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9 similar compounds to monomer 50308954

Wt: 391.4
BDBM50308945
Wt: 405.4
BDBM50308946
Wt: 421.4
BDBM50308947
Wt: 390.4
BDBM50308948
Wt: 420.4
BDBM50308949
Wt: 392.4
BDBM50308950
Wt: 376.4
BDBM50308951
Wt: 390.4
BDBM50308952
Wt: 378.4
BDBM50308953

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50308945,50308946,50308947,50308948,50308949,50308950,50308951,50308952,50308953   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 3 (PDE3)


(Homo sapiens (human))
BDBM50308945
PNG
(4-Methyl-6-({3-[(4-methylpiperazino)carbonyl]-benz...)
Show SMILES CN1CCN(CC1)C(=O)c1cccc(COc2ccc3[nH]c(=O)cc(C)c3c2)c1
Show InChI InChI=1S/C23H25N3O3/c1-16-12-22(27)24-21-7-6-19(14-20(16)21)29-15-17-4-3-5-18(13-17)23(28)26-10-8-25(2)9-11-26/h3-7,12-14H,8-11,15H2,1-2H3,(H,24,27)
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n/an/a 1.76E+3n/an/an/an/an/an/a



Islamic Azad University

Curated by ChEMBL


Assay Description
Inhibition of human PDE3A by fluorescence microplate reader


Bioorg Med Chem 18: 855-62 (2010)

More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50308953
PNG
(4-Methyl-6-{[3-(morpholinocarbonyl)benzyl]oxy}-1,2...)
Show SMILES Cc1cc(=O)[nH]c2ccc(OCc3cccc(c3)C(=O)N3CCOCC3)cc12
Show InChI InChI=1S/C22H22N2O4/c1-15-11-21(25)23-20-6-5-18(13-19(15)20)28-14-16-3-2-4-17(12-16)22(26)24-7-9-27-10-8-24/h2-6,11-13H,7-10,14H2,1H3,(H,23,25)
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n/an/a 1.54E+3n/an/an/an/an/an/a



Islamic Azad University

Curated by ChEMBL


Assay Description
Inhibition of human PDE3B by fluorescence microplate reader


Bioorg Med Chem 18: 855-62 (2010)

More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (human))
BDBM50308947
PNG
(6-[(3-{[4-(2-Hydroxyethyl)piperazino]carbonyl}-ben...)
Show SMILES Cc1cc(=O)[nH]c2ccc(OCc3cccc(c3)C(=O)N3CCN(CCO)CC3)cc12
Show InChI InChI=1S/C24H27N3O4/c1-17-13-23(29)25-22-6-5-20(15-21(17)22)31-16-18-3-2-4-19(14-18)24(30)27-9-7-26(8-10-27)11-12-28/h2-6,13-15,28H,7-12,16H2,1H3,(H,25,29)
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n/an/a 1.65E+3n/an/an/an/an/an/a



Islamic Azad University

Curated by ChEMBL


Assay Description
Inhibition of human PDE3A by fluorescence microplate reader


Bioorg Med Chem 18: 855-62 (2010)

More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (human))
BDBM50308948
PNG
(4-Methyl-6-(3-[(4-oxopiperidino)carbonyl]benzyloxy...)
Show SMILES Cc1cc(=O)[nH]c2ccc(OCc3cccc(c3)C(=O)N3CCC(=O)CC3)cc12
Show InChI InChI=1S/C23H22N2O4/c1-15-11-22(27)24-21-6-5-19(13-20(15)21)29-14-16-3-2-4-17(12-16)23(28)25-9-7-18(26)8-10-25/h2-6,11-13H,7-10,14H2,1H3,(H,24,27)
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n/an/a 1.26E+3n/an/an/an/an/an/a



Islamic Azad University

Curated by ChEMBL


Assay Description
Inhibition of human PDE3A by fluorescence microplate reader


Bioorg Med Chem 18: 855-62 (2010)

