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15 molecules are shown

Wt: 304.2
BDBM50295739
Wt: 347.3
BDBM50295744
Wt: 346.3
BDBM50295745
Wt: 429.4
BDBM50295746
Wt: 487.5
BDBM50295747
Wt: 387.4
BDBM50295748
Wt: 489.5
BDBM50295754
Wt: 303.2
BDBM50295734
Wt: 303.2
BDBM50295735
Wt: 292.7
BDBM50295728
Wt: 258.2
BDBM50295729
Purchase
Wt: 292.7
BDBM50295730
Wt: 327.1
BDBM50295733
Wt: 273.3
BDBM50295737
Wt: 403.4
BDBM50351649

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 30 hits for monomerid = 50295739,50295744,50295745,50295746,50295747,50295748,50295754,50295734,50295735,50295728,50295729,50295730,50295733,50295737,50351649   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50295728
PNG
(1-(3-chlorophenylsulfonyl)-1H-pyrrolo[3,2-b]pyridi...)
Show SMILES Clc1cccc(c1)S(=O)(=O)n1ccc2ncccc12
Show InChI InChI=1S/C13H9ClN2O2S/c14-10-3-1-4-11(9-10)19(17,18)16-8-6-12-13(16)5-2-7-15-12/h1-9H
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n/an/a 5.67E+3n/an/an/an/an/an/a



UCB Celltech

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged c-Met by TR-FRET assay


Bioorg Med Chem Lett 19: 2780-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.110
BindingDB Entry DOI: 10.7270/Q2BV7GN9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50295730
PNG
(1-(2-chlorophenylsulfonyl)-1H-pyrrolo[3,2-b]pyridi...)
Show SMILES Clc1ccccc1S(=O)(=O)n1ccc2ncccc12
Show InChI InChI=1S/C13H9ClN2O2S/c14-10-4-1-2-6-13(10)19(17,18)16-9-7-11-12(16)5-3-8-15-11/h1-9H
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n/an/a 900n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50295730
PNG
(1-(2-chlorophenylsulfonyl)-1H-pyrrolo[3,2-b]pyridi...)
Show SMILES Clc1ccccc1S(=O)(=O)n1ccc2ncccc12
Show InChI InChI=1S/C13H9ClN2O2S/c14-10-4-1-2-6-13(10)19(17,18)16-9-7-11-12(16)5-3-8-15-11/h1-9H
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n/an/a 900n/an/an/an/an/an/a



UCB Celltech

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged c-Met by TR-FRET assay


Bioorg Med Chem Lett 19: 2780-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.110
BindingDB Entry DOI: 10.7270/Q2BV7GN9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50295733
PNG
(1-(2,6-dichlorophenylsulfonyl)-1H-pyrrolo[3,2-b]py...)
Show SMILES Clc1cccc(Cl)c1S(=O)(=O)n1ccc2ncccc12
Show InChI InChI=1S/C13H8Cl2N2O2S/c14-9-3-1-4-10(15)13(9)20(18,19)17-8-6-11-12(17)5-2-7-16-11/h1-8H
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n/an/a 480n/an/an/an/an/an/a



UCB Celltech

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged c-Met by TR-FRET assay


Bioorg Med Chem Lett 19: 2780-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.110
BindingDB Entry DOI: 10.7270/Q2BV7GN9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50295734
PNG
(1-(3-nitrophenylsulfonyl)-1H-pyrrolo[3,2-b]pyridin...)
Show SMILES [O-][N+](=O)c1cccc(c1)S(=O)(=O)n1ccc2ncccc12
Show InChI InChI=1S/C13H9N3O4S/c17-16(18)10-3-1-4-11(9-10)21(19,20)15-8-6-12-13(15)5-2-7-14-12/h1-9H
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n/an/a 70n/an/an/an/an/an/a



