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10 similar compounds to monomer 50400612

Wt: 379.4
BDBM50310633
Wt: 379.4
BDBM50310634
Wt: 395.4
BDBM50310636
Wt: 395.4
BDBM50310637
Wt: 429.4
BDBM50310639
Wt: 429.4
BDBM50310628
Wt: 491.5
BDBM50400603
Wt: 504.6
BDBM50400604
Wt: 393.4
BDBM50400613
Wt: 490.5
BDBM50400614

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 32 hits for monomerid = 50310633,50310634,50310636,50310637,50310639,50310628,50400603,50400604,50400613,50400614   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50310628
PNG
(AB-460 | CHEMBL1081509 | N-(4-(3-(5-tert-butylisox...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3cc4ccccc4cn3)cc2)no1
Show InChI InChI=1S/C24H23N5O3/c1-24(2,3)20-13-21(29-32-20)28-23(31)27-18-10-8-17(9-11-18)26-22(30)19-12-15-6-4-5-7-16(15)14-25-19/h4-14H,1-3H3,(H,26,30)(H2,27,28,29,31)
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n/an/an/a>200n/an/an/an/an/a



Ambit Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity to VEGFR2


Bioorg Med Chem Lett 19: 5182-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.024
BindingDB Entry DOI: 10.7270/Q2PG1RVB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50400614
PNG
(CHEMBL2203426)
Show SMILES CCN1CCC(CC1)c1ccc(nc1)C(=O)Nc1ccc(NC(=O)Nc2cc(on2)C(C)(C)C)cc1
Show InChI InChI=1S/C27H34N6O3/c1-5-33-14-12-18(13-15-33)19-6-11-22(28-17-19)25(34)29-20-7-9-21(10-8-20)30-26(35)31-24-16-23(36-32-24)27(2,3)4/h6-11,16-18H,5,12-15H2,1-4H3,(H,29,34)(H2,30,31,32,35)
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TBA

Curated by ChEMBL


Assay Description
Binding affinity to FLT3 expressed in HEK-293 cells after 1 hr


ACS Med Chem Lett 3: 997-1002 (2012)


Article DOI: 10.1021/ml300214g
BindingDB Entry DOI: 10.7270/Q22V2H9V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50310634
PNG
(CHEMBL1078027 | N-(4-(3-(5-tert-butylisoxazol-3-yl...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3cccnc3)cc2)no1
Show InChI InChI=1S/C20H21N5O3/c1-20(2,3)16-11-17(25-28-16)24-19(27)23-15-8-6-14(7-9-15)22-18(26)13-5-4-10-21-12-13/h4-12H,1-3H3,(H,22,26)(H2,23,24,25,27)
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Ambit Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity to FLT3


Bioorg Med Chem Lett 19: 5182-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.024
BindingDB Entry DOI: 10.7270/Q2PG1RVB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50310636
PNG
(CHEMBL1079544 | N-(4-(3-(5-tert-butylisoxazol-3-yl...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3cccc(=O)[nH]3)cc2)no1
Show InChI InChI=1S/C20H21N5O4/c1-20(2,3)15-11-16(25-29-15)24-19(28)22-13-9-7-12(8-10-13)21-18(27)14-5-4-6-17(26)23-14/h4-11H,1-3H3,(H,21,27)(H,23,26)(H2,22,24,25,28)
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n/an/an/a 2.5n/an/an/an/an/a



Ambit Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity to FLT3


Bioorg Med Chem Lett 19: 5182-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.024
BindingDB Entry DOI: 10.7270/Q2PG1RVB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50310637
PNG
(CHEMBL1079545 | N-(4-(3-(5-tert-butylisoxazol-3-yl...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3ncccc3O)cc2)no1
Show InChI InChI=1S/C20H21N5O4/c1-20(2,3)15-11-16(25-29-15)24-19(28)23-13-8-6-12(7-9-13)22-18(27)17-14(26)5-4-10-21-17/h4-11,26H,1-3H3,(H,22,27)(H2,23,24,25,28)
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n/an/an/a 0.740n/an/an/an/an/a



