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8 similar compounds to monomer 50299643

Compile data set for download or QSAR
Wt: 270.3
BDBM50299630
Wt: 288.3
BDBM50299631
Wt: 270.3
BDBM50299635
Wt: 286.3
BDBM50299651
Wt: 286.3
BDBM50299658
Wt: 304.3
BDBM50299653
Wt: 304.3
BDBM50299655
Wt: 304.3
BDBM50299656

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50299630,50299631,50299635,50299651,50299658,50299653,50299655,50299656   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Estradiol 17-beta-dehydrogenase 1 (17beta-HSD1)


(Homo sapiens (Human))
BDBM50299653
PNG
(2,6-Difluoro-4-[5-(3-hydroxyphenyl)-2-thienyl]phen...)
Show SMILES Oc1cccc(c1)-c1ccc(s1)-c1cc(F)c(O)c(F)c1
Show InChI InChI=1S/C16H10F2O2S/c17-12-7-10(8-13(18)16(12)20)15-5-4-14(21-15)9-2-1-3-11(19)6-9/h1-8,19-20H
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n/an/a 56n/an/an/an/an/an/a



Saarland University

Curated by ChEMBL


Assay Description
Inhibition of human placental 17betaHSD1 by radiodetection assay


J Med Chem 52: 6724-43 (2009)


Article DOI: 10.1021/jm901195w
BindingDB Entry DOI: 10.7270/Q2CR5TDT
More data for this
Ligand-Target Pair
Estradiol 17-beta-dehydrogenase 2


(Homo sapiens (Human))
BDBM50299658
PNG
(2-Fluoro-5-[5-(4-hydroxyphenyl)-2-thienyl]phenol |...)
Show SMILES Oc1ccc(cc1)-c1ccc(s1)-c1ccc(F)c(O)c1
Show InChI InChI=1S/C16H11FO2S/c17-13-6-3-11(9-14(13)19)16-8-7-15(20-16)10-1-4-12(18)5-2-10/h1-9,18-19H
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n/an/a 183n/an/an/an/an/an/a



Saarland University

Curated by ChEMBL


Assay Description
Inhibition of human placental 17betaHSD2 by radiodetection assay


J Med Chem 52: 6724-43 (2009)


Article DOI: 10.1021/jm901195w
BindingDB Entry DOI: 10.7270/Q2CR5TDT
More data for this
Ligand-Target Pair
Estradiol 17-beta-dehydrogenase 1 (17beta-HSD1)


(Homo sapiens (Human))
BDBM50299658
PNG
(2-Fluoro-5-[5-(4-hydroxyphenyl)-2-thienyl]phenol |...)
Show SMILES Oc1ccc(cc1)-c1ccc(s1)-c1ccc(F)c(O)c1
Show InChI InChI=1S/C16H11FO2S/c17-13-6-3-11(9-14(13)19)16-8-7-15(20-16)10-1-4-12(18)5-2-10/h1-9,18-19H
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n/an/a 113n/an/an/an/an/an/a



Saarland University

Curated by ChEMBL


Assay Description
Inhibition of human placental 17betaHSD1 by radiodetection assay


J Med Chem 52: 6724-43 (2009)


Article DOI: 10.1021/jm901195w
BindingDB Entry DOI: 10.7270/Q2CR5TDT
More data for this
Ligand-Target Pair
Estradiol 17-beta-dehydrogenase 1 (17beta-HSD1)


(Homo sapiens (Human))
BDBM50299635
PNG
(3-[5-(3-Fluorophenyl)-2-thienyl]phenol | CHEMBL576...)
Show SMILES Oc1cccc(c1)-c1ccc(s1)-c1cccc(F)c1
Show InChI InChI=1S/C16H11FOS/c17-13-5-1-3-11(9-13)15-7-8-16(19-15)12-4-2-6-14(18)10-12/h1-10,18H
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n/an/a 535n/an/an/an/an/an/a



Saarland University

Curated by ChEMBL


Assay Description
Inhibition of human placental 17betaHSD1 by radiodetection assay


J Med Chem 52: 6724-43 (2009)


Article DOI: 10.1021/jm901195w
BindingDB Entry DOI: 10.7270/Q2CR5TDT
More data for this
Ligand-Target Pair
Estradiol 17-beta-dehydrogenase 1 (17beta-HSD1)


(Homo sapiens (Human))
BDBM50299630
PNG
(3-[5-(4-Fluorophenyl)-2-thienyl]phenol | CHEMBL570...)
Show SMILES Oc1cccc(c1)-c1ccc(s1)-c1ccc(F)cc1
Show InChI InChI=1S/C16H11FOS/c17-13-6-4-11(5-7-13)15-8-9-16(19-15)12-2-1-3-14(18)10-12/h1-10,18H
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n/an/a 717n/an/an/an/an/an/a



Saarland University

Curated by ChEMBL


Assay Description
Inhibition of human placental 17betaHSD1 by radiodetection assay


J Med Chem 52: 6724-43 (2009)


Article DOI: 10.1021/jm901195w
BindingDB Entry DOI: 10.7270/Q2CR5TDT
More data for this
Ligand-Target Pair
Estradiol 17-beta-dehydrogenase 1 (17beta-HSD1)


