21,22)23)10-16(19(17)25-18)13-3-2-4-15(9-13)28(29)30/h2-4,9-12H,5-8H2,1H3
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n/an/a 1.29E+4n/an/an/an/an/an/a



UCB Celltech

Curated by ChEMBL


Assay Description
Inhibition of human recombinant his-tagged c-Met by TR-FRET assay


Bioorg Med Chem Lett 19: 397-400 (2008)


Article DOI: 10.1016/j.bmcl.2008.11.062
BindingDB Entry DOI: 10.7270/Q2ZC82QC
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50265866
PNG
(8-(1H-indol-6-yl)-2-(4-methylpiperazin-1-yl)-6-(tr...)
Show SMILES CN1CCN(CC1)c1cnc2cc(cc(-c3ccc4cc[nH]c4c3)c2n1)C(F)(F)F
Show InChI InChI=1S/C22H20F3N5/c1-29-6-8-30(9-7-29)20-13-27-19-12-16(22(23,24)25)11-17(21(19)28-20)15-3-2-14-4-5-26-18(14)10-15/h2-5,10-13,26H,6-9H2,1H3
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n/an/a 2.00E+3n/an/an/an/an/an/a



UCB Celltech

Curated by ChEMBL


Assay Description
Inhibition of human recombinant his-tagged c-Met by TR-FRET assay


Bioorg Med Chem Lett 19: 397-400 (2008)


Article DOI: 10.1016/j.bmcl.2008.11.062
BindingDB Entry DOI: 10.7270/Q2ZC82QC
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50265922
PNG
(5-(3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)q...)
Show SMILES CN1CCN(CC1)c1cnc2cc(cc(-c3ccc4[nH]c(=O)[nH]c4c3)c2n1)C(F)(F)F
Show InChI InChI=1S/C21H19F3N6O/c1-29-4-6-30(7-5-29)18-11-25-17-10-13(21(22,23)24)9-14(19(17)28-18)12-2-3-15-16(8-12)27-20(31)26-15/h2-3,8-11H,4-7H2,1H3,(H2,26,27,31)
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n/an/a 390n/an/an/an/an/an/a



UCB Celltech

Curated by ChEMBL


Assay Description
Inhibition of human recombinant his-tagged c-Met by TR-FRET assay


Bioorg Med Chem Lett 19: 397-400 (2008)


Article DOI: 10.1016/j.bmcl.2008.11.062
BindingDB Entry DOI: 10.7270/Q2ZC82QC
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50265923
PNG
(5-(3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)q...)
Show SMILES CN1CCN(CC1)c1cnc2cc(cc(-c3ccc4NC(=O)Cc4c3)c2n1)C(F)(F)F
Show InChI InChI=1S/C22H20F3N5O/c1-29-4-6-30(7-5-29)19-12-26-18-11-15(22(23,24)25)10-16(21(18)28-19)13-2-3-17-14(8-13)9-20(31)27-17/h2-3,8,10-12H,4-7,9H2,1H3,(H,27,31)
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n/an/a 170n/an/an/an/an/an/a



UCB Celltech

Curated by ChEMBL


Assay Description
Inhibition of human recombinant his-tagged c-Met by TR-FRET assay


Bioorg Med Chem Lett 19: 397-400 (2008)


