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20 similar compounds to monomer 50307469

Wt: 328.4
BDBM50307457
Wt: 346.4
BDBM50307458
Wt: 328.4
BDBM50307459
Wt: 346.4
BDBM50307460
Wt: 282.3
BDBM50307461
Wt: 300.3
BDBM50307462
Wt: 314.3
BDBM50307463
Wt: 314.3
BDBM50307464
Wt: 314.3
BDBM50307465
Wt: 314.3
BDBM50307466
Wt: 328.4
BDBM50307467
Wt: 342.4
BDBM50307468
Wt: 334.8
BDBM50307470
Wt: 314.3
BDBM50307472
Wt: 356.4
BDBM50307473
Displayed 1 to 15 (of 20 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 36 hits for monomerid = 50307457,50307458,50307459,50307460,50307461,50307462,50307463,50307464,50307465,50307466,50307467,50307468,50307470,50307472,50307473   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium-dependent noradrenaline transporter


(Homo sapiens (human))
BDBM50307461
PNG
((1S,2R)-1-(2,3-Dihydro-1H-indol-1-yl)-3-(methylami...)
Show SMILES CNC[C@@H](O)[C@@H](N1CCc2ccccc12)c1ccccc1
Show InChI InChI=1S/C18H22N2O/c1-19-13-17(21)18(15-8-3-2-4-9-15)20-12-11-14-7-5-6-10-16(14)20/h2-10,17-19,21H,11-13H2,1H3/t17-,18+/m1/s1
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n/an/a 9.70n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of norepinephrine uptake at human NET expressed in MDCK-Net6 cells


Citation and Details
More data for this
Ligand-Target Pair
Serotonin and norepinephrine transporters (SERT/NET)


(Homo sapiens (human))
BDBM50307460
PNG
((1S,2R)-1-(7-Fluoro-3,3-dimethyl-2,3-dihydro-1H-in...)
Show SMILES CNC[C@@H](O)[C@@H](N1CC(C)(C)c2cccc(F)c12)c1cccc(F)c1
Show InChI InChI=1S/C20H24F2N2O/c1-20(2)12-24(19-15(20)8-5-9-16(19)22)18(17(25)11-23-3)13-6-4-7-14(21)10-13/h4-10,17-18,23,25H,11-12H2,1-3H3/t17-,18+/m1/s1
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n/an/a 1.61E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of serotonin uptake at human SERT expressed in human JAR cells


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (human))
BDBM50307463
PNG
((1S,2R)-1-(3-Fluorophenyl)-3-(methylamino)-1-(2-me...)
Show SMILES CNC[C@@H](O)[C@@H](N1C(C)Cc2ccccc12)c1cccc(F)c1
Show InChI InChI=1S/C19H23FN2O/c1-13-10-14-6-3-4-9-17(14)22(13)19(18(23)12-21-2)15-7-5-8-16(20)11-15/h3-9,11,13,18-19,21,23H,10,12H2,1-2H3/t13?,18-,19+/m1/s1
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n/an/a 72n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of norepinephrine uptake at human NET expressed in MDCK-Net6 cells


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (human))
BDBM50307464
PNG
((1S,2R)-1-(3-Fluorophenyl)-3-(methylamino)-1-(3-me...)
Show SMILES CNC[C@@H](O)[C@@H](N1CC(C)c2ccccc12)c1cccc(F)c1
Show InChI InChI=1S/C19H23FN2O/c1-13-12-22(17-9-4-3-8-16(13)17)19(18(23)11-21-2)14-6-5-7-15(20)10-14/h3-10,13,18-19,21,23H,11-12H2,1-2H3/t13?,18-,19+/m1/s1
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n/an/a 6.20n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of norepinephrine uptake at human NET expressed in MDCK-Net6 cells


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (human))
BDBM50307465
PNG
((1S,2R)-1-(3-Fluorophenyl)-3-(methylamino)-1-[(3S)...)
Show SMILES CNC[C@@H](O)[C@@H](N1C[C@@H](C)c2ccccc12)c1cccc(F)c1
Show InChI InChI=1S/C19H23FN2O/c1-13-12-22(17-9-4-3-8-16(13)17)19(18(23)11-21-2)14-6-5-7-15(20)10-14/h3-10,13,18-19,21,23H,11-12H2,1-2H3/t13-,18-,19+/m1/s1
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n/an/a 8.5n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of norepinephrine uptake at human NET expressed in MDCK-Net6 cells


