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20 similar compounds to monomer 50279717

Compile data set for download or QSAR
Wt: 400.4
BDBM50279433
Wt: 418.9
BDBM50279434
Wt: 398.4
BDBM50279435
Wt: 415.4
BDBM50279436
Wt: 429.5
BDBM50279453
Wt: 443.5
BDBM50279454
Wt: 457.5
BDBM50279455
Wt: 399.4
BDBM50279456
Wt: 419.9
BDBM50279471
Wt: 414.4
BDBM50279738
Wt: 428.5
BDBM50279739
Wt: 442.5
BDBM50279740
Wt: 456.5
BDBM50279741
Wt: 429.5
BDBM50279700
Wt: 443.5
BDBM50279701
Displayed 1 to 15 (of 20 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 30 hits for monomerid = 50279433,50279434,50279435,50279436,50279453,50279454,50279455,50279456,50279471,50279738,50279739,50279740,50279741,50279700,50279701   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50279453
PNG
(1-(6-ethoxy-2,3-dihydrochromen-4-ylideneamino)-3-(...)
Show SMILES CCOc1ccc2OCCC(=Nn3cc(O)n(CCCN4CCN(C)CC4)c3=O)c2c1
Show InChI InChI=1S/C22H31N5O4/c1-3-30-17-5-6-20-18(15-17)19(7-14-31-20)23-27-16-21(28)26(22(27)29)9-4-8-25-12-10-24(2)11-13-25/h5-6,15-16,28H,3-4,7-14H2,1-2H3
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n/an/a 27n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of KVLQT1/minK in guinea pig ventricular myocytes assessed as blockade of slow delayed rectifier potassium current by whole cell patch-cla...


Bioorg Med Chem Lett 19: 1477-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.022
BindingDB Entry DOI: 10.7270/Q22J6BQK
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50279740
PNG
(1-(2,3-dihydro-6-propoxychromen-4-ylideneamino)-3-...)
Show SMILES CCCOc1ccc2OCCC(=Nn3cc(O)n(CCCCN4CCCCC4)c3=O)c2c1
Show InChI InChI=1S/C24H34N4O4/c1-2-15-31-19-8-9-22-20(17-19)21(10-16-32-22)25-28-18-23(29)27(24(28)30)14-7-6-13-26-11-4-3-5-12-26/h8-9,17-18,29H,2-7,10-16H2,1H3
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n/an/a 3.20n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of KVLQT1/minK in guinea pig ventricular myocytes assessed as blockade of slow delayed rectifier potassium current by whole cell patch-cla...


Bioorg Med Chem Lett 19: 1477-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.022
BindingDB Entry DOI: 10.7270/Q22J6BQK
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50279456
PNG
(1-(2,3-dihydro-6-methylchromen-4-ylideneamino)-3-(...)
Show SMILES CN1CCN(CCCn2c(O)cn(N=C3CCOc4ccc(C)cc34)c2=O)CC1
Show InChI InChI=1S/C21H29N5O3/c1-16-4-5-19-17(14-16)18(6-13-29-19)22-26-15-20(27)25(21(26)28)8-3-7-24-11-9-23(2)10-12-24/h4-5,14-15,27H,3,6-13H2,1-2H3
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n/an/a 304n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of KVLQT1/minK in guinea pig ventricular myocytes assessed as blockade of slow delayed rectifier potassium current by whole cell patch-cla...


Bioorg Med Chem Lett 19: 1477-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.022
BindingDB Entry DOI: 10.7270/Q22J6BQK
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Cavia porcellus)
BDBM50279740
PNG
(1-(2,3-dihydro-6-propoxychromen-4-ylideneamino)-3-...)
Show SMILES CCCOc1ccc2OCCC(=Nn3cc(O)n(CCCCN4CCCCC4)c3=O)c2c1
Show InChI InChI=1S/C24H34N4O4/c1-2-15-31-19-8-9-22-20(17-19)21(10-16-32-22)25-28-18-23(29)27(24(28)30)14-7-6-13-26-11-4-3-5-12-26/h8-9,17-18,29H,2-7,10-16H2,1H3
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n/an/a 400n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of ERG in guinea pig ventricular myocytes assessed as blockade of rapid delayed rectifier potassium current by whole cell patch-clamp tech...