UCB Celltech

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged c-Met by TR-FRET assay


Bioorg Med Chem Lett 19: 2780-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.110
BindingDB Entry DOI: 10.7270/Q2BV7GN9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50295735
PNG
(1-(2-nitrophenylsulfonyl)-1H-pyrrolo[3,2-b]pyridin...)
Show SMILES [O-][N+](=O)c1ccccc1S(=O)(=O)n1ccc2ncccc12
Show InChI InChI=1S/C13H9N3O4S/c17-16(18)12-4-1-2-6-13(12)21(19,20)15-9-7-10-11(15)5-3-8-14-10/h1-9H
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n/an/a 20n/an/an/an/an/an/a



UCB Celltech

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged c-Met by TR-FRET assay


Bioorg Med Chem Lett 19: 2780-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.110
BindingDB Entry DOI: 10.7270/Q2BV7GN9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50295737
PNG
(3-(1H-pyrrolo[3,2-b]pyridin-1-ylsulfonyl)benzenami...)
Show SMILES Nc1cccc(c1)S(=O)(=O)n1ccc2ncccc12
Show InChI InChI=1S/C13H11N3O2S/c14-10-3-1-4-11(9-10)19(17,18)16-8-6-12-13(16)5-2-7-15-12/h1-9H,14H2
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n/an/a 4.40E+3n/an/an/an/an/an/a



UCB Celltech

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged c-Met by TR-FRET assay


Bioorg Med Chem Lett 19: 2780-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.110
BindingDB Entry DOI: 10.7270/Q2BV7GN9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50295739
PNG
(5-(3-nitrophenylsulfonyl)-5H-pyrrolo[3,2-b]pyrazin...)
Show SMILES [O-][N+](=O)c1cccc(c1)S(=O)(=O)n1ccc2nccnc12
Show InChI InChI=1S/C12H8N4O4S/c17-16(18)9-2-1-3-10(8-9)21(19,20)15-7-4-11-12(15)14-6-5-13-11/h1-8H
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n/an/a 1.73E+3n/an/an/an/an/an/a



UCB Celltech

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged c-Met by TR-FRET assay


Bioorg Med Chem Lett 19: 2780-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.110
BindingDB Entry DOI: 10.7270/Q2BV7GN9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50295744
PNG
(1-(2-nitrophenylsulfonyl)-1H-pyrrolo[3,2-b]pyridin...)
Show SMILES OC(=O)c1cnc2ccn(c2c1)S(=O)(=O)c1ccccc1[N+]([O-])=O
Show InChI InChI=1S/C14H9N3O6S/c18-14(19)9-7-12-10(15-8-9)5-6-16(12)24(22,23)13-4-2-1-3-11(13)17(20)21/h1-8H,(H,18,19)
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n/an/a 310n/an/an/an/an/an/a



UCB Celltech

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged c-Met by TR-FRET assay


Bioorg Med Chem Lett 19: 2780-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.110
BindingDB Entry DOI: 10.7270/Q2BV7GN9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50295745
PNG
(1-(2-nitrophenylsulfonyl)-1H-pyrrolo[3,2-b]pyridin...)
Show SMILES NC(=O)c1cnc2ccn(c2c1)S(=O)(=O)c1ccccc1[N+]([O-])=O
Show InChI InChI=1S/C14H10N4O5S/c15-14(19)9-7-12-10(16-8-9)5-6-17(12)24(22,23)13-4-2-1-3-11(13)18(20)21/h1-8H,(H2,15,19)
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n/an/a 82n/an/an/an/an/an/a



UCB Celltech

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged c-Met by TR-FRET assay


Bioorg Med Chem Lett 19: 2780-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.110
BindingDB Entry DOI: 10.7270/Q2BV7GN9
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50295746
PNG
((4-methylpiperazin-1-yl)(1-(2-nitrophenylsulfonyl)...)
Show SMILES CN1CCN(CC1)C(=O)c1cnc2ccn(c2c1)S(=O)(=O)c1ccccc1[N+]([O-])=O
Show InChI InChI=1S/C19H19N5O5S/c1-21-8-10-22(11-9-21)19(25)14-12-17-15(20-13-14)6-7-23(17)30(28,29)18-5-3-2-4-16(18)24(26)27/h2-7,12-13H,8-11H2,1H3
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n/an/a 300n/an/an/an/an/an/a