Ambit Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity to FLT3


Bioorg Med Chem Lett 19: 5182-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.024
BindingDB Entry DOI: 10.7270/Q2PG1RVB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50310639
PNG
(CHEMBL1080064 | N-(4-(3-(5-tert-butylisoxazol-3-yl...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3nccc4ccccc34)cc2)no1
Show InChI InChI=1S/C24H23N5O3/c1-24(2,3)19-14-20(29-32-19)28-23(31)27-17-10-8-16(9-11-17)26-22(30)21-18-7-5-4-6-15(18)12-13-25-21/h4-14H,1-3H3,(H,26,30)(H2,27,28,29,31)
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n/an/an/a 0.740n/an/an/an/an/a



Ambit Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity to FLT3


Bioorg Med Chem Lett 19: 5182-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.024
BindingDB Entry DOI: 10.7270/Q2PG1RVB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50310628
PNG
(AB-460 | CHEMBL1081509 | N-(4-(3-(5-tert-butylisox...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3cc4ccccc4cn3)cc2)no1
Show InChI InChI=1S/C24H23N5O3/c1-24(2,3)20-13-21(29-32-20)28-23(31)27-18-10-8-17(9-11-18)26-22(30)19-12-15-6-4-5-7-16(15)14-25-19/h4-14H,1-3H3,(H,26,30)(H2,27,28,29,31)
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n/an/an/a 1.10n/an/an/an/an/a



Ambit Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity to FLT3


Bioorg Med Chem Lett 19: 5182-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.024
BindingDB Entry DOI: 10.7270/Q2PG1RVB
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50310637
PNG
(CHEMBL1079545 | N-(4-(3-(5-tert-butylisoxazol-3-yl...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3ncccc3O)cc2)no1
Show InChI InChI=1S/C20H21N5O4/c1-20(2,3)15-11-16(25-29-15)24-19(28)23-13-8-6-12(7-9-13)22-18(27)17-14(26)5-4-10-21-17/h4-11,26H,1-3H3,(H,22,27)(H2,23,24,25,28)
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n/an/an/a 0.960n/an/an/an/an/a



Ambit Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity to KIT


Bioorg Med Chem Lett 19: 5182-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.024
BindingDB Entry DOI: 10.7270/Q2PG1RVB
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50310628
PNG
(AB-460 | CHEMBL1081509 | N-(4-(3-(5-tert-butylisox...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3cc4ccccc4cn3)cc2)no1
Show InChI InChI=1S/C24H23N5O3/c1-24(2,3)20-13-21(29-32-20)28-23(31)27-18-10-8-17(9-11-18)26-22(30)19-12-15-6-4-5-7-16(15)14-25-19/h4-14H,1-3H3,(H,26,30)(H2,27,28,29,31)
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n/an/an/a 1.80n/an/an/an/an/a



Ambit Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity to KIT


Bioorg Med Chem Lett 19: 5182-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.024
BindingDB Entry DOI: 10.7270/Q2PG1RVB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM50310637
PNG
(CHEMBL1079545 | N-(4-(3-(5-tert-butylisoxazol-3-yl...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3ncccc3O)cc2)no1
Show InChI InChI=1S/C20H21N5O4/c1-20(2,3)15-11-16(25-29-15)24-19(28)23-13-8-6-12(7-9-13)22-18(27)17-14(26)5-4-10-21-17/h4-11,26H,1-3H3,(H,22,27)(H2,23,24,25,28)
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n/an/an/a 4.40n/an/an/an/an/a



Ambit Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity to CSF1R


Bioorg Med Chem Lett 19: 5182-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.024
BindingDB Entry DOI: 10.7270/Q2PG1RVB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM50310628
PNG
(AB-460 | CHEMBL1081509 | N-(4-(3-(5-tert-butylisox...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3cc4ccccc4cn3)cc2)no1
Show InChI InChI=1S/C24H23N5O3/c1-24(2,3)20-13-21(29-32-20)28-23(31)27-18-10-8-17(9-11-18)26-22(30)19-12-15-6-4-5-7-16(15)14-25-19/h4-14H,1-3H3,(H,26,30)(H2,27,28,29,31)
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n/an/an/a 8.5n/an/an/an/an/a