Bioorg Med Chem Lett 19: 1477-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.022
BindingDB Entry DOI: 10.7270/Q22J6BQK
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Cavia porcellus)
BDBM50279739
PNG
(1-(6-ethoxy-2,3-dihydrochromen-4-ylideneamino)-3-(...)
Show SMILES CCOc1ccc2OCCC(=Nn3cc(O)n(CCCCN4CCCCC4)c3=O)c2c1
Show InChI InChI=1S/C23H32N4O4/c1-2-30-18-8-9-21-19(16-18)20(10-15-31-21)24-27-17-22(28)26(23(27)29)14-7-6-13-25-11-4-3-5-12-25/h8-9,16-17,28H,2-7,10-15H2,1H3
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n/an/a 450n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of ERG in guinea pig ventricular myocytes assessed as blockade of rapid delayed rectifier potassium current by whole cell patch-clamp tech...


Bioorg Med Chem Lett 19: 1477-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.022
BindingDB Entry DOI: 10.7270/Q22J6BQK
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Cavia porcellus)
BDBM50279436
PNG
(1-(2,3-dihydro-6-methoxychromen-4-ylideneamino)-3-...)
Show SMILES COc1ccc2OCCC(=Nn3cc(O)n(CCCN4CCN(C)CC4)c3=O)c2c1
Show InChI InChI=1S/C21H29N5O4/c1-23-9-11-24(12-10-23)7-3-8-25-20(27)15-26(21(25)28)22-18-6-13-30-19-5-4-16(29-2)14-17(18)19/h4-5,14-15,27H,3,6-13H2,1-2H3
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n/an/a 540n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of ERG in guinea pig ventricular myocytes assessed as blockade of rapid delayed rectifier potassium current by whole cell patch-clamp tech...


Bioorg Med Chem Lett 19: 1477-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.022
BindingDB Entry DOI: 10.7270/Q22J6BQK
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Cavia porcellus)
BDBM50279456
PNG
(1-(2,3-dihydro-6-methylchromen-4-ylideneamino)-3-(...)
Show SMILES CN1CCN(CCCn2c(O)cn(N=C3CCOc4ccc(C)cc34)c2=O)CC1
Show InChI InChI=1S/C21H29N5O3/c1-16-4-5-19-17(14-16)18(6-13-29-19)22-26-15-20(27)25(21(26)28)8-3-7-24-11-9-23(2)10-12-24/h4-5,14-15,27H,3,6-13H2,1-2H3
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n/an/a 619n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of ERG in guinea pig ventricular myocytes assessed as blockade of rapid delayed rectifier potassium current by whole cell patch-clamp tech...


Bioorg Med Chem Lett 19: 1477-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.022
BindingDB Entry DOI: 10.7270/Q22J6BQK
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50279700
PNG
(1-(2,3-dihydro-6-methoxychromen-4-ylideneamino)-3-...)
Show SMILES COc1ccc2OCCC(=Nn3cc(O)n(CCCCN4CCN(C)CC4)c3=O)c2c1
Show InChI InChI=1S/C22H31N5O4/c1-24-10-12-25(13-11-24)8-3-4-9-26-21(28)16-27(22(26)29)23-19-7-14-31-20-6-5-17(30-2)15-18(19)20/h5-6,15-16,28H,3-4,7-14H2,1-2H3
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n/an/a 650n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of KVLQT1/minK in guinea pig ventricular myocytes assessed as blockade of slow delayed rectifier potassium current by whole cell patch-cla...