Article DOI: 10.1016/j.bmcl.2008.11.062
BindingDB Entry DOI: 10.7270/Q2ZC82QC
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50266254
PNG
(2-(4-methylpiperazin-1-yl)-8-phenyl-6-(trifluorome...)
Show SMILES CN1CCN(CC1)c1cnc2cc(cc(-c3ccccc3)c2n1)C(F)(F)F
Show InChI InChI=1S/C20H19F3N4/c1-26-7-9-27(10-8-26)18-13-24-17-12-15(20(21,22)23)11-16(19(17)25-18)14-5-3-2-4-6-14/h2-6,11-13H,7-10H2,1H3
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n/an/a 1.30E+3n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50266257
PNG
(CHEMBL456722 | N,N-dimethyl-8-phenyl-6-(trifluorom...)
Show SMILES CN(C)c1cnc2cc(cc(-c3ccccc3)c2n1)C(F)(F)F
Show InChI InChI=1S/C17H14F3N3/c1-23(2)15-10-21-14-9-12(17(18,19)20)8-13(16(14)22-15)11-6-4-3-5-7-11/h3-10H,1-2H3
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n/an/a 5.30E+3n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50266327
PNG
(6-methyl-2-(4-methylpiperazin-1-yl)-8-phenylquinox...)
Show SMILES CN1CCN(CC1)c1cnc2cc(C)cc(-c3ccccc3)c2n1
Show InChI InChI=1S/C20H22N4/c1-15-12-17(16-6-4-3-5-7-16)20-18(13-15)21-14-19(22-20)24-10-8-23(2)9-11-24/h3-7,12-14H,8-11H2,1-2H3
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n/an/a 5.00E+3n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50265839
PNG
(4-(3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)q...)
Show SMILES CN1CCN(CC1)c1cnc2cc(cc(-c3ccc(O)cc3)c2n1)C(F)(F)F
Show InChI InChI=1S/C20H19F3N4O/c1-26-6-8-27(9-7-26)18-12-24-17-11-14(20(21,22)23)10-16(19(17)25-18)13-2-4-15(28)5-3-13/h2-5,10-12,28H,6-9H2,1H3
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n/an/a 800n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50265866
PNG
(8-(1H-indol-6-yl)-2-(4-methylpiperazin-1-yl)-6-(tr...)
Show SMILES CN1CCN(CC1)c1cnc2cc(cc(-c3ccc4cc[nH]c4c3)c2n1)C(F)(F)F
Show InChI InChI=1S/C22H20F3N5/c1-29-6-8-30(9-7-29)20-13-27-19-12-16(22(23,24)25)11-17(21(19)28-20)15-3-2-14-4-5-26-18(14)10-15/h2-5,10-13,26H,6-9H2,1H3
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n/an/a 2.00E+3n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50266287
PNG
(1-(4-(8-phenyl-6-(trifluoromethyl)quinoxalin-2-yl)...)
Show SMILES CC(=O)N1CCN(CC1)c1cnc2cc(cc(-c3ccccc3)c2n1)C(F)(F)F
Show InChI InChI=1S/C21H19F3N4O/c1-14(29)27-7-9-28(10-8-27)19-13-25-18-12-16(21(22,23)24)11-17(20(18)26-19)15-5-3-2-4-6-15/h2-6,11-13H,7-10H2,1H3
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n/an/a 1.30E+3n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50266329
PNG
(8-(3,4-dimethoxyphenyl)-2-(4-methylpiperazin-1-yl)...)
Show SMILES COc1ccc(cc1OC)-c1cc(cc2ncc(nc12)N1CCN(C)CC1)C(F)(F)F
Show InChI InChI=1S/C22H23F3N4O2/c1-28-6-8-29(9-7-28)20-13-26-17-12-15(22(23,24)25)11-16(21(17)27-20)14-4-5-18(30-2)19(10-14)31-3/h4-5,10-13H,6-9H2,1-3H3
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n/an/a 1.50E+3n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50266330
PNG
(8-(2,3-dichlorophenyl)-2-(4-methylpiperazin-1-yl)-...)
Show SMILES CN1CCN(CC1)c1cnc2cc(cc(-c3cccc(Cl)c3Cl)c2n1)C(F)(F)F
Show InChI InChI=1S/C20H17Cl2F3N4/c1-28-5-7-29(8-6-28)17-11-26-16-10-12(20(23,24)25)9-14(19(16)27-17)13-3-2-4-15(21)18(13)22/h2-4,9-11H,5-8H2,1H3
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n/an/a 1.80E+3n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50265837
PNG
(3-(3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)q...)
Show SMILES CN1CCN(CC1)c1cnc2cc(cc(-c3cccc(c3)C(N)=O)c2n1)C(F)(F)F
Show InChI InChI=1S/C21H20F3N5O/c1-28-5-7-29(8-6-28)18-12-26-17-11-15(21(22,23)24)10-16(19(17)27-18)13-3-2-4-14(9-13)20(25)30/h2-4,9-12H,5-8H2,1H3,(H2,25,30)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50265838
PNG
(3-(3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)q...)
Show SMILES CN1CCN(CC1)c1cnc2cc(cc(-c3cccc(O)c3)c2n1)C(F)(F)F
Show InChI InChI=1S/C20H19F3N4O/c1-26-5-7-27(8-6-26)18-12-24-17-11-14(20(21,22)23)10-16(19(17)25-18)13-3-2-4-15(28)9-13/h2-4,9-12,28H,5-8H2,1H3
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n/an/a 900n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50265923
PNG
(5-(3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)q...)
Show SMILES CN1CCN(CC1)c1cnc2cc(cc(-c3ccc4NC(=O)Cc4c3)c2n1)C(F)(F)F
Show InChI InChI=1S/C22H20F3N5O/c1-29-4-6-30(7-5-29)19-12-26-18-11-15(22(23,24)25)10-16(21(18)28-19)13-2-3-17-14(8-13)9-20(31)27-17/h2-3,8,10-12H,4-7,9H2,1H3,(H,27,31)
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n/an/a 170n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50266257
PNG
(CHEMBL456722 | N,N-dimethyl-8-phenyl-6-(trifluorom...)
Show SMILES CN(C)c1cnc2cc(cc(-c3ccccc3)c2n1)C(F)(F)F
Show InChI InChI=1S/C17H14F3N3/c1-23(2)15-10-21-14-9-12(17(18,19)20)8-13(16(14)22-15)11-6-4-3-5-7-11/h3-10H,1-2H3
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n/an/a 5.30E+3n/an/an/an/an/an/a



UCB Celltech

Curated by ChEMBL


Assay Description
Inhibition of human recombinant his-tagged c-Met by TR-FRET assay


Bioorg Med Chem Lett 19: 397-400 (2008)


Article DOI: 10.1016/j.bmcl.2008.11.062
BindingDB Entry DOI: 10.7270/Q2ZC82QC
More data for this
Ligand-Target Pair