Ambit Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity to CSF1R


Bioorg Med Chem Lett 19: 5182-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.024
BindingDB Entry DOI: 10.7270/Q2PG1RVB
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM50310637
PNG
(CHEMBL1079545 | N-(4-(3-(5-tert-butylisoxazol-3-yl...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3ncccc3O)cc2)no1
Show InChI InChI=1S/C20H21N5O4/c1-20(2,3)15-11-16(25-29-15)24-19(28)23-13-8-6-12(7-9-13)22-18(27)17-14(26)5-4-10-21-17/h4-11,26H,1-3H3,(H,22,27)(H2,23,24,25,28)
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n/an/an/a 4.70n/an/an/an/an/a



Ambit Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity to RET


Bioorg Med Chem Lett 19: 5182-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.024
BindingDB Entry DOI: 10.7270/Q2PG1RVB
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM50310628
PNG
(AB-460 | CHEMBL1081509 | N-(4-(3-(5-tert-butylisox...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3cc4ccccc4cn3)cc2)no1
Show InChI InChI=1S/C24H23N5O3/c1-24(2,3)20-13-21(29-32-20)28-23(31)27-18-10-8-17(9-11-18)26-22(30)19-12-15-6-4-5-7-16(15)14-25-19/h4-14H,1-3H3,(H,26,30)(H2,27,28,29,31)
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n/an/an/a 7.30n/an/an/an/an/a



Ambit Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity to RET


Bioorg Med Chem Lett 19: 5182-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.024
BindingDB Entry DOI: 10.7270/Q2PG1RVB
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Homo sapiens (Human))
BDBM50310637
PNG
(CHEMBL1079545 | N-(4-(3-(5-tert-butylisoxazol-3-yl...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3ncccc3O)cc2)no1
Show InChI InChI=1S/C20H21N5O4/c1-20(2,3)15-11-16(25-29-15)24-19(28)23-13-8-6-12(7-9-13)22-18(27)17-14(26)5-4-10-21-17/h4-11,26H,1-3H3,(H,22,27)(H2,23,24,25,28)
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n/an/an/a 1n/an/an/an/an/a



Ambit Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity to PDGFRalpha


Bioorg Med Chem Lett 19: 5182-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.024
BindingDB Entry DOI: 10.7270/Q2PG1RVB
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Homo sapiens (Human))
BDBM50310628
PNG
(AB-460 | CHEMBL1081509 | N-(4-(3-(5-tert-butylisox...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3cc4ccccc4cn3)cc2)no1
Show InChI InChI=1S/C24H23N5O3/c1-24(2,3)20-13-21(29-32-20)28-23(31)27-18-10-8-17(9-11-18)26-22(30)19-12-15-6-4-5-7-16(15)14-25-19/h4-14H,1-3H3,(H,26,30)(H2,27,28,29,31)
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n/an/an/a 9.90n/an/an/an/an/a



Ambit Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity to PDGFRalpha


Bioorg Med Chem Lett 19: 5182-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.024
BindingDB Entry DOI: 10.7270/Q2PG1RVB
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM50310637
PNG
(CHEMBL1079545 | N-(4-(3-(5-tert-butylisoxazol-3-yl...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3ncccc3O)cc2)no1
Show InChI InChI=1S/C20H21N5O4/c1-20(2,3)15-11-16(25-29-15)24-19(28)23-13-8-6-12(7-9-13)22-18(27)17-14(26)5-4-10-21-17/h4-11,26H,1-3H3,(H,22,27)(H2,23,24,25,28)
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n/an/an/a 2.60n/an/an/an/an/a



Ambit Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity to PDGFRbeta


Bioorg Med Chem Lett 19: 5182-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.024
BindingDB Entry DOI: 10.7270/Q2PG1RVB
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM50310628
PNG
(AB-460 | CHEMBL1081509 | N-(4-(3-(5-tert-butylisox...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3cc4ccccc4cn3)cc2)no1
Show InChI InChI=1S/C24H23N5O3/c1-24(2,3)20-13-21(29-32-20)28-23(31)27-18-10-8-17(9-11-18)26-22(30)19-12-15-6-4-5-7-16(15)14-25-19/h4-14H,1-3H3,(H,26,30)(H2,27,28,29,31)
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n/an/an/a 7n/an/an/an/an/a



