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6 similar compounds to monomer 50306402

Wt: 297.3
BDBM50306401
Wt: 311.3
BDBM50306403
Wt: 311.3
BDBM50306404
Wt: 283.3
BDBM50306405
Wt: 223.2
BDBM50350488
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Wt: 235.3
BDBM50350499

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50306401,50306403,50306404,50306405,50350488,50350499   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
CDGSH iron-sulfur domain-containing protein 1


(Homo sapiens)
BDBM50350488
PNG
(CHEMBL1061)
Show SMILES Oc1[nH]c(=O)sc1Cc1ccc(O)cc1
Show InChI InChI=1S/C10H9NO3S/c12-7-3-1-6(2-4-7)5-8-9(13)11-10(14)15-8/h1-4,12-13H,5H2,(H,11,14)
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PubMed
598n/an/an/an/an/an/an/an/a



West Virginia University

Curated by ChEMBL


Assay Description
Displacement of [3H]rosiglitazone from recombinant human C-terminal His-tagged MitoNEET cytosolic domain (32 to 108 residues) expressed in Escherichi...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM50306403
PNG
(5-(4-phenethylbenzyl)thiazolidine-2,4-dione | CHEM...)
Show SMILES Oc1[nH]c(=O)sc1Cc1ccc(CCc2ccccc2)cc1
Show InChI InChI=1S/C18H17NO2S/c20-17-16(22-18(21)19-17)12-15-10-8-14(9-11-15)7-6-13-4-2-1-3-5-13/h1-5,8-11,20H,6-7,12H2,(H,19,21)
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n/an/an/an/a 1.08E+3n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSA


Bioorg Med Chem Lett 20: 1298-301 (2010)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM50306404
PNG
(5-(4-benzoylbenzyl)thiazolidine-2,4-dione | CHEMBL...)
Show SMILES Oc1[nH]c(=O)sc1Cc1ccc(cc1)C(=O)c1ccccc1
Show InChI InChI=1S/C17H13NO3S/c19-15(12-4-2-1-3-5-12)13-8-6-11(7-9-13)10-14-16(20)18-17(21)22-14/h1-9,20H,10H2,(H,18,21)
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n/an/an/an/a 5.30E+3n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSA


Bioorg Med Chem Lett 20: 1298-301 (2010)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM50306405
PNG
(5-(biphenyl-4-ylmethyl)thiazolidine-2,4-dione | CH...)
Show SMILES Oc1[nH]c(=O)sc1Cc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C16H13NO2S/c18-15-14(20-16(19)17-15)10-11-6-8-13(9-7-11)12-4-2-1-3-5-12/h1-9,18H,10H2,(H,17,19)
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n/an/an/an/a 2.22E+3n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSA


Bioorg Med Chem Lett 20: 1298-301 (2010)

More data for this
Ligand-Target Pair
CDGSH iron-sulfur domain-containing protein 1


(Homo sapiens)
BDBM50350488
PNG
(CHEMBL1061)
Show SMILES Oc1[nH]c(=O)sc1Cc1ccc(O)cc1
Show InChI InChI=1S/C10H9NO3S/c12-7-3-1-6(2-4-7)5-8-9(13)11-10(14)15-8/h1-4,12-13H,5H2,(H,11,14)
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PubMed
n/an/a 1.40E+4n/an/an/an/an/an/a



Northeast Ohio Medical University

Curated by ChEMBL


Assay Description
Displacement of [3H]-rosiglitazone from human recombinant C-terminal His-tagged cytosolic domain of mitoNEET (32-108) by scintillation proximity assa...