Bioorg Med Chem Lett 19: 1477-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.022
BindingDB Entry DOI: 10.7270/Q22J6BQK
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Cavia porcellus)
BDBM50279700
PNG
(1-(2,3-dihydro-6-methoxychromen-4-ylideneamino)-3-...)
Show SMILES COc1ccc2OCCC(=Nn3cc(O)n(CCCCN4CCN(C)CC4)c3=O)c2c1
Show InChI InChI=1S/C22H31N5O4/c1-24-10-12-25(13-11-24)8-3-4-9-26-21(28)16-27(22(26)29)23-19-7-14-31-20-6-5-17(30-2)15-18(19)20/h5-6,15-16,28H,3-4,7-14H2,1-2H3
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n/an/a 1.01E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of ERG in guinea pig ventricular myocytes assessed as blockade of rapid delayed rectifier potassium current by whole cell patch-clamp tech...


Bioorg Med Chem Lett 19: 1477-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.022
BindingDB Entry DOI: 10.7270/Q22J6BQK
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50279741
PNG
(1-(6-butoxy-2,3-dihydrochromen-4-ylideneamino)-3-(...)
Show SMILES CCCCOc1ccc2OCCC(=Nn3cc(O)n(CCCCN4CCCCC4)c3=O)c2c1
Show InChI InChI=1S/C25H36N4O4/c1-2-3-16-32-20-9-10-23-21(18-20)22(11-17-33-23)26-29-19-24(30)28(25(29)31)15-8-7-14-27-12-5-4-6-13-27/h9-10,18-19,30H,2-8,11-17H2,1H3
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n/an/a 1.03E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of KVLQT1/minK in guinea pig ventricular myocytes assessed as blockade of slow delayed rectifier potassium current by whole cell patch-cla...


Bioorg Med Chem Lett 19: 1477-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.022
BindingDB Entry DOI: 10.7270/Q22J6BQK
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50279739
PNG
(1-(6-ethoxy-2,3-dihydrochromen-4-ylideneamino)-3-(...)
Show SMILES CCOc1ccc2OCCC(=Nn3cc(O)n(CCCCN4CCCCC4)c3=O)c2c1
Show InChI InChI=1S/C23H32N4O4/c1-2-30-18-8-9-21-19(16-18)20(10-15-31-21)24-27-17-22(28)26(23(27)29)14-7-6-13-25-11-4-3-5-12-25/h8-9,16-17,28H,2-7,10-15H2,1H3
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n/an/a 1.04E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of KVLQT1/minK in guinea pig ventricular myocytes assessed as blockade of slow delayed rectifier potassium current by whole cell patch-cla...


Bioorg Med Chem Lett 19: 1477-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.022
BindingDB Entry DOI: 10.7270/Q22J6BQK
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50279455
PNG
(1-(6-butoxy-2,3-dihydrochromen-4-ylideneamino)-3-(...)
Show SMILES CCCCOc1ccc2OCCC(=Nn3cc(O)n(CCCN4CCN(C)CC4)c3=O)c2c1
Show InChI InChI=1S/C24H35N5O4/c1-3-4-15-32-19-6-7-22-20(17-19)21(8-16-33-22)25-29-18-23(30)28(24(29)31)10-5-9-27-13-11-26(2)12-14-27/h6-7,17-18,30H,3-5,8-16H2,1-2H3
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n/an/a 1.23E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of KVLQT1/minK in guinea pig ventricular myocytes assessed as blockade of slow delayed rectifier potassium current by whole cell patch-cla...


