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13 similar compounds to monomer 50311017

Compile data set for download or QSAR
Wt: 375.4
BDBM50310992
Wt: 414.4
BDBM50311013
Wt: 400.4
BDBM50311015
Wt: 428.4
BDBM50311018
Wt: 442.5
BDBM50311020
Wt: 428.4
BDBM50311021
Wt: 428.4
BDBM50311022
Wt: 444.4
BDBM50311023
Wt: 428.4
BDBM50311026
Wt: 432.4
BDBM50311027
Wt: 414.4
BDBM50311028
Wt: 430.5
BDBM50311029
Wt: 427.5
BDBM50311032

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 50310992,50311013,50311015,50311018,50311020,50311021,50311022,50311023,50311026,50311027,50311028,50311029,50311032   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50310992
PNG
(4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benza...)
Show SMILES NC(=O)c1ccc(cc1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1
Show InChI InChI=1S/C21H21N5O2/c22-20(27)16-3-1-15(2-4-16)19-9-10-23-21(25-19)24-17-5-7-18(8-6-17)26-11-13-28-14-12-26/h1-10H,11-14H2,(H2,22,27)(H,23,24,25)
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n/an/a 326n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK2 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50311032
PNG
(CHEMBL1078934 | N-(cyanomethyl)-4-(2-(4-(4-methylp...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)-c2ccc(cc2)C(=O)NCC#N)cc1
Show InChI InChI=1S/C24H25N7O/c1-30-14-16-31(17-15-30)21-8-6-20(7-9-21)28-24-27-12-10-22(29-24)18-2-4-19(5-3-18)23(32)26-13-11-25/h2-10,12H,13-17H2,1H3,(H,26,32)(H,27,28,29)
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n/an/a 192n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK3 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50311015
PNG
(2-(3-(2-(4-morpholinophenylamino)pyrimidin-4-yl)be...)
Show SMILES N#CCNCc1cccc(c1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1
Show InChI InChI=1S/C23H24N6O/c24-9-11-25-17-18-2-1-3-19(16-18)22-8-10-26-23(28-22)27-20-4-6-21(7-5-20)29-12-14-30-15-13-29/h1-8,10,16,25H,11-15,17H2,(H,26,27,28)
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n/an/a 132n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK2 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50311018
PNG
(CHEMBL1078363 | N-(cyanomethyl)-2-methyl-4-(2-(4-m...)
Show SMILES Cc1cc(ccc1C(=O)NCC#N)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1
Show InChI InChI=1S/C24H24N6O2/c1-17-16-18(2-7-21(17)23(31)26-11-9-25)22-8-10-27-24(29-22)28-19-3-5-20(6-4-19)30-12-14-32-15-13-30/h2-8,10,16H,11-15H2,1H3,(H,26,31)(H,27,28,29)
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n/an/a 65n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK2 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50311020
PNG
(CHEMBL1078453 | N-(2-cyanopropan-2-yl)-4-(2-(4-mor...)
Show SMILES CC(C)(NC(=O)c1ccc(cc1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1)C#N
Show InChI InChI=1S/C25H26N6O2/c1-25(2,17-26)30-23(32)19-5-3-18(4-6-19)22-11-12-27-24(29-22)28-20-7-9-21(10-8-20)31-13-15-33-16-14-31/h3-12H,13-16H2,1-2H3,(H,30,32)(H,27,28,29)
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n/an/a 549n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK2 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50311021
PNG
(CHEMBL1078370 | N-(cyanomethyl)-N-methyl-4-(2-(4-m...)
Show SMILES CN(CC#N)C(=O)c1ccc(cc1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1
Show InChI InChI=1S/C24H24N6O2/c1-29(13-11-25)23(31)19-4-2-18(3-5-19)22-10-12-26-24(28-22)27-20-6-8-21(9-7-20)30-14-16-32-17-15-30/h2-10,12H,13-17H2,1H3,(H,26,27,28)
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n/an/a 298n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK2 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50311022
PNG
(CHEMBL1078005 | N-(cyanomethyl)-4-(5-methyl-2-(4-m...)
Show SMILES Cc1cnc(Nc2ccc(cc2)N2CCOCC2)nc1-c1ccc(cc1)C(=O)NCC#N
Show InChI InChI=1S/C24H24N6O2/c1-17-16-27-24(28-20-6-8-21(9-7-20)30-12-14-32-15-13-30)29-22(17)18-2-4-19(5-3-18)23(31)26-11-10-25/h2-9,16H,11-15H2,1H3,(H,26,31)(H,27,28,29)
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n/an/a 8n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK2 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50311023
PNG
(CHEMBL1079120 | N-(cyanomethyl)-4-(5-methoxy-2-(4-...)
Show SMILES COc1cnc(Nc2ccc(cc2)N2CCOCC2)nc1-c1ccc(cc1)C(=O)NCC#N
Show InChI InChI=1S/C24H24N6O3/c1-32-21-16-27-24(28-19-6-8-20(9-7-19)30-12-14-33-15-13-30)29-22(21)17-2-4-18(5-3-17)23(31)26-11-10-25/h2-9,16H,11-15H2,1H3,(H,26,31)(H,27,28,29)
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n/an/a 186n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK2 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50311026
PNG
(CHEMBL1078721 | N-(cyanomethyl)-4-(2-(4-(morpholin...)