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (human))
BDBM50307466
PNG
((1S,2R)-1-(3-Fluorophenyl)-3-(methylamino)-1-[(3R)...)
Show SMILES CNC[C@@H](O)[C@@H](N1C[C@H](C)c2ccccc12)c1cccc(F)c1
Show InChI InChI=1S/C19H23FN2O/c1-13-12-22(17-9-4-3-8-16(13)17)19(18(23)11-21-2)14-6-5-7-15(20)10-14/h3-10,13,18-19,21,23H,11-12H2,1-2H3/t13-,18+,19-/m0/s1
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n/an/a 3.70n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of norepinephrine uptake at human NET expressed in MDCK-Net6 cells


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (human))
BDBM50307467
PNG
((1S,2R)-1-(3-Ethyl-2,3-dihydro-1H-indol-1-yl)-1-(3...)
Show SMILES CCC1CN([C@H]([C@H](O)CNC)c2cccc(F)c2)c2ccccc12
Show InChI InChI=1S/C20H25FN2O/c1-3-14-13-23(18-10-5-4-9-17(14)18)20(19(24)12-22-2)15-7-6-8-16(21)11-15/h4-11,14,19-20,22,24H,3,12-13H2,1-2H3/t14?,19-,20+/m1/s1
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n/an/a 14n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of norepinephrine uptake at human NET expressed in MDCK-Net6 cells


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (human))
BDBM50307468
PNG
((1S,2R)-1-(3-Fluorophenyl)-1-(3-isopropyl-2,3-dihy...)
Show SMILES CNC[C@@H](O)[C@@H](N1CC(C(C)C)c2ccccc12)c1cccc(F)c1
Show InChI InChI=1S/C21H27FN2O/c1-14(2)18-13-24(19-10-5-4-9-17(18)19)21(20(25)12-23-3)15-7-6-8-16(22)11-15/h4-11,14,18,20-21,23,25H,12-13H2,1-3H3/t18?,20-,21+/m1/s1
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n/an/a 23n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of norepinephrine uptake at human NET expressed in MDCK-Net6 cells


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (human))
BDBM50307470
PNG
((1S,2R)-1-(5-Chloro-2,3-dihydro-1H-indol-1-yl)-1-(...)
Show SMILES CNC[C@@H](O)[C@@H](N1CCc2cc(Cl)ccc12)c1cccc(F)c1
Show InChI InChI=1S/C18H20ClFN2O/c1-21-11-17(23)18(13-3-2-4-15(20)10-13)22-8-7-12-9-14(19)5-6-16(12)22/h2-6,9-10,17-18,21,23H,7-8,11H2,1H3/t17-,18+/m1/s1
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n/an/a 7.60n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of norepinephrine uptake at human NET expressed in MDCK-Net6 cells


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (human))
BDBM50307472
PNG
((1S,2R)-1-(3-Fluorophenyl)-3-(methylamino)-1-(7-me...)
Show SMILES CNC[C@@H](O)[C@@H](N1CCc2cccc(C)c12)c1cccc(F)c1
Show InChI InChI=1S/C19H23FN2O/c1-13-5-3-6-14-9-10-22(18(13)14)19(17(23)12-21-2)15-7-4-8-16(20)11-15/h3-8,11,17,19,21,23H,9-10,12H2,1-2H3/t17-,19+/m1/s1
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n/an/a 170n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of norepinephrine uptake at human NET expressed in MDCK-Net6 cells


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (human))
BDBM50307457
PNG
((1S,2R)-1-(3,3-Dimethyl-2,3-dihydro-1H-indol-1-yl)...)
Show SMILES CNC[C@@H](O)[C@@H](N1CC(C)(C)c2ccccc12)c1cccc(F)c1
Show InChI InChI=1S/C20H25FN2O/c1-20(2)13-23(17-10-5-4-9-16(17)20)19(18(24)12-22-3)14-7-6-8-15(21)11-14/h4-11,18-19,22,24H,12-13H2,1-3H3/t18-,19+/m1/s1
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n/an/a 2.60n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cells


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (human))
BDBM50307458
PNG
((1S,2R)-1-(3,5-Difluorophenyl)-1-(3,3-dimethyl-2,3...)
Show SMILES CNC[C@@H](O)[C@@H](N1CC(C)(C)c2ccccc12)c1cc(F)cc(F)c1
Show InChI InChI=1S/C20H24F2N2O/c1-20(2)12-24(17-7-5-4-6-16(17)20)19(18(25)11-23-3)13-8-14(21)10-15(22)9-13/h4-10,18-19,23,25H,11-12H2,1-3H3/t18-,19+/m1/s1
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n/an/a 4.10n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cells