Bioorg Med Chem Lett 19: 1477-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.022
BindingDB Entry DOI: 10.7270/Q22J6BQK
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Cavia porcellus)
BDBM50279471
PNG
(1-(2,3-dihydro-6-chlorochromen-4-ylideneamino)-3-(...)
Show SMILES CN1CCN(CCCn2c(O)cn(N=C3CCOc4ccc(Cl)cc34)c2=O)CC1
Show InChI InChI=1S/C20H26ClN5O3/c1-23-8-10-24(11-9-23)6-2-7-25-19(27)14-26(20(25)28)22-17-5-12-29-18-4-3-15(21)13-16(17)18/h3-4,13-14,27H,2,5-12H2,1H3
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n/an/a 3.87E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of ERG in guinea pig ventricular myocytes assessed as blockade of rapid delayed rectifier potassium current by whole cell patch-clamp tech...


Bioorg Med Chem Lett 19: 1477-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.022
BindingDB Entry DOI: 10.7270/Q22J6BQK
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Cavia porcellus)
BDBM50279453
PNG
(1-(6-ethoxy-2,3-dihydrochromen-4-ylideneamino)-3-(...)
Show SMILES CCOc1ccc2OCCC(=Nn3cc(O)n(CCCN4CCN(C)CC4)c3=O)c2c1
Show InChI InChI=1S/C22H31N5O4/c1-3-30-17-5-6-20-18(15-17)19(7-14-31-20)23-27-16-21(28)26(22(27)29)9-4-8-25-12-10-24(2)11-13-25/h5-6,15-16,28H,3-4,7-14H2,1-2H3
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n/an/a 4.34E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of ERG in guinea pig ventricular myocytes assessed as blockade of rapid delayed rectifier potassium current by whole cell patch-clamp tech...


Bioorg Med Chem Lett 19: 1477-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.022
BindingDB Entry DOI: 10.7270/Q22J6BQK
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50279433
PNG
(1-(2,3-dihydro-6-hydroxychromen-4-ylideneamino)-3-...)
Show SMILES Oc1cn(N=C2CCOc3ccc(O)cc23)c(=O)n1CCCCN1CCCCC1
Show InChI InChI=1S/C21H28N4O4/c26-16-6-7-19-17(14-16)18(8-13-29-19)22-25-15-20(27)24(21(25)28)12-5-4-11-23-9-2-1-3-10-23/h6-7,14-15,26-27H,1-5,8-13H2
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n/an/a 5.40E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of KVLQT1/minK in guinea pig ventricular myocytes assessed as blockade of slow delayed rectifier potassium current by whole cell patch-cla...


Bioorg Med Chem Lett 19: 1477-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.022
BindingDB Entry DOI: 10.7270/Q22J6BQK
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Cavia porcellus)
BDBM50279701
PNG
(1-(6-ethoxy-2,3-dihydrochromen-4-ylideneamino)-3-(...)
Show SMILES CCOc1ccc2OCCC(=Nn3cc(O)n(CCCCN4CCN(C)CC4)c3=O)c2c1
Show InChI InChI=1S/C23H33N5O4/c1-3-31-18-6-7-21-19(16-18)20(8-15-32-21)24-28-17-22(29)27(23(28)30)10-5-4-9-26-13-11-25(2)12-14-26/h6-7,16-17,29H,3-5,8-15H2,1-2H3
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n/an/a 6.15E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of ERG in guinea pig ventricular myocytes assessed as blockade of rapid delayed rectifier potassium current by whole cell patch-clamp tech...


Bioorg Med Chem Lett 19: 1477-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.022
BindingDB Entry DOI: 10.7270/Q22J6BQK
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Cavia porcellus)
BDBM50279738
PNG
(1-(2,3-dihydro-6-methoxychromen-4-ylideneamino)-3-...)
Show SMILES COc1ccc2OCCC(=Nn3cc(O)n(CCCCN4CCCCC4)c3=O)c2c1
Show InChI InChI=1S/C22H30N4O4/c1-29-17-7-8-20-18(15-17)19(9-14-30-20)23-26-16-21(27)25(22(26)28)13-6-5-12-24-10-3-2-4-11-24/h7-8,15-16,27H,2-6,9-14H2,1H3
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n/an/a 7.47E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of ERG in guinea pig ventricular myocytes assessed as blockade of rapid delayed rectifier potassium current by whole cell patch-clamp tech...