(Homo sapiens (Human))
BDBM50299655
PNG
(2-Fluoro-4-[5-(3-fluoro-5-hydroxyphenyl)thien-2-yl...)
Show SMILES Oc1cc(F)cc(c1)-c1ccc(s1)-c1ccc(O)c(F)c1
Show InChI InChI=1S/C16H10F2O2S/c17-11-5-10(6-12(19)8-11)16-4-3-15(21-16)9-1-2-14(20)13(18)7-9/h1-8,19-20H
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n/an/a 29n/an/an/an/an/an/a



Saarland University

Curated by ChEMBL


Assay Description
Inhibition of human placental 17betaHSD1 by radiodetection assay


J Med Chem 52: 6724-43 (2009)


Article DOI: 10.1021/jm901195w
BindingDB Entry DOI: 10.7270/Q2CR5TDT
More data for this
Ligand-Target Pair
Estradiol 17-beta-dehydrogenase 1 (17beta-HSD1)


(Homo sapiens (Human))
BDBM50299651
PNG
(3-Fluoro-5-[5-(4-hydroxyphenyl)-2-thienyl]phenol |...)
Show SMILES Oc1ccc(cc1)-c1ccc(s1)-c1cc(O)cc(F)c1
Show InChI InChI=1S/C16H11FO2S/c17-12-7-11(8-14(19)9-12)16-6-5-15(20-16)10-1-3-13(18)4-2-10/h1-9,18-19H
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n/an/a 42n/an/an/an/an/an/a



Saarland University

Curated by ChEMBL


Assay Description
Inhibition of human placental 17betaHSD1 by radiodetection assay


J Med Chem 52: 6724-43 (2009)


Article DOI: 10.1021/jm901195w
BindingDB Entry DOI: 10.7270/Q2CR5TDT
More data for this
Ligand-Target Pair
Estradiol 17-beta-dehydrogenase 1 (17beta-HSD1)


(Homo sapiens (Human))
BDBM50299631
PNG
(3-[5-(3,4-Difluorophenyl)-2-thienyl]phenol | CHEMB...)
Show SMILES Oc1cccc(c1)-c1ccc(s1)-c1ccc(F)c(F)c1
Show InChI InChI=1S/C16H10F2OS/c17-13-5-4-11(9-14(13)18)16-7-6-15(20-16)10-2-1-3-12(19)8-10/h1-9,19H
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n/an/a 780n/an/an/an/an/an/a



Saarland University

Curated by ChEMBL


Assay Description
Inhibition of human placental 17betaHSD1 by radiodetection assay


J Med Chem 52: 6724-43 (2009)


Article DOI: 10.1021/jm901195w
BindingDB Entry DOI: 10.7270/Q2CR5TDT
More data for this
Ligand-Target Pair
Estradiol 17-beta-dehydrogenase 2


(Homo sapiens (Human))
BDBM50299630
PNG
(3-[5-(4-Fluorophenyl)-2-thienyl]phenol | CHEMBL570...)
Show SMILES Oc1cccc(c1)-c1ccc(s1)-c1ccc(F)cc1
Show InChI InChI=1S/C16H11FOS/c17-13-6-4-11(5-7-13)15-8-9-16(19-15)12-2-1-3-14(18)10-12/h1-10,18H
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n/an/a 3.66E+3n/an/an/an/an/an/a



Saarland University

Curated by ChEMBL


Assay Description
Inhibition of human placental 17betaHSD2 by radiodetection assay


J Med Chem 52: 6724-43 (2009)


Article DOI: 10.1021/jm901195w
BindingDB Entry DOI: 10.7270/Q2CR5TDT
More data for this
Ligand-Target Pair
Estradiol 17-beta-dehydrogenase 2


(Homo sapiens (Human))
BDBM50299631
PNG
(3-[5-(3,4-Difluorophenyl)-2-thienyl]phenol | CHEMB...)
Show SMILES Oc1cccc(c1)-c1ccc(s1)-c1ccc(F)c(F)c1
Show InChI InChI=1S/C16H10F2OS/c17-13-5-4-11(9-14(13)18)16-7-6-15(20-16)10-2-1-3-12(19)8-10/h1-9,19H
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n/an/a 2.64E+3n/an/an/an/an/an/a



Saarland University

Curated by ChEMBL


Assay Description
Inhibition of human placental 17betaHSD2 by radiodetection assay


J Med Chem 52: 6724-43 (2009)


Article DOI: 10.1021/jm901195w
BindingDB Entry DOI: 10.7270/Q2CR5TDT
More data for this
Ligand-Target Pair
Estradiol 17-beta-dehydrogenase 2


(Homo sapiens (Human))
BDBM50299635
PNG
(3-[5-(3-Fluorophenyl)-2-thienyl]phenol | CHEMBL576...)
Show SMILES Oc1cccc(c1)-c1ccc(s1)-c1cccc(F)c1
Show InChI InChI=1S/C16H11FOS/c17-13-5-1-3-11(9-13)15-7-8-16(19-15)12-4-2-6-14(18)10-12/h1-10,18H
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n/an/a 1.82E+3n/an/an/an/an/an/a