UCB Celltech

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged c-Met by TR-FRET assay


Bioorg Med Chem Lett 19: 2780-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.110
BindingDB Entry DOI: 10.7270/Q2BV7GN9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50295747
PNG
(CHEMBL556627 | tert-butyl 4-(1-(2-nitrophenylsulfo...)
Show SMILES CC(C)(C)OC(=O)N1CCN(CC1)c1cnc2ccn(c2c1)S(=O)(=O)c1ccccc1[N+]([O-])=O
Show InChI InChI=1S/C22H25N5O6S/c1-22(2,3)33-21(28)25-12-10-24(11-13-25)16-14-19-17(23-15-16)8-9-26(19)34(31,32)20-7-5-4-6-18(20)27(29)30/h4-9,14-15H,10-13H2,1-3H3
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n/an/a 20n/an/an/an/an/an/a



UCB Celltech

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged c-Met by TR-FRET assay


Bioorg Med Chem Lett 19: 2780-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.110
BindingDB Entry DOI: 10.7270/Q2BV7GN9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50295748
PNG
(1-(2-nitrophenylsulfonyl)-6-(piperazin-1-yl)-1H-py...)
Show SMILES [O-][N+](=O)c1ccccc1S(=O)(=O)n1ccc2ncc(cc12)N1CCNCC1
Show InChI InChI=1S/C17H17N5O4S/c23-22(24)15-3-1-2-4-17(15)27(25,26)21-8-5-14-16(21)11-13(12-19-14)20-9-6-18-7-10-20/h1-5,8,11-12,18H,6-7,9-10H2
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n/an/a 20n/an/an/an/an/an/a



UCB Celltech

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged c-Met by TR-FRET assay


Bioorg Med Chem Lett 19: 2780-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.110
BindingDB Entry DOI: 10.7270/Q2BV7GN9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50295754
PNG
((4-(1-(benzo[c][1,2,5]oxadiazol-4-ylsulfonyl)-1H-p...)
Show SMILES O=C(N1CCN(CC1)c1cnc2ccn(c2c1)S(=O)(=O)c1cccc2nonc12)c1cccnc1
Show InChI InChI=1S/C23H19N7O4S/c31-23(16-3-2-7-24-14-16)29-11-9-28(10-12-29)17-13-20-18(25-15-17)6-8-30(20)35(32,33)21-5-1-4-19-22(21)27-34-26-19/h1-8,13-15H,9-12H2
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n/an/a 11n/an/an/an/an/an/a



UCB Celltech

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged c-Met by TR-FRET assay


Bioorg Med Chem Lett 19: 2780-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.110
BindingDB Entry DOI: 10.7270/Q2BV7GN9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50295754
PNG
((4-(1-(benzo[c][1,2,5]oxadiazol-4-ylsulfonyl)-1H-p...)
Show SMILES O=C(N1CCN(CC1)c1cnc2ccn(c2c1)S(=O)(=O)c1cccc2nonc12)c1cccnc1
Show InChI InChI=1S/C23H19N7O4S/c31-23(16-3-2-7-24-14-16)29-11-9-28(10-12-29)17-13-20-18(25-15-17)6-8-30(20)35(32,33)21-5-1-4-19-22(21)27-34-26-19/h1-8,13-15H,9-12H2
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n/an/a 480n/an/an/an/an/an/a



UCB Celltech

Curated by ChEMBL


Assay Description
Inhibition of c-Met phosphorylation in human MKN45 cells after 1 hr


