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26 similar compounds to monomer 50305129

Compile data set for download or QSAR
Wt: 497.5
BDBM50305131
Wt: 456.4
BDBM50305132
Wt: 496.6
BDBM50305133
Wt: 469.4
BDBM50305134
Wt: 470.4
BDBM50305135
Wt: 468.5
BDBM50305136
Wt: 503.5
BDBM50305137
Wt: 525.5
BDBM50305138
Wt: 538.6
BDBM50305139
Wt: 455.5
BDBM50305140
Wt: 497.5
BDBM50305141
Wt: 456.4
BDBM50305142
Wt: 469.4
BDBM50305143
Wt: 503.5
BDBM50305144
Wt: 503.5
BDBM50305145
Displayed 1 to 15 (of 26 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50305131,50305132,50305133,50305134,50305135,50305136,50305137,50305138,50305139,50305140,50305141,50305142,50305143,50305144,50305145   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50305131
PNG
(6-(3-(dimethylamino)propoxy)-2-(4-phenoxyphenyl)-9...)
Show SMILES CN(C)CCCOc1ccc2CCn3nc(c(C(N)=O)c3Nc2c1)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C29H31N5O3/c1-33(2)16-6-18-36-24-14-9-20-15-17-34-29(31-25(20)19-24)26(28(30)35)27(32-34)21-10-12-23(13-11-21)37-22-7-4-3-5-8-22/h3-5,7-14,19,31H,6,15-18H2,1-2H3,(H2,30,35)
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n/an/a 0.510n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human LCK by scintillation counting


Bioorg Med Chem Lett 20: 112-6 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.013
BindingDB Entry DOI: 10.7270/Q22Z15NV
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50305145
PNG
(2-(4-phenoxyphenyl)-7-(pyridin-3-ylmethoxy)-9,10-d...)
Show SMILES NC(=O)c1c2Nc3ccc(OCc4cccnc4)cc3CCn2nc1-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C30H25N5O3/c31-29(36)27-28(21-8-10-24(11-9-21)38-23-6-2-1-3-7-23)34-35-16-14-22-17-25(12-13-26(22)33-30(27)35)37-19-20-5-4-15-32-18-20/h1-13,15,17-18,33H,14,16,19H2,(H2,31,36)
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n/an/a 2.80n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human LCK by scintillation counting


Bioorg Med Chem Lett 20: 112-6 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.013
BindingDB Entry DOI: 10.7270/Q22Z15NV
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50305133
PNG
(6-(4-methylpentyloxy)-2-(4-phenoxyphenyl)-9,10-dih...)
Show SMILES CC(C)CCCOc1ccc2CCn3nc(c(C(N)=O)c3Nc2c1)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C30H32N4O3/c1-20(2)7-6-18-36-25-15-10-21-16-17-34-30(32-26(21)19-25)27(29(31)35)28(33-34)22-11-13-24(14-12-22)37-23-8-4-3-5-9-23/h3-5,8-15,19-20,32H,6-7,16-18H2,1-2H3,(H2,31,35)
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n/an/a>100n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human LCK by scintillation counting


Bioorg Med Chem Lett 20: 112-6 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.013
BindingDB Entry DOI: 10.7270/Q22Z15NV
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50305134
PNG
(6-(2-amino-2-oxoethoxy)-2-(4-phenoxyphenyl)-9,10-d...)
Show SMILES NC(=O)COc1ccc2CCn3nc(c(C(N)=O)c3Nc2c1)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C26H23N5O4/c27-22(32)15-34-20-11-6-16-12-13-31-26(29-21(16)14-20)23(25(28)33)24(30-31)17-7-9-19(10-8-17)35-18-4-2-1-3-5-18/h1-11,14,29H,12-13,15H2,(H2,27,32)(H2,28,33)
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n/an/a 1.5n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human LCK by scintillation counting