Bioorg Med Chem Lett 21: 5498-501 (2011)

More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM50350488
PNG
(CHEMBL1061)
Show SMILES Oc1[nH]c(=O)sc1Cc1ccc(O)cc1
Show InChI InChI=1S/C10H9NO3S/c12-7-3-1-6(2-4-7)5-8-9(13)11-10(14)15-8/h1-4,12-13H,5H2,(H,11,14)
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PubMed
n/an/a 2.25E+5n/an/an/an/an/an/a



Northeastern Ohio Universities Colleges of Medicine and Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MAOB by amplex red assay


Bioorg Med Chem Lett 21: 4798-803 (2011)

More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM50350488
PNG
(CHEMBL1061)
Show SMILES Oc1[nH]c(=O)sc1Cc1ccc(O)cc1
Show InChI InChI=1S/C10H9NO3S/c12-7-3-1-6(2-4-7)5-8-9(13)11-10(14)15-8/h1-4,12-13H,5H2,(H,11,14)
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PubMed
n/an/a 1.94E+5n/an/an/an/an/an/a



Northeastern Ohio Universities Colleges of Medicine and Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MAOA assessed as inhibition of kynuramine conversion to fluorescent metabolite 4-hydroxyquinoline by fluorimetry


Bioorg Med Chem Lett 21: 4798-803 (2011)

More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM50350499
PNG
(CHEMBL1814636)
Show SMILES Cc1cc(C)cc(Cc2sc(=O)[nH]c2O)c1
Show InChI InChI=1S/C12H13NO2S/c1-7-3-8(2)5-9(4-7)6-10-11(14)13-12(15)16-10/h3-5,14H,6H2,1-2H3,(H,13,15)
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n/an/a 5.05E+4n/an/an/an/an/an/a



Northeastern Ohio Universities Colleges of Medicine and Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MAOA assessed as inhibition of kynuramine conversion to fluorescent metabolite 4-hydroxyquinoline by fluorimetry


Bioorg Med Chem Lett 21: 4798-803 (2011)

More data for this
Ligand-Target Pair
CDGSH iron-sulfur domain-containing protein 1


(Homo sapiens)
BDBM50350488
PNG
(CHEMBL1061)
Show SMILES Oc1[nH]c(=O)sc1Cc1ccc(O)cc1
Show InChI InChI=1S/C10H9NO3S/c12-7-3-1-6(2-4-7)5-8-9(13)11-10(14)15-8/h1-4,12-13H,5H2,(H,11,14)
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PubMed
n/an/a 1.40E+4n/an/an/an/an/an/a



West Virginia University

Curated by ChEMBL


Assay Description
Displacement of [3H]rosiglitazone from recombinant human C-terminal His-tagged MitoNEET cytosolic domain (32 to 108 residues) expressed in Escherichi...


Citation and Details
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM50306401
PNG
(5-(4-benzylbenzyl)thiazolidine-2,4-dione | CHEMBL5...)
Show SMILES Oc1[nH]c(=O)sc1Cc1ccc(Cc2ccccc2)cc1
Show InChI InChI=1S/C17H15NO2S/c19-16-15(21-17(20)18-16)11-14-8-6-13(7-9-14)10-12-4-2-1-3-5-12/h1-9,19H,10-11H2,(H,18,20)
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n/an/an/an/a 9.28E+3n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSA


Bioorg Med Chem Lett 20: 1298-301 (2010)

More data for this
Ligand-Target Pair
CDGSH iron-sulfur domain-containing protein 1


(Homo sapiens)
BDBM50350499
PNG
(CHEMBL1814636)
Show SMILES Cc1cc(C)cc(Cc2sc(=O)[nH]c2O)c1
Show InChI InChI=1S/C12H13NO2S/c1-7-3-8(2)5-9(4-7)6-10-11(14)13-12(15)16-10/h3-5,14H,6H2,1-2H3,(H,13,15)
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PubMed
n/an/a 1.33E+4n/an/an/an/an/an/a



Northeast Ohio Medical University

Curated by ChEMBL


Assay Description
Displacement of [3H]-rosiglitazone from human recombinant C-terminal His-tagged cytosolic domain of mitoNEET (32-108) by scintillation proximity assa...


Bioorg Med Chem Lett 21: 5498-501 (2011)

More data for this
Ligand-Target Pair