Bioorg Med Chem Lett 19: 2780-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.110
BindingDB Entry DOI: 10.7270/Q2BV7GN9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50295754
PNG
((4-(1-(benzo[c][1,2,5]oxadiazol-4-ylsulfonyl)-1H-p...)
Show SMILES O=C(N1CCN(CC1)c1cnc2ccn(c2c1)S(=O)(=O)c1cccc2nonc12)c1cccnc1
Show InChI InChI=1S/C23H19N7O4S/c31-23(16-3-2-7-24-14-16)29-11-9-28(10-12-29)17-13-20-18(25-15-17)6-8-30(20)35(32,33)21-5-1-4-19-22(21)27-34-26-19/h1-8,13-15H,9-12H2
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n/an/a 430n/an/an/an/an/an/a



UCB Celltech

Curated by ChEMBL


Assay Description
Inhibition of c-Met phosphorylation in human A549 cells after 1 hr


Bioorg Med Chem Lett 19: 2780-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.110
BindingDB Entry DOI: 10.7270/Q2BV7GN9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50295729
PNG
(1-(phenylsulfonyl)-1H-pyrrolo[3,2-b]pyridine | CHE...)
Show SMILES O=S(=O)(c1ccccc1)n1ccc2ncccc12
Show InChI InChI=1S/C13H10N2O2S/c16-18(17,11-5-2-1-3-6-11)15-10-8-12-13(15)7-4-9-14-12/h1-10H
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n/an/a 3.50E+3n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50295733
PNG
(1-(2,6-dichlorophenylsulfonyl)-1H-pyrrolo[3,2-b]py...)
Show SMILES Clc1cccc(Cl)c1S(=O)(=O)n1ccc2ncccc12
Show InChI InChI=1S/C13H8Cl2N2O2S/c14-9-3-1-4-10(15)13(9)20(18,19)17-8-6-11-12(17)5-2-7-16-11/h1-8H
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n/an/a 480n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50295735
PNG
(1-(2-nitrophenylsulfonyl)-1H-pyrrolo[3,2-b]pyridin...)
Show SMILES [O-][N+](=O)c1ccccc1S(=O)(=O)n1ccc2ncccc12
Show InChI InChI=1S/C13H9N3O4S/c17-16(18)12-4-1-2-6-13(12)21(19,20)15-9-7-10-11(15)5-3-8-14-10/h1-9H
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n/an/a 20n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50295737
PNG
(3-(1H-pyrrolo[3,2-b]pyridin-1-ylsulfonyl)benzenami...)
Show SMILES Nc1cccc(c1)S(=O)(=O)n1ccc2ncccc12
Show InChI InChI=1S/C13H11N3O2S/c14-10-3-1-4-11(9-10)19(17,18)16-8-6-12-13(16)5-2-7-15-12/h1-9H,14H2
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n/an/a 4.40E+3n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50295739
PNG
(5-(3-nitrophenylsulfonyl)-5H-pyrrolo[3,2-b]pyrazin...)
Show SMILES [O-][N+](=O)c1cccc(c1)S(=O)(=O)n1ccc2nccnc12
Show InChI InChI=1S/C12H8N4O4S/c17-16(18)9-2-1-3-10(8-9)21(19,20)15-7-4-11-12(15)14-6-5-13-11/h1-8H
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n/an/a 1.73E+3n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50295745
PNG
(1-(2-nitrophenylsulfonyl)-1H-pyrrolo[3,2-b]pyridin...)
Show SMILES NC(=O)c1cnc2ccn(c2c1)S(=O)(=O)c1ccccc1[N+]([O-])=O
Show InChI InChI=1S/C14H10N4O5S/c15-14(19)9-7-12-10(16-8-9)5-6-17(12)24(22,23)13-4-2-1-3-11(13)18(20)21/h1-8H,(H2,15,19)
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n/an/a 82n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50295746
PNG
((4-methylpiperazin-1-yl)(1-(2-nitrophenylsulfonyl)...)
Show SMILES CN1CCN(CC1)C(=O)c1cnc2ccn(c2c1)S(=O)(=O)c1ccccc1[N+]([O-])=O
