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8 molecules are shown

Compile data set for download or QSAR
Wt: 361.3
BDBM50306579
Wt: 472.2
BDBM50306580
Wt: 449.4
BDBM50306581
Wt: 440.4
BDBM50306582
Wt: 393.3
BDBM50306583
Wt: 388.3
BDBM50306584
Wt: 411.3
BDBM50306585
Wt: 343.3
BDBM50306586

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50306579,50306580,50306581,50306582,50306583,50306584,50306585,50306586   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50306579
PNG
((R)-2-(carboxyformamido)-3-(4-(2-fluorobenzyloxy)p...)
Show SMILES OC(=O)[C@@H](Cc1ccc(OCc2ccccc2F)cc1)NC(=O)C(O)=O
Show InChI InChI=1S/C18H16FNO6/c19-14-4-2-1-3-12(14)10-26-13-7-5-11(6-8-13)9-15(17(22)23)20-16(21)18(24)25/h1-8,15H,9-10H2,(H,20,21)(H,22,23)(H,24,25)/t15-/m1/s1
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n/an/a 1.00E+4n/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of JMJD2A by MALDI-TOF assay


J Med Chem 53: 1810-8 (2010)


Article DOI: 10.1021/jm901680b
BindingDB Entry DOI: 10.7270/Q2959HPQ
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50306583
PNG
((R)-2-(carboxyformamido)-3-(4-(phenylsulfonyloxy)p...)
Show SMILES OC(=O)[C@@H](Cc1ccc(OS(=O)(=O)c2ccccc2)cc1)NC(=O)C(O)=O
Show InChI InChI=1S/C17H15NO8S/c19-15(17(22)23)18-14(16(20)21)10-11-6-8-12(9-7-11)26-27(24,25)13-4-2-1-3-5-13/h1-9,14H,10H2,(H,18,19)(H,20,21)(H,22,23)/t14-/m1/s1
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n/an/a 1.40E+4n/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of JMJD2A by MALDI-TOF assay


J Med Chem 53: 1810-8 (2010)


Article DOI: 10.1021/jm901680b
BindingDB Entry DOI: 10.7270/Q2959HPQ
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50306584
PNG
((R)-2-(carboxyformamido)-3-(4-(2-nitrobenzyloxy)ph...)
Show SMILES OC(=O)[C@@H](Cc1ccc(OCc2ccccc2[N+]([O-])=O)cc1)NC(=O)C(O)=O
Show InChI InChI=1S/C18H16N2O8/c21-16(18(24)25)19-14(17(22)23)9-11-5-7-13(8-6-11)28-10-12-3-1-2-4-15(12)20(26)27/h1-8,14H,9-10H2,(H,19,21)(H,22,23)(H,24,25)/t14-/m1/s1
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n/an/a 1.70E+4n/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of JMJD2A by MALDI-TOF assay


J Med Chem 53: 1810-8 (2010)


Article DOI: 10.1021/jm901680b
BindingDB Entry DOI: 10.7270/Q2959HPQ
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50306581
PNG
((R)-3-(4-(4-tert-butylphenylsulfonyloxy)phenyl)-2-...)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)Oc1ccc(C[C@@H](NC(=O)C(O)=O)C(O)=O)cc1
Show InChI InChI=1S/C21H23NO8S/c1-21(2,3)14-6-10-16(11-7-14)31(28,29)30-15-8-4-13(5-9-15)12-17(19(24)25)22-18(23)20(26)27/h4-11,17H,12H2,1-3H3,(H,22,23)(H,24,25)(H,26,27)/t17-/m1/s1
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n/an/a 1.30E+4n/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of JMJD2A by MALDI-TOF assay


J Med Chem 53: 1810-8 (2010)


Article DOI: 10.1021/jm901680b
BindingDB Entry DOI: 10.7270/Q2959HPQ
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50306580
PNG
((R)-3-(4-(4-bromophenylsulfonyloxy)phenyl)-2-(carb...)
Show SMILES OC(=O)[C@@H](Cc1ccc(OS(=O)(=O)c2ccc(Br)cc2)cc1)NC(=O)C(O)=O
Show InChI InChI=1S/C17H14BrNO8S/c18-11-3-7-13(8-4-11)28(25,26)27-12-5-1-10(2-6-12)9-14(16(21)22)19-15(20)17(23)24/h1-8,14H,9H2,(H,19,20)(H,21,22)(H,23,24)/t14-/m1/s1
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n/an/a 1.20E+4n/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of JMJD2A by MALDI-TOF assay


J Med Chem 53: 1810-8 (2010)


Article DOI: 10.1021/jm901680b
BindingDB Entry DOI: 10.7270/Q2959HPQ
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50306580
PNG
((R)-3-(4-(4-bromophenylsulfonyloxy)phenyl)-2-(carb...)
Show SMILES OC(=O)[C@@H](Cc1ccc(OS(=O)(=O)c2ccc(Br)cc2)cc1)NC(=O)C(O)=O
Show InChI InChI=1S/C17H14BrNO8S/c18-11-3-7-13(8-4-11)28(25,26)27-12-5-1-10(2-6-12)9-14(16(21)22)19-15(20)17(23)24/h1-8,14H,9H2,(H,19,20)(H,21,22)(H,23,24)/t14-/m1/s1
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n/an/a 1.20E+4n/an/an/an/an/an/a



Kyoto Prefectural University of Medicine

Curated by ChEMBL


Assay Description
Inhibition of KDM4A


J Med Chem 54: 8236-50 (2011)