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (human))
BDBM50307459
PNG
((1S,2R)-1-(7-Fluoro-3,3-dimethyl-2,3-dihydro-1H-in...)
Show SMILES CNC[C@@H](O)[C@@H](N1CC(C)(C)c2cccc(F)c12)c1ccccc1
Show InChI InChI=1S/C20H25FN2O/c1-20(2)13-23(19-15(20)10-7-11-16(19)21)18(17(24)12-22-3)14-8-5-4-6-9-14/h4-11,17-18,22,24H,12-13H2,1-3H3/t17-,18+/m1/s1
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n/an/a 1.60n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cells


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (human))
BDBM50307460
PNG
((1S,2R)-1-(7-Fluoro-3,3-dimethyl-2,3-dihydro-1H-in...)
Show SMILES CNC[C@@H](O)[C@@H](N1CC(C)(C)c2cccc(F)c12)c1cccc(F)c1
Show InChI InChI=1S/C20H24F2N2O/c1-20(2)12-24(19-15(20)8-5-9-16(19)22)18(17(25)11-23-3)13-6-4-7-14(21)10-13/h4-10,17-18,23,25H,11-12H2,1-3H3/t17-,18+/m1/s1
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n/an/a 1.40n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cells


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM50307459
PNG
((1S,2R)-1-(7-Fluoro-3,3-dimethyl-2,3-dihydro-1H-in...)
Show SMILES CNC[C@@H](O)[C@@H](N1CC(C)(C)c2cccc(F)c12)c1ccccc1
Show InChI InChI=1S/C20H25FN2O/c1-20(2)13-23(19-15(20)10-7-11-16(19)21)18(17(24)12-22-3)14-8-5-4-6-9-14/h4-11,17-18,22,24H,12-13H2,1-3H3/t17-,18+/m1/s1
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n/an/a 2.09E+4n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]WIN35428 from human DAT expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM50307460
PNG
((1S,2R)-1-(7-Fluoro-3,3-dimethyl-2,3-dihydro-1H-in...)
Show SMILES CNC[C@@H](O)[C@@H](N1CC(C)(C)c2cccc(F)c12)c1cccc(F)c1
Show InChI InChI=1S/C20H24F2N2O/c1-20(2)12-24(19-15(20)8-5-9-16(19)22)18(17(25)11-23-3)13-6-4-7-14(21)10-13/h4-10,17-18,23,25H,11-12H2,1-3H3/t17-,18+/m1/s1
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n/an/a 2.28E+4n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]WIN35428 from human DAT expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (human))
BDBM50307457
PNG
((1S,2R)-1-(3,3-Dimethyl-2,3-dihydro-1H-indol-1-yl)...)
Show SMILES CNC[C@@H](O)[C@@H](N1CC(C)(C)c2ccccc12)c1cccc(F)c1
Show InChI InChI=1S/C20H25FN2O/c1-20(2)13-23(17-10-5-4-9-16(17)20)19(18(24)12-22-3)14-7-6-8-15(21)11-14/h4-11,18-19,22,24H,12-13H2,1-3H3/t18-,19+/m1/s1
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n/an/a 6.30n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of norepinephrine uptake at human NET expressed in MDCK-Net6 cells


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (human))
BDBM50307473
PNG
((1S,2R)-1-(3,3-Diethyl-2,3-dihydro-1H-indol-1-yl)-...)
Show SMILES CCC1(CC)CN([C@H]([C@H](O)CNC)c2cccc(F)c2)c2ccccc12
Show InChI InChI=1S/C22H29FN2O/c1-4-22(5-2)15-25(19-12-7-6-11-18(19)22)21(20(26)14-24-3)16-9-8-10-17(23)13-16/h6-13,20-21,24,26H,4-5,14-15H2,1-3H3/t20-,21+/m1/s1
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n/an/a 150n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of norepinephrine uptake at human NET expressed in MDCK-Net6 cells


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (human))
BDBM50307458
PNG
((1S,2R)-1-(3,5-Difluorophenyl)-1-(3,3-dimethyl-2,3...)
Show SMILES CNC[C@@H](O)[C@@H](N1CC(C)(C)c2ccccc12)c1cc(F)cc(F)c1
Show InChI InChI=1S/C20H24F2N2O/c1-20(2)12-24(17-7-5-4-6-16(17)20)19(18(25)11-23-3)13-8-14(21)10-15(22)9-13/h4-10,18-19,23,25H,11-12H2,1-3H3/t18-,19+/m1/s1
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n/an/a 6.5n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of norepinephrine uptake at human NET expressed in MDCK-Net6 cells


