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5 similar compounds to monomer 50276571

Wt: 369.2
BDBM50276628
Wt: 376.8
BDBM50276629
Wt: 334.7
BDBM50276570
Wt: 318.7
BDBM50276572
Wt: 364.8
BDBM50276573

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50276628,50276629,50276570,50276572,50276573   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM50276570
PNG
(4-chloro-6-(5-(4-methoxyphenyl)-1,2,3-thiadiazol-4...)
Show SMILES COc1ccc(cc1)-c1snnc1-c1cc(Cl)c(O)cc1O
Show InChI InChI=1S/C15H11ClN2O3S/c1-21-9-4-2-8(3-5-9)15-14(17-18-22-15)10-6-11(16)13(20)7-12(10)19/h2-7,19-20H,1H3
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PDB
Article
PubMed
n/an/an/a 13n/an/an/an/an/a



Fermentas UAB

Curated by ChEMBL


Assay Description
Binding affinity to human full length Histidine6-tagged Hsp90alpha expressed in Escherichia coli BL21 DE3 by ITC


Bioorg Med Chem Lett 19: 1089-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.003
BindingDB Entry DOI: 10.7270/Q27944KP
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM50276572
PNG
(4-chloro-6-(5-p-tolyl-1,2,3-thiadiazol-4-yl)benzen...)
Show SMILES Cc1ccc(cc1)-c1snnc1-c1cc(Cl)c(O)cc1O
Show InChI InChI=1S/C15H11ClN2O2S/c1-8-2-4-9(5-3-8)15-14(17-18-21-15)10-6-11(16)13(20)7-12(10)19/h2-7,19-20H,1H3
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Article
PubMed
n/an/an/a 17n/an/an/an/an/a



Fermentas UAB

Curated by ChEMBL


Assay Description
Binding affinity to human full length Histidine6-tagged Hsp90alpha expressed in Escherichia coli BL21 DE3 by ITC


Bioorg Med Chem Lett 19: 1089-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.003
BindingDB Entry DOI: 10.7270/Q27944KP
More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM50276629
PNG
(2-chloro-4-(5-(4-ethoxyphenyl)-1,2,3-thiadiazol-4-...)
Show SMILES CCOc1ccc(cc1)-c1snnc1-c1cc(CC)c(O)c(Cl)c1O
Show InChI InChI=1S/C18H17ClN2O3S/c1-3-10-9-13(17(23)14(19)16(10)22)15-18(25-21-20-15)11-5-7-12(8-6-11)24-4-2/h5-9,22-23H,3-4H2,1-2H3
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PubMed
n/an/an/a>2.00E+4n/an/an/an/an/a



Fermentas UAB

Curated by ChEMBL


Assay Description
Binding affinity to human full length Histidine6-tagged Hsp90alpha expressed in Escherichia coli BL21 DE3 by ITC


Bioorg Med Chem Lett 19: 1089-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.003
BindingDB Entry DOI: 10.7270/Q27944KP
More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM50276628
PNG
(2,4-dichloro-6-(5-(4-methoxyphenyl)-1,2,3-thiadiaz...)
Show SMILES COc1ccc(cc1)-c1snnc1-c1cc(Cl)c(O)c(Cl)c1O
Show InChI InChI=1S/C15H10Cl2N2O3S/c1-22-8-4-2-7(3-5-8)15-12(18-19-23-15)9-6-10(16)14(21)11(17)13(9)20/h2-6,20-21H,1H3
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PubMed
n/an/an/a>2.00E+4n/an/an/an/an/a



Fermentas UAB

Curated by ChEMBL


Assay Description
Binding affinity to human full length Histidine6-tagged Hsp90alpha expressed in Escherichia coli BL21 DE3 by ITC


Bioorg Med Chem Lett 19: 1089-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.003
BindingDB Entry DOI: 10.7270/Q27944KP
More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM50276573
PNG
(4-chloro-6-(5-(3,4-dimethoxyphenyl)-1,2,3-thiadiaz...)
Show SMILES COc1ccc(cc1OC)-c1snnc1-c1cc(Cl)c(O)cc1O
Show InChI InChI=1S/C16H13ClN2O4S/c1-22-13-4-3-8(5-14(13)23-2)16-15(18-19-24-16)9-6-10(17)12(21)7-11(9)20/h3-7,20-21H,1-2H3
PDB
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PDB
Article
PubMed
n/an/an/a 34n/an/an/an/an/a



Fermentas UAB

Curated by ChEMBL


Assay Description
Binding affinity to human full length Histidine6-tagged Hsp90alpha expressed in Escherichia coli BL21 DE3 by ITC


Bioorg Med Chem Lett 19: 1089-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.003
BindingDB Entry DOI: 10.7270/Q27944KP
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)