Bioorg Med Chem Lett 20: 112-6 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.013
BindingDB Entry DOI: 10.7270/Q22Z15NV
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50305135
PNG
(2-(3-carbamoyl-2-(4-phenoxyphenyl)-9,10-dihydro-4H...)
Show SMILES NC(=O)c1c2Nc3cc(OCC(O)=O)ccc3CCn2nc1-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C26H22N4O5/c27-25(33)23-24(17-7-9-19(10-8-17)35-18-4-2-1-3-5-18)29-30-13-12-16-6-11-20(34-15-22(31)32)14-21(16)28-26(23)30/h1-11,14,28H,12-13,15H2,(H2,27,33)(H,31,32)
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n/an/a 1n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human LCK by scintillation counting


Bioorg Med Chem Lett 20: 112-6 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.013
BindingDB Entry DOI: 10.7270/Q22Z15NV
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50305136
PNG
(6-(2-oxopropoxy)-2-(4-phenoxyphenyl)-9,10-dihydro-...)
Show SMILES CC(=O)COc1ccc2CCn3nc(c(C(N)=O)c3Nc2c1)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C27H24N4O4/c1-17(32)16-34-22-12-7-18-13-14-31-27(29-23(18)15-22)24(26(28)33)25(30-31)19-8-10-21(11-9-19)35-20-5-3-2-4-6-20/h2-12,15,29H,13-14,16H2,1H3,(H2,28,33)
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n/an/a 3.90n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human LCK by scintillation counting


Bioorg Med Chem Lett 20: 112-6 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.013
BindingDB Entry DOI: 10.7270/Q22Z15NV
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50305137
PNG
(2-(4-phenoxyphenyl)-6-(pyridin-3-ylmethoxy)-9,10-d...)
Show SMILES NC(=O)c1c2Nc3cc(OCc4cccnc4)ccc3CCn2nc1-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C30H25N5O3/c31-29(36)27-28(22-9-11-24(12-10-22)38-23-6-2-1-3-7-23)34-35-16-14-21-8-13-25(17-26(21)33-30(27)35)37-19-20-5-4-15-32-18-20/h1-13,15,17-18,33H,14,16,19H2,(H2,31,36)
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n/an/a 8.20n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human LCK by scintillation counting


Bioorg Med Chem Lett 20: 112-6 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.013
BindingDB Entry DOI: 10.7270/Q22Z15NV
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50305138
PNG
(6-(2-morpholinoethoxy)-2-(4-phenoxyphenyl)-9,10-di...)
Show SMILES NC(=O)c1c2Nc3cc(OCCN4CCOCC4)ccc3CCn2nc1-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C30H31N5O4/c31-29(36)27-28(22-7-9-24(10-8-22)39-23-4-2-1-3-5-23)33-35-13-12-21-6-11-25(20-26(21)32-30(27)35)38-19-16-34-14-17-37-18-15-34/h1-11,20,32H,12-19H2,(H2,31,36)
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n/an/a 0.770n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human LCK by scintillation counting


Bioorg Med Chem Lett 20: 112-6 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.013
BindingDB Entry DOI: 10.7270/Q22Z15NV
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50305139
PNG
(6-(2-(4-methylpiperazin-1-yl)ethoxy)-2-(4-phenoxyp...)
Show SMILES CN1CCN(CCOc2ccc3CCn4nc(c(C(N)=O)c4Nc3c2)-c2ccc(Oc3ccccc3)cc2)CC1
Show InChI InChI=1S/C31H34N6O3/c1-35-15-17-36(18-16-35)19-20-39-26-12-7-22-13-14-37-31(33-27(22)21-26)28(30(32)38)29(34-37)23-8-10-25(11-9-23)40-24-5-3-2-4-6-24/h2-12,21,33H,13-20H2,1H3,(H2,32,38)
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n/an/a 0.550n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human LCK by scintillation counting


Bioorg Med Chem Lett 20: 112-6 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.013
BindingDB Entry DOI: 10.7270/Q22Z15NV
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50305140
PNG
(7-(2-aminoethoxy)-2-(4-phenoxyphenyl)-9,10-dihydro...)
Show SMILES NCCOc1ccc2Nc3c(C(N)=O)c(nn3CCc2c1)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C26H25N5O3/c27-13-15-33-21-10-11-22-18(16-21)12-14-31-26(29-22)23(25(28)32)24(30-31)17-6-8-20(9-7-17)34-19-4-2-1-3-5-19/h1-11,16,29H,12-15,27H2,(H2,28,32)
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n/an/a 0.410n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human LCK by scintillation counting


