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6 similar compounds to monomer 50443746

Compile data set for download or QSAR
Wt: 373.3
BDBM50276519
Wt: 279.2
BDBM50443761
Wt: 315.2
BDBM50443743
Wt: 315.2
BDBM50443744
Wt: 315.2
BDBM50443745
Wt: 261.2
BDBM50443753

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50276519,50443761,50443743,50443744,50443745,50443753   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast activation protein alpha


(Homo sapiens (Human))
BDBM50443743
PNG
(CHEMBL3093915)
Show SMILES N[C@@H](Cc1cc(F)cc(F)c1F)C(=O)N1C[C@@H](F)C[C@H]1C#N
Show InChI InChI=1S/C14H13F4N3O/c15-8-1-7(13(18)11(17)4-8)2-12(20)14(22)21-6-9(16)3-10(21)5-19/h1,4,9-10,12H,2-3,6,20H2/t9-,10-,12-/m0/s1
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n/an/a 900n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of 6xHis-tagged recombinant FAP (unknown origin) expressed in baculovirus expression system assessed as hydrolysis of Nle-Pro-aminomethylc...


Bioorg Med Chem 21: 7418-29 (2013)


Article DOI: 10.1016/j.bmc.2013.09.048
BindingDB Entry DOI: 10.7270/Q2WS8VPZ
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50276519
PNG
((2R,4R)-1-((S)-2-amino-3,3-bis(4-fluorophenyl)prop...)
Show SMILES N[C@@H](C(c1ccc(F)cc1)c1ccc(F)cc1)C(=O)N1C[C@H](F)C[C@@H]1C#N
Show InChI InChI=1S/C20H18F3N3O/c21-14-5-1-12(2-6-14)18(13-3-7-15(22)8-4-13)19(25)20(27)26-11-16(23)9-17(26)10-24/h1-8,16-19H,9,11,25H2/t16-,17-,19+/m1/s1
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n/an/a 22n/an/an/an/an/an/a



Matrix Laboratories Limited

Curated by ChEMBL


Assay Description
Inhibition of DPP4


Bioorg Med Chem 17: 1783-802 (2009)


Article DOI: 10.1016/j.bmc.2009.01.061
BindingDB Entry DOI: 10.7270/Q2VD70DJ
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50443743
PNG
(CHEMBL3093915)
Show SMILES N[C@@H](Cc1cc(F)cc(F)c1F)C(=O)N1C[C@@H](F)C[C@H]1C#N
Show InChI InChI=1S/C14H13F4N3O/c15-8-1-7(13(18)11(17)4-8)2-12(20)14(22)21-6-9(16)3-10(21)5-19/h1,4,9-10,12H,2-3,6,20H2/t9-,10-,12-/m0/s1
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n/an/a 2.35E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of 6xHis-tagged recombinant DPP8 (unknown origin) expressed in baculovirus expression system assessed as hydrolysis of Ala-Pro-aminomethyl...


Bioorg Med Chem 21: 7418-29 (2013)


Article DOI: 10.1016/j.bmc.2013.09.048
BindingDB Entry DOI: 10.7270/Q2WS8VPZ
More data for this
Ligand-Target Pair
Fibroblast activation protein alpha


(Homo sapiens (Human))
BDBM50443744
PNG
(CHEMBL3091488)
Show SMILES N[C@@H](Cc1ccc(F)c(F)c1F)C(=O)N1C[C@@H](F)C[C@H]1C#N
Show InChI InChI=1S/C14H13F4N3O/c15-8-4-9(5-19)21(6-8)14(22)11(20)3-7-1-2-10(16)13(18)12(7)17/h1-2,8-9,11H,3-4,6,20H2/t8-,9-,11-/m0/s1
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Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of 6xHis-tagged recombinant FAP (unknown origin) expressed in baculovirus expression system assessed as hydrolysis of Nle-Pro-aminomethylc...


Bioorg Med Chem 21: 7418-29 (2013)


Article DOI: 10.1016/j.bmc.2013.09.048
BindingDB Entry DOI: 10.7270/Q2WS8VPZ
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM50443744
PNG
(CHEMBL3091488)
Show SMILES N[C@@H](Cc1ccc(F)c(F)c1F)C(=O)N1C[C@@H](F)C[C@H]1C#N
Show InChI InChI=1S/C14H13F4N3O/c15-8-4-9(5-19)21(6-8)14(22)11(20)3-7-1-2-10(16)13(18)12(7)17/h1-2,8-9,11H,3-4,6,20H2/t8-,9-,11-/m0/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of 6xHis-tagged recombinant DPP9 (unknown origin) expressed in baculovirus expression system assessed as hydrolysis of Ala-Pro-aminomethyl...