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (human))
BDBM50307459
PNG
((1S,2R)-1-(7-Fluoro-3,3-dimethyl-2,3-dihydro-1H-in...)
Show SMILES CNC[C@@H](O)[C@@H](N1CC(C)(C)c2cccc(F)c12)c1ccccc1
Show InChI InChI=1S/C20H25FN2O/c1-20(2)13-23(19-15(20)10-7-11-16(19)21)18(17(24)12-22-3)14-8-5-4-6-9-14/h4-11,17-18,22,24H,12-13H2,1-3H3/t17-,18+/m1/s1
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n/an/a 2.70n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of norepinephrine uptake at human NET expressed in MDCK-Net6 cells


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (human))
BDBM50307460
PNG
((1S,2R)-1-(7-Fluoro-3,3-dimethyl-2,3-dihydro-1H-in...)
Show SMILES CNC[C@@H](O)[C@@H](N1CC(C)(C)c2cccc(F)c12)c1cccc(F)c1
Show InChI InChI=1S/C20H24F2N2O/c1-20(2)12-24(19-15(20)8-5-9-16(19)22)18(17(25)11-23-3)13-6-4-7-14(21)10-13/h4-10,17-18,23,25H,11-12H2,1-3H3/t17-,18+/m1/s1
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n/an/a 5.5n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of norepinephrine uptake at human NET expressed in MDCK-Net6 cells


Citation and Details
More data for this
Ligand-Target Pair
Serotonin and norepinephrine transporters (SERT/NET)


(Homo sapiens (human))
BDBM50307461
PNG
((1S,2R)-1-(2,3-Dihydro-1H-indol-1-yl)-3-(methylami...)
Show SMILES CNC[C@@H](O)[C@@H](N1CCc2ccccc12)c1ccccc1
Show InChI InChI=1S/C18H22N2O/c1-19-13-17(21)18(15-8-3-2-4-9-15)20-12-11-14-7-5-6-10-16(14)20/h2-10,17-19,21H,11-13H2,1H3/t17-,18+/m1/s1
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n/an/a 29n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of serotonin uptake at human SERT expressed in human JAR cells


Citation and Details
More data for this
Ligand-Target Pair
Serotonin and norepinephrine transporters (SERT/NET)


(Homo sapiens (human))
BDBM50307462
PNG
((1S,2R)-1-(2,3-Dihydro-1H-indol-1-yl)-1-(3-fluorop...)
Show SMILES CNC[C@@H](O)[C@@H](N1CCc2ccccc12)c1cccc(F)c1
Show InChI InChI=1S/C18H21FN2O/c1-20-12-17(22)18(14-6-4-7-15(19)11-14)21-10-9-13-5-2-3-8-16(13)21/h2-8,11,17-18,20,22H,9-10,12H2,1H3/t17-,18+/m1/s1
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n/an/a 21n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of serotonin uptake at human SERT expressed in human JAR cells


Citation and Details
More data for this
Ligand-Target Pair
Serotonin and norepinephrine transporters (SERT/NET)


(Homo sapiens (human))
BDBM50307463
PNG
((1S,2R)-1-(3-Fluorophenyl)-3-(methylamino)-1-(2-me...)
Show SMILES CNC[C@@H](O)[C@@H](N1C(C)Cc2ccccc12)c1cccc(F)c1
Show InChI InChI=1S/C19H23FN2O/c1-13-10-14-6-3-4-9-17(14)22(13)19(18(23)12-21-2)15-7-5-8-16(20)11-15/h3-9,11,13,18-19,21,23H,10,12H2,1-2H3/t13?,18-,19+/m1/s1
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n/an/a 84n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of serotonin uptake at human SERT expressed in human JAR cells


Citation and Details
More data for this
Ligand-Target Pair
Serotonin and norepinephrine transporters (SERT/NET)


(Homo sapiens (human))
BDBM50307464
PNG
((1S,2R)-1-(3-Fluorophenyl)-3-(methylamino)-1-(3-me...)
Show SMILES CNC[C@@H](O)[C@@H](N1CC(C)c2ccccc12)c1cccc(F)c1
Show InChI InChI=1S/C19H23FN2O/c1-13-12-22(17-9-4-3-8-16(13)17)19(18(23)11-21-2)14-6-5-7-15(20)10-14/h3-10,13,18-19,21,23H,11-12H2,1-2H3/t13?,18-,19+/m1/s1
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n/an/a 329n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of serotonin uptake at human SERT expressed in human JAR cells