Ambit Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity to PDGFRbeta


Bioorg Med Chem Lett 19: 5182-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.024
BindingDB Entry DOI: 10.7270/Q2PG1RVB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM50400603
PNG
(CHEMBL2203428)
Show SMILES CN1CCN(Cc2ccc(nc2)C(=O)Nc2ccc(NC(=O)Nc3cc(on3)C(C)(C)C)cc2)CC1
Show InChI InChI=1S/C26H33N7O3/c1-26(2,3)22-15-23(31-36-22)30-25(35)29-20-8-6-19(7-9-20)28-24(34)21-10-5-18(16-27-21)17-33-13-11-32(4)12-14-33/h5-10,15-16H,11-14,17H2,1-4H3,(H,28,34)(H2,29,30,31,35)
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n/an/a 109n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of CSF1R in mouse M-NFS-60 cells assessed as inhibition of cell proliferation after 72 hrs by Celltiter-Blue assay


ACS Med Chem Lett 3: 997-1002 (2012)


Article DOI: 10.1021/ml300214g
BindingDB Entry DOI: 10.7270/Q22V2H9V
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM50400603
PNG
(CHEMBL2203428)
Show SMILES CN1CCN(Cc2ccc(nc2)C(=O)Nc2ccc(NC(=O)Nc3cc(on3)C(C)(C)C)cc2)CC1
Show InChI InChI=1S/C26H33N7O3/c1-26(2,3)22-15-23(31-36-22)30-25(35)29-20-8-6-19(7-9-20)28-24(34)21-10-5-18(16-27-21)17-33-13-11-32(4)12-14-33/h5-10,15-16H,11-14,17H2,1-4H3,(H,28,34)(H2,29,30,31,35)
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n/an/an/a 4.90n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to CSF1R expressed in HEK-293 cells after 1 hr


ACS Med Chem Lett 3: 997-1002 (2012)


Article DOI: 10.1021/ml300214g
BindingDB Entry DOI: 10.7270/Q22V2H9V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50400603
PNG
(CHEMBL2203428)
Show SMILES CN1CCN(Cc2ccc(nc2)C(=O)Nc2ccc(NC(=O)Nc3cc(on3)C(C)(C)C)cc2)CC1
Show InChI InChI=1S/C26H33N7O3/c1-26(2,3)22-15-23(31-36-22)30-25(35)29-20-8-6-19(7-9-20)28-24(34)21-10-5-18(16-27-21)17-33-13-11-32(4)12-14-33/h5-10,15-16H,11-14,17H2,1-4H3,(H,28,34)(H2,29,30,31,35)
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n/an/an/a 0.900n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to FLT3 expressed in HEK-293 cells after 1 hr


ACS Med Chem Lett 3: 997-1002 (2012)


Article DOI: 10.1021/ml300214g
BindingDB Entry DOI: 10.7270/Q22V2H9V
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM50400604
PNG
(CHEMBL2203427)
Show SMILES CCN1CCC(Cc2ccc(nc2)C(=O)Nc2ccc(NC(=O)Nc3cc(on3)C(C)(C)C)cc2)CC1
Show InChI InChI=1S/C28H36N6O3/c1-5-34-14-12-19(13-15-34)16-20-6-11-23(29-18-20)26(35)30-21-7-9-22(10-8-21)31-27(36)32-25-17-24(37-33-25)28(2,3)4/h6-11,17-19H,5,12-16H2,1-4H3,(H,30,35)(H2,31,32,33,36)
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n/an/a 67.4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of CSF1R in mouse M-NFS-60 cells assessed as inhibition of cell proliferation after 72 hrs by Celltiter-Blue assay


ACS Med Chem Lett 3: 997-1002 (2012)


Article DOI: 10.1021/ml300214g
BindingDB Entry DOI: 10.7270/Q22V2H9V
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM50400604
PNG
(CHEMBL2203427)
Show SMILES CCN1CCC(Cc2ccc(nc2)C(=O)Nc2ccc(NC(=O)Nc3cc(on3)C(C)(C)C)cc2)CC1
Show InChI InChI=1S/C28H36N6O3/c1-5-34-14-12-19(13-15-34)16-20-6-11-23(29-18-20)26(35)30-21-7-9-22(10-8-21)31-27(36)32-25-17-24(37-33-25)28(2,3)4/h6-11,17-19H,5,12-16H2,1-4H3,(H,30,35)(H2,31,32,33,36)
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n/an/an/a 1n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to CSF1R expressed in HEK-293 cells after 1 hr