Show SMILES O=C(NCC#N)c1ccc(cc1)-c1ccnc(Nc2ccc(CN3CCOCC3)cc2)n1
Show InChI InChI=1S/C24H24N6O2/c25-10-12-26-23(31)20-5-3-19(4-6-20)22-9-11-27-24(29-22)28-21-7-1-18(2-8-21)17-30-13-15-32-16-14-30/h1-9,11H,12-17H2,(H,26,31)(H,27,28,29)
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n/an/a 163n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK2 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50311027
PNG
(CHEMBL1078228 | N-(cyanomethyl)-4-(2-(3-fluoro-4-m...)
Show SMILES Fc1cc(Nc2nccc(n2)-c2ccc(cc2)C(=O)NCC#N)ccc1N1CCOCC1
Show InChI InChI=1S/C23H21FN6O2/c24-19-15-18(5-6-21(19)30-11-13-32-14-12-30)28-23-27-9-7-20(29-23)16-1-3-17(4-2-16)22(31)26-10-8-25/h1-7,9,15H,10-14H2,(H,26,31)(H,27,28,29)
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n/an/a 116n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK2 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50311028
PNG
(CHEMBL1078229 | N-(cyanomethyl)-4-(2-(3-morpholino...)
Show SMILES O=C(NCC#N)c1ccc(cc1)-c1ccnc(Nc2cccc(c2)N2CCOCC2)n1
Show InChI InChI=1S/C23H22N6O2/c24-9-11-25-22(30)18-6-4-17(5-7-18)21-8-10-26-23(28-21)27-19-2-1-3-20(16-19)29-12-14-31-15-13-29/h1-8,10,16H,11-15H2,(H,25,30)(H,26,27,28)
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n/an/a 113n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK2 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50311029
PNG
(CHEMBL1077841 | N-(cyanomethyl)-4-(2-(4-thiomorpho...)
Show SMILES O=C(NCC#N)c1ccc(cc1)-c1ccnc(Nc2ccc(cc2)N2CCSCC2)n1
Show InChI InChI=1S/C23H22N6OS/c24-10-12-25-22(30)18-3-1-17(2-4-18)21-9-11-26-23(28-21)27-19-5-7-20(8-6-19)29-13-15-31-16-14-29/h1-9,11H,12-16H2,(H,25,30)(H,26,27,28)
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n/an/a 69n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK2 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50311032
PNG
(CHEMBL1078934 | N-(cyanomethyl)-4-(2-(4-(4-methylp...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)-c2ccc(cc2)C(=O)NCC#N)cc1
Show InChI InChI=1S/C24H25N7O/c1-30-14-16-31(17-15-30)21-8-6-20(7-9-21)28-24-27-12-10-22(29-24)18-2-4-19(5-3-18)23(32)26-13-11-25/h2-10,12H,13-17H2,1H3,(H,26,32)(H,27,28,29)
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n/an/a 41n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK2 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50311013
PNG
(CHEMBL1078159 | N-(cyanomethyl)-3-(2-(4-morpholino...)
Show SMILES O=C(NCC#N)c1cccc(c1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1
Show InChI InChI=1S/C23H22N6O2/c24-9-11-25-22(30)18-3-1-2-17(16-18)21-8-10-26-23(28-21)27-19-4-6-20(7-5-19)29-12-14-31-15-13-29/h1-8,10,16H,11-15H2,(H,25,30)(H,26,27,28)
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n/an/a>5.00E+3n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK3 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50311015
PNG
(2-(3-(2-(4-morpholinophenylamino)pyrimidin-4-yl)be...)
Show SMILES N#CCNCc1cccc(c1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1
Show InChI InChI=1S/C23H24N6O/c24-9-11-25-17-18-2-1-3-19(16-18)22-8-10-26-23(28-22)27-20-4-6-21(7-5-20)29-12-14-30-15-13-29/h1-8,10,16,25H,11-15,17H2,(H,26,27,28)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK3 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50311018
PNG
(CHEMBL1078363 | N-(cyanomethyl)-2-methyl-4-(2-(4-m...)
Show SMILES Cc1cc(ccc1C(=O)NCC#N)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1
Show InChI InChI=1S/C24H24N6O2/c1-17-16-18(2-7-21(17)23(31)26-11-9-25)22-8-10-27-24(29-22)28-19-3-5-20(6-4-19)30-12-14-32-15-13-30/h2-8,10,16H,11-15H2,1H3,(H,26,31)(H,27,28,29)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK3 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50311020
PNG
(CHEMBL1078453 | N-(2-cyanopropan-2-yl)-4-(2-(4-mor...)