Bioorg Med Chem 21: 7418-29 (2013)


Article DOI: 10.1016/j.bmc.2013.09.048
BindingDB Entry DOI: 10.7270/Q2WS8VPZ
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50443744
PNG
(CHEMBL3091488)
Show SMILES N[C@@H](Cc1ccc(F)c(F)c1F)C(=O)N1C[C@@H](F)C[C@H]1C#N
Show InChI InChI=1S/C14H13F4N3O/c15-8-4-9(5-19)21(6-8)14(22)11(20)3-7-1-2-10(16)13(18)12(7)17/h1-2,8-9,11H,3-4,6,20H2/t8-,9-,11-/m0/s1
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n/an/a 1.07E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of 6xHis-tagged recombinant DPP8 (unknown origin) expressed in baculovirus expression system assessed as hydrolysis of Ala-Pro-aminomethyl...


Bioorg Med Chem 21: 7418-29 (2013)


Article DOI: 10.1016/j.bmc.2013.09.048
BindingDB Entry DOI: 10.7270/Q2WS8VPZ
More data for this
Ligand-Target Pair
Fibroblast activation protein alpha


(Homo sapiens (Human))
BDBM50443745
PNG
(CHEMBL3093914)
Show SMILES N[C@@H](Cc1cc(F)c(F)cc1F)C(=O)N1C[C@@H](F)C[C@H]1C#N
Show InChI InChI=1S/C14H13F4N3O/c15-8-3-9(5-19)21(6-8)14(22)13(20)2-7-1-11(17)12(18)4-10(7)16/h1,4,8-9,13H,2-3,6,20H2/t8-,9-,13-/m0/s1
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Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of 6xHis-tagged recombinant FAP (unknown origin) expressed in baculovirus expression system assessed as hydrolysis of Nle-Pro-aminomethylc...


Bioorg Med Chem 21: 7418-29 (2013)


Article DOI: 10.1016/j.bmc.2013.09.048
BindingDB Entry DOI: 10.7270/Q2WS8VPZ
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM50443745
PNG
(CHEMBL3093914)
Show SMILES N[C@@H](Cc1cc(F)c(F)cc1F)C(=O)N1C[C@@H](F)C[C@H]1C#N
Show InChI InChI=1S/C14H13F4N3O/c15-8-3-9(5-19)21(6-8)14(22)13(20)2-7-1-11(17)12(18)4-10(7)16/h1,4,8-9,13H,2-3,6,20H2/t8-,9-,13-/m0/s1
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n/an/a 2.74E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of 6xHis-tagged recombinant DPP9 (unknown origin) expressed in baculovirus expression system assessed as hydrolysis of Ala-Pro-aminomethyl...


Bioorg Med Chem 21: 7418-29 (2013)


Article DOI: 10.1016/j.bmc.2013.09.048
BindingDB Entry DOI: 10.7270/Q2WS8VPZ
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50443745
PNG
(CHEMBL3093914)
Show SMILES N[C@@H](Cc1cc(F)c(F)cc1F)C(=O)N1C[C@@H](F)C[C@H]1C#N
Show InChI InChI=1S/C14H13F4N3O/c15-8-3-9(5-19)21(6-8)14(22)13(20)2-7-1-11(17)12(18)4-10(7)16/h1,4,8-9,13H,2-3,6,20H2/t8-,9-,13-/m0/s1
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n/an/a 3.35E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of 6xHis-tagged recombinant DPP8 (unknown origin) expressed in baculovirus expression system assessed as hydrolysis of Ala-Pro-aminomethyl...


Bioorg Med Chem 21: 7418-29 (2013)


Article DOI: 10.1016/j.bmc.2013.09.048
BindingDB Entry DOI: 10.7270/Q2WS8VPZ
More data for this
Ligand-Target Pair
Fibroblast activation protein alpha


(Homo sapiens (Human))
BDBM50443753
PNG
(CHEMBL3093902)
Show SMILES N[C@@H](Cc1ccccc1)C(=O)N1C[C@@H](F)C[C@H]1C#N
Show InChI InChI=1S/C14H16FN3O/c15-11-7-12(8-16)18(9-11)14(19)13(17)6-10-4-2-1-3-5-10/h1-5,11-13H,6-7,9,17H2/t11-,12-,13-/m0/s1
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n/an/a 1.53E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of 6xHis-tagged recombinant FAP (unknown origin) expressed in baculovirus expression system assessed as hydrolysis of Nle-Pro-aminomethylc...


Bioorg Med Chem 21: 7418-29 (2013)


Article DOI: 10.1016/j.bmc.2013.09.048
BindingDB Entry DOI: 10.7270/Q2WS8VPZ
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM50443753
PNG
(CHEMBL3093902)
Show SMILES N[C@@H](Cc1ccccc1)C(=O)N1C[C@@H](F)C[C@H]1C#N
Show InChI InChI=1S/C14H16FN3O/c15-11-7-12(8-16)18(9-11)14(19)13(17)6-10-4-2-1-3-5-10/h1-5,11-13H,6-7,9,17H2/t11-,12-,13-/m0/s1
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n/an/a 1.98E+4n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of 6xHis-tagged recombinant DPP9 (unknown origin) expressed in baculovirus expression system assessed as hydrolysis of Ala-Pro-aminomethyl...