Bioorg Med Chem Lett 19: 1477-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.022
BindingDB Entry DOI: 10.7270/Q22J6BQK
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50279435
PNG
(1-(2,3-dihydro-6-methylchromen-4-ylideneamino)-3-(...)
Show SMILES Cc1ccc2OCCC(=Nn3cc(O)n(CCCCN4CCCCC4)c3=O)c2c1
Show InChI InChI=1S/C22H30N4O3/c1-17-7-8-20-18(15-17)19(9-14-29-20)23-26-16-21(27)25(22(26)28)13-6-5-12-24-10-3-2-4-11-24/h7-8,15-16,27H,2-6,9-14H2,1H3
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n/an/a 1.89E+4n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of KVLQT1/minK in guinea pig ventricular myocytes assessed as blockade of slow delayed rectifier potassium current by whole cell patch-cla...


Bioorg Med Chem Lett 19: 1477-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.022
BindingDB Entry DOI: 10.7270/Q22J6BQK
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Cavia porcellus)
BDBM50279435
PNG
(1-(2,3-dihydro-6-methylchromen-4-ylideneamino)-3-(...)
Show SMILES Cc1ccc2OCCC(=Nn3cc(O)n(CCCCN4CCCCC4)c3=O)c2c1
Show InChI InChI=1S/C22H30N4O3/c1-17-7-8-20-18(15-17)19(9-14-29-20)23-26-16-21(27)25(22(26)28)13-6-5-12-24-10-3-2-4-11-24/h7-8,15-16,27H,2-6,9-14H2,1H3
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PubMed
n/an/a 2.20E+4n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of ERG in guinea pig ventricular myocytes assessed as blockade of rapid delayed rectifier potassium current by whole cell patch-clamp tech...


Bioorg Med Chem Lett 19: 1477-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.022
BindingDB Entry DOI: 10.7270/Q22J6BQK
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50279738
PNG
(1-(2,3-dihydro-6-methoxychromen-4-ylideneamino)-3-...)
Show SMILES COc1ccc2OCCC(=Nn3cc(O)n(CCCCN4CCCCC4)c3=O)c2c1
Show InChI InChI=1S/C22H30N4O4/c1-29-17-7-8-20-18(15-17)19(9-14-30-20)23-26-16-21(27)25(22(26)28)13-6-5-12-24-10-3-2-4-11-24/h7-8,15-16,27H,2-6,9-14H2,1H3
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n/an/a 2.20E+4n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of KVLQT1/minK in guinea pig ventricular myocytes assessed as blockade of slow delayed rectifier potassium current by whole cell patch-cla...


Bioorg Med Chem Lett 19: 1477-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.022
BindingDB Entry DOI: 10.7270/Q22J6BQK
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Cavia porcellus)
BDBM50279455
PNG
(1-(6-butoxy-2,3-dihydrochromen-4-ylideneamino)-3-(...)
Show SMILES CCCCOc1ccc2OCCC(=Nn3cc(O)n(CCCN4CCN(C)CC4)c3=O)c2c1
Show InChI InChI=1S/C24H35N5O4/c1-3-4-15-32-19-6-7-22-20(17-19)21(8-16-33-22)25-29-18-23(30)28(24(29)31)10-5-9-27-13-11-26(2)12-14-27/h6-7,17-18,30H,3-5,8-16H2,1-2H3
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n/an/a 3.97E+4n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of ERG in guinea pig ventricular myocytes assessed as blockade of rapid delayed rectifier potassium current by whole cell patch-clamp tech...