Citation and Details
More data for this
Ligand-Target Pair
Serotonin and norepinephrine transporters (SERT/NET)


(Homo sapiens (human))
BDBM50307465
PNG
((1S,2R)-1-(3-Fluorophenyl)-3-(methylamino)-1-[(3S)...)
Show SMILES CNC[C@@H](O)[C@@H](N1C[C@@H](C)c2ccccc12)c1cccc(F)c1
Show InChI InChI=1S/C19H23FN2O/c1-13-12-22(17-9-4-3-8-16(13)17)19(18(23)11-21-2)14-6-5-7-15(20)10-14/h3-10,13,18-19,21,23H,11-12H2,1-2H3/t13-,18-,19+/m1/s1
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n/an/a 154n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of serotonin uptake at human SERT expressed in human JAR cells


Citation and Details
More data for this
Ligand-Target Pair
Serotonin and norepinephrine transporters (SERT/NET)


(Homo sapiens (human))
BDBM50307466
PNG
((1S,2R)-1-(3-Fluorophenyl)-3-(methylamino)-1-[(3R)...)
Show SMILES CNC[C@@H](O)[C@@H](N1C[C@H](C)c2ccccc12)c1cccc(F)c1
Show InChI InChI=1S/C19H23FN2O/c1-13-12-22(17-9-4-3-8-16(13)17)19(18(23)11-21-2)14-6-5-7-15(20)10-14/h3-10,13,18-19,21,23H,11-12H2,1-2H3/t13-,18+,19-/m0/s1
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n/an/a 194n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of serotonin uptake at human SERT expressed in human JAR cells


Citation and Details
More data for this
Ligand-Target Pair
Serotonin and norepinephrine transporters (SERT/NET)


(Homo sapiens (human))
BDBM50307467
PNG
((1S,2R)-1-(3-Ethyl-2,3-dihydro-1H-indol-1-yl)-1-(3...)
Show SMILES CCC1CN([C@H]([C@H](O)CNC)c2cccc(F)c2)c2ccccc12
Show InChI InChI=1S/C20H25FN2O/c1-3-14-13-23(18-10-5-4-9-17(14)18)20(19(24)12-22-2)15-7-6-8-16(21)11-15/h4-11,14,19-20,22,24H,3,12-13H2,1-2H3/t14?,19-,20+/m1/s1
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n/an/a 499n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of serotonin uptake at human SERT expressed in human JAR cells


Citation and Details
More data for this
Ligand-Target Pair
Serotonin and norepinephrine transporters (SERT/NET)


(Homo sapiens (human))
BDBM50307468
PNG
((1S,2R)-1-(3-Fluorophenyl)-1-(3-isopropyl-2,3-dihy...)
Show SMILES CNC[C@@H](O)[C@@H](N1CC(C(C)C)c2ccccc12)c1cccc(F)c1
Show InChI InChI=1S/C21H27FN2O/c1-14(2)18-13-24(19-10-5-4-9-17(18)19)21(20(25)12-23-3)15-7-6-8-16(22)11-15/h4-11,14,18,20-21,23,25H,12-13H2,1-3H3/t18?,20-,21+/m1/s1
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n/an/a 1.12E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of serotonin uptake at human SERT expressed in human JAR cells


Citation and Details
More data for this
Ligand-Target Pair
Serotonin and norepinephrine transporters (SERT/NET)


(Homo sapiens (human))
BDBM50307470
PNG
((1S,2R)-1-(5-Chloro-2,3-dihydro-1H-indol-1-yl)-1-(...)
Show SMILES CNC[C@@H](O)[C@@H](N1CCc2cc(Cl)ccc12)c1cccc(F)c1
Show InChI InChI=1S/C18H20ClFN2O/c1-21-11-17(23)18(13-3-2-4-15(20)10-13)22-8-7-12-9-14(19)5-6-16(12)22/h2-6,9-10,17-18,21,23H,7-8,11H2,1H3/t17-,18+/m1/s1
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n/an/a 2.80n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of serotonin uptake at human SERT expressed in human JAR cells


Citation and Details
More data for this
Ligand-Target Pair
Serotonin and norepinephrine transporters (SERT/NET)