ACS Med Chem Lett 3: 997-1002 (2012)


Article DOI: 10.1021/ml300214g
BindingDB Entry DOI: 10.7270/Q22V2H9V
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM50400613
PNG
(CHEMBL2203429)
Show SMILES Cc1ccnc(c1)C(=O)Nc1ccc(NC(=O)Nc2cc(on2)C(C)(C)C)cc1
Show InChI InChI=1S/C21H23N5O3/c1-13-9-10-22-16(11-13)19(27)23-14-5-7-15(8-6-14)24-20(28)25-18-12-17(29-26-18)21(2,3)4/h5-12H,1-4H3,(H,23,27)(H2,24,25,26,28)
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n/an/a 63.9n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of CSF1R in mouse M-NFS-60 cells assessed as inhibition of cell proliferation after 72 hrs by Celltiter-Blue assay


ACS Med Chem Lett 3: 997-1002 (2012)


Article DOI: 10.1021/ml300214g
BindingDB Entry DOI: 10.7270/Q22V2H9V
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM50400613
PNG
(CHEMBL2203429)
Show SMILES Cc1ccnc(c1)C(=O)Nc1ccc(NC(=O)Nc2cc(on2)C(C)(C)C)cc1
Show InChI InChI=1S/C21H23N5O3/c1-13-9-10-22-16(11-13)19(27)23-14-5-7-15(8-6-14)24-20(28)25-18-12-17(29-26-18)21(2,3)4/h5-12H,1-4H3,(H,23,27)(H2,24,25,26,28)
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n/an/an/a 2n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to CSF1R expressed in HEK-293 cells after 1 hr


ACS Med Chem Lett 3: 997-1002 (2012)


Article DOI: 10.1021/ml300214g
BindingDB Entry DOI: 10.7270/Q22V2H9V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50400613
PNG
(CHEMBL2203429)
Show SMILES Cc1ccnc(c1)C(=O)Nc1ccc(NC(=O)Nc2cc(on2)C(C)(C)C)cc1
Show InChI InChI=1S/C21H23N5O3/c1-13-9-10-22-16(11-13)19(27)23-14-5-7-15(8-6-14)24-20(28)25-18-12-17(29-26-18)21(2,3)4/h5-12H,1-4H3,(H,23,27)(H2,24,25,26,28)
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n/an/an/a 0.800n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to FLT3 expressed in HEK-293 cells after 1 hr


ACS Med Chem Lett 3: 997-1002 (2012)


Article DOI: 10.1021/ml300214g
BindingDB Entry DOI: 10.7270/Q22V2H9V
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM50310628
PNG
(AB-460 | CHEMBL1081509 | N-(4-(3-(5-tert-butylisox...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3cc4ccccc4cn3)cc2)no1
Show InChI InChI=1S/C24H23N5O3/c1-24(2,3)20-13-21(29-32-20)28-23(31)27-18-10-8-17(9-11-18)26-22(30)19-12-15-6-4-5-7-16(15)14-25-19/h4-14H,1-3H3,(H,26,30)(H2,27,28,29,31)
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n/an/a 53n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of CSF1R in mouse M-NFS-60 cells assessed as inhibition of cell proliferation after 72 hrs by Celltiter-Blue assay


ACS Med Chem Lett 3: 997-1002 (2012)


Article DOI: 10.1021/ml300214g
BindingDB Entry DOI: 10.7270/Q22V2H9V
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM50310628
PNG
(AB-460 | CHEMBL1081509 | N-(4-(3-(5-tert-butylisox...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3cc4ccccc4cn3)cc2)no1
Show InChI InChI=1S/C24H23N5O3/c1-24(2,3)20-13-21(29-32-20)28-23(31)27-18-10-8-17(9-11-18)26-22(30)19-12-15-6-4-5-7-16(15)14-25-19/h4-14H,1-3H3,(H,26,30)(H2,27,28,29,31)
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n/an/an/a 8.5n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to CSF1R expressed in HEK-293 cells after 1 hr


ACS Med Chem Lett 3: 997-1002 (2012)