Bioorg Med Chem Lett 19: 1477-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.022
BindingDB Entry DOI: 10.7270/Q22J6BQK
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50279434
PNG
(1-(2,3-dihydro-6-chlorochromen-4-ylideneamino)-3-(...)
Show SMILES Oc1cn(N=C2CCOc3ccc(Cl)cc23)c(=O)n1CCCCN1CCCCC1
Show InChI InChI=1S/C21H27ClN4O3/c22-16-6-7-19-17(14-16)18(8-13-29-19)23-26-15-20(27)25(21(26)28)12-5-4-11-24-9-2-1-3-10-24/h6-7,14-15,27H,1-5,8-13H2
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n/an/a 6.10E+4n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of KVLQT1/minK in guinea pig ventricular myocytes assessed as blockade of slow delayed rectifier potassium current by whole cell patch-cla...


Bioorg Med Chem Lett 19: 1477-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.022
BindingDB Entry DOI: 10.7270/Q22J6BQK
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Cavia porcellus)
BDBM50279433
PNG
(1-(2,3-dihydro-6-hydroxychromen-4-ylideneamino)-3-...)
Show SMILES Oc1cn(N=C2CCOc3ccc(O)cc23)c(=O)n1CCCCN1CCCCC1
Show InChI InChI=1S/C21H28N4O4/c26-16-6-7-19-17(14-16)18(8-13-29-19)22-25-15-20(27)24(21(25)28)12-5-4-11-23-9-2-1-3-10-23/h6-7,14-15,26-27H,1-5,8-13H2
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n/an/a>1.00E+4n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of ERG in guinea pig ventricular myocytes assessed as blockade of rapid delayed rectifier potassium current by whole cell patch-clamp tech...


Bioorg Med Chem Lett 19: 1477-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.022
BindingDB Entry DOI: 10.7270/Q22J6BQK
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50279701
PNG
(1-(6-ethoxy-2,3-dihydrochromen-4-ylideneamino)-3-(...)
Show SMILES CCOc1ccc2OCCC(=Nn3cc(O)n(CCCCN4CCN(C)CC4)c3=O)c2c1
Show InChI InChI=1S/C23H33N5O4/c1-3-31-18-6-7-21-19(16-18)20(8-15-32-21)24-28-17-22(29)27(23(28)30)10-5-4-9-26-13-11-25(2)12-14-26/h6-7,16-17,29H,3-5,8-15H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of KVLQT1/minK in guinea pig ventricular myocytes assessed as blockade of slow delayed rectifier potassium current by whole cell patch-cla...


Bioorg Med Chem Lett 19: 1477-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.022
BindingDB Entry DOI: 10.7270/Q22J6BQK
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50279471
PNG
(1-(2,3-dihydro-6-chlorochromen-4-ylideneamino)-3-(...)
Show SMILES CN1CCN(CCCn2c(O)cn(N=C3CCOc4ccc(Cl)cc34)c2=O)CC1
Show InChI InChI=1S/C20H26ClN5O3/c1-23-8-10-24(11-9-23)6-2-7-25-19(27)14-26(20(25)28)22-17-5-12-29-18-4-3-15(21)13-16(17)18/h3-4,13-14,27H,2,5-12H2,1H3
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n/an/a 5.80n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of KVLQT1/minK in guinea pig ventricular myocytes assessed as blockade of slow delayed rectifier potassium current by whole cell patch-cla...


Bioorg Med Chem Lett 19: 1477-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.022
BindingDB Entry DOI: 10.7270/Q22J6BQK
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Cavia porcellus)
BDBM50279434
PNG
(1-(2,3-dihydro-6-chlorochromen-4-ylideneamino)-3-(...)
Show SMILES Oc1cn(N=C2CCOc3ccc(Cl)cc23)c(=O)n1CCCCN1CCCCC1
Show InChI InChI=1S/C21H27ClN4O3/c22-16-6-7-19-17(14-16)18(8-13-29-19)23-26-15-20(27)25(21(26)28)12-5-4-11-24-9-2-1-3-10-24/h6-7,14-15,27H,1-5,8-13H2
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n/an/a 6.20n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of ERG in guinea pig ventricular myocytes assessed as blockade of rapid delayed rectifier potassium current by whole cell patch-clamp tech...