Article DOI: 10.1021/jm201048w
BindingDB Entry DOI: 10.7270/Q2D50NFR
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50306582
PNG
((R)-2-(carboxyformamido)-3-(4-(2-oxo-2-(4-(pyrroli...)
Show SMILES OC(=O)[C@@H](Cc1ccc(OCC(=O)c2ccc(cc2)N2CCCC2)cc1)NC(=O)C(O)=O
Show InChI InChI=1S/C23H24N2O7/c26-20(16-5-7-17(8-6-16)25-11-1-2-12-25)14-32-18-9-3-15(4-10-18)13-19(22(28)29)24-21(27)23(30)31/h3-10,19H,1-2,11-14H2,(H,24,27)(H,28,29)(H,30,31)/t19-/m1/s1
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n/an/a 1.30E+4n/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of JMJD2A by MALDI-TOF assay


J Med Chem 53: 1810-8 (2010)


Article DOI: 10.1021/jm901680b
BindingDB Entry DOI: 10.7270/Q2959HPQ
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50306586
PNG
((R)-3-(4-(benzyloxy)phenyl)-2-(carboxyformamido)pr...)
Show SMILES OC(=O)[C@@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)C(O)=O
Show InChI InChI=1S/C18H17NO6/c20-16(18(23)24)19-15(17(21)22)10-12-6-8-14(9-7-12)25-11-13-4-2-1-3-5-13/h1-9,15H,10-11H2,(H,19,20)(H,21,22)(H,23,24)/t15-/m1/s1
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n/an/a 3.30E+4n/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of JMJD2A by MALDI-TOF assay


J Med Chem 53: 1810-8 (2010)


Article DOI: 10.1021/jm901680b
BindingDB Entry DOI: 10.7270/Q2959HPQ
More data for this
Ligand-Target Pair
Histone Lysine Demethylase


(Homo sapiens (human))
BDBM50306581
PNG
((R)-3-(4-(4-tert-butylphenylsulfonyloxy)phenyl)-2-...)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)Oc1ccc(C[C@@H](NC(=O)C(O)=O)C(O)=O)cc1
Show InChI InChI=1S/C21H23NO8S/c1-21(2,3)14-6-10-16(11-7-14)31(28,29)30-15-8-4-13(5-9-15)12-17(19(24)25)22-18(23)20(26)27/h4-11,17H,12H2,1-3H3,(H,22,23)(H,24,25)(H,26,27)/t17-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
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n/an/a 5.00E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Binding affinity to JMJD2E


Bioorg Med Chem 19: 3625-36 (2011)


Article DOI: 10.1016/j.bmc.2011.01.046
BindingDB Entry DOI: 10.7270/Q23X870S
More data for this
Ligand-Target Pair
Histone Lysine Demethylase


(Homo sapiens (human))
BDBM50306585
PNG
((R)-2-(carboxyformamido)-3-(4-(4-fluorophenylsulfo...)
Show SMILES OC(=O)[C@@H](Cc1ccc(OS(=O)(=O)c2ccc(F)cc2)cc1)NC(=O)C(O)=O
Show InChI InChI=1S/C17H14FNO8S/c18-11-3-7-13(8-4-11)28(25,26)27-12-5-1-10(2-6-12)9-14(16(21)22)19-15(20)17(23)24/h1-8,14H,9H2,(H,19,20)(H,21,22)(H,23,24)/t14-/m1/s1
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KEGG

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PubMed
n/an/a 5.00E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Binding affinity to JMJD2E


Bioorg Med Chem 19: 3625-36 (2011)


Article DOI: 10.1016/j.bmc.2011.01.046
BindingDB Entry DOI: 10.7270/Q23X870S
More data for this
Ligand-Target Pair
Histone Lysine Demethylase


(Homo sapiens (human))
BDBM50306580
PNG
((R)-3-(4-(4-bromophenylsulfonyloxy)phenyl)-2-(carb...)
Show SMILES OC(=O)[C@@H](Cc1ccc(OS(=O)(=O)c2ccc(Br)cc2)cc1)NC(=O)C(O)=O
Show InChI InChI=1S/C17H14BrNO8S/c18-11-3-7-13(8-4-11)28(25,26)27-12-5-1-10(2-6-12)9-14(16(21)22)19-15(20)17(23)24/h1-8,14H,9H2,(H,19,20)(H,21,22)(H,23,24)/t14-/m1/s1
PDB
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KEGG

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PubMed
n/an/a 5.40E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Binding affinity to JMJD2E


Bioorg Med Chem 19: 3625-36 (2011)


Article DOI: 10.1016/j.bmc.2011.01.046
BindingDB Entry DOI: 10.7270/Q23X870S
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50306585
PNG
((R)-2-(carboxyformamido)-3-(4-(4-fluorophenylsulfo...)
Show SMILES OC(=O)[C@@H](Cc1ccc(OS(=O)(=O)c2ccc(F)cc2)cc1)NC(=O)C(O)=O
Show InChI InChI=1S/C17H14FNO8S/c18-11-3-7-13(8-4-11)28(25,26)27-12-5-1-10(2-6-12)9-14(16(21)22)19-15(20)17(23)24/h1-8,14H,9H2,(H,19,20)(H,21,22)(H,23,24)/t14-/m1/s1
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n/an/a 2.00E+4n/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of JMJD2A by MALDI-TOF assay


J Med Chem 53: 1810-8 (2010)


Article DOI: 10.1021/jm901680b
BindingDB Entry DOI: 10.7270/Q2959HPQ
More data for this
Ligand-Target Pair