Article DOI: 10.1021/ml300214g
BindingDB Entry DOI: 10.7270/Q22V2H9V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50310628
PNG
(AB-460 | CHEMBL1081509 | N-(4-(3-(5-tert-butylisox...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3cc4ccccc4cn3)cc2)no1
Show InChI InChI=1S/C24H23N5O3/c1-24(2,3)20-13-21(29-32-20)28-23(31)27-18-10-8-17(9-11-18)26-22(30)19-12-15-6-4-5-7-16(15)14-25-19/h4-14H,1-3H3,(H,26,30)(H2,27,28,29,31)
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n/an/an/a 0.700n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to FLT3 expressed in HEK-293 cells after 1 hr


ACS Med Chem Lett 3: 997-1002 (2012)


Article DOI: 10.1021/ml300214g
BindingDB Entry DOI: 10.7270/Q22V2H9V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50400604
PNG
(CHEMBL2203427)
Show SMILES CCN1CCC(Cc2ccc(nc2)C(=O)Nc2ccc(NC(=O)Nc3cc(on3)C(C)(C)C)cc2)CC1
Show InChI InChI=1S/C28H36N6O3/c1-5-34-14-12-19(13-15-34)16-20-6-11-23(29-18-20)26(35)30-21-7-9-22(10-8-21)31-27(36)32-25-17-24(37-33-25)28(2,3)4/h6-11,17-19H,5,12-16H2,1-4H3,(H,30,35)(H2,31,32,33,36)
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n/an/an/a 0.400n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to FLT3 expressed in HEK-293 cells after 1 hr


ACS Med Chem Lett 3: 997-1002 (2012)


Article DOI: 10.1021/ml300214g
BindingDB Entry DOI: 10.7270/Q22V2H9V
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM50400614
PNG
(CHEMBL2203426)
Show SMILES CCN1CCC(CC1)c1ccc(nc1)C(=O)Nc1ccc(NC(=O)Nc2cc(on2)C(C)(C)C)cc1
Show InChI InChI=1S/C27H34N6O3/c1-5-33-14-12-18(13-15-33)19-6-11-22(28-17-19)25(34)29-20-7-9-21(10-8-20)30-26(35)31-24-16-23(36-32-24)27(2,3)4/h6-11,16-18H,5,12-15H2,1-4H3,(H,29,34)(H2,30,31,32,35)
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n/an/a 37n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of CSF1R in mouse M-NFS-60 cells assessed as inhibition of cell proliferation after 72 hrs by Celltiter-Blue assay


ACS Med Chem Lett 3: 997-1002 (2012)


Article DOI: 10.1021/ml300214g
BindingDB Entry DOI: 10.7270/Q22V2H9V
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM50400614
PNG
(CHEMBL2203426)
Show SMILES CCN1CCC(CC1)c1ccc(nc1)C(=O)Nc1ccc(NC(=O)Nc2cc(on2)C(C)(C)C)cc1
Show InChI InChI=1S/C27H34N6O3/c1-5-33-14-12-18(13-15-33)19-6-11-22(28-17-19)25(34)29-20-7-9-21(10-8-20)30-26(35)31-24-16-23(36-32-24)27(2,3)4/h6-11,16-18H,5,12-15H2,1-4H3,(H,29,34)(H2,30,31,32,35)
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n/an/an/a 3.10n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to CSF1R expressed in HEK-293 cells after 1 hr


ACS Med Chem Lett 3: 997-1002 (2012)


Article DOI: 10.1021/ml300214g
BindingDB Entry DOI: 10.7270/Q22V2H9V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50310633
PNG
(CHEMBL1081346 | N-(4-(3-(5-tert-butylisoxazol-3-yl...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3ccccn3)cc2)no1
Show InChI InChI=1S/C20H21N5O3/c1-20(2,3)16-12-17(25-28-16)24-19(27)23-14-9-7-13(8-10-14)22-18(26)15-6-4-5-11-21-15/h4-12H,1-3H3,(H,22,26)(H2,23,24,25,27)
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n/an/an/a 0.760n/an/an/an/an/a



Ambit Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity to FLT3


Bioorg Med Chem Lett 19: 5182-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.024
BindingDB Entry DOI: 10.7270/Q2PG1RVB
More data for this
Ligand-Target Pair