More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (human))
BDBM50308949
PNG
(1-(3-{[(4-Methyl-2-oxo-1,2-dihydro-6-quinolinyl)ox...)
Show SMILES Cc1cc(=O)[nH]c2ccc(OCc3cccc(c3)C(=O)N3CCC(CC3)C(O)=O)cc12
Show InChI InChI=1S/C24H24N2O5/c1-15-11-22(27)25-21-6-5-19(13-20(15)21)31-14-16-3-2-4-18(12-16)23(28)26-9-7-17(8-10-26)24(29)30/h2-6,11-13,17H,7-10,14H2,1H3,(H,25,27)(H,29,30)
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n/an/a 840n/an/an/an/an/an/a



Islamic Azad University

Curated by ChEMBL


Assay Description
Inhibition of human PDE3A by fluorescence microplate reader


Bioorg Med Chem 18: 855-62 (2010)

More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (human))
BDBM50308950
PNG
(6-({3-[(4-Hydroxypiperidino)carbonyl]benzyl}oxy)-4...)
Show SMILES Cc1cc(=O)[nH]c2ccc(OCc3cccc(c3)C(=O)N3CCC(O)CC3)cc12
Show InChI InChI=1S/C23H24N2O4/c1-15-11-22(27)24-21-6-5-19(13-20(15)21)29-14-16-3-2-4-17(12-16)23(28)25-9-7-18(26)8-10-25/h2-6,11-13,18,26H,7-10,14H2,1H3,(H,24,27)
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n/an/a 1.35E+3n/an/an/an/an/an/a



Islamic Azad University

Curated by ChEMBL


Assay Description
Inhibition of human PDE3A by fluorescence microplate reader


Bioorg Med Chem 18: 855-62 (2010)

More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (human))
BDBM50308951
PNG
(4-Methyl-6-{[3-(piperidinocarbonyl)benzyl]oxy}-1,2...)
Show SMILES Cc1cc(=O)[nH]c2ccc(OCc3cccc(c3)C(=O)N3CCCCC3)cc12
Show InChI InChI=1S/C23H24N2O3/c1-16-12-22(26)24-21-9-8-19(14-20(16)21)28-15-17-6-5-7-18(13-17)23(27)25-10-3-2-4-11-25/h5-9,12-14H,2-4,10-11,15H2,1H3,(H,24,26)
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n/an/a 660n/an/an/an/an/an/a



Islamic Azad University

Curated by ChEMBL


Assay Description
Inhibition of human PDE3A by fluorescence microplate reader


Bioorg Med Chem 18: 855-62 (2010)

More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (human))
BDBM50308952
PNG
(4-Methyl-6-({3-[(4-methylpiperidino)carbonyl]-benz...)
Show SMILES CC1CCN(CC1)C(=O)c1cccc(COc2ccc3[nH]c(=O)cc(C)c3c2)c1
Show InChI InChI=1S/C24H26N2O3/c1-16-8-10-26(11-9-16)24(28)19-5-3-4-18(13-19)15-29-20-6-7-22-21(14-20)17(2)12-23(27)25-22/h3-7,12-14,16H,8-11,15H2,1-2H3,(H,25,27)
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n/an/a 430n/an/an/an/an/an/a



Islamic Azad University

Curated by ChEMBL


Assay Description
Inhibition of human PDE3A by fluorescence microplate reader


Bioorg Med Chem 18: 855-62 (2010)

More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (human))
BDBM50308953
PNG
(4-Methyl-6-{[3-(morpholinocarbonyl)benzyl]oxy}-1,2...)
Show SMILES Cc1cc(=O)[nH]c2ccc(OCc3cccc(c3)C(=O)N3CCOCC3)cc12
Show InChI InChI=1S/C22H22N2O4/c1-15-11-21(25)23-20-6-5-18(13-19(15)20)28-14-16-3-2-4-17(12-16)22(26)24-7-9-27-10-8-24/h2-6,11-13H,7-10,14H2,1H3,(H,23,25)
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n/an/a 1.34E+3n/an/an/an/an/an/a