(Homo sapiens (human))
BDBM50307472
PNG
((1S,2R)-1-(3-Fluorophenyl)-3-(methylamino)-1-(7-me...)
Show SMILES CNC[C@@H](O)[C@@H](N1CCc2cccc(C)c12)c1cccc(F)c1
Show InChI InChI=1S/C19H23FN2O/c1-13-5-3-6-14-9-10-22(18(13)14)19(17(23)12-21-2)15-7-4-8-16(20)11-15/h3-8,11,17,19,21,23H,9-10,12H2,1-2H3/t17-,19+/m1/s1
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n/an/a 280n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of serotonin uptake at human SERT expressed in human JAR cells


Citation and Details
More data for this
Ligand-Target Pair
Serotonin and norepinephrine transporters (SERT/NET)


(Homo sapiens (human))
BDBM50307457
PNG
((1S,2R)-1-(3,3-Dimethyl-2,3-dihydro-1H-indol-1-yl)...)
Show SMILES CNC[C@@H](O)[C@@H](N1CC(C)(C)c2ccccc12)c1cccc(F)c1
Show InChI InChI=1S/C20H25FN2O/c1-20(2)13-23(17-10-5-4-9-16(17)20)19(18(24)12-22-3)14-7-6-8-15(21)11-14/h4-11,18-19,22,24H,12-13H2,1-3H3/t18-,19+/m1/s1
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n/an/a 4.52E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of serotonin uptake at human SERT expressed in human JAR cells


Citation and Details
More data for this
Ligand-Target Pair
Serotonin and norepinephrine transporters (SERT/NET)


(Homo sapiens (human))
BDBM50307473
PNG
((1S,2R)-1-(3,3-Diethyl-2,3-dihydro-1H-indol-1-yl)-...)
Show SMILES CCC1(CC)CN([C@H]([C@H](O)CNC)c2cccc(F)c2)c2ccccc12
Show InChI InChI=1S/C22H29FN2O/c1-4-22(5-2)15-25(19-12-7-6-11-18(19)22)21(20(26)14-24-3)16-9-8-10-17(23)13-16/h6-13,20-21,24,26H,4-5,14-15H2,1-3H3/t20-,21+/m1/s1
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n/an/a 8.97E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of serotonin uptake at human SERT expressed in human JAR cells


Citation and Details
More data for this
Ligand-Target Pair
Serotonin and norepinephrine transporters (SERT/NET)


(Homo sapiens (human))
BDBM50307458
PNG
((1S,2R)-1-(3,5-Difluorophenyl)-1-(3,3-dimethyl-2,3...)
Show SMILES CNC[C@@H](O)[C@@H](N1CC(C)(C)c2ccccc12)c1cc(F)cc(F)c1
Show InChI InChI=1S/C20H24F2N2O/c1-20(2)12-24(17-7-5-4-6-16(17)20)19(18(25)11-23-3)13-8-14(21)10-15(22)9-13/h4-10,18-19,23,25H,11-12H2,1-3H3/t18-,19+/m1/s1
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n/an/a 5.29E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of serotonin uptake at human SERT expressed in human JAR cells


Citation and Details
More data for this
Ligand-Target Pair
Serotonin and norepinephrine transporters (SERT/NET)


(Homo sapiens (human))
BDBM50307459
PNG
((1S,2R)-1-(7-Fluoro-3,3-dimethyl-2,3-dihydro-1H-in...)
Show SMILES CNC[C@@H](O)[C@@H](N1CC(C)(C)c2cccc(F)c12)c1ccccc1
Show InChI InChI=1S/C20H25FN2O/c1-20(2)13-23(19-15(20)10-7-11-16(19)21)18(17(24)12-22-3)14-8-5-4-6-9-14/h4-11,17-18,22,24H,12-13H2,1-3H3/t17-,18+/m1/s1
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n/an/a 1.10E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of serotonin uptake at human SERT expressed in human JAR cells


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (human))
BDBM50307462
PNG
((1S,2R)-1-(2,3-Dihydro-1H-indol-1-yl)-1-(3-fluorop...)
Show SMILES CNC[C@@H](O)[C@@H](N1CCc2ccccc12)c1cccc(F)c1
Show InChI InChI=1S/C18H21FN2O/c1-20-12-17(22)18(14-6-4-7-15(19)11-14)21-10-9-13-5-2-3-8-16(13)21/h2-8,11,17-18,20,22H,9-10,12H2,1H3/t17-,18+/m1/s1
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n/an/a 4.60n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of norepinephrine uptake at human NET expressed in MDCK-Net6 cells


Citation and Details
More data for this
Ligand-Target Pair