Show InChI InChI=1S/C19H19N5O5S/c1-21-8-10-22(11-9-21)19(25)14-12-17-15(20-13-14)6-7-23(17)30(28,29)18-5-3-2-4-16(18)24(26)27/h2-7,12-13H,8-11H2,1H3
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n/an/a 300n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50351649
PNG
(CHEMBL1822362)
Show SMILES CC(C)(C)OC(=O)c1cnc2ccn(c2c1)S(=O)(=O)c1ccccc1[N+]([O-])=O
Show InChI InChI=1S/C18H17N3O6S/c1-18(2,3)27-17(22)12-10-15-13(19-11-12)8-9-20(15)28(25,26)16-7-5-4-6-14(16)21(23)24/h4-11H,1-3H3
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n/an/a 20n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50295734
PNG
(1-(3-nitrophenylsulfonyl)-1H-pyrrolo[3,2-b]pyridin...)
Show SMILES [O-][N+](=O)c1cccc(c1)S(=O)(=O)n1ccc2ncccc12
Show InChI InChI=1S/C13H9N3O4S/c17-16(18)10-3-1-4-11(9-10)21(19,20)15-8-6-12-13(15)5-2-7-14-12/h1-9H
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n/an/a 70n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50295744
PNG
(1-(2-nitrophenylsulfonyl)-1H-pyrrolo[3,2-b]pyridin...)
Show SMILES OC(=O)c1cnc2ccn(c2c1)S(=O)(=O)c1ccccc1[N+]([O-])=O
Show InChI InChI=1S/C14H9N3O6S/c18-14(19)9-7-12-10(15-8-9)5-6-16(12)24(22,23)13-4-2-1-3-11(13)17(20)21/h1-8H,(H,18,19)
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n/an/a 310n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50295748
PNG
(1-(2-nitrophenylsulfonyl)-6-(piperazin-1-yl)-1H-py...)
Show SMILES [O-][N+](=O)c1ccccc1S(=O)(=O)n1ccc2ncc(cc12)N1CCNCC1
Show InChI InChI=1S/C17H17N5O4S/c23-22(24)15-3-1-2-4-17(15)27(25,26)21-8-5-14-16(21)11-13(12-19-14)20-9-6-18-7-10-20/h1-5,8,11-12,18H,6-7,9-10H2
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n/an/a 20n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50295754
PNG
((4-(1-(benzo[c][1,2,5]oxadiazol-4-ylsulfonyl)-1H-p...)
Show SMILES O=C(N1CCN(CC1)c1cnc2ccn(c2c1)S(=O)(=O)c1cccc2nonc12)c1cccnc1
Show InChI InChI=1S/C23H19N7O4S/c31-23(16-3-2-7-24-14-16)29-11-9-28(10-12-29)17-13-20-18(25-15-17)6-8-30(20)35(32,33)21-5-1-4-19-22(21)27-34-26-19/h1-8,13-15H,9-12H2
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n/an/a 11n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50295728
PNG
(1-(3-chlorophenylsulfonyl)-1H-pyrrolo[3,2-b]pyridi...)
Show SMILES Clc1cccc(c1)S(=O)(=O)n1ccc2ncccc12
Show InChI InChI=1S/C13H9ClN2O2S/c14-10-3-1-4-11(9-10)19(17,18)16-8-6-12-13(16)5-2-7-15-12/h1-9H
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n/an/a 5.67E+3n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50295729
PNG
(1-(phenylsulfonyl)-1H-pyrrolo[3,2-b]pyridine | CHE...)
Show SMILES O=S(=O)(c1ccccc1)n1ccc2ncccc12
Show InChI InChI=1S/C13H10N2O2S/c16-18(17,11-5-2-1-3-6-11)15-10-8-12-13(15)7-4-9-14-12/h1-10H
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n/an/a 3.50E+3n/an/an/an/an/an/a



UCB Celltech

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged c-Met by TR-FRET assay


Bioorg Med Chem Lett 19: 2780-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.110
BindingDB Entry DOI: 10.7270/Q2BV7GN9
More data for this
Ligand-Target Pair