Islamic Azad University

Curated by ChEMBL


Assay Description
Inhibition of human PDE3A by fluorescence microplate reader


Bioorg Med Chem 18: 855-62 (2010)

More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50308945
PNG
(4-Methyl-6-({3-[(4-methylpiperazino)carbonyl]-benz...)
Show SMILES CN1CCN(CC1)C(=O)c1cccc(COc2ccc3[nH]c(=O)cc(C)c3c2)c1
Show InChI InChI=1S/C23H25N3O3/c1-16-12-22(27)24-21-7-6-19(14-20(16)21)29-15-17-4-3-5-18(13-17)23(28)26-10-8-25(2)9-11-26/h3-7,12-14H,8-11,15H2,1-2H3,(H,24,27)
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n/an/a 3.51E+3n/an/an/an/an/an/a



Islamic Azad University

Curated by ChEMBL


Assay Description
Inhibition of human PDE3B by fluorescence microplate reader


Bioorg Med Chem 18: 855-62 (2010)

More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50308946
PNG
(4-Methyl-6-({3-[(4-ethylpiperazino)carbonyl]-benzy...)
Show SMILES CCN1CCN(CC1)C(=O)c1cccc(COc2ccc3[nH]c(=O)cc(C)c3c2)c1
Show InChI InChI=1S/C24H27N3O3/c1-3-26-9-11-27(12-10-26)24(29)19-6-4-5-18(14-19)16-30-20-7-8-22-21(15-20)17(2)13-23(28)25-22/h4-8,13-15H,3,9-12,16H2,1-2H3,(H,25,28)
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n/an/a 1.93E+3n/an/an/an/an/an/a



Islamic Azad University

Curated by ChEMBL


Assay Description
Inhibition of human PDE3B by fluorescence microplate reader


Bioorg Med Chem 18: 855-62 (2010)

More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50308947
PNG
(6-[(3-{[4-(2-Hydroxyethyl)piperazino]carbonyl}-ben...)
Show SMILES Cc1cc(=O)[nH]c2ccc(OCc3cccc(c3)C(=O)N3CCN(CCO)CC3)cc12
Show InChI InChI=1S/C24H27N3O4/c1-17-13-23(29)25-22-6-5-20(15-21(17)22)31-16-18-3-2-4-19(14-18)24(30)27-9-7-26(8-10-27)11-12-28/h2-6,13-15,28H,7-12,16H2,1H3,(H,25,29)
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n/an/a 2.80E+3n/an/an/an/an/an/a



Islamic Azad University

Curated by ChEMBL


Assay Description
Inhibition of human PDE3B by fluorescence microplate reader


Bioorg Med Chem 18: 855-62 (2010)

More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50308948
PNG
(4-Methyl-6-(3-[(4-oxopiperidino)carbonyl]benzyloxy...)
Show SMILES Cc1cc(=O)[nH]c2ccc(OCc3cccc(c3)C(=O)N3CCC(=O)CC3)cc12
Show InChI InChI=1S/C23H22N2O4/c1-15-11-22(27)24-21-6-5-19(13-20(15)21)29-14-16-3-2-4-17(12-16)23(28)25-9-7-18(26)8-10-25/h2-6,11-13H,7-10,14H2,1H3,(H,24,27)
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n/an/a 1.14E+3n/an/an/an/an/an/a



Islamic Azad University

Curated by ChEMBL


Assay Description
Inhibition of human PDE3B by fluorescence microplate reader


Bioorg Med Chem 18: 855-62 (2010)