Show SMILES CC(C)(NC(=O)c1ccc(cc1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1)C#N
Show InChI InChI=1S/C25H26N6O2/c1-25(2,17-26)30-23(32)19-5-3-18(4-6-19)22-11-12-27-24(29-22)28-20-7-9-21(10-8-20)31-13-15-33-16-14-31/h3-12H,13-16H2,1-2H3,(H,30,32)(H,27,28,29)
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n/an/a 3.91E+3n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK3 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50311021
PNG
(CHEMBL1078370 | N-(cyanomethyl)-N-methyl-4-(2-(4-m...)
Show SMILES CN(CC#N)C(=O)c1ccc(cc1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1
Show InChI InChI=1S/C24H24N6O2/c1-29(13-11-25)23(31)19-4-2-18(3-5-19)22-10-12-26-24(28-22)27-20-6-8-21(9-7-20)30-14-16-32-17-15-30/h2-10,12H,13-17H2,1H3,(H,26,27,28)
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n/an/a 1.42E+3n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK3 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50311022
PNG
(CHEMBL1078005 | N-(cyanomethyl)-4-(5-methyl-2-(4-m...)
Show SMILES Cc1cnc(Nc2ccc(cc2)N2CCOCC2)nc1-c1ccc(cc1)C(=O)NCC#N
Show InChI InChI=1S/C24H24N6O2/c1-17-16-27-24(28-20-6-8-21(9-7-20)30-12-14-32-15-13-30)29-22(17)18-2-4-19(5-3-18)23(31)26-11-10-25/h2-9,16H,11-15H2,1H3,(H,26,31)(H,27,28,29)
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n/an/a 85n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK3 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50311023
PNG
(CHEMBL1079120 | N-(cyanomethyl)-4-(5-methoxy-2-(4-...)
Show SMILES COc1cnc(Nc2ccc(cc2)N2CCOCC2)nc1-c1ccc(cc1)C(=O)NCC#N
Show InChI InChI=1S/C24H24N6O3/c1-32-21-16-27-24(28-19-6-8-20(9-7-19)30-12-14-33-15-13-30)29-22(21)17-2-4-18(5-3-17)23(31)26-11-10-25/h2-9,16H,11-15H2,1H3,(H,26,31)(H,27,28,29)
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n/an/a 2.31E+3n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK3 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50311026
PNG
(CHEMBL1078721 | N-(cyanomethyl)-4-(2-(4-(morpholin...)
Show SMILES O=C(NCC#N)c1ccc(cc1)-c1ccnc(Nc2ccc(CN3CCOCC3)cc2)n1
Show InChI InChI=1S/C24H24N6O2/c25-10-12-26-23(31)20-5-3-19(4-6-20)22-9-11-27-24(29-22)28-21-7-1-18(2-8-21)17-30-13-15-32-16-14-30/h1-9,11H,12-17H2,(H,26,31)(H,27,28,29)
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n/an/a 1.45E+3n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK3 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50311027
PNG
(CHEMBL1078228 | N-(cyanomethyl)-4-(2-(3-fluoro-4-m...)
Show SMILES Fc1cc(Nc2nccc(n2)-c2ccc(cc2)C(=O)NCC#N)ccc1N1CCOCC1
Show InChI InChI=1S/C23H21FN6O2/c24-19-15-18(5-6-21(19)30-11-13-32-14-12-30)28-23-27-9-7-20(29-23)16-1-3-17(4-2-16)22(31)26-10-8-25/h1-7,9,15H,10-14H2,(H,26,31)(H,27,28,29)
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n/an/a 274n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK3 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50311028
PNG
(CHEMBL1078229 | N-(cyanomethyl)-4-(2-(3-morpholino...)
Show SMILES O=C(NCC#N)c1ccc(cc1)-c1ccnc(Nc2cccc(c2)N2CCOCC2)n1
Show InChI InChI=1S/C23H22N6O2/c24-9-11-25-22(30)18-6-4-17(5-7-18)21-8-10-26-23(28-21)27-19-2-1-3-20(16-19)29-12-14-31-15-13-29/h1-8,10,16H,11-15H2,(H,25,30)(H,26,27,28)
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n/an/a 1.88E+3n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK3 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50311029
PNG
(CHEMBL1077841 | N-(cyanomethyl)-4-(2-(4-thiomorpho...)
Show SMILES O=C(NCC#N)c1ccc(cc1)-c1ccnc(Nc2ccc(cc2)N2CCSCC2)n1
Show InChI InChI=1S/C23H22N6OS/c24-10-12-25-22(30)18-3-1-17(2-4-18)21-9-11-26-23(28-21)27-19-5-7-20(8-6-19)29-13-15-31-16-14-29/h1-9,11H,12-16H2,(H,25,30)(H,26,27,28)
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n/an/a 364n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK3 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50311013
PNG
(CHEMBL1078159 | N-(cyanomethyl)-3-(2-(4-morpholino...)
Show SMILES O=C(NCC#N)c1cccc(c1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1
Show InChI InChI=1S/C23H22N6O2/c24-9-11-25-22(30)18-3-1-2-17(16-18)21-8-10-26-23(28-21)27-19-4-6-20(7-5-19)29-12-14-31-15-13-29/h1-8,10,16H,11-15H2,(H,25,30)(H,26,27,28)
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n/an/a 545n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK2 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair