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5 similar compounds to monomer 50311974

Compile data set for download or QSAR
Wt: 308.3
BDBM50311972
Wt: 322.3
BDBM50311973
Wt: 350.4
BDBM50311975
Wt: 378.4
BDBM50311976
Wt: 469.5
BDBM50311977

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50311972,50311973,50311975,50311976,50311977   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Angiopoietin-1 receptor


(Homo sapiens (Human))
BDBM50311972
PNG
(2-(1-methyl-4-phenyl-1H-imidazol-5-yl)thiazolo[5,4...)
Show SMILES Cn1cnc(c1-c1nc2c(N)ncnc2s1)-c1ccccc1
Show InChI InChI=1S/C15H12N6S/c1-21-8-19-10(9-5-3-2-4-6-9)12(21)15-20-11-13(16)17-7-18-14(11)22-15/h2-8H,1H3,(H2,16,17,18)
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n/an/a 2.70E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of Tie-2 phosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6670-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.001
BindingDB Entry DOI: 10.7270/Q2FN16BJ
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))
BDBM50311973
PNG
(2-(1-ethyl-4-phenyl-1H-imidazol-5-yl)thiazolo[5,4-...)
Show SMILES CCn1cnc(c1-c1nc2c(N)ncnc2s1)-c1ccccc1
Show InChI InChI=1S/C16H14N6S/c1-2-22-9-20-11(10-6-4-3-5-7-10)13(22)16-21-12-14(17)18-8-19-15(12)23-16/h3-9H,2H2,1H3,(H2,17,18,19)
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n/an/a 3.00E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of Tie-2 phosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6670-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.001
BindingDB Entry DOI: 10.7270/Q2FN16BJ
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))
BDBM50311975
PNG
(2-(1-isobutyl-4-phenyl-1H-imidazol-5-yl)thiazolo[5...)
Show SMILES CC(C)Cn1cnc(c1-c1nc2c(N)ncnc2s1)-c1ccccc1
Show InChI InChI=1S/C18H18N6S/c1-11(2)8-24-10-22-13(12-6-4-3-5-7-12)15(24)18-23-14-16(19)20-9-21-17(14)25-18/h3-7,9-11H,8H2,1-2H3,(H2,19,20,21)
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n/an/a 490n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of Tie-2 phosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6670-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.001
BindingDB Entry DOI: 10.7270/Q2FN16BJ
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50311972
PNG
(2-(1-methyl-4-phenyl-1H-imidazol-5-yl)thiazolo[5,4...)
Show SMILES Cn1cnc(c1-c1nc2c(N)ncnc2s1)-c1ccccc1
Show InChI InChI=1S/C15H12N6S/c1-21-8-19-10(9-5-3-2-4-6-9)12(21)15-20-11-13(16)17-7-18-14(11)22-15/h2-8H,1H3,(H2,16,17,18)
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n/an/a 4.40E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of FLt


Bioorg Med Chem Lett 19: 6670-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.001
BindingDB Entry DOI: 10.7270/Q2FN16BJ
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))
BDBM50311977
PNG
(2-(1-(2-morpholinobenzyl)-4-phenyl-1H-imidazol-5-y...)
Show SMILES Nc1ncnc2sc(nc12)-c1c(ncn1Cc1ccccc1N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C25H23N7OS/c26-23-21-24(28-15-27-23)34-25(30-21)22-20(17-6-2-1-3-7-17)29-16-32(22)14-18-8-4-5-9-19(18)31-10-12-33-13-11-31/h1-9,15-16H,10-14H2,(H2,26,27,28)
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n/an/a 440n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of Tie-2 phosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6670-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.001
BindingDB Entry DOI: 10.7270/Q2FN16BJ
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))
BDBM50311972
PNG
(2-(1-methyl-4-phenyl-1H-imidazol-5-yl)thiazolo[5,4...)
Show SMILES Cn1cnc(c1-c1nc2c(N)ncnc2s1)-c1ccccc1
Show InChI InChI=1S/C15H12N6S/c1-21-8-19-10(9-5-3-2-4-6-9)12(21)15-20-11-13(16)17-7-18-14(11)22-15/h2-8H,1H3,(H2,16,17,18)
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n/an/a 2.00E+4n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of Tie-2


Bioorg Med Chem Lett 19: 6670-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.001
BindingDB Entry DOI: 10.7270/Q2FN16BJ
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50311972
PNG
(2-(1-methyl-4-phenyl-1H-imidazol-5-yl)thiazolo[5,4...)
Show SMILES Cn1cnc(c1-c1nc2c(N)ncnc2s1)-c1ccccc1
Show InChI InChI=1S/C15H12N6S/c1-21-8-19-10(9-5-3-2-4-6-9)12(21)15-20-11-13(16)17-7-18-14(11)22-15/h2-8H,1H3,(H2,16,17,18)
PDB
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n/an/a 8.40E+4n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 19: 6670-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.001
BindingDB Entry DOI: 10.7270/Q2FN16BJ
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))
BDBM50311976
PNG
((R)-2-(4-phenyl-1-((tetrahydrofuran-2-yl)methyl)-1...)
Show SMILES Nc1ncnc2sc(nc12)-c1c(ncn1C[C@H]1CCCO1)-c1ccccc1
Show InChI InChI=1/C19H18N6OS/c20-17-15-18(22-10-21-17)27-19(24-15)16-14(12-5-2-1-3-6-12)23-11-25(16)9-13-7-4-8-26-13/h1-3,5-6,10-11,13H,4,7-9H2,(H2,20,21,22)/t13-/s2
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n/an/a 370n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of Tie-2 phosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6670-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.001
BindingDB Entry DOI: 10.7270/Q2FN16BJ
More data for this
Ligand-Target Pair