More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50308949
PNG
(1-(3-{[(4-Methyl-2-oxo-1,2-dihydro-6-quinolinyl)ox...)
Show SMILES Cc1cc(=O)[nH]c2ccc(OCc3cccc(c3)C(=O)N3CCC(CC3)C(O)=O)cc12
Show InChI InChI=1S/C24H24N2O5/c1-15-11-22(27)25-21-6-5-19(13-20(15)21)31-14-16-3-2-4-18(12-16)23(28)26-9-7-17(8-10-26)24(29)30/h2-6,11-13,17H,7-10,14H2,1H3,(H,25,27)(H,29,30)
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n/an/a 1.28E+3n/an/an/an/an/an/a



Islamic Azad University

Curated by ChEMBL


Assay Description
Inhibition of human PDE3B by fluorescence microplate reader


Bioorg Med Chem 18: 855-62 (2010)

More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50308950
PNG
(6-({3-[(4-Hydroxypiperidino)carbonyl]benzyl}oxy)-4...)
Show SMILES Cc1cc(=O)[nH]c2ccc(OCc3cccc(c3)C(=O)N3CCC(O)CC3)cc12
Show InChI InChI=1S/C23H24N2O4/c1-15-11-22(27)24-21-6-5-19(13-20(15)21)29-14-16-3-2-4-17(12-16)23(28)25-9-7-18(26)8-10-25/h2-6,11-13,18,26H,7-10,14H2,1H3,(H,24,27)
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n/an/a 910n/an/an/an/an/an/a



Islamic Azad University

Curated by ChEMBL


Assay Description
Inhibition of human PDE3B by fluorescence microplate reader


Bioorg Med Chem 18: 855-62 (2010)

More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50308951
PNG
(4-Methyl-6-{[3-(piperidinocarbonyl)benzyl]oxy}-1,2...)
Show SMILES Cc1cc(=O)[nH]c2ccc(OCc3cccc(c3)C(=O)N3CCCCC3)cc12
Show InChI InChI=1S/C23H24N2O3/c1-16-12-22(26)24-21-9-8-19(14-20(16)21)28-15-17-6-5-7-18(13-17)23(27)25-10-3-2-4-11-25/h5-9,12-14H,2-4,10-11,15H2,1H3,(H,24,26)
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n/an/a 1.73E+3n/an/an/an/an/an/a



Islamic Azad University

Curated by ChEMBL


Assay Description
Inhibition of human PDE3B by fluorescence microplate reader


Bioorg Med Chem 18: 855-62 (2010)

More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM50308952
PNG
(4-Methyl-6-({3-[(4-methylpiperidino)carbonyl]-benz...)
Show SMILES CC1CCN(CC1)C(=O)c1cccc(COc2ccc3[nH]c(=O)cc(C)c3c2)c1
Show InChI InChI=1S/C24H26N2O3/c1-16-8-10-26(11-9-16)24(28)19-5-3-4-18(13-19)15-29-20-6-7-22-21(14-20)17(2)12-23(27)25-22/h3-7,12-14,16H,8-11,15H2,1-2H3,(H,25,27)
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n/an/a 1.61E+3n/an/an/an/an/an/a



Islamic Azad University

Curated by ChEMBL


Assay Description
Inhibition of human PDE3B by fluorescence microplate reader


Bioorg Med Chem 18: 855-62 (2010)

More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (human))
BDBM50308946
PNG
(4-Methyl-6-({3-[(4-ethylpiperazino)carbonyl]-benzy...)
Show SMILES CCN1CCN(CC1)C(=O)c1cccc(COc2ccc3[nH]c(=O)cc(C)c3c2)c1
Show InChI InChI=1S/C24H27N3O3/c1-3-26-9-11-27(12-10-26)24(29)19-6-4-5-18(14-19)16-30-20-7-8-22-21(15-20)17(2)13-23(28)25-22/h4-8,13-15H,3,9-12,16H2,1-2H3,(H,25,28)
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n/an/a 1.44E+3n/an/an/an/an/an/a



Islamic Azad University

Curated by ChEMBL


Assay Description
Inhibition of human PDE3A by fluorescence microplate reader


Bioorg Med Chem 18: 855-62 (2010)

More data for this
Ligand-Target Pair