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3 similar compounds to monomer 50314442

Compile data set for download or QSAR
Wt: 414.5
BDBM50314443
Wt: 408.9
BDBM50314444
Wt: 336.4
BDBM50314445

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50314443,50314444,50314445   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM50314443
PNG
(2-(1-benzofuran-2-yl)-10-thia-5,7,12-triazatetracy...)
Show SMILES Nc1ncnc2c1sc1nc3CCCCCCCc3c(-c3cc4ccccc4o3)c21
Show InChI InChI=1S/C24H22N4OS/c25-23-22-21(26-13-27-23)20-19(18-12-14-8-6-7-11-17(14)29-18)15-9-4-2-1-3-5-10-16(15)28-24(20)30-22/h6-8,11-13H,1-5,9-10H2,(H2,25,26,27)
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PC cid
PC sid
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Article
PubMed
n/an/a>2.00E+4n/an/an/an/an/an/a



Myriad Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST tagged eEf2K expressed in Escherichia coli by fluorometric method


Bioorg Med Chem Lett 20: 2283-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.005
BindingDB Entry DOI: 10.7270/Q2F18ZVT
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM50314445
PNG
(5-Furan-2-yl-7,8,9,10-tetrahydro-6H-12-thia-2,4,11...)
Show SMILES Nc1ncnc2c1sc1nc3CCCCCc3c(-c3ccco3)c21
Show InChI InChI=1S/C18H16N4OS/c19-17-16-15(20-9-21-17)14-13(12-7-4-8-23-12)10-5-2-1-3-6-11(10)22-18(14)24-16/h4,7-9H,1-3,5-6H2,(H2,19,20,21)
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n/an/a 4.70E+3n/an/an/an/an/an/a



Myriad Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST tagged eEf2K expressed in Escherichia coli by fluorometric method


Bioorg Med Chem Lett 20: 2283-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.005
BindingDB Entry DOI: 10.7270/Q2F18ZVT
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM50314444
PNG
(2-(4-chlorophenyl)-10-thia-5,7,12-triazatetracyclo...)
Show SMILES Nc1ncnc2c1sc1nc3CCCCCCCc3c(-c3ccc(Cl)cc3)c21
Show InChI InChI=1S/C22H21ClN4S/c23-14-10-8-13(9-11-14)17-15-6-4-2-1-3-5-7-16(15)27-22-18(17)19-20(28-22)21(24)26-12-25-19/h8-12H,1-7H2,(H2,24,25,26)
PDB

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PC cid
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PubMed
n/an/a 110n/an/an/an/an/an/a



Myriad Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST tagged eEf2K expressed in Escherichia coli by fluorometric method


Bioorg Med Chem Lett 20: 2283-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.005
BindingDB Entry DOI: 10.7270/Q2F18ZVT
More data for this
Ligand-Target Pair