Bioorg Med Chem 21: 7418-29 (2013)


Article DOI: 10.1016/j.bmc.2013.09.048
BindingDB Entry DOI: 10.7270/Q2WS8VPZ
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50443753
PNG
(CHEMBL3093902)
Show SMILES N[C@@H](Cc1ccccc1)C(=O)N1C[C@@H](F)C[C@H]1C#N
Show InChI InChI=1S/C14H16FN3O/c15-11-7-12(8-16)18(9-11)14(19)13(17)6-10-4-2-1-3-5-10/h1-5,11-13H,6-7,9,17H2/t11-,12-,13-/m0/s1
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n/an/a 2.25E+4n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of 6xHis-tagged recombinant DPP8 (unknown origin) expressed in baculovirus expression system assessed as hydrolysis of Ala-Pro-aminomethyl...


Bioorg Med Chem 21: 7418-29 (2013)


Article DOI: 10.1016/j.bmc.2013.09.048
BindingDB Entry DOI: 10.7270/Q2WS8VPZ
More data for this
Ligand-Target Pair
Fibroblast activation protein alpha


(Homo sapiens (Human))
BDBM50443761
PNG
(CHEMBL3093903)
Show SMILES N[C@@H](Cc1ccc(F)cc1)C(=O)N1C[C@@H](F)C[C@H]1C#N
Show InChI InChI=1S/C14H15F2N3O/c15-10-3-1-9(2-4-10)5-13(18)14(20)19-8-11(16)6-12(19)7-17/h1-4,11-13H,5-6,8,18H2/t11-,12-,13-/m0/s1
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n/an/a 82n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of 6xHis-tagged recombinant FAP (unknown origin) expressed in baculovirus expression system assessed as hydrolysis of Nle-Pro-aminomethylc...


Bioorg Med Chem 21: 7418-29 (2013)


Article DOI: 10.1016/j.bmc.2013.09.048
BindingDB Entry DOI: 10.7270/Q2WS8VPZ
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM50443761
PNG
(CHEMBL3093903)
Show SMILES N[C@@H](Cc1ccc(F)cc1)C(=O)N1C[C@@H](F)C[C@H]1C#N
Show InChI InChI=1S/C14H15F2N3O/c15-10-3-1-9(2-4-10)5-13(18)14(20)19-8-11(16)6-12(19)7-17/h1-4,11-13H,5-6,8,18H2/t11-,12-,13-/m0/s1
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n/an/a 1.39E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of 6xHis-tagged recombinant DPP9 (unknown origin) expressed in baculovirus expression system assessed as hydrolysis of Ala-Pro-aminomethyl...


Bioorg Med Chem 21: 7418-29 (2013)


Article DOI: 10.1016/j.bmc.2013.09.048
BindingDB Entry DOI: 10.7270/Q2WS8VPZ
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50443761
PNG
(CHEMBL3093903)
Show SMILES N[C@@H](Cc1ccc(F)cc1)C(=O)N1C[C@@H](F)C[C@H]1C#N
Show InChI InChI=1S/C14H15F2N3O/c15-10-3-1-9(2-4-10)5-13(18)14(20)19-8-11(16)6-12(19)7-17/h1-4,11-13H,5-6,8,18H2/t11-,12-,13-/m0/s1
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n/an/a 2.91E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of 6xHis-tagged recombinant DPP8 (unknown origin) expressed in baculovirus expression system assessed as hydrolysis of Ala-Pro-aminomethyl...


Bioorg Med Chem 21: 7418-29 (2013)


Article DOI: 10.1016/j.bmc.2013.09.048
BindingDB Entry DOI: 10.7270/Q2WS8VPZ
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM50443743
PNG
(CHEMBL3093915)
Show SMILES N[C@@H](Cc1cc(F)cc(F)c1F)C(=O)N1C[C@@H](F)C[C@H]1C#N
Show InChI InChI=1S/C14H13F4N3O/c15-8-1-7(13(18)11(17)4-8)2-12(20)14(22)21-6-9(16)3-10(21)5-19/h1,4,9-10,12H,2-3,6,20H2/t9-,10-,12-/m0/s1
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n/an/a 7.36E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of 6xHis-tagged recombinant DPP9 (unknown origin) expressed in baculovirus expression system assessed as hydrolysis of Ala-Pro-aminomethyl...


Bioorg Med Chem 21: 7418-29 (2013)


Article DOI: 10.1016/j.bmc.2013.09.048
BindingDB Entry DOI: 10.7270/Q2WS8VPZ
More data for this
Ligand-Target Pair