Saarland University

Curated by ChEMBL


Assay Description
Inhibition of human placental 17betaHSD2 by radiodetection assay


J Med Chem 52: 6724-43 (2009)


Article DOI: 10.1021/jm901195w
BindingDB Entry DOI: 10.7270/Q2CR5TDT
More data for this
Ligand-Target Pair
Estradiol 17-beta-dehydrogenase 2


(Homo sapiens (Human))
BDBM50299651
PNG
(3-Fluoro-5-[5-(4-hydroxyphenyl)-2-thienyl]phenol |...)
Show SMILES Oc1ccc(cc1)-c1ccc(s1)-c1cc(O)cc(F)c1
Show InChI InChI=1S/C16H11FO2S/c17-12-7-11(8-14(19)9-12)16-6-5-15(20-16)10-1-3-13(18)4-2-10/h1-9,18-19H
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PubMed
n/an/a 463n/an/an/an/an/an/a



Saarland University

Curated by ChEMBL


Assay Description
Inhibition of human placental 17betaHSD2 by radiodetection assay


J Med Chem 52: 6724-43 (2009)


Article DOI: 10.1021/jm901195w
BindingDB Entry DOI: 10.7270/Q2CR5TDT
More data for this
Ligand-Target Pair
Estradiol 17-beta-dehydrogenase 2


(Homo sapiens (Human))
BDBM50299653
PNG
(2,6-Difluoro-4-[5-(3-hydroxyphenyl)-2-thienyl]phen...)
Show SMILES Oc1cccc(c1)-c1ccc(s1)-c1cc(F)c(O)c(F)c1
Show InChI InChI=1S/C16H10F2O2S/c17-12-7-10(8-13(18)16(12)20)15-5-4-14(21-15)9-2-1-3-11(19)6-9/h1-8,19-20H
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PubMed
n/an/a 312n/an/an/an/an/an/a



Saarland University

Curated by ChEMBL


Assay Description
Inhibition of human placental 17betaHSD2 by radiodetection assay


J Med Chem 52: 6724-43 (2009)


Article DOI: 10.1021/jm901195w
BindingDB Entry DOI: 10.7270/Q2CR5TDT
More data for this
Ligand-Target Pair
Estradiol 17-beta-dehydrogenase 2


(Homo sapiens (Human))
BDBM50299655
PNG
(2-Fluoro-4-[5-(3-fluoro-5-hydroxyphenyl)thien-2-yl...)
Show SMILES Oc1cc(F)cc(c1)-c1ccc(s1)-c1ccc(O)c(F)c1
Show InChI InChI=1S/C16H10F2O2S/c17-11-5-10(6-12(19)8-11)16-4-3-15(21-16)9-1-2-14(20)13(18)7-9/h1-8,19-20H
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n/an/a 227n/an/an/an/an/an/a



Saarland University

Curated by ChEMBL


Assay Description
Inhibition of human placental 17betaHSD2 by radiodetection assay


J Med Chem 52: 6724-43 (2009)


Article DOI: 10.1021/jm901195w
BindingDB Entry DOI: 10.7270/Q2CR5TDT
More data for this
Ligand-Target Pair
Estradiol 17-beta-dehydrogenase 2


(Homo sapiens (Human))
BDBM50299656
PNG
(2-Fluoro-4-[5-(4-fluoro-3-hydroxyphenyl)thien-2-yl...)
Show SMILES Oc1ccc(cc1F)-c1ccc(s1)-c1ccc(F)c(O)c1
Show InChI InChI=1S/C16H10F2O2S/c17-11-3-1-10(8-14(11)20)16-6-5-15(21-16)9-2-4-13(19)12(18)7-9/h1-8,19-20H
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n/an/a 218n/an/an/an/an/an/a



Saarland University

Curated by ChEMBL


Assay Description
Inhibition of human placental 17betaHSD2 by radiodetection assay


J Med Chem 52: 6724-43 (2009)


Article DOI: 10.1021/jm901195w
BindingDB Entry DOI: 10.7270/Q2CR5TDT
More data for this
Ligand-Target Pair
Estradiol 17-beta-dehydrogenase 1 (17beta-HSD1)


(Homo sapiens (Human))
BDBM50299656
PNG
(2-Fluoro-4-[5-(4-fluoro-3-hydroxyphenyl)thien-2-yl...)
Show SMILES Oc1ccc(cc1F)-c1ccc(s1)-c1ccc(F)c(O)c1
Show InChI InChI=1S/C16H10F2O2S/c17-11-3-1-10(8-14(11)20)16-6-5-15(21-16)9-2-4-13(19)12(18)7-9/h1-8,19-20H
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n/an/a 17n/an/an/an/an/an/a



Saarland University

Curated by ChEMBL


Assay Description
Inhibition of human placental 17betaHSD1 by radiodetection assay


J Med Chem 52: 6724-43 (2009)


Article DOI: 10.1021/jm901195w
BindingDB Entry DOI: 10.7270/Q2CR5TDT
More data for this
Ligand-Target Pair