Bioorg Med Chem Lett 19: 1477-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.022
BindingDB Entry DOI: 10.7270/Q22J6BQK
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50279454
PNG
(1-(2,3-dihydro-6-propoxychromen-4-ylideneamino)-3-...)
Show SMILES CCCOc1ccc2OCCC(=Nn3cc(O)n(CCCN4CCN(C)CC4)c3=O)c2c1
Show InChI InChI=1S/C23H33N5O4/c1-3-14-31-18-5-6-21-19(16-18)20(7-15-32-21)24-28-17-22(29)27(23(28)30)9-4-8-26-12-10-25(2)11-13-26/h5-6,16-17,29H,3-4,7-15H2,1-2H3
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n/an/a 9.5n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of KVLQT1/minK in guinea pig ventricular myocytes assessed as blockade of slow delayed rectifier potassium current by whole cell patch-cla...


Bioorg Med Chem Lett 19: 1477-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.022
BindingDB Entry DOI: 10.7270/Q22J6BQK
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Cavia porcellus)
BDBM50279741
PNG
(1-(6-butoxy-2,3-dihydrochromen-4-ylideneamino)-3-(...)
Show SMILES CCCCOc1ccc2OCCC(=Nn3cc(O)n(CCCCN4CCCCC4)c3=O)c2c1
Show InChI InChI=1S/C25H36N4O4/c1-2-3-16-32-20-9-10-23-21(18-20)22(11-17-33-23)26-29-19-24(30)28(25(29)31)15-8-7-14-27-12-5-4-6-13-27/h9-10,18-19,30H,2-8,11-17H2,1H3
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n/an/a 17n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of ERG in guinea pig ventricular myocytes assessed as blockade of rapid delayed rectifier potassium current by whole cell patch-clamp tech...


Bioorg Med Chem Lett 19: 1477-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.022
BindingDB Entry DOI: 10.7270/Q22J6BQK
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50279436
PNG
(1-(2,3-dihydro-6-methoxychromen-4-ylideneamino)-3-...)
Show SMILES COc1ccc2OCCC(=Nn3cc(O)n(CCCN4CCN(C)CC4)c3=O)c2c1
Show InChI InChI=1S/C21H29N5O4/c1-23-9-11-24(12-10-23)7-3-8-25-20(27)15-26(21(25)28)22-18-6-13-30-19-5-4-16(29-2)14-17(18)19/h4-5,14-15,27H,3,6-13H2,1-2H3
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n/an/a 1.90n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of KVLQT1/minK in guinea pig ventricular myocytes assessed as blockade of slow delayed rectifier potassium current by whole cell patch-cla...


Bioorg Med Chem Lett 19: 1477-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.022
BindingDB Entry DOI: 10.7270/Q22J6BQK
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Cavia porcellus)
BDBM50279454
PNG
(1-(2,3-dihydro-6-propoxychromen-4-ylideneamino)-3-...)
Show SMILES CCCOc1ccc2OCCC(=Nn3cc(O)n(CCCN4CCN(C)CC4)c3=O)c2c1
Show InChI InChI=1S/C23H33N5O4/c1-3-14-31-18-5-6-21-19(16-18)20(7-15-32-21)24-28-17-22(29)27(23(28)30)9-4-8-26-12-10-25(2)11-13-26/h5-6,16-17,29H,3-4,7-15H2,1-2H3
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n/an/a 106n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of ERG in guinea pig ventricular myocytes assessed as blockade of rapid delayed rectifier potassium current by whole cell patch-clamp tech...


Bioorg Med Chem Lett 19: 1477-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.022
BindingDB Entry DOI: 10.7270/Q22J6BQK
More data for this
Ligand-Target Pair