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4 similar compounds to monomer 50294264

Wt: 296.4
BDBM50294260
Wt: 296.4
BDBM50294267
Wt: 296.4
BDBM50294268
Wt: 296.4
BDBM50294273

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50294260,50294267,50294268,50294273   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium-dependent noradrenaline transporter


(Homo sapiens (human))
BDBM50294260
PNG
(CHEMBL550289 | rac-3-((2-ethylphenoxy)(piperidin-4...)
Show SMILES CCc1ccccc1OC(C1CCNCC1)c1cccnc1
Show InChI InChI=1S/C19H24N2O/c1-2-15-6-3-4-8-18(15)22-19(16-9-12-20-13-10-16)17-7-5-11-21-14-17/h3-8,11,14,16,19-20H,2,9-10,12-13H2,1H3
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PubMed
n/an/a 91n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]NA uptake at human NET expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM50294260
PNG
(CHEMBL550289 | rac-3-((2-ethylphenoxy)(piperidin-4...)
Show SMILES CCc1ccccc1OC(C1CCNCC1)c1cccnc1
Show InChI InChI=1S/C19H24N2O/c1-2-15-6-3-4-8-18(15)22-19(16-9-12-20-13-10-16)17-7-5-11-21-14-17/h3-8,11,14,16,19-20H,2,9-10,12-13H2,1H3
NCI pathway
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PubMed
n/an/a>4.00E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA uptake at human DAT expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM50294268
PNG
(CHEMBL562444 | rac-3-((4-ethylphenoxy)(piperidin-4...)
Show SMILES CCc1ccc(OC(C2CCNCC2)c2cccnc2)cc1
Show InChI InChI=1S/C19H24N2O/c1-2-15-5-7-18(8-6-15)22-19(16-9-12-20-13-10-16)17-4-3-11-21-14-17/h3-8,11,14,16,19-20H,2,9-10,12-13H2,1H3
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PubMed
n/an/a 7.83E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA uptake at human DAT expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM50294273
PNG
(CHEMBL562854 | rac-3-((2,3-dimethylphenoxy)(piperi...)
Show SMILES Cc1cccc(OC(C2CCNCC2)c2cccnc2)c1C
Show InChI InChI=1S/C19H24N2O/c1-14-5-3-7-18(15(14)2)22-19(16-8-11-20-12-9-16)17-6-4-10-21-13-17/h3-7,10,13,16,19-20H,8-9,11-12H2,1-2H3
NCI pathway
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PubMed
n/an/a 1.27E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA uptake at human DAT expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (human))
BDBM50294267
PNG
(CHEMBL551443 | rac-3-((3-ethylphenoxy)(piperidin-4...)
Show SMILES CCc1cccc(OC(C2CCNCC2)c2cccnc2)c1
Show InChI InChI=1S/C19H24N2O/c1-2-15-5-3-7-18(13-15)22-19(16-8-11-20-12-9-16)17-6-4-10-21-14-17/h3-7,10,13-14,16,19-20H,2,8-9,11-12H2,1H3
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Article
PubMed
n/an/a 404n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]NA uptake at human NET expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
Serotonin and norepinephrine transporters (SERT/NET)


(Homo sapiens (human))
BDBM50294273
PNG
(CHEMBL562854 | rac-3-((2,3-dimethylphenoxy)(piperi...)
Show SMILES Cc1cccc(OC(C2CCNCC2)c2cccnc2)c1C
Show InChI InChI=1S/C19H24N2O/c1-14-5-3-7-18(15(14)2)22-19(16-8-11-20-12-9-16)17-6-4-10-21-13-17/h3-7,10,13,16,19-20H,8-9,11-12H2,1-2H3
PDB

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Article
PubMed
n/an/a 3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]5-HT uptake at human 5HTT expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (human))
BDBM50294273
PNG
(CHEMBL562854 | rac-3-((2,3-dimethylphenoxy)(piperi...)
Show SMILES Cc1cccc(OC(C2CCNCC2)c2cccnc2)c1C
Show InChI InChI=1S/C19H24N2O/c1-14-5-3-7-18(15(14)2)22-19(16-8-11-20-12-9-16)17-6-4-10-21-13-17/h3-7,10,13,16,19-20H,8-9,11-12H2,1-2H3
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Article
PubMed
n/an/a 42n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]NA uptake at human NET expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
Serotonin and norepinephrine transporters (SERT/NET)


(Homo sapiens (human))
BDBM50294260
PNG
(CHEMBL550289 | rac-3-((2-ethylphenoxy)(piperidin-4...)
Show SMILES CCc1ccccc1OC(C1CCNCC1)c1cccnc1
Show InChI InChI=1S/C19H24N2O/c1-2-15-6-3-4-8-18(15)22-19(16-9-12-20-13-10-16)17-7-5-11-21-14-17/h3-8,11,14,16,19-20H,2,9-10,12-13H2,1H3
PDB

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CHEMBL
PC cid
PC sid
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AffyNet 
Article
PubMed
n/an/a 61n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]5-HT uptake at human 5HTT expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
Serotonin and norepinephrine transporters (SERT/NET)


(Homo sapiens (human))
BDBM50294267
PNG
(CHEMBL551443 | rac-3-((3-ethylphenoxy)(piperidin-4...)
Show SMILES CCc1cccc(OC(C2CCNCC2)c2cccnc2)c1
Show InChI InChI=1S/C19H24N2O/c1-2-15-5-3-7-18(13-15)22-19(16-8-11-20-12-9-16)17-6-4-10-21-14-17/h3-7,10,13-14,16,19-20H,2,8-9,11-12H2,1H3
PDB

KEGG

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AffyNet 
CHEMBL
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PC sid
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AffyNet 
Article
PubMed
n/an/a 7n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]5-HT uptake at human 5HTT expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
Serotonin and norepinephrine transporters (SERT/NET)


(Homo sapiens (human))
BDBM50294268
PNG
(CHEMBL562444 | rac-3-((4-ethylphenoxy)(piperidin-4...)
Show SMILES CCc1ccc(OC(C2CCNCC2)c2cccnc2)cc1
Show InChI InChI=1S/C19H24N2O/c1-2-15-5-7-18(8-6-15)22-19(16-9-12-20-13-10-16)17-4-3-11-21-14-17/h3-8,11,14,16,19-20H,2,9-10,12-13H2,1H3
PDB

KEGG

UniProtKB/SwissProt

DrugBank
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GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 5n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]5-HT uptake at human 5HTT expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (human))
BDBM50294268
PNG
(CHEMBL562444 | rac-3-((4-ethylphenoxy)(piperidin-4...)
Show SMILES CCc1ccc(OC(C2CCNCC2)c2cccnc2)cc1
Show InChI InChI=1S/C19H24N2O/c1-2-15-5-7-18(8-6-15)22-19(16-9-12-20-13-10-16)17-4-3-11-21-14-17/h3-8,11,14,16,19-20H,2,9-10,12-13H2,1H3
Reactome pathway
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Article
PubMed
n/an/a 4.85E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]NA uptake at human NET expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair