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5 similar compounds to monomer 50321377

Wt: 327.3
BDBM50321376
Wt: 357.4
BDBM50321378
Wt: 371.4
BDBM50321379
Wt: 396.2
BDBM50321380
Wt: 396.2
BDBM50321381

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50321376,50321378,50321379,50321380,50321381   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
3-phosphoinositide dependent protein kinase-1


(Homo sapiens (human))
BDBM50321376
PNG
(2-(2-oxo-3-(phenylthio)-2,3,4,5-tetrahydro-1H-benz...)
Show SMILES OC(=O)CN1c2ccccc2CCC(Sc2ccccc2)C1=O
Show InChI InChI=1S/C18H17NO3S/c20-17(21)12-19-15-9-5-4-6-13(15)10-11-16(18(19)22)23-14-7-2-1-3-8-14/h1-9,16H,10-12H2,(H,20,21)
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PubMed
n/an/an/an/a 1.01E+5n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Displacement of PIFtide from His-tagged PDK1 by HTRF assay


Bioorg Med Chem Lett 20: 3897-902 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.019
BindingDB Entry DOI: 10.7270/Q2Z60Q1H
More data for this
Ligand-Target Pair
3-phosphoinositide dependent protein kinase-1


(Homo sapiens (human))
BDBM50321378
PNG
(2-(3-(4-methoxyphenylthio)-2-oxo-2,3,4,5-tetrahydr...)
Show SMILES COc1ccc(SC2CCc3ccccc3N(CC(O)=O)C2=O)cc1
Show InChI InChI=1S/C19H19NO4S/c1-24-14-7-9-15(10-8-14)25-17-11-6-13-4-2-3-5-16(13)20(19(17)23)12-18(21)22/h2-5,7-10,17H,6,11-12H2,1H3,(H,21,22)
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n/an/an/an/a 5.30E+4n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Displacement of PIFtide from His-tagged PDK1 by HTRF assay


Bioorg Med Chem Lett 20: 3897-902 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.019
BindingDB Entry DOI: 10.7270/Q2Z60Q1H
More data for this
Ligand-Target Pair
3-phosphoinositide dependent protein kinase-1


(Homo sapiens (human))
BDBM50321381
PNG
(2-(3-(2,6-dichlorophenylthio)-2-oxo-2,3,4,5-tetrah...)
Show SMILES OC(=O)CN1c2ccccc2CCC(Sc2c(Cl)cccc2Cl)C1=O
Show InChI InChI=1S/C18H15Cl2NO3S/c19-12-5-3-6-13(20)17(12)25-15-9-8-11-4-1-2-7-14(11)21(18(15)24)10-16(22)23/h1-7,15H,8-10H2,(H,22,23)
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n/an/an/an/a 4.50E+4n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Displacement of PIFtide from His-tagged PDK1 by HTRF assay


Bioorg Med Chem Lett 20: 3897-902 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.019
BindingDB Entry DOI: 10.7270/Q2Z60Q1H
More data for this
Ligand-Target Pair
3-phosphoinositide dependent protein kinase-1


(Homo sapiens (human))
BDBM50321380
PNG
(4-(1-(carboxymethyl)-2-oxo-2,3,4,5-tetrahydro-1H-b...)
Show SMILES OC(=O)CN1c2ccccc2CCC(Sc2ccc(Cl)cc2Cl)C1=O
Show InChI InChI=1S/C18H15Cl2NO3S/c19-12-6-8-15(13(20)9-12)25-16-7-5-11-3-1-2-4-14(11)21(18(16)24)10-17(22)23/h1-4,6,8-9,16H,5,7,10H2,(H,22,23)
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n/an/an/an/a 7.50E+4n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Displacement of PIFtide from His-tagged PDK1 by HTRF assay


Bioorg Med Chem Lett 20: 3897-902 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.019
BindingDB Entry DOI: 10.7270/Q2Z60Q1H
More data for this
Ligand-Target Pair
3-phosphoinositide dependent protein kinase-1


(Homo sapiens (human))
BDBM50321379
PNG
(4-(1-(carboxymethyl)-2-oxo-2,3,4,5-tetrahydro-1H-b...)
Show SMILES OC(=O)CN1c2ccccc2CCC(Sc2ccc(cc2)C(O)=O)C1=O
Show InChI InChI=1S/C19H17NO5S/c21-17(22)11-20-15-4-2-1-3-12(15)7-10-16(18(20)23)26-14-8-5-13(6-9-14)19(24)25/h1-6,8-9,16H,7,10-11H2,(H,21,22)(H,24,25)
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n/an/an/an/a 1.87E+5n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Displacement of PIFtide from His-tagged PDK1 by HTRF assay


Bioorg Med Chem Lett 20: 3897-902 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.019
BindingDB Entry DOI: 10.7270/Q2Z60Q1H
More data for this
Ligand-Target Pair