Bioorg Med Chem Lett 20: 112-6 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.013
BindingDB Entry DOI: 10.7270/Q22Z15NV
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50305141
PNG
(7-(3-(dimethylamino)propoxy)-2-(4-phenoxyphenyl)-9...)
Show SMILES CN(C)CCCOc1ccc2Nc3c(C(N)=O)c(nn3CCc2c1)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C29H31N5O3/c1-33(2)16-6-18-36-24-13-14-25-21(19-24)15-17-34-29(31-25)26(28(30)35)27(32-34)20-9-11-23(12-10-20)37-22-7-4-3-5-8-22/h3-5,7-14,19,31H,6,15-18H2,1-2H3,(H2,30,35)
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n/an/a 1n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human LCK by scintillation counting


Bioorg Med Chem Lett 20: 112-6 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.013
BindingDB Entry DOI: 10.7270/Q22Z15NV
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50305142
PNG
(7-(2-hydroxyethoxy)-2-(4-phenoxyphenyl)-9,10-dihyd...)
Show SMILES NC(=O)c1c2Nc3ccc(OCCO)cc3CCn2nc1-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C26H24N4O4/c27-25(32)23-24(17-6-8-20(9-7-17)34-19-4-2-1-3-5-19)29-30-13-12-18-16-21(33-15-14-31)10-11-22(18)28-26(23)30/h1-11,16,28,31H,12-15H2,(H2,27,32)
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n/an/a 0.75n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human LCK by scintillation counting


Bioorg Med Chem Lett 20: 112-6 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.013
BindingDB Entry DOI: 10.7270/Q22Z15NV
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50305143
PNG
(7-(2-amino-2-oxoethoxy)-2-(4-phenoxyphenyl)-9,10-d...)
Show SMILES NC(=O)COc1ccc2Nc3c(C(N)=O)c(nn3CCc2c1)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C26H23N5O4/c27-22(32)15-34-20-10-11-21-17(14-20)12-13-31-26(29-21)23(25(28)33)24(30-31)16-6-8-19(9-7-16)35-18-4-2-1-3-5-18/h1-11,14,29H,12-13,15H2,(H2,27,32)(H2,28,33)
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n/an/a 1.20n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human LCK by scintillation counting


Bioorg Med Chem Lett 20: 112-6 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.013
BindingDB Entry DOI: 10.7270/Q22Z15NV
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50305144
PNG
(2-(4-phenoxyphenyl)-7-(pyridin-2-ylmethoxy)-9,10-d...)
Show SMILES NC(=O)c1c2Nc3ccc(OCc4ccccn4)cc3CCn2nc1-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C30H25N5O3/c31-29(36)27-28(20-9-11-24(12-10-20)38-23-7-2-1-3-8-23)34-35-17-15-21-18-25(13-14-26(21)33-30(27)35)37-19-22-6-4-5-16-32-22/h1-14,16,18,33H,15,17,19H2,(H2,31,36)
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n/an/a 5.40n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human LCK by scintillation counting


Bioorg Med Chem Lett 20: 112-6 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.013
BindingDB Entry DOI: 10.7270/Q22Z15NV
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50305132
PNG
(6-(2-hydroxyethoxy)-2-(4-phenoxyphenyl)-9,10-dihyd...)
Show SMILES NC(=O)c1c2Nc3cc(OCCO)ccc3CCn2nc1-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C26H24N4O4/c27-25(32)23-24(18-7-9-20(10-8-18)34-19-4-2-1-3-5-19)29-30-13-12-17-6-11-21(33-15-14-31)16-22(17)28-26(23)30/h1-11,16,28,31H,12-15H2,(H2,27,32)
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n/an/a 1.5n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human LCK by scintillation counting


Bioorg Med Chem Lett 20: 112-6 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.013
BindingDB Entry DOI: 10.7270/Q22Z15NV
More data for